1
40
40
-
Text
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<a href="http://doi.org/10.3892/ijmm.2018.3889" target="_blank" rel="noreferrer noopener">http://doi.org/10.3892/ijmm.2018.3889</a>
Pages
2991–2997
Issue
6
Volume
42
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Title
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TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review).
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International journal of molecular medicine
Date
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2018
2018-12
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Mbimba Thomas; Hussein Nazar J; Najeed Ayesha; Safadi Fayez F
Description
An account of the resource
Trafficking protein particle complex 9 (TRAPPC9) is a protein subunit of the transport protein particle II (TRAPPII), which has been reported to be important in the trafficking of cargo from the endoplasmic reticulum (ER) to the Golgi, and in intraGolgi and endosometoGolgi transport in yeast cells. In mammalian cells, TRAPPII has been shown to be important in Golgi vesicle tethering and intraGolgi transport. TRAPPC9 is considered to be a novel molecule capable of modulating the activation of nuclear factorkappaB (NFkappaB). Mutations in TRAPPC9 have been linked to a rare consanguineous hereditary form of mental retardation, as part of the NFkappaB pathways. In addition, TRAPPC9 has been reported to be involved in breast and colon cancer and liver diseases. The present review highlights the most recent publications on the structure, expression and function of TRAPPC9, and its association with various human diseases.
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<a href="http://doi.org/10.3892/ijmm.2018.3889" target="_blank" rel="noreferrer noopener">10.3892/ijmm.2018.3889</a>
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2018
Department of Anatomy & Neurobiology
Hussein Nazar J
International journal of molecular medicine
Mbimba Thomas
Najeed Ayesha
NEOMED College of Medicine
Safadi Fayez F
-
Text
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<a href="http://doi.org/10.1523/JNEUROSCI.0665-18.2018" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.0665-18.2018</a>
Pages
6445–6460
Issue
29
Volume
38
Dublin Core
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Postsynaptic FMRP Regulates Synaptogenesis In Vivo in the Developing Cochlear Nucleus.
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The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-07
Subject
The topic of the resource
auditory processing; dendritic maturation; endbulb synapse; fragile X mental retardation protein; trans-synaptic regulation
Creator
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Wang Xiaoyu; Zorio Diego A R; Schecterson Leslayann; Lu Yong; Wang Yuan
Description
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A global loss of the fragile X mental retardation protein (FMRP; encoded by the Fmr1 gene) leads to sensory dysfunction and intellectual disabilities. One underlying mechanism of these phenotypes is structural and functional deficits in synapses. Here, we determined the autonomous function of postsynaptic FMRP in circuit formation, synaptogenesis, and synaptic maturation. In normal cochlea nucleus, presynaptic auditory axons form large axosomatic endbulb synapses on cell bodies of postsynaptic bushy neurons. In ovo electroporation of drug-inducible Fmr1-shRNA constructs produced a mosaicism of FMRP expression in chicken (either sex) bushy neurons, leading to reduced FMRP levels in transfected, but not neighboring nontransfected, neurons. Structural analyses revealed that postsynaptic FMRP reduction led to smaller size and abnormal morphology of individual presynaptic endbulbs at both early and later developmental stages. We further examined whether FMRP reduction affects dendritic development, as a potential mechanism underlying defective endbulb formation. Normally, chicken bushy neurons grow extensive dendrites at early stages and retract these dendrites when endbulbs begin to form. Neurons transfected with Fmr1 shRNA exhibited a remarkable delay in branch retraction, failing to provide necessary somatic surface for timely formation and growth of large endbulbs. Patch-clamp recording verified functional consequences of dendritic and synaptic deficits on neurotransmission, showing smaller amplitudes and slower kinetics of spontaneous and evoked EPSCs. Together, these data demonstrate that proper levels of postsynaptic FMRP are required for timely maturation of somatodendritic morphology, a delay of which may affect synaptogenesis and thus contribute to long-lasting deficits of excitatory synapses.SIGNIFICANCE STATEMENT Fragile X mental retardation protein (FMRP) regulates a large variety of neuronal activities. A global loss of FMRP affects neural circuit development and synaptic function, leading to fragile X syndrome (FXS). Using temporally and spatially controlled genetic manipulations, this study provides the first in vivo report that autonomous FMRP regulates multiple stages of dendritic development, and that selective reduction of postsynaptic FMRP leads to abnormal development of excitatory presynaptic terminals and compromised neurotransmission. These observations demonstrate secondary influence of developmentally transient deficits in neuronal morphology and connectivity to the development of long-lasting synaptic pathology in FXS.
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<a href="http://doi.org/10.1523/JNEUROSCI.0665-18.2018" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.0665-18.2018</a>
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2018
auditory processing
dendritic maturation
Department of Anatomy & Neurobiology
endbulb synapse
fragile X mental retardation protein
Lu Yong
NEOMED College of Medicine
Schecterson Leslayann
The Journal of neuroscience : the official journal of the Society for Neuroscience
trans-synaptic regulation
Wang Xiaoyu
Wang Yuan
Zorio Diego A R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.0603-18.2018" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.0603-18.2018</a>
Pages
8187–8199
Issue
38
Volume
38
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Title
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Neurotransmitter- and Release-Mode-Specific Modulation of Inhibitory Transmission by Group I Metabotropic Glutamate Receptors in Central Auditory Neurons of the Mouse.
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The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-09
Subject
The topic of the resource
GABA; glycine; IPSC; mGluR; MNTB; neuromodulation
Creator
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Curry Rebecca J; Peng Kang; Lu Yong
Description
An account of the resource
Neuromodulation mediated by metabotropic glutamate receptors (mGluRs) regulates many brain functions. However, the functions of mGluRs in the auditory system under normal and diseased states are not well understood. The medial nucleus of the trapezoid body (MNTB) is a critical nucleus in the auditory brainstem nuclei involved in sound localization. In addition to the classical calyx excitatory inputs, MNTB neurons also receive synaptic inhibition and it remains entirely unknown how this inhibition is regulated. Here, using whole-cell voltage clamp in brain slices, we investigated group I mGluR (mGluR I)-mediated modulation of the glycinergic and GABAergic inputs to MNTB neurons in both WT mice and a fragile X syndrome (FXS) mouse model (both sexes) in which the fragile X mental retardation gene 1 is knocked out (Fmr1 KO), causing exaggerated activity of mGluR I and behavioral phenotypes. Activation of mGluR I by (RS)-3,5-dihydroxyphenylglycine (3,5-DHPG) increased the frequency and amplitude of glycinergic spontaneous IPSCs (sIPSCs) in both WT and Fmr1 KO neurons in a voltage-gated sodium channel-dependent fashion, but did not modulate glycinergic evoked IPSCs (eIPSCs). In contrast, 3,5-DHPG did not affect GABAergic sIPSCs, but did suppress eIPSCs in WT neurons via endocannabinoid signaling. In the KO, the effect of 3,5-DHPG on GABAergic eIPSCs was highly variable, which supports the notion of impaired GABAergic signaling in the FXS model. The differential modulation of sIPSC and eIPSC and differential modulation of glycinergic and GABAergic transmission suggest distinct mechanisms responsible for spontaneous and evoked release of inhibitory transmitters and their modulation through the mGluR I signaling pathway.SIGNIFICANCE STATEMENT Neurons communicate with each other through the release of neurotransmitters, which assumes two basic modes, spontaneous and evoked release. These two release modes are believed to function using the same vesicle pool and machinery. Recent works have challenged this dogma, pointing to distinct vesicle release mechanisms underlying the two release modes. Here, we provide the first evidence in the central auditory system supporting this novel concept. We discovered neural-transmitter- and release-mode-specific neuromodulation of inhibitory transmission by metabotropic glutamate receptors and revealed part of the signaling pathways underlying this differential modulation. The results establish the foundation for a multitude of directions to study physiological significance of different release modes in auditory processing.
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<a href="http://doi.org/10.1523/JNEUROSCI.0603-18.2018" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.0603-18.2018</a>
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2018
Curry Rebecca J
Department of Anatomy & Neurobiology
GABA
glycine
IPSC
Lu Yong
mGluR
MNTB
NEOMED College of Medicine
neuromodulation
Peng Kang
The Journal of neuroscience : the official journal of the Society for Neuroscience
-
Text
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URL Address
<a href="http://doi.org/10.1523/ENEURO.0406-18.2018" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/ENEURO.0406-18.2018</a>
Issue
5
Volume
5
Dublin Core
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Title
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Inhibitory Projections from the Inferior Colliculus to the Medial Geniculate body Originate from Four Subtypes of GABAergic Cells.
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eNeuro
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-10
Subject
The topic of the resource
*GABA; *perineuronal net; *soma size; *tectothalamic; *thalamus; *VGLUT2
Creator
An entity primarily responsible for making the resource
Beebe N L; Mellott J G; Schofield B R
Description
An account of the resource
GABAergic cells constitute 20-40% of the cells that project from the inferior colliculus [(IC) a midbrain auditory hub] to the medial geniculate body [(MG) the main auditory nucleus of the thalamus]. Four subtypes of GABAergic IC cells have been identified based on their association with perineuronal nets (PNs) and dense rings of axosomatic terminals expressing vesicular glutamate transporter 2 (VGLUT2 rings). These subtypes differ in their soma size and distribution within the IC. Based on previous work emphasizing large GABAergic cells as the origin of GABAergic IC-MG projections, we hypothesized that GABAergic IC cells surrounded by PNs and VGLUT2 rings, which tend to have larger somas, were more likely to project to the MG than smaller cells lacking these extracellular markers. Here, we injected retrograde tract tracers into the MG of guinea pigs of either sex and analyzed retrogradely labeled GABAergic cells in the ipsilateral IC for soma size and association with PNs and/or VGLUT2 rings. We found a range of GABAergic soma sizes present within the IC-MG pathway, which were reflective of the full range of GABAergic soma sizes present within the IC. Further, we found that all four subtypes of GABAergic IC cells participate in the IC-MG pathway, and that GABAergic cells lacking PNs and VGLUT2 rings were more prevalent within the pathway than would be expected based on their overall prevalence in the IC. These results may provide an anatomical substrate for the multiple roles of inhibition in the IC-MG pathway, which have emerged in electrophysiological studies.
