Browse Items (28 total)
- Tags: Department of Anatomy & Neurobiology, 2017
Sucrose, But Not Glucose, Blocks IL1-beta-Induced Inflammatory Response in Human Chondrocytes by Inducing Autophagy via AKT/mTOR Pathway.
Tags: *AUTOPHAGY, *CHONDROCYTES, *OSTEOARTHRITIS, *SUCROSE, 2017, Adult, Aged, Ansari Mohammad Y, Autophagy/*drug effects, Chondrocytes/*metabolism/pathology, Department of Anatomy & Neurobiology, Female, Glucose/*pharmacology, Haqqi Tariq M, Humans, Inflammation/chemically induced/metabolism/pathology, Interleukin-1beta/*pharmacology, Journal of cellular biochemistry, Khan Nazir M, Male, Middle Aged, NEOMED College of Medicine, Osteoarthritis/*metabolism/pathology, Proto-Oncogene Proteins c-akt/*metabolism, Signal Transduction/*drug effects, Sucrose/*pharmacology, TOR Serine-Threonine Kinases/*metabolism
Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes.
Tags: *c-FOS/AP-1, *harpagoside, *IL-6, *MMP-13, *OSTEOARTHRITIS, 2017, Ansari Mohammad Yunus, CCAAT-Enhancer-Binding Protein-beta/metabolism, Chemokines/metabolism, Chondrocytes/*drug effects/metabolism, Department of Anatomy & Neurobiology, Drug Evaluation, Glycosides/pharmacology/*therapeutic use, Haqqi Tariq M, Harpagophytum, Haseeb Abdul, Humans, Interleukin-1beta, Interleukin-6/antagonists & inhibitors/*metabolism, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, Matrix Metalloproteinase 13/metabolism, NEOMED College of Medicine, NF-kappa B/metabolism, Osteoarthritis/*drug therapy/metabolism, Phytotherapy, Plant Extracts/pharmacology/therapeutic use, Preclinical, Primary Cell Culture, Proto-Oncogene Proteins c-fos/metabolism, Pyrans/pharmacology/*therapeutic use, Reactive Oxygen Species/metabolism, Transcription Factor AP-1/metabolism
A Polyphenol-rich Pomegranate Fruit Extract Suppresses NF-kappaB and IL-6 Expression by Blocking the Activation of IKKbeta and NIK in Primary Human Chondrocytes.
Tags: 2017, Ashruf Omer S, Chondrocytes, Chondrocytes – Drug Effects, Chondrocytes/drug effects, Department of Anatomy & Neurobiology, Fruit, Fruit/chemistry, Gene Expression Regulation/drug effects, Genes – Drug Effects, Haqqi Tariq M, Haseeb Abdul, Humans, I-kappa B Kinase/genetics/*metabolism, IkappaB, IKKbeta, IL-1beta, Interleukin 1 – Metabolism, Interleukin-1beta/metabolism, Interleukin-6/genetics/*metabolism, Interleukins, Interleukins – Metabolism, Khan Nazir M, NEOMED College of Medicine, NF-kappa B, NF-kappa B – Metabolism, NF-kappa B/genetics/*metabolism, NF-kappaB, NIK, Osteoarthritis, Phosphorylation – Drug Effects, Phosphorylation/drug effects, Phytotherapy research : PTR, Plant Extracts, Plant Extracts – Pharmacodynamics, Plant Extracts/chemistry/*pharmacology, Polyphenols – Pharmacodynamics, Polyphenols/pharmacology, Pomegranate, Protein-Serine-Threonine Kinases/genetics/*metabolism, Proteins – Metabolism, Punicaceae/*chemistry, Signal Transduction – Drug Effects, Signal Transduction/drug effects, Transcription Factor RelA/metabolism, Transferases, Transferases – Metabolism
Beyond thermoregulation: metabolic function of cetacean blubber in migrating bowhead and beluga whales.