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<a href="http://doi.org/10.1523/ENEURO.0406-18.2018" target="_blank" rel="noreferrer noopener">10.1523/ENEURO.0406-18.2018</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*GABA
*perineuronal net
*soma size
*tectothalamic
*thalamus
*VGLUT2
2018
Beebe N L
Department of Anatomy & Neurobiology
eNeuro
Mellott J G
NEOMED College of Medicine
Schofield B R
-
Text
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<a href="http://doi.org/10.1371/journal.pone.0206314" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0206314</a>
Pages
e0206314–e0206314
Issue
11
Volume
13
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Title
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First record of the Miocene hominoid Sivapithecus from Kutch, Gujarat state, western India.
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PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-7
Creator
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Bhandari Ansuya; Kay Richard F; Williams Blythe A; Tiwari Brahma Nand; Bajpai Sunil; Hieronymus Tobin
Description
An account of the resource
Hominoid remains from Miocene deposits in India and Pakistan have played a pivotal role in understanding the evolution of great apes and humans since they were first described in the 19th Century. We describe here a hominoid maxillary fragment preserving the canine and cheek teeth collected in 2011 from the Kutch (= Kachchh) basin in the Kutch district, Gujarat state, western India. A basal Late Miocene age is proposed based on the associated faunal assemblage that includes Hipparion and other age-diagnostic mammalian taxa. Miocene Hominoidea are known previously from several areas of the Siwalik Group in the outer western Himalayas of India, Pakistan, and Nepal. This is the first record of a hominoid from the Neogene of the Kutch Basin and represents a significant southern range extension of Miocene hominoids in the Indian peninsula. The specimen is assigned to the Genus Sivapithecus, species unspecified.
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<a href="http://doi.org/10.1371/journal.pone.0206314" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0206314</a>
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2018
Bajpai Sunil
Bhandari Ansuya
Department of Anatomy & Neurobiology
Hieronymus Tobin
Kay Richard F
NEOMED College of Medicine
PloS one
Tiwari Brahma Nand
Williams Blythe A
-
Text
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<a href="http://doi.org/10.1371/journal.pone.0196154" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0196154</a>
Pages
e0196154–e0196154
Issue
5
Volume
13
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Title
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Comparative metabolomics of aging in a long-lived bat: Insights into the physiology of extreme longevity.
Publisher
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PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-7
Subject
The topic of the resource
Animals; *Metabolomics; Chiroptera/*physiology; Feces/*chemistry; Longevity/*physiology
Creator
An entity primarily responsible for making the resource
Ball Hope C; Levari-Shariati Shiva; Cooper Lisa Noelle; Aliani Michel
Description
An account of the resource
Vespertilionid bats (Mammalia: Order Chiroptera) live 3-10 times longer than other mammals of an equivalent body size. At present, nothing is known of how bat fecal metabolic profiles shift with age in any taxa. This study established the feasibility of using a non-invasive, fecal metabolomics approach to examine age-related differences in the fecal metabolome of young and elderly adult big brown bats (Eptesicus fuscus) as an initial investigation into using metabolomics for age determination. Samples were collected from captive, known-aged big brown bats (Eptesicus fuscus) from 1 to over 14 years of age: these two ages represent age groups separated by approximately 75% of the known natural lifespan of this taxon. Results showed 41 metabolites differentiated young (n = 22) and elderly (n = 6) Eptesicus. Significant differences in metabolites between young and elderly bats were associated with tryptophan metabolism and incomplete protein digestion. Results support further exploration of the physiological mechanisms bats employ to achieve exceptional longevity.
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<a href="http://doi.org/10.1371/journal.pone.0196154" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0196154</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Metabolomics
2018
Aliani Michel
Animals
Ball Hope C
Chiroptera/*physiology
Cooper Lisa Noelle
Department of Anatomy & Neurobiology
Feces/*chemistry
Levari-Shariati Shiva
Longevity/*physiology
NEOMED College of Medicine
PloS one
-
Text
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URL Address
<a href="http://doi.org/10.1371/journal.pone.0190498" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0190498</a>
Pages
e0190498–e0190498
Issue
1
Volume
13
Dublin Core
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Title
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Validation of Growth Layer Group (GLG) depositional rate using daily incremental growth lines in the dentin of beluga (Delphinapterus leucas (Pallas, 1776)) teeth.
Publisher
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PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-07
Subject
The topic of the resource
Animals; *Beluga Whale; Dentin/*growth & development; Tooth/*growth & development
Creator
An entity primarily responsible for making the resource
Waugh David A; Suydam Robert S; Ortiz Joseph D; Thewissen J G M
Description
An account of the resource
Counts of Growth Layer Groups (GLGs) in the dentin of marine mammal teeth are widely used as indicators of age. In most marine mammals, observations document that GLGs are deposited yearly, but in beluga whales, some studies have supported the view that two GLGs are deposited each year. Our understanding of beluga life-history differs substantially depending on assumptions regarding the timing of GLG deposition; therefore, resolving this issue has important considerations for population assessments. In this study, we used incremental lines that represent daily pulses of dentin mineralization to test the hypothesis that GLGs in beluga dentin are deposited on a yearly basis. Our estimate of the number of daily growth lines within one GLG is remarkably close to 365 days within error, supporting the hypothesis that GLGs are deposited annually in beluga. We show that measurement of daily growth increments can be used to validate the time represented by GLGs in beluga. Furthermore, we believe this methodology may have broader applications to age estimation in other taxa.
Identifier
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<a href="http://doi.org/10.1371/journal.pone.0190498" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0190498</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Beluga Whale
2018
Animals
Dentin/*growth & development
Department of Anatomy & Neurobiology
NEOMED College of Medicine
Ortiz Joseph D
PloS one
Suydam Robert S
Thewissen J G M
Tooth/*growth & development
Waugh David A
-
Text
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URL Address
<a href="http://doi.org/10.1186/s12974-018-1100-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1186/s12974-018-1100-1</a>
Pages
73–73
Issue
1
Volume
15
Dublin Core
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Title
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The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor.
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Journal of neuroinflammation
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-03
Subject
The topic of the resource
Astrocyte; CD44; GPNMB; Neuroinflammation; Parkinson's disease
Creator
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Neal Matthew L; Boyle Alexa M; Budge Kevin M; Safadi Fayez F; Richardson Jason R
Description
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BACKGROUND: Neuroinflammation is one of the hallmarks of neurodegenerative diseases, such as Parkinson's disease (PD). Activation of glial cells, including microglia and astrocytes, is a characteristic of the inflammatory response. Glycoprotein non-metastatic melanoma protein B (GPNMB) is a transmembrane glycoprotein that releases a soluble signaling peptide when cleaved by ADAM10 or other extracellular proteases. GPNMB has demonstrated a neuroprotective role in animal models of ALS and ischemia. However, the mechanism of this protection has not been well established. CD44 is a receptor expressed on astrocytes that can bind GPNMB, and CD44 activation has been demonstrated to reduce NFkappaB activation and subsequent inflammatory responses in macrophages. GPNMB signaling has not been investigated in models of PD or specifically in astrocytes. More recently, genetic studies have linked polymorphisms in GPNMB with risk for PD. Therefore, it is important to understand the role this signaling protein plays in PD. METHODS: We used data mining techniques to evaluate mRNA expression of GPNMB and its receptor CD44 in the substantia nigra of PD and control brains. Immunofluorescence and qPCR techniques were used to assess GPNMB and CD44 levels in mice treated with MPTP. In vitro experiments utilized the immortalized mouse astrocyte cell line IMA2.1 and purified primary mouse astrocytes. The effects of recombinant GPNMB on cytokine-induced astrocyte activation was determined by qPCR, immunofluorescence, and measurement of nitric oxide and reactive oxygen production. RESULTS: Increased GPNMB and CD44 expression was observed in the substantia nigra of human PD brains and in GFAP-positive astrocytes in an animal model of PD. GPNMB treatment attenuated cytokine-induced levels of inducible nitric oxide synthase, nitric oxide, reactive oxygen species, and the inflammatory cytokine IL-6 in an astrocyte cell line and primary mouse astrocytes. Using primary mouse astrocytes from CD44 knockout mice, we found that the anti-inflammatory effects of GPNMB are CD44-mediated. CONCLUSIONS: These results demonstrate that GPNMB may exert its neuroprotective effect through reducing astrocyte-mediated neuroinflammation in a CD44-dependent manner, providing novel mechanistic insight into the neuroprotective properties of GPNMB.
Identifier
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<a href="http://doi.org/10.1186/s12974-018-1100-1" target="_blank" rel="noreferrer noopener">10.1186/s12974-018-1100-1</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Astrocyte
Boyle Alexa M
Budge Kevin M
CD44
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
GPNMB
Journal of neuroinflammation
Neal Matthew L
NEOMED College of Medicine
NEOMED College of Pharmacy
Neuroinflammation
Parkinson's disease
Richardson Jason R
Safadi Fayez F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000493225" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000493225</a>
Pages
932–946
Issue
3
Volume
49
Dublin Core
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Title
A name given to the resource
Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1beta Stimulated Human Chondrocytes.
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018
Subject
The topic of the resource
AMP-Activated Protein Kinases/metabolism; AMPK; Articular/cytology/pathology; Autophagy; Autophagy-Related Protein 5/antagonists & inhibitors/genetics/metabolism; Autophagy-Related Protein-1 Homolog/metabolism; Autophagy/*drug effects; Butein; Cartilage; Cell Survival/drug effects; Cells; Chalcones/*pharmacology; Chondrocytes/cytology/drug effects/metabolism; Cultured; Humans; Inflammation; Interleukin-1beta/*pharmacology; Interleukin-6/genetics/*metabolism; Intracellular Signaling Peptides and Proteins/metabolism; mTOR; Osteoarthritis; Osteoarthritis/metabolism/pathology; Phosphorylation/drug effects; Reactive Oxygen Species/metabolism; RNA; RNA Interference; Signal Transduction/*drug effects; Small Interfering/metabolism; TOR Serine-Threonine Kinases/metabolism; TSC2; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins/metabolism; ULK1
Creator
An entity primarily responsible for making the resource
Ansari Mohammad Y; Ahmad Nashrah; Haqqi Tariq M
Description
An account of the resource
BACKGROUND/AIMS: Butein (2',3,4,4'-Tetrahydroxychalcone), a polyphenol produced by several plants including Butea monoserpma, has been reported to exert potent anti-inflammatory activity but the mechanism remains unknown. In the present work we investigated the mechanism of Butein-mediated suppression of IL-6 expression in normal and human osteoarthritis (OA) chondrocytes under pathological conditions. METHODS: Expression level of interleukin-6 (IL-6) protein in OA cartilage was analyzed by immunohistochemistry using a validated antibody. Chondrocytes derived from normal or OA cartilage by enzymatic digestion were pretreated with Butein followed by stimulation with interleukin-1beta (IL-1beta) and the levels of IL-6 mRNA were quantified by TaqMan assay and the protein levels were measured by Western immunoblotting. Autophagy activation was determined by Western blotting and confocal microscopy. Autophagy was inhibited by siRNA mediated knockdown of ATG5. RESULTS: Expression of IL-6 protein was high in the OA cartilage compared to smooth cartilage from the same patient. OA chondrocytes and cartilage explants stimulated with IL-1beta showed high level expression of IL-6 mRNA and protein. Butein increased the phosphorylation of AMPKalphaThr-172, TSC2Ser-1387 and ULK1Ser-317 and inhibited the phosphorylation of mTORSer-2448 and its downstream target p70S6K and increased autophagy flux that correlated with the suppression of the IL-1beta mediated expression of IL-6 in normal and OA chondrocytes. In OA chondrocytes with siRNA-mediated knockdown of ATG5 expression, treatment with Butein failed to activate autophagy and abrogated the suppression of IL-1beta induced IL-6 expression. CONCLUSION: Our findings demonstrate for the first time that Butein activate autophagy in OA chondrocytes via AMPK/TSC2/ULK1/mTOR pathway. Additionally, activation of autophagy was essential to block the IL-1beta-induced expression of IL-6 in OA chondrocytes. These data support further studies to evaluate the use of Butein or compounds derived from it for the management of OA.
Identifier
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<a href="http://doi.org/10.1159/000493225" target="_blank" rel="noreferrer noopener">10.1159/000493225</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Ahmad Nashrah
AMP-Activated Protein Kinases/metabolism
AMPK
Ansari Mohammad Y
Articular/cytology/pathology
Autophagy
Autophagy-Related Protein 5/antagonists & inhibitors/genetics/metabolism
Autophagy-Related Protein-1 Homolog/metabolism
Autophagy/*drug effects
Butein
Cartilage
Cell Survival/drug effects
Cells
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Chalcones/*pharmacology
Chondrocytes/cytology/drug effects/metabolism
Cultured
Department of Anatomy & Neurobiology
Haqqi Tariq M
Humans
Inflammation
Interleukin-1beta/*pharmacology
Interleukin-6/genetics/*metabolism
Intracellular Signaling Peptides and Proteins/metabolism
mTOR
NEOMED College of Medicine
Osteoarthritis
Osteoarthritis/metabolism/pathology
Phosphorylation/drug effects
Reactive Oxygen Species/metabolism
RNA
RNA Interference
Signal Transduction/*drug effects
Small Interfering/metabolism
TOR Serine-Threonine Kinases/metabolism
TSC2
Tuberous Sclerosis Complex 2 Protein
Tumor Suppressor Proteins/metabolism
ULK1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1155/2018/6537072" target="_blank" rel="noreferrer noopener">http://doi.org/10.1155/2018/6537072</a>
Pages
6537072–6537072
Volume
2018
Dublin Core
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Title
A name given to the resource
Evidence of Oropharyngeal Dysfunction in Feeding in the Rat Rotenone Model of Parkinson's Disease.
Publisher
An entity responsible for making the resource available
Parkinson's disease
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-07
Subject
The topic of the resource
Animal Studies; Deglutition – Drug Effects; Deglutition Disorders; Eating – Drug Effects; Feeding Methods; Isoflavones – Administration and Dosage; Isoflavones – Pharmacodynamics; Mastication; Oropharynx – Pathology; Parkinson Disease; Phenotype; Rats
Creator
An entity primarily responsible for making the resource
Gould Francois D H; Gross Andrew; German Rebecca Z; Richardson Jason R
Description
An account of the resource
Swallowing disorders in Parkinson's disease are not responsive to dopamine depletion therapy and contribute to morbidity. They are poorly understood owing to a lack of adequate models. We present the first evidence of oropharyngeal changes in a rotenone toxicity model of Parkinson's disease. Rats were recorded while feeding before and after daily rotenone injections at two different doses (2.75 mg/kg and 3 mg/kg). The higher dose had a much more severe parkinsonian phenotype than the low dose. Timing and amplitude of chewing changed, as did the coordination of chewing and swallowing. Dose-dependent effects were evident. These preliminary results indicate that future research in toxicological models of Parkinson's disease should incorporate the study of oropharyngeal dysfunction. A better understanding of nongenetic models of Parkinson's disease in feeding may open new avenues for research into the neurological and behavioral bases for swallowing dysfunction in Parkinson's disease.
Identifier
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<a href="http://doi.org/10.1155/2018/6537072" target="_blank" rel="noreferrer noopener">10.1155/2018/6537072</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Animal Studies
Deglutition – Drug Effects
Deglutition disorders
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Eating – Drug Effects
Feeding Methods
German Rebecca Z
Gould François D H
Gross Andrew
Isoflavones – Administration and Dosage
Isoflavones – Pharmacodynamics
Mastication
NEOMED College of Medicine
NEOMED College of Pharmacy
Oropharynx – Pathology
Parkinson Disease
Parkinson's disease
Phenotype
Rats
Richardson Jason R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00114.2018" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00114.2018</a>
Pages
1558–1571
Issue
4
Volume
120
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Late maturation of backward masking in auditory cortex.
Publisher
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-10
Subject
The topic of the resource
auditory; cortex; detection; development; masking
Creator
An entity primarily responsible for making the resource
Mattingly Michelle M; Donell Brittany M; Rosen Merri J
Description
An account of the resource
Speech perception relies on the accurate resolution of brief, successive sounds that change rapidly over time. Deficits in the perception of such sounds, indicated by a reduced ability to detect signals during auditory backward masking, strongly relate to language processing difficulties in children. Backward masking during normal development has a longer maturational trajectory than many other auditory percepts, implicating the involvement of central auditory neural mechanisms with protracted developmental time courses. Despite the importance of this percept, its neural correlates are not well described at any developmental stage. We therefore measured auditory cortical responses to masked signals in juvenile and adult Mongolian gerbils and quantified the detection ability of individual neurons and neural populations in a manner comparable with psychoacoustic measurements. Perceptually, auditory backward masking manifests as higher thresholds for detection of a short signal followed by a masker than for the same signal in silence. Cortical masking was driven by a combination of suppressed responses to the signal and a reduced dynamic range available for signal detection in the presence of the masker. Both coding elements contributed to greater masked threshold shifts in juveniles compared with adults, but signal-evoked firing suppression was more pronounced in juveniles. Neural threshold shifts were a better match to human psychophysical threshold shifts when quantified with a longer temporal window that included the response to the delayed masker, suggesting that temporally selective listening may contribute to age-related differences in backward masking. NEW & NOTEWORTHY In children, auditory detection of backward masked signals is immature well into adolescence, and detection deficits correlate with problems in speech processing. Our auditory cortical recordings reveal immature backward masking in adolescent animals that mirrors the prolonged development seen in children. This is driven by both signal-evoked suppression and dynamic range reduction. An extended window of analysis suggests that differences in temporally focused listening may contribute to late maturing thresholds for backward masked signals.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00114.2018" target="_blank" rel="noreferrer noopener">10.1152/jn.00114.2018</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Auditory
cortex
Department of Anatomy & Neurobiology
detection
development
Donell Brittany M
Journal of neurophysiology
masking
Mattingly Michelle M
NEOMED College of Medicine
Rosen Merri J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/japplphysiol.00963.2017" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/japplphysiol.00963.2017</a>
Pages
159–166
Issue
1
Volume
125
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Impact of recurrent laryngeal nerve lesion on oropharyngeal muscle activity and sensorimotor integration in an infant pig model.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-07
Subject
The topic of the resource
deglutition; electromyography RLN; sensorimotor integration; swallowing
Creator
An entity primarily responsible for making the resource
DeLozier Katherine R; Gould Francois D H; Ohlemacher Jocelyn; Thexton Allan J; German Rebecca Z
Description
An account of the resource
The successful performance of a swallow requires dynamic integration between a wide range of sensory inputs and muscle activities to produce the coordinated kinematics of oropharyngeal structures. Damage to the recurrent laryngeal nerve (RLN) produces dysphagia in infants, with food or liquid entering the airway despite this nerve having minimal direct sensory or motor connections to the act of swallowing, apart from vocal fold closure. Previous results have demonstrated that a complete RLN lesion disrupts both performance and kinematics before initiation of the pharyngeal swallow in infants. We tested the hypothesis that a RLN lesion produces changes in the normal activity of oral floor, tongue, and infrahyoid muscles during a swallow. We recorded swallowing in our validated infant pig model, with synchronous high-speed imaging and fine-wire, chronic electromyography. We found changes in the timing, duration, and amplitude of the motor pattern in an array of muscles that are supplied by several different cranial and cervical nerves. Some of these changes in muscle activity are associated with the preparatory aspects of bolus aggregation or movement and so occur before the pharyngeal swallow. Taken with previous biomechanical results, these patterns suggest an intricate brain stem sensorimotor integration that occurs as part of a swallow. In particular, the execution of oral motor function is changed as a result of this simple lesion. NEW & NOTEWORTHY Damage to the recurrent laryngeal nerve compromises swallowing despite an absent or minimal contribution to either the motor or sensory aspects of this function. This study documents EMG changes, following RLN lesion, to non-RLN innervated muscles that are active during swallowing in an infant model. Some of these muscles fire before the pharyngeal swallow and are associated with the preparatory aspects of bolus aggregation and movement, suggesting important sensorimotor integration at a brain stem level.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/japplphysiol.00963.2017" target="_blank" rel="noreferrer noopener">10.1152/japplphysiol.00963.2017</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Deglutition
DeLozier Katherine R
Department of Anatomy & Neurobiology
electromyography RLN
German Rebecca Z
Gould François D H
Journal of applied physiology (Bethesda, Md. : 1985)
NEOMED College of Medicine
Ohlemacher Jocelyn
sensorimotor integration
swallowing
Thexton Allan J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1121/1.5049369" target="_blank" rel="noreferrer noopener">http://doi.org/10.1121/1.5049369</a>
Pages
667–667
Issue
2
Volume
144
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Development of perception and perceptual learning for multi-timescale filtered speech.