Tags: *Lipid Metabolism, 2017, Adipose Tissue/*metabolism, Aging/metabolism, Amino Acid Sequence, Animals, Ball H C, Base Sequence, Beluga Whale/*physiology, Blubber, Body Temperature Regulation, bowhead whale, Bowhead Whale/*physiology, Department of Anatomy & Neurobiology, Department of Family & Community Medicine, development, Duff R J, Female, George John C, Humans, Inbred C57BL, Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, leptin, Leptin/genetics, Leptin/genetics/metabolism, Lipase/genetics, Londraville R L, Long-Evans, Male, Metabolic activity, Mice, NEOMED College of Medicine, Prokop J W, Rats, Receptors, Seasons, Suydam R S, Thewissen J G M, Vinyard C
Pre-pharyngeal Swallow Effects of Recurrent Laryngeal Nerve Lesion on Bolus Shape and Airway Protection in an Infant Pig Model.
Tags: *Aspiration, *Deglutition, *Deglutition disorders, *Infant, *Oro-pharyngeal pathophysiology, *Recurrent laryngeal nerve, 2017, Animal Studies, Animals, Aspiration – Etiology, Aspiration/etiology, Deglutition – Physiology, Deglutition Disorders – Etiology, Deglutition Disorders – Physiopathology, Deglutition Disorders/*etiology/physiopathology, Deglutition/physiology, Department of Anatomy & Neurobiology, Dysphagia, German R Z, Gould Francois D H, Laryngeal Nerve Injuries/*complications, Laryngeal Nerves – Injuries, NEOMED College of Medicine, Newborn, Ohlemacher J, Pneumonia, Swine, Yglesias B
Animal Models for Dysphagia Studies: What Have We Learnt So Far.
Tags: *Animal models, *Deglutition, *Deglutition disorders, *Disease Models, *Pathophysiology, *Performance, 2017, Animal, Animals, Biological, Biomedical Research/*methods, Crompton A W, Deglutition – Physiology, Deglutition Disorders – Physiopathology, Deglutition Disorders/*physiopathology, Deglutition/physiology, Department of Anatomy & Neurobiology, Dysphagia, German Rebecca Z, Gould Francois D H, Humans, Medical – Methods, Models, NEOMED College of Medicine, Research, Thexton Allan J
Long-Lasting forward Suppression of Spontaneous Firing in Auditory Neurons: Implication to the Residual Inhibition of Tinnitus.
Tags: 2017, Acoustic trauma, Animals, Brain Stem – Physiology, Clinical Assessment Tools, Cochlear Nerve – Physiology, Cochlear Nerve/*physiology, Department of Anatomy & Neurobiology, Galazyuk A V, Inbred CBA, Inferior Colliculi/*physiology, inferior colliculus, Journal of the Association for Research in Otolaryngology : JARO, Longenecker R J, Male, Mice, NEOMED College of Medicine, residual inhibition, Sound, Tinnitus – Physiopathology, Tinnitus/*physiopathology, Voytenko S V
An effective and efficient method of transfecting primary human chondrocytes in suspension.
Tags: *CHONDROCYTES, *OSTEOARTHRITIS, *siRNA, *Transfection, 2017, Aggrecans/genetics, Akhtar Nahid, Analytical biochemistry, Articular/metabolism/pathology, Cartilage, Cells, Chondrocytes/cytology/*metabolism, Collagen Type II/genetics, Cultured, Department of Anatomy & Neurobiology, Haqqi Tariq M, Humans, Makki Mohammad Shahidul, Messenger/*genetics, mRNA Cleavage and Polyadenylation Factors/antagonists & inhibitors/genetics, NEOMED College of Medicine, Nucleotidyltransferases/antagonists & inhibitors/genetics, Plasmids/*genetics, RNA, Small Interfering/*genetics, Transfection/*methods
A standardized extract of Butea monosperma (Lam.) flowers suppresses the
Tags: *Butea, 2017, Aged, Ansari Mohammad Y, Autophagy, Autophagy/drug effects/physiology, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Butea monosperma (Lam.), Chondrocytes/drug effects/*metabolism, Department of Anatomy & Neurobiology, Dose-Response Relationship, Drug, Flowers, Gene Expression, Haqqi Tariq M, Humans, Interleukin-1beta/*pharmacology, Interleukin-6/*biosynthesis/genetics, Khan Nazir M, Matrix Metalloproteinase 13/biosynthesis/genetics, Matrix Metalloproteinase 3/biosynthesis/genetics, Matrix Metalloproteinase 9/biosynthesis/genetics, Matrix Metalloproteinases/*biosynthesis/genetics, Middle Aged, mTOR, NEOMED College of Medicine, Nutraceuticals, Osteoarthritis, Osteoarthritis/*metabolism, Plant Extracts/isolation & purification/pharmacology
Wogonin, a natural flavonoid, intercalates with genomic DNA and exhibits protective effects in IL-1beta stimulated osteoarthritis chondrocytes.