Publisher
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The Journal of the Acoustical Society of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-08
Creator
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Huyck Julia Jones; Rosen Merri J
Description
An account of the resource
The perception of temporally changing auditory signals has a gradual developmental trajectory. Speech is a time-varying signal, and slow changes in speech (filtered at 0-4 Hz) are preferentially processed by the right hemisphere, while the left extracts faster changes (filtered at 22-40 Hz). This work examined the ability of 8- to 19-year-olds to both perceive and learn to perceive filtered speech presented diotically for each filter type (low vs high) and dichotically for preferred or non-preferred laterality. Across conditions, performance improved with increasing age, indicating that the ability to perceive filtered speech continues to develop into adolescence. Across age, performance was best when both bands were presented dichotically, but with no benefit for presentation to the preferred hemisphere. Listeners thus integrated slow and fast transitions between the two ears, benefitting from more signal information, but not in a hemisphere-specific manner. After accounting for potential ceiling effects, learning was greatest when both bands were presented dichotically. These results do not support the idea that cochlear implants could be improved by providing differentially filtered information to each ear. Listeners who started with poorer performance learned more, a factor which could contribute to the positive cochlear implant outcomes typically seen in younger children.
Identifier
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<a href="http://doi.org/10.1121/1.5049369" target="_blank" rel="noreferrer noopener">10.1121/1.5049369</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Department of Anatomy & Neurobiology
Huyck Julia Jones
NEOMED College of Medicine
Rosen Merri J
The Journal of the Acoustical Society of America
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1113/JP275735" target="_blank" rel="noreferrer noopener">http://doi.org/10.1113/JP275735</a>
Pages
1981–1997
Issue
10
Volume
596
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Activity-dependent synaptic integration and modulation of bilateral excitatory inputs in an auditory coincidence detection circuit.
Publisher
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The Journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-05
Subject
The topic of the resource
EPSC; mGluR; neuromodulation; synaptic integration
Creator
An entity primarily responsible for making the resource
Lu Yong; Liu Yu-Wei; Curry Rebecca J
Description
An account of the resource
KEY POINTS: Binaural excitatory inputs to coincidence detection neurons in nucleus laminaris (NL) play essential roles in interaural time difference coding for sound localization. Here, we show that the two excitatory inputs are physiologically nearly completely segregated. Synaptic integration shows linear summation of EPSPs, ensuring high efficiency of coincidence detection of the bilateral excitatory inputs. We further show that the two excitatory inputs to single NL neurons are symmetrical in synaptic strength, kinetics and short-term plasticity. Modulation of the EPSCs by metabotropic glutamate receptors (mGluRs) is identical between the two excitatory inputs, maintaining balanced bilateral excitation under neuromodulatory conditions. Unilateral hearing deprivation reduces synaptic excitation and paradoxically strengthens mGluR modulation of EPSCs, suggesting activity-dependent anti-homeostatic regulation, a novel synaptic plasticity in response to sensory manipulations. ABSTRACT: Neurons in the avian nucleus laminaris (NL) receive bilateral excitatory inputs from the cochlear nucleus magnocellularis, via morphologically symmetrical dorsal (ipsilateral) and ventral (contralateral) dendrites. Using in vitro whole-cell patch recordings in chicken brainstem slices, we investigated synaptic integration and modulation of the bilateral inputs to NL under normal and hearing deprivation conditions. We found that the two excitatory inputs onto single NL neurons were nearly completely segregated, and integration of the two inputs was linear for EPSPs. The two inputs had similar synaptic strength, kinetics and short-term plasticity. EPSCs in low but not middle and high frequency neurons were suppressed by activation of group I and II metabotropic glutamate receptors (mGluR I and II), with similar modulatory strength between the ipsilateral and contralateral inputs. Unilateral hearing deprivation by cochlea removal reduced the excitatory transmission on the deprived dendritic domain of NL. Interestingly, EPSCs evoked at the deprived domain were modulated more strongly by mGluR II than at the counterpart domain that received intact input in low frequency neurons, suggesting anti-homeostatic regulation. This was supported by a stronger expression of mGluR II protein on the deprived neuropils of NL. Under mGluR II modulation, EPSCs on the deprived input show transient synaptic facilitation, forming a striking contrast with normal hearing conditions under which pure synaptic depression is observed. These results demonstrate physiological symmetry and thus balanced bilateral excitatory inputs to NL neurons. The activity-dependent anti-homeostatic plasticity of mGluR modulation constitutes a novel mechanism regulating synaptic transmission in response to sensory input manipulations.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1113/JP275735" target="_blank" rel="noreferrer noopener">10.1113/JP275735</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Curry Rebecca J
Department of Anatomy & Neurobiology
EPSC
Liu Yu-Wei
Lu Yong
mGluR
NEOMED College of Medicine
neuromodulation
synaptic integration
The Journal of physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.phrs.2017.08.007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.phrs.2017.08.007</a>
Pages
73–79
Volume
128
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics.
Publisher
An entity responsible for making the resource available
Pharmacological research
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-02
Subject
The topic of the resource
*DNA methylation; *Epigenetics; *HDACs; *lncRNA; *miRNA; *Osteoarthritis; Animals; Epigenesis; Genetic; Histone Deacetylase Inhibitors/*therapeutic use; Humans; Osteoarthritis/*drug therapy/*genetics
Creator
An entity primarily responsible for making the resource
Khan Nazir M; Haqqi Tariq M
Description
An account of the resource
Osteoarthritis (OA) is the most common joint disease and the leading cause of chronic disability in middle-aged and older populations worldwide. The development of disease modifying therapy for OA is in its infancy largely because the regulatory mechanisms for the molecular effectors of OA pathogenesis are poorly understood. Recent studies identified epigenetic events as a critical regulator of molecular players involved in the induction and development of OA. Epigenetic mechanisms include DNA methylation, non-coding RNA and histone modifications. The aim of this review is to briefly highlight the recent advances in the epigenetics of cartilage and potential of HDACs (Histone deacetylases) inhibitors in the therapeutic management of OA. We summarize the recent studies utilizing HDAC inhibitors as potential therapeutics for inhibiting disease progression and preventing the cartilage destruction in OA. HDACs control normal cartilage development and homeostasis and understanding the impact of HDACs inhibitors on the disease pathogenesis is of interest because of its importance in affecting overall cartilage health and homeostasis. These findings also shed new light on cartilage disease pathophysiology and provide substantial evidence that HDACs may be potential novel therapeutic targets in OA.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.phrs.2017.08.007" target="_blank" rel="noreferrer noopener">10.1016/j.phrs.2017.08.007</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*DNA methylation
*Epigenetics
*HDACs
*lncRNA
*miRNA
*OSTEOARTHRITIS
2018
Animals
Department of Anatomy & Neurobiology
Epigenesis
Genetic
Haqqi Tariq M
Histone Deacetylase Inhibitors/*therapeutic use
Humans
Khan Nazir M
NEOMED College of Medicine
Osteoarthritis/*drug therapy/*genetics
Pharmacological research
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroimage.2018.08.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroimage.2018.08.013</a>
Pages
300–313
Volume
183
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A three-dimensional digital neurological atlas of the mustached bat (Pteronotus parnellii).
Publisher
An entity responsible for making the resource available
NeuroImage
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-12
Subject
The topic of the resource
*Atlases as Topic; Animals; Auditory Cortex/anatomy & histology/diagnostic imaging; Brain Stem/anatomy & histology/diagnostic imaging; Brain/*anatomy & histology/diagnostic imaging; Chiroptera/*anatomy & histology; Diffusion Tensor Imaging/methods; Imaging; Magnetic Resonance Imaging/*methods; Male; Skull/anatomy & histology/diagnostic imaging; Three-Dimensional/*methods; Tomography; X-Ray Computed/*methods
Creator
An entity primarily responsible for making the resource
Washington Stuart D; Hamaide Julie; Jeurissen Ben; van Steenkiste Gwendolyn; Huysmans Toon; Sijbers Jan; Deleye Steven; Kanwal Jagmeet S; De Groof Geert; Liang Sayuan; Van Audekerke Johan; Wenstrup Jeffrey J; Van der Linden Annemie; Radtke-Schuller Susanne; Verhoye Marleen
Description
An account of the resource
Substantial knowledge of auditory processing within mammalian nervous systems emerged from neurophysiological studies of the mustached bat (Pteronotus parnellii). This highly social and vocal species retrieves precise information about the velocity and range of its targets through echolocation. Such high acoustic processing demands were likely the evolutionary pressures driving the over-development at peripheral (cochlea), metencephalic (cochlear nucleus), mesencephalic (inferior colliculus), diencephalic (medial geniculate body of the thalamus), and telencephalic (auditory cortex) auditory processing levels in this species. Auditory researchers stand to benefit from a three dimensional brain atlas of this species, due to its considerable contribution to auditory neuroscience. Our MRI-based atlas was generated from 2 sets of image data of an ex-vivo male mustached bat's brain: a detailed 3D-T2-weighted-RARE scan [(59x63 x 85) mum(3)] and track density images based on super resolution diffusion tensor images [(78) mum(3)] reconstructed from a set of low resolution diffusion weighted images using Super-Resolution-Reconstruction (SRR). By surface-rendering these delineations and extrapolating from cortical landmarks and data from previous studies, we generated overlays that estimate the locations of classic functional subregions within mustached bat auditory cortex. This atlas is freely available from our website and can simplify future electrophysiological, microinjection, and neuroimaging studies in this and related species.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuroimage.2018.08.013" target="_blank" rel="noreferrer noopener">10.1016/j.neuroimage.2018.08.013</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Atlases as Topic
2018
Animals
Auditory Cortex/anatomy & histology/diagnostic imaging
Brain Stem/anatomy & histology/diagnostic imaging
Brain/*anatomy & histology/diagnostic imaging
Chiroptera/*anatomy & histology
College of Anatomy & Neurobiology
De Groof Geert
Deleye Steven
Department of Anatomy & Neurobiology
Diffusion Tensor Imaging/methods
Hamaide Julie
Huysmans Toon
Imaging
Jeurissen Ben
Kanwal Jagmeet S
Liang Sayuan
Magnetic Resonance Imaging/*methods
Male
NEOMED College of Medicine
NeuroImage
Radtke-Schuller Susanne
Sijbers Jan
Skull/anatomy & histology/diagnostic imaging
Three-Dimensional/*methods
Tomography
Van Audekerke Johan
Van der Linden Annemie
van Steenkiste Gwendolyn
Verhoye Marleen
Washington Stuart D
Wenstrup Jeffrey J
X-Ray Computed/*methods
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neurobiolaging.2018.03.021" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neurobiolaging.2018.03.021</a>
Pages
148–158
Volume
67
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Evidence of Wnt/beta-catenin alterations in brain and bone of a tauopathy mouse model of Alzheimer's disease.
Publisher
An entity responsible for making the resource available
Neurobiology of aging
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-07
Subject
The topic of the resource
*Alzheimer's disease; *Beta catenin; *Bone mineral density; *Neurodegeneration; *Tauopathy; *Wnt proteins; *Wnt Signaling Pathway; Alzheimer Disease/*genetics/*metabolism; Animal; Animals; beta Catenin/metabolism; Bone and Bones/*metabolism; Bone Density; Bone Remodeling/genetics; Brain/*metabolism; Disease Models; Female; Gene Expression; Male; Mice; Osteogenesis/genetics; Osteoporosis/etiology/genetics; tau Proteins/*metabolism; Tauopathies/genetics/*metabolism; Wnt Proteins/metabolism
Creator
An entity primarily responsible for making the resource
Dengler-Crish Christine M; Ball Hope C; Lin Li; Novak Kimberly M; Cooper Lisa Noelle
Description
An account of the resource
Low bone mineral density (BMD) is a significant comorbidity in Alzheimer's disease (AD) and may reflect systemic regulatory pathway dysfunction. Low BMD has been identified in several AD mouse models selective for amyloid-beta or tau pathology, but these deficits were attributed to diverse mechanisms. In this study, we identified common pathophysiological mechanisms accounting for bone loss and neurodegeneration in the htau mouse, a tauopathy model with an early low BMD phenotype. We investigated the Wnt/beta-catenin pathway-a cellular signaling cascade linked to both bone loss and neuropathology. We showed that low BMD persisted in male htau mice aged from 6 to 14 months, remaining significantly lower than tau-null and C57BL/6J controls. Osteogenic gene expression in female and male htau mice was markedly reduced from controls, indicating impaired bone remodeling. In both the bone and brain, htau mice showed alterations in Wnt/beta-catenin signaling genes suggestive of increased inhibition of this pathway. These findings implicate dysfunctional Wnt signaling as a potential target for addressing bone loss in AD.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neurobiolaging.2018.03.021" target="_blank" rel="noreferrer noopener">10.1016/j.neurobiolaging.2018.03.021</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Alzheimer's disease
*Beta catenin
*Bone mineral density
*neurodegeneration
*Tauopathy
*Wnt proteins
*Wnt Signaling Pathway
2018
Alzheimer Disease/*genetics/*metabolism
Animal
Animals
Ball Hope C
beta Catenin/metabolism
Bone and Bones/*metabolism
Bone Density
Bone Remodeling/genetics
Brain/*metabolism
Cooper Lisa Noelle
Dengler-Crish Christine M
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Disease Models
Female
Gene Expression
Lin Li
Male
Mice
NEOMED College of Medicine
NEOMED College of Pharmacy
Neurobiology of aging
Novak Kimberly M
Osteogenesis/genetics
Osteoporosis/etiology/genetics
tau Proteins/*metabolism
Tauopathies/genetics/*metabolism
Wnt Proteins/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.joca.2017.07.020" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.joca.2017.07.020</a>
Pages
1087–1097
Issue
8
Volume
26
Dublin Core
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Title
A name given to the resource
Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes.
Publisher
An entity responsible for making the resource available
Osteoarthritis and cartilage
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-08
Subject
The topic of the resource
Chondrocytes; Mitochondrial dysfunction; Osteoarthritis; Parkin; ROS
Creator
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Ansari M Y; Khan N M; Ahmad I; Haqqi T M
Description
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OBJECTIVE: Mitochondrial dysfunction, oxidative stress and chondrocyte death are important contributors to the development and pathogenesis of osteoarthritis (OA). In this study, we determined the expression and role of Parkin in the clearance of damaged/dysfunctional mitochondria, regulation of reactive oxygen species (ROS) levels and chondrocyte survival under pathological conditions. METHODS: Human chondrocytes were from the unaffected area of knee OA cartilage (n = 12) and were stimulated with IL-1beta to mimic pathological conditions. Mitochondrial membrane depolarization and ROS levels were determined using specific dyes and flow cytometry. Autophagy was determined by Western blotting for ATG5, Beclin1, immunofluorescence staining and confocal microscopy. Gene expression was determined by RT-qPCR. siRNA, wild-type and mutant Parkin plasmids were transfected using Amaxa system. Apoptosis was determined by PI staining of chondrocytes and TUNEL assay. RESULTS: IL-1beta-stimulated OA chondrocytes showed high levels of ROS generation, mitochondrial membrane damage, accumulation of damaged mitochondria and higher incidence of apoptosis. IL-1beta stimulation of chondrocytes with depleted Parkin expression resulted in sustained high levels of ROS, accumulation of damaged/dysfunctional mitochondria and enhanced apoptosis. Parkin translocation to depolarized/damaged mitochondria and recruitment of p62/SQSTM1 was required for the elimination of damaged/dysfunctional mitochondria in IL-1beta-stimulated OA chondrocytes. Importantly we demonstrate that Parkin elimination of depolarized/damaged mitochondria required the Parkin ubiquitin ligase activity and resulted in reduced ROS levels and inhibition of apoptosis in OA chondrocytes under pathological conditions. CONCLUSIONS: Our data demonstrates that Parkin functions to eliminate depolarized/damaged mitochondria in chondrocytes which is necessary for mitochondrial quality control, regulation of ROS levels and chondrocyte survival under pathological conditions.
Identifier
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<a href="http://doi.org/10.1016/j.joca.2017.07.020" target="_blank" rel="noreferrer noopener">10.1016/j.joca.2017.07.020</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Ahmad I
Ansari M Y
Chondrocytes
Department of Anatomy & Neurobiology
Haqqi T M
Khan N M
Mitochondrial dysfunction
NEOMED College of Medicine
Osteoarthritis
Osteoarthritis and cartilage
Parkin
ROS
-
Text
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URL Address
<a href="http://doi.org/10.1016/j.jid.2017.08.034" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jid.2017.08.034</a>
Pages
219–227
Issue
1
Volume
138
Dublin Core
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Title
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Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk between Macrophages and Mesenchymal Stem Cells toward Wound Repair.
Publisher
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The Journal of investigative dermatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-01
Creator
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Yu Bing; Alboslemy Talib; Safadi Fayez; Kim Min-Ho
Description
An account of the resource
The process of wound repair requires the coordinated participation of multiple types of cells, which are sequentially recruited during the healing process. In response to tissue injury, both macrophages and mesenchymal stem cells (MSCs) are recruited to the site of injury, where they participate in the repair process. Despite considerable understanding of the role of each cell type in the process of wound repair, the nature of the dynamic interplay between these two cell types and how this interaction influences the process of wound repair are not well understood. Here, using an in vivo model of cutaneous wound healing in mice, we provide evidence that GPNMB is functionally important in promoting the recruitment of MSCs to the site of skin injury, which in turn modulates inflammatory responses by directing the M2 polarization of macrophages in acute wound healing. Furthermore, we show that GPNMB activity is impaired in a diabetic wound environment, which is associated with impaired MSC recruitment that is reversed by the topical administration of recombinant GPNMB protein to the wounds of diabetic mice. Our study provides important insight into the crosstalk between macrophages and endogenous MSCs toward wound repair.
Identifier
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<a href="http://doi.org/10.1016/j.jid.2017.08.034" target="_blank" rel="noreferrer noopener">10.1016/j.jid.2017.08.034</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Alboslemy Talib
Department of Anatomy & Neurobiology
Kim Min-Ho
NEOMED College of Medicine
Safadi Fayez
The Journal of investigative dermatology
Yu Bing
-
Text
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URL Address
<a href="http://doi.org/10.1016/j.heares.2018.10.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2018.10.001</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Subtypes of GABAergic cells in the inferior colliculus.
Publisher
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Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-10
Subject
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Auditory system; Cell type; GABA; Inhibition; Perineuronal net
Creator
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Schofield Brett R; Beebe Nichole L
Description
An account of the resource
The inferior colliculus occupies a central position in ascending and descending auditory pathways. A substantial proportion of its neurons are GABAergic, and these neurons contribute to intracollicular circuits as well as to extrinsic projections to numerous targets. A variety of types of evidence - morphology, physiology, molecular markers - indicate that the GABAergic cells can be divided into at least four subtypes that serve different functions. However, there has yet to emerge a unified scheme for distinguishing these subtypes. The present review discusses these criteria and, where possible, relates the different properties. In contrast to GABAergic cells in cerebral cortex, where subtypes are much more thoroughly characterized, those in the inferior colliculus contribute substantially to numerous long range extrinsic projections. At present, the best characterized subtype is a GABAergic cell with a large soma, dense perisomatic synaptic inputs and a large axon that provides rapid auditory input to the thalamus. This large GABAergic subtype projects to additional targets, and other subtypes also project to the thalamus. The eventual characterization of these subtypes can be expected to reveal multiple functions of these inhibitory cells and the many circuits to which they contribute.