Tags: 2017, Ahmad Imran, Ansari Mohammad Y, Apoptosis/drug effects, Binding Sites, Cells, Chemico-biological interactions, Chondrocytes/cytology/*drug effects/metabolism, Chondroprotective effects, Cultured, Denaturation, Department of Anatomy & Neurobiology, DNA binding, DNA/chemistry/*metabolism, Flavanones/chemistry/metabolism/*pharmacology, Flavonoids/chemistry/pharmacology, Fluorescence Resonance Energy Transfer, Haqqi Tariq M, Humans, Intercalating Agents/chemistry/metabolism/*pharmacology, Interleukin-1beta/*pharmacology, Khan Nazir M, Molecular Docking Simulation, NEOMED College of Medicine, Nucleic Acid Conformation, Osteoarthritis, Osteoarthritis/metabolism/pathology, Protective Agents/chemistry/metabolism/*pharmacology, Reactive Oxygen Species/metabolism, Up-Regulation/drug effects, Wogonin
Dataset of effect of Wogonin, a natural flavonoid, on the viability and activation of NF-kappaB and MAPKs in IL-1beta-stimulated human OA chondrocytes.
Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes.
Tags: *ERK1/2, *Nrf2, *OSTEOARTHRITIS, *Redox, *Wogonin, 2017, Ansari Mohammad Y, Anti-Inflammatory Agents/administration & dosage, Chondrocytes/drug effects/pathology, Department of Anatomy & Neurobiology, Devarapalli Pratap, Flavanones/*administration & dosage, Free radical biology & medicine, Gene Expression Regulation/drug effects, Haqqi Tariq M, Haseeb Abdul, Haynie Sara, Humans, Inflammation/*drug therapy/metabolism/pathology, Kelch-Like ECH-Associated Protein 1/chemistry/*genetics/metabolism, Khan Nazir M, MAP Kinase Signaling System/drug effects, Molecular Docking Simulation, NEOMED College of Medicine, NF-E2-Related Factor 2/antagonists & inhibitors/chemistry/*genetics/metabolism, Osteoarthritis/*drug therapy/metabolism/pathology, Protein Binding, Reactive Oxygen Species/metabolism, Signal Transduction/drug effects
Noise-induced cochlear synaptopathy: Past findings and future studies.
Tags: *Auditory Perception, *Hearing, *Hearing loss, *Molecular approach, *Preclinical model, *Spiral ganglion, *Synaptic loss, *Synaptic Transmission, 2017, Animals, Auditory, Bao Jianxin, Department of Anatomy & Neurobiology, Hair Cells, Hawks John W, Hearing Loss, Hearing research, Hearing Tests, Humans, Inner/*pathology, Kobel Megan, Le Prell Colleen G, Liu Jennifer, NEOMED College of Medicine, Noise-Induced/diagnosis/*pathology/physiopathology/psychology, Noise/*adverse effects, Predictive Value of Tests, Psychoacoustics, Spiral Ganglion/*pathology/physiopathology, Synapses/*pathology
Metabotropic glutamate and GABA receptors modulate cellular excitability and glutamatergic transmission in chicken cochlear nucleus angularis neurons.