Identifier
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<a href="http://doi.org/10.1016/j.heares.2018.10.001" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2018.10.001</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Auditory system
Beebe Nichole L
Cell type
Department of Anatomy & Neurobiology
GABA
Hearing research
inhibition
NEOMED College of Medicine
perineuronal net
Schofield Brett R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2018.07.008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2018.07.008</a>
Pages
88–96
Volume
367
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Detection of single mRNAs in individual cells of the auditory system.
Publisher
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Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-09
Subject
The topic of the resource
Cochlea; Immunohistochemistry; Inner hair cell; Outer hair cell; Single-molecule fluorescence in situ hybridization; Spiral ganglion neuron
Creator
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Salehi Pezhman; Nelson Charlie N; Chen Yingying; Lei Debin; Crish Samuel D; Nelson Jovitha; Zuo Hongyan; Bao Jianxin
Description
An account of the resource
Gene expression analysis is essential for understanding the rich repertoire of cellular functions. With the development of sensitive molecular tools such as single-cell RNA sequencing, extensive gene expression data can be obtained and analyzed from various tissues. Single-molecule fluorescence in situ hybridization (smFISH) has emerged as a powerful complementary tool for single-cell genomics studies because of its ability to map and quantify the spatial distributions of single mRNAs at the subcellular level in their native tissue. Here, we present a detailed method to study the copy numbers and spatial localizations of single mRNAs in the cochlea and inferior colliculus. First, we demonstrate that smFISH can be performed successfully in adult cochlear tissue after decalcification. Second, we show that the smFISH signals can be detected with high specificity. Third, we adapt an automated transcript analysis pipeline to quantify and identify single mRNAs in a cell-specific manner. Lastly, we show that our method can be used to study possible correlations between transcriptional and translational activities of single genes. Thus, we have developed a detailed smFISH protocol that can be used to study the expression of single mRNAs in specific cell types of the peripheral and central auditory systems.
Identifier
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<a href="http://doi.org/10.1016/j.heares.2018.07.008" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2018.07.008</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Bao Jianxin
Chen Yingying
Cochlea
Crish Samuel D
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Hearing research
Immunohistochemistry
Inner hair cell
Lei Debin
Nelson Charlie N
Nelson Jovitha
NEOMED College of Medicine
NEOMED College of Pharmacy
Outer hair cell
Salehi Pezhman
Single-molecule fluorescence in situ hybridization
Spiral ganglion neuron
Zuo Hongyan
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2018.03.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2018.03.013</a>
Pages
119–135
Volume
363
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Addressing variability in the acoustic startle reflex for accurate gap detection assessment.
Publisher
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Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-06
Subject
The topic of the resource
Acoustic startle response magnitude; Circadian rhythm; Gap-induced prepulse inhibition of the acoustic startle reflex; Prepulse facilitation; Tinnitus
Creator
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Longenecker Ryan J; Kristaponyte Inga; Nelson Gregg L; Young Jesse W; Galazyuk Alexander V
Description
An account of the resource
The acoustic startle reflex (ASR) is subject to substantial variability. This inherent variability consequently shapes the conclusions drawn from gap-induced prepulse inhibition of the acoustic startle reflex (GPIAS) assessments. Recent studies have cast doubt as to the efficacy of this methodology as it pertains to tinnitus assessment, partially, due to variability in and between data sets. The goal of this study was to examine the variance associated with several common data collection variables and data analyses with the aim to improve GPIAS reliability. To study this the GPIAS tests were conducted in adult male and female CBA/CaJ mice. Factors such as inter-trial interval, circadian rhythm, sex differences, and sensory adaptation were each evaluated. We then examined various data analysis factors which influence GPIAS assessment. Gap-induced facilitation, data processing options, and assessments of tinnitus were studied. We found that the startle reflex is highly variable in CBA/CaJ mice, but this can be minimized by certain data collection factors. We also found that careful consideration of temporal fluctuations of the ASR and controlling for facilitation can lead to more accurate GPIAS results. This study provides a guide for reducing variance in the GPIAS methodology - thereby improving the diagnostic power of the test.
Identifier
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<a href="http://doi.org/10.1016/j.heares.2018.03.013" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2018.03.013</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Acoustic startle response magnitude
Circadian Rhythm
Department of Anatomy & Neurobiology
Galazyuk Alexander V
Gap-induced prepulse inhibition of the acoustic startle reflex
Hearing research
Kristaponyte Inga
Longenecker Ryan J
Nelson Gregg L
NEOMED College of Medicine
Prepulse facilitation
Tinnitus
Young Jesse W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.freeradbiomed.2018.01.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.freeradbiomed.2018.01.013</a>
Pages
159–171
Volume
116
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis.
Publisher
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Free radical biology & medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-02
Subject
The topic of the resource
*Apoptosis; *ERK1/2; *Nrf2; *Osteoarthritis; *Redox
Creator
An entity primarily responsible for making the resource
Khan Nazir M; Ahmad Imran; Haqqi Tariq M
Description
An account of the resource
Nrf2, a redox regulated transcription factor, has recently been shown to play a role in cartilage integrity but the mechanism remains largely unknown. Osteoarthritis (OA) is a multifactorial disease in which focal degradation of cartilage occurs. Here, we studied whether Nrf2 exerts chondroprotective effects by suppressing the oxidative stress and apoptosis in IL-1beta stimulated human OA chondrocytes. Expression of Nrf2 and its target genes HO-1, NQO1 and SOD2 was significantly high in OA cartilage compared to normal cartilage and was also higher in damaged area compared to smooth area of OA cartilage of the same patient. Human chondrocytes treated with IL-1beta resulted in robust Nrf2/ARE reporter activity, which was inhibited by pretreatment with antioxidants indicating that Nrf2 activity was due to IL-1beta-induced ROS generation. Ectopic expression of Nrf2 significantly suppressed the IL-1beta-induced generation of ROS while Nrf2 knockdown significantly increased the basal as well as
Identifier
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<a href="http://doi.org/10.1016/j.freeradbiomed.2018.01.013" target="_blank" rel="noreferrer noopener">10.1016/j.freeradbiomed.2018.01.013</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Apoptosis
*ERK1/2
*Nrf2
*OSTEOARTHRITIS
*Redox
2018
Ahmad Imran
Department of Anatomy & Neurobiology
Free radical biology & medicine
Haqqi Tariq M
Khan Nazir M
NEOMED College of Medicine
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s12035-017-0707-z" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s12035-017-0707-z</a>
Pages
5167–5176
Issue
6
Volume
55
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Glycoprotein NMB: an Emerging Role in Neurodegenerative Disease.
Publisher
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Molecular neurobiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-06
Subject
The topic of the resource
Animals; GPNMB; Humans; Immune System/metabolism; Membrane Glycoproteins/chemistry/*metabolism; Nerve Degeneration/pathology; Neurodegeneration; Neurodegenerative Diseases/*metabolism/therapy; Neuroinflammation; Neuroprotection
Creator
An entity primarily responsible for making the resource
Budge Kevin M; Neal Matthew L; Richardson Jason R; Safadi Fayez F
Description
An account of the resource
Neurodegeneration is characterized by severe neuronal loss leading to the cognitive and physical impairments that define various neurodegenerative diseases. Neuroinflammation is one hallmark of neurodegenerative diseases and can ultimately contribute to disease progression. Increased inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-1beta (IL-1 beta), and tumor necrosis factor-alpha (TNF-alpha) are associated with Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Unfortunately, current therapeutic options lack ability to stop or effectively slow progression of these diseases and are primarily aimed at alleviating symptoms. Thus, it is crucial to discover novel treatment candidates for neurodegenerative diseases. Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a type-I transmembrane glycoprotein first identified in a melanoma cell line. GPNMB augments bone mineral deposition by stimulating osteoblast differentiation. Aside from its anabolic function in the bone, emerging evidence suggests that GPNMB has anti-inflammatory and reparative functions. GPNMB has also been demonstrated to be neuroprotective in an animal model of ALS, cerebral ischemia, and other disease models. Given these discoveries, GPNMB should be investigated as a potential therapeutic option for multiple neurodegenerative diseases.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s12035-017-0707-z" target="_blank" rel="noreferrer noopener">10.1007/s12035-017-0707-z</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Animals
Budge Kevin M
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
GPNMB
Humans
Immune System/metabolism
Membrane Glycoproteins/chemistry/*metabolism
Molecular neurobiology
Neal Matthew L
NEOMED College of Medicine
NEOMED College of Pharmacy
Nerve Degeneration/pathology
Neurodegeneration
Neurodegenerative Diseases/*metabolism/therapy
Neuroinflammation
Neuroprotection
Richardson Jason R
Safadi Fayez F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s10162-018-00690-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s10162-018-00690-3</a>
Pages
653–668
Issue
6
Volume
19
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma.
Publisher
An entity responsible for making the resource available
Journal of the Association for Research in Otolaryngology : JARO
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-12
Subject
The topic of the resource
calcium channel; hair cells; noise-induced hearing loss; spiral ganglion neurons; Stephania tetrandra; synapse; Tetrandrine
Creator
An entity primarily responsible for making the resource
Yu Yan; Hu Bing; Bao Jianxin; Mulvany Jessica; Bielefeld Eric; Harrison Ryan T; Neton Sarah A; Thirumala Partha; Chen Yingying; Lei Debin; Qiu Ziyu; Zheng Qingyin; Ren Jihao; Perez-Flores Maria Cristina; Yamoah Ebenezer N; Salehi Pezhman
Description
An account of the resource
Noise is the most common occupational and environmental hazard, and noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit. Although therapeutics that target the free-radical pathway have shown promise, none of these compounds is currently approved against NIHL by the United States Food and Drug Administration. The present study has demonstrated that tetrandrine (TET), a traditional Chinese medicinal alkaloid and the main chemical isolate of the Stephania tetrandra S. Moore herb, significantly attenuated NIHL in CBA/CaJ mice. TET is known to exert antihypertensive and antiarrhythmic effects through the blocking of calcium channels. Whole-cell patch-clamp recording from adult spiral ganglion neurons showed that TET blocked the transient Ca(2+) current in a dose-dependent manner and the half-blocking concentration was 0.6 + 0.1 muM. Consistent with previous findings that modulations of calcium-based signaling pathways have both prophylactic and therapeutic effects against neural trauma, NIHL was significantly diminished by TET administration. Importantly, TET has a long-lasting protective effect after noise exposure (48 weeks) in comparison to 2 weeks after noise exposure. The otoprotective effects of TET were achieved mainly by preventing outer hair cell damage and synapse loss between inner hair cells and spiral ganglion neurons. Thus, our data indicate that TET has great potential in the prevention and treatment of NIHL.
Identifier
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<a href="http://doi.org/10.1007/s10162-018-00690-3" target="_blank" rel="noreferrer noopener">10.1007/s10162-018-00690-3</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Bao Jianxin
Bielefeld Eric
calcium channel
Chen Yingying
Department of Anatomy & Neurobiology
Hair Cells
Harrison Ryan T
Hu Bing
Journal of the Association for Research in Otolaryngology : JARO
Lei Debin
Mulvany Jessica
NEOMED College of Medicine
Neton Sarah A
Noise-induced hearing loss
Perez-Flores Maria Cristina
Qiu Ziyu
Ren Jihao
Salehi Pezhman
spiral ganglion neurons
Stephania tetrandra
synapse
Tetrandrine
Thirumala Partha
Yamoah Ebenezer N
Yu Yan
Zheng Qingyin
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00455-018-9881-z" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00455-018-9881-z</a>
Pages
627–635
Issue
5
Volume
33
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Maturation of the Coordination Between Respiration and Deglutition with and Without Recurrent Laryngeal Nerve Lesion in an Animal Model.
Publisher
An entity responsible for making the resource available
Dysphagia
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-10
Subject
The topic of the resource
*Animal model; *Deglutition; *Development; *Infant; *Recurrent laryngeal nerve; *Respiration; *Sensorimotor; Animal; Animal Population Groups; Animals; Biological; Deglutition – Physiology; Deglutition Disorders; Deglutition/*physiology; Disease Models; Humans; Laryngeal Nerves – Injuries; Laryngeal Nerves – Physiology; Larynx – Physiology; Larynx/*physiology; Models; Newborn; Questionnaires; Recurrent Laryngeal Nerve Injuries/*complications; Recurrent Laryngeal Nerve/physiology; Respiration; Swine
Creator
An entity primarily responsible for making the resource
Ballester Ashley; Gould Francois; Bond Laura; Stricklen Bethany; Ohlemacher Jocelyn; Gross Andrew; DeLozier Katherine R; Buddington Randall; Buddington Karyl; Danos Nicole; German Rebecca
Description
An account of the resource
The timing of the occurrence of a swallow in a respiratory cycle is critical for safe swallowing, and changes with infant development. Infants with damage to the recurrent laryngeal nerve, which receives sensory information from the larynx and supplies the intrinsic muscles of the larynx, experience a significant incidence of dysphagia. Using our validated infant pig model, we determined the interaction between this nerve damage and the coordination between respiration and swallowing during postnatal development. We recorded 23 infant pigs at two ages (neonatal and older, pre-weaning) feeding on milk with barium using simultaneous high-speed videofluoroscopy and measurements of thoracic movement. With a complete linear model, we tested for changes with maturation, and whether these changes are the same in control and lesioned individuals. We found (1) the timing of swallowing and respiration coordination changes with maturation; (2) no overall effect of RLN lesion on the timing of coordination, but (3) a greater magnitude of maturational change occurs with RLN injury. We also determined that animals with no surgical intervention did not differ from animals that had surgery for marker placement and a sham procedure for nerve lesion. The coordination between respiration and swallowing changes in normal, intact individuals to provide increased airway protection prior to weaning. Further, in animals with an RLN lesion, the maturation process has a larger effect. Finally, these results suggest a high level of brainstem sensorimotor interactions with respect to these two functions.
Identifier
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<a href="http://doi.org/10.1007/s00455-018-9881-z" target="_blank" rel="noreferrer noopener">10.1007/s00455-018-9881-z</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Animal model
*Deglutition
*Development
*Infant
*Recurrent laryngeal nerve
*Respiration
*Sensorimotor
2018
Animal
Animal Population Groups
Animals
Ballester Ashley
Biological
Bond Laura
Buddington Karyl
Buddington Randall
Danos Nicole
Deglutition – Physiology
Deglutition disorders
Deglutition/*physiology
DeLozier Katherine R
Department of Anatomy & Neurobiology
Disease Models
Dysphagia
German Rebecca
Gould Francois
Gross Andrew
Humans
Laryngeal Nerves – Injuries
Laryngeal Nerves – Physiology
Larynx – Physiology
Larynx/*physiology
Models
NEOMED College of Medicine
Newborn
Ohlemacher Jocelyn
Questionnaires
Recurrent Laryngeal Nerve Injuries/*complications
Recurrent Laryngeal Nerve/physiology
Respiration
Stricklen Bethany
Swine
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00455-017-9832-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00455-017-9832-0</a>
Pages
51–62
Issue
1
Volume
33
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
LVC Timing in Infant Pig Swallowing and the Effect of Safe Swallowing.
Publisher
An entity responsible for making the resource available
Dysphagia
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-02
Subject
The topic of the resource
*Animal model; *Aspiration; *Deglutition; *Deglutition disorders; *Dysphagia; *Infant; *Laryngeal vestibule closure; *Recurrent laryngeal nerve; Animal; Animal Population Groups; Animals; Aspiration – Etiology; Aspiration/*etiology; Biological; Deglutition – Physiology; Deglutition Disorders – Etiology; Deglutition Disorders/*etiology; Deglutition/*physiology; Disease Models; Humans; Laryngeal Nerve Injuries/*complications; Laryngeal Nerves – Injuries; Larynx; Models; Newborn; Oropharynx; Pneumonia; Questionnaires; Swine
Creator
An entity primarily responsible for making the resource
Gross Andrew; Ohlemacher Jocelyn; German Rebecca; Gould Francois
Description
An account of the resource
Recurrent laryngeal nerve (RLN) injury in neonates, a complication of head and neck surgeries, leads to increased aspiration risk and swallowing dysfunction. The severity of resulting sequelae range from morbidity, such as aspiration pneumonia, to mortality from infection and failure to thrive. The timing of airway protective events including laryngeal vestibule closure (LVC) is implicated in aspiration. We unilaterally transected the RLN in an infant pig model to observe changes in the timing of swallowing kinematics with lesion and aspiration. We recorded swallows using high-speed video-fluoroscopic swallow studies (VFSS) and scored them using the Infant Mammalian Penetration and Aspiration Scale (IMPAS). We hypothesized that changes would occur in swallowing kinematics (1) between RLN lesion and control animals, and (2) among safe swallows (IMPAS 1), penetration swallows (IMPAS 3), and aspiration swallows (IMPAS 7). We observed numerous changes in timing following RLN lesion in safe and unsafe swallows, suggesting pervasive changes in the coordination of oropharyngeal function. The timing of LVC, posterior tongue, and hyoid movements differed between pre- and post-lesion in safe swallows. Posterior tongue kinematics differed for post-lesion swallows with penetration. The timing and duration of LVC and posterior tongue movement differed between aspiration swallows pre- and post-lesion. After lesion, safe swallows and swallows with aspiration differed in timing of LVC, laryngeal vestibule opening, and posterior tongue and hyoid movements. The timing of thyrohyoid muscle activity varied with IMPAS, but not lesion. Further study into the pathophysiology of RLN lesion-induced swallowing dysfunction is important to developing novel therapies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00455-017-9832-0" target="_blank" rel="noreferrer noopener">10.1007/s00455-017-9832-0</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Animal model
*Aspiration
*Deglutition
*Deglutition disorders
*Dysphagia
*Infant
*Laryngeal vestibule closure
*Recurrent laryngeal nerve
2018
Animal
Animal Population Groups
Animals
Aspiration – Etiology
Aspiration/*etiology
Biological
Deglutition – Physiology
Deglutition Disorders – Etiology
Deglutition Disorders/*etiology
Deglutition/*physiology
Department of Anatomy & Neurobiology
Disease Models
Dysphagia
German Rebecca
Gould Francois
Gross Andrew
Humans
Laryngeal Nerve Injuries/*complications
Laryngeal Nerves – Injuries
Larynx
Models
NEOMED College of Medicine
Newborn
Ohlemacher Jocelyn
Oropharynx
Pneumonia
Questionnaires
Swine
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00429-017-1599-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00429-017-1599-4</a>
Pages
1923–1936
Issue
4
Volume
223
Dublin Core
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Title
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GABAergic and non-GABAergic projections to the superior colliculus from the auditory brainstem.
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Brain structure & function
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-05
Subject
The topic of the resource
Animals; Attention; Auditory Pathways/*physiology; Avoidance behavior; Brain Mapping; Escape; Female; Fluorescent Dyes/metabolism; Functional Laterality; GABAergic Neurons/*physiology; Glutamate Decarboxylase/*metabolism; Guinea Pigs; Inferior colliculus; Inhibition; Male; Nitric Oxide Synthase/metabolism; Nucleus of the brachium of the inferior colliculus; Orienting; Superior Colliculi/*cytology
Creator
An entity primarily responsible for making the resource
Mellott Jeffrey G; Beebe Nichole L; Schofield Brett R
Description
An account of the resource
The superior colliculus (SC) contains an auditory space map that is shaped by projections from several subcortical auditory nuclei. Both GABAergic (inhibitory) and excitatory cells contribute to these inputs, but there are contradictory reports regarding the sources of these inputs. We used retrograde tracing techniques in guinea pigs to identify cells in the auditory brainstem that project to the SC. We combined retrograde tracing with immunohistochemistry for glutamic acid decarboxylase (GAD) to identify putative GABAergic cells that participate in this pathway. Following a tracer injection in the SC, the nucleus of the brachium of the inferior colliculus (NBIC) contained the most labeled cells, followed by the inferior colliculus (IC). Smaller populations were observed in the sagulum, paralemniscal area, periolivary nuclei and ventrolateral tegmental nucleus. Overall, only 10% of the retrogradely labeled cells were GAD immunopositive. The presumptive inhibitory cells were observed in the NBIC, IC, superior paraolivary nucleus, sagulum and paralemniscal area. We conclude that the guinea pig SC receives input from a diverse set of auditory brainstem nuclei, some of which provide GABAergic input. These diverse origins of input to the SC likely represent a variety of functions. Inputs from the NBIC and IC likely provide spatial information for guiding orienting behaviors. Inputs from subcollicular nuclei are less likely to provide spatial information; rather, they may provide a shorter route for auditory information to reach the SC, and could generate avoidance or escape responses to an external threat.