Tags: *Cellular excitability, *GABA(B)R, *mGluR, *Neuromodulation, *Nucleus angularis, *Synaptic Transmission, 2017, Action Potentials/drug effects, Animals, Chick Embryo, Cochlear Nucleus/cytology/*physiology, Department of Anatomy & Neurobiology, Excitatory Postsynaptic Potentials/drug effects, GABA-B Receptor Agonists/pharmacology, GABA-B/*physiology, Glutamic Acid/*physiology, Hearing research, Lu Yong, Metabotropic Glutamate/agonists/classification/*physiology, NEOMED College of Medicine, Neurons/drug effects/physiology, Patch-Clamp Techniques, Receptors, Shi Wei, Synaptic Transmission/drug effects
An operant-based detection method for inferring tinnitus in mice.
Tags: *Conditioning, *Disease Models, *Inferior colliculus, *Mouse model, *Noise-induced hearing loss, *Operant conditioning, *Sodium salicylate, *Tinnitus, 2017, Acoustic Stimulation, Analysis of Variance, Animal, Animals, Auditory, Avoidance Learning, Bao Jianxin, Brain Stem/physiology, Department of Anatomy & Neurobiology, Electroshock, Equipment Design, Evoked Potentials, Female, Howie Benjamin, Inbred C57BL, Inferior Colliculi/physiopathology, Journal of neuroscience methods, Lei Debin, Male, Mice, Motor Activity, Mulvany Jessica, NEOMED College of Medicine, Neurons/physiology, Operant, Otoacoustic Emissions, Sivaramakrishnan Shobhana, Sodium Salicylate, Spontaneous/physiology, Tinnitus/*diagnosis/physiopathology, Tissue Culture Techniques, Voltage-Sensitive Dye Imaging, Zuo Hongyan
Inhibition of cartilage degradation and suppression of PGE2 and MMPs expression by pomegranate fruit extract in a model of posttraumatic osteoarthritis.
Tags: *Phytotherapy, *Punicaceae, 2017, ACLT, Akhtar Nahid, Animal, Animals, Anterior Cruciate Ligament/drug effects/metabolism/pathology, Apoptosis, Ashruf Omer S, Cartilage/cytology/*drug effects/metabolism/pathology, Chondrocytes/drug effects/metabolism/pathology, Collagen Type II/genetics/metabolism, Department of Anatomy & Neurobiology, Dinoprostone/*metabolism, Disease Models, Disease Progression, Female, Fruit, Haqqi Tariq M, Interleukins/metabolism, Joints/cytology/*drug effects/metabolism/pathology, Khan Nazir M, Male, Messenger/metabolism, Metalloproteases/genetics/*metabolism, Mitogen-Activated Protein Kinases/metabolism, MMPs, NEOMED College of Medicine, NF-kappa B/metabolism, Nutrition (Burbank, Los Angeles County, Calif.), Osteoarthritis, Osteoarthritis/*drug therapy/etiology/metabolism/pathology, PGE(2), Plant Extracts/pharmacology/therapeutic use, Pomegranate, Rabbit, Rabbits, RNA, Synovial Fluid/metabolism
Deep sequencing and analyses of miRNAs, isomiRs and miRNA induced silencing complex (miRISC)-associated miRNome in primary human chondrocytes.
A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1beta-induced activation of AP-1 in human OA chondrocytes.
Tags: 2017, Ansari Mohammad Y, Cells, Chemical Fractionation/methods, Chondrocytes/*drug effects/metabolism, Cultured, Cyclooxygenase 2/genetics/metabolism, Department of Anatomy & Neurobiology, Flavanones/*pharmacology, Gene Expression Regulation/drug effects, Haqqi Tariq M, Haseeb Abdul, Humans, Interleukin-1beta/pharmacology, Interleukin-6/genetics/metabolism, Khan Nazir M, NEOMED College of Medicine, Osteoarthritis/pathology, Plant Extracts/*pharmacology, Plant Roots/*chemistry, Protective Agents/pharmacology, Reactive Oxygen Species/metabolism, Scientific reports, Scutellaria baicalensis/*chemistry, Transcription Factor AP-1/genetics/*metabolism
Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1beta-induced IL-6 expression in human OA chondrocytes.
Tags: *IL-6, *MCPIP1, *miRNA, *OSTEOARTHRITIS, *Vorinostat, 2017, Adult, Aged, CCAAT-Enhancer-Binding Proteins/genetics/metabolism, Cells, Chondrocytes/*metabolism/pathology, Connective tissue research, Cultured, Department of Anatomy & Neurobiology, Female, Gene Expression Regulation/*drug effects, Genetic, Haqqi Tariq M, Humans, Hydroxamic Acids/*pharmacology, Interleukin-1beta/genetics/*metabolism, Interleukin-6/genetics/*metabolism, Makki Mohammad S, Male, MicroRNAs/genetics/*metabolism, Middle Aged, NEOMED College of Medicine, Osteoarthritis/drug therapy/genetics/*metabolism/pathology, Promoter Regions, Ribonucleases/*biosynthesis/genetics, Transcription Factors/*biosynthesis/genetics, Vorinostat
Surprising absence of heparin in the intestinal mucosa of baby pigs.
Tags: *Antibiotics, *heparin, *intestine, *microbiome, *pig, 2017, Animals, Anticoagulants/*metabolism, Chen Yin, Chondroitin Sulfates/metabolism, Department of Anatomy & Neurobiology, German Rebecca, Glycobiology, Gould Francois, Heparin/biosynthesis/isolation & purification/*metabolism, Heparitin Sulfate/metabolism, Intestinal Mucosa/*metabolism, Linhardt Robert J, Mast Cells/metabolism, Mikael Paiyz, NEOMED College of Medicine, Newborn/*metabolism, Ohlemacher Jocelyn, Stalcup Apryll M, Swine, Yu Yanlei, Zhang Fuming, Zhang Hong
Evolutionary aspects of the development of teeth and baleen in the bowhead whale.
Tags: *Biological Evolution, 2017, Animals, baleen, baleen whales, bowhead whale, Bowhead Whale/anatomy & histology/*embryology, Cetacea, Dentition, Department of Anatomy & Neurobiology, embryology, Female, FGF, George John C, Hieronymus Tobin L, Jaw/anatomy & histology/embryology, Journal of anatomy, keratin, McBurney Denise, Mixed, Mouth/anatomy & histology/*embryology, mysticetes, NEOMED College of Medicine, ontogeny, Pregnancy, Stimmelmayr Raphaela, Suydam Robert, Thewissen J G M, tooth development, Tooth/anatomy & histology/*embryology
Brief Stimulus Exposure Fully Remediates Temporal Processing Deficits Induced by Early Hearing Loss.
Tags: *auditory cortex, *Development, *gap detection, *Hearing loss, *remediation, *temporal coding, 2017, Acoustic Stimulation/*methods, Age Factors, Animals, Auditory, Auditory Cortex/*physiology/*physiopathology, Auditory Perception/*physiology, Brain Stem/*physiology, Department of Anatomy & Neurobiology, Evoked Potentials, Female, Gay Jennifer D, Gerbillinae, Green David B, Hearing Loss/*physiopathology, Male, Mattingly Michelle M, NEOMED College of Medicine, Rosen Merri J, The Journal of neuroscience : the official journal of the Society for Neuroscience, Ye Yi
Identification of Novel Agents for the Treatment of Brain Metastases of Breast Cancer.
Tags: 2017, ADME, Animals, Antineoplastic Agents/*therapeutic use, Apoptosis, Brain cancer, Brain Neoplasms/*drug therapy/pathology/*secondary, Breast Neoplasms/*pathology, Cell Line, Chemotherapy, CNS, Current cancer drug targets, Department of Anatomy & Neurobiology, distribution, Drug Discovery, Drug Resistance, Female, Geldenhuys Werner J, Griffith Jessica I G, Humans, Lockman Paul R, Mice, NEOMED College of Medicine, Safadi Fayez F, Sondag Gregory R, Terell-Hall Tori B, Tumor, Venishetty Vinay K