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<a href="http://doi.org/10.1007/s00429-017-1599-4" target="_blank" rel="noreferrer noopener">10.1007/s00429-017-1599-4</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Animals
Attention
Auditory Pathways/*physiology
Avoidance behavior
Beebe Nichole L
Brain Mapping
Brain structure & function
Department of Anatomy & Neurobiology
Escape
Female
Fluorescent Dyes/metabolism
Functional Laterality
GABAergic Neurons/*physiology
Glutamate Decarboxylase/*metabolism
Guinea Pigs
inferior colliculus
inhibition
Male
Mellott Jeffrey G
NEOMED College of Medicine
Nitric Oxide Synthase/metabolism
Nucleus of the brachium of the inferior colliculus
Orienting
Schofield Brett R
Superior Colliculi/*cytology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/978-1-4939-7407-8_15" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/978-1-4939-7407-8_15</a>
Pages
171–185
Volume
1695
Dublin Core
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Title
A name given to the resource
Anterograde Tract Tracing for Assaying Axonopathy and Transport Deficits in Glaucoma.
Publisher
An entity responsible for making the resource available
Methods in molecular biology (Clifton, N.J.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-07
Subject
The topic of the resource
*Axonal transport; *Axonopathy; *Neuronal tracing; *Optic nerve; *Superior colliculus; Animal; Animals; Axonal Transport; Axons/metabolism/*pathology/physiology; Cholera Toxin/*metabolism; Confocal; Disease Models; Glaucoma/*diagnostic imaging/metabolism/physiopathology; Humans; Mice; Microscopy; Rats; Visual Pathways
Creator
An entity primarily responsible for making the resource
Crish Samuel D; Schofield Brett R
Description
An account of the resource
Whether to stage degeneration or investigate early pathology in glaucoma, examination of axonal structure and function is essential. There are a wide variety of methods available to investigators using animal models of glaucoma, with varying utilities depending on the questions asked. Here, we describe the use of anterograde neuronal tract tracing using cholera toxin B (CTB) for the determination of axon transport integrity of the retinofugal projection. This method reveals the structure of the retinal axons as well as the functional integrity of anterograde transport systems.
Identifier
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<a href="http://doi.org/10.1007/978-1-4939-7407-8_15" target="_blank" rel="noreferrer noopener">10.1007/978-1-4939-7407-8_15</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Axonal transport
*Axonopathy
*Neuronal tracing
*Optic nerve
*superior colliculus
2018
Animal
Animals
Axonal Transport
Axons/metabolism/*pathology/physiology
Cholera Toxin/*metabolism
Confocal
Crish Samuel D
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Disease Models
Glaucoma/*diagnostic imaging/metabolism/physiopathology
Humans
Methods in molecular biology (Clifton, N.J.)
Mice
Microscopy
NEOMED College of Medicine
NEOMED College of Pharmacy
Rats
Schofield Brett R
Visual Pathways
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jcp.25900" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jcp.25900</a>
Pages
409–421
Issue
1
Volume
233
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Osteoactivin regulates head and neck squamous cell carcinoma invasion by modulating matrix metalloproteases.
Publisher
An entity responsible for making the resource available
Journal of cellular physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-01
Subject
The topic of the resource
*Cell Movement; Carcinoma; Cell Line; cell lines; Enzymologic; extracellular matrix; Gene Expression Regulation; Head and Neck Neoplasms/*enzymology/genetics/pathology; human; Humans; matrix metalloproteinases; Matrix Metalloproteinases; Membrane Glycoproteins/genetics/*metabolism; Messenger/genetics/metabolism; neoplasm invasion; Neoplasm Invasiveness; Neoplastic; RNA; RNA Interference; Secreted/genetics/*metabolism; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Squamous Cell/*enzymology/genetics/pathology; Transfection; Tumor
Creator
An entity primarily responsible for making the resource
Arosarena Oneida A; Barr Eric W; Thorpe Ryan; Yankey Hilary; Tarr Joseph T; Safadi Fayez F
Description
An account of the resource
Nearly 60% of patients with head and neck squamous cell carcinoma (HNSCC) die of metastases or locoregional recurrence. Metastasis is mediated by cancer cell migration and invasion, which are in part dependent on extracellular matrix degradation by matrix metalloproteinases. Osteoactivin (OA) overexpression plays a role in metastases in several malignancies, and has been shown to upregulate matrix metalloproteinase (MMP) expression and activity. To determine how OA modulates MMP expression and activity in HNSCC, and to investigate OA effects on cell invasion, we assessed effects of OA treatment on MMP mRNA and protein expression, as well as gelatinase and caseinolytic activity in HNSCC cell lines. We assessed the effects of OA gene silencing on MMP expression, gelatinase and caseinolytic activity, and cell invasion. OA treatment had differential effects on MMP mRNA expression. OA treatment upregulated MMP-10 expression in UMSCC14a (p = 0.0431) and SCC15 (p \textless 0.0001) cells, but decreased MMP-9 expression in UMSCC14a cells (p = 0.0002). OA gene silencing decreased MMP-10 expression in UMSCC12 cells (p = 0.0001), and MMP-3 (p = 0.0005) and -9 (p = 0.0036) expression in SCC25 cells. In SCC15 and SCC25 cells, OA treatment increased MMP-2 (p = 0.0408) and MMP-9 gelatinase activity (p \textless 0.0001), respectively. OA depletion decreased MMP-2 (p = 0.0023) and -9 (p \textless 0.0001) activity in SCC25 cells. OA treatment increased 70 kDa caseinolytic activity in UMSCC12 cells consistent with tissue type plasminogen activator (p = 0.0078). OA depletion decreased invasive capacity of UMSCC12 cells (p \textless 0.0001). OA's effects on MMP expression in HNSCC are variable, and may promote cancer cell invasion.
Identifier
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<a href="http://doi.org/10.1002/jcp.25900" target="_blank" rel="noreferrer noopener">10.1002/jcp.25900</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Cell Movement
2018
Arosarena Oneida A
Barr Eric W
Carcinoma
Cell Line
cell lines
Department of Anatomy & Neurobiology
Enzymologic
Extracellular Matrix
Gene Expression Regulation
Head and Neck Neoplasms/*enzymology/genetics/pathology
Human
Humans
Journal of cellular physiology
matrix metalloproteinases
Membrane Glycoproteins/genetics/*metabolism
Messenger/genetics/metabolism
NEOMED College of Medicine
neoplasm invasion
Neoplasm Invasiveness
Neoplastic
RNA
RNA Interference
Safadi Fayez F
Secreted/genetics/*metabolism
Signal Transduction
Squamous Cell Carcinoma of Head and Neck
Squamous Cell/*enzymology/genetics/pathology
Tarr Joseph T
Thorpe Ryan
Transfection
Tumor
Yankey Hilary
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/dvg.23076" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/dvg.23076</a>
Issue
1
Volume
56
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Review and experimental evaluation of the embryonic development and evolutionary history of flipper development and hyperphalangy in dolphins (Cetacea: Mammalia).
Publisher
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Genesis (New York, N.Y. : 2000)
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-01
Subject
The topic of the resource
*Biological Evolution; *cetacea; *FGF; *flipper; *WNT; Animals; Body Patterning; Dolphins/*embryology; Extremities/*embryology; Mammals
Creator
An entity primarily responsible for making the resource
Cooper Lisa Noelle; Sears Karen E; Armfield Brooke A; Kala Bhavneet; Hubler Merla; Thewissen J G M
Description
An account of the resource
Cetaceans are the only mammals to have evolved hyperphalangy, an increase in the number of phalanges beyond the mammalian plesiomorphic condition of three phalanges per digit. In this study, cetaceans were used as a novel model to review previous studies of mammalian hyperphalangy and contribute new experimental evidence as to the molecular origins of this phenotype in embryos of the pantropical spotted dolphin (Stenella attenuata). Results show embryos of dolphins, mice, and pigs share similar spatiotemporal patterns of signaling proteins known to shape limbs of mammals (e.g., FGF8, BMP2/4, WNT, GREM). However, fetal dolphins differ in that their interdigital tissues are retained, instead of undergoing apoptosis, and that multiple waves of interdigital signals likely contribute to the patterning of supernumerary joints and phalanges in adjacent digits. Integration of fossil and experimental evidence suggests that the presence of interdigital webbing within the fossils of semi-aquatic cetaceans, recovered from the Eocene Epoch (49Ma), was probably the result of
Identifier
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<a href="http://doi.org/10.1002/dvg.23076" target="_blank" rel="noreferrer noopener">10.1002/dvg.23076</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Biological Evolution
*cetacea
*FGF
*flipper
*WNT
2018
Animals
Armfield Brooke A
Body Patterning
Cooper Lisa Noelle
Department of Anatomy & Neurobiology
Dolphins/*embryology
Extremities/*embryology
Genesis (New York, N.Y. : 2000)
Hubler Merla
Kala Bhavneet
Mammals
NEOMED College of Medicine
Sears Karen E
Thewissen J G M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/cne.24383" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/cne.24383</a>
Pages
972–989
Issue
6
Volume
526
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Perineuronal nets in subcortical auditory nuclei of four rodent species with differing hearing ranges.
Publisher
An entity responsible for making the resource available
The Journal of comparative neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-04
Subject
The topic of the resource
guinea pig; inferior colliculus; mouse; naked mole-rat; plasticity; rat; RRID: AB141637; RRID: AB1500687; RRID: AB2336066; RRID: AB2336874; RRID: AB2336881; RRID: AB90460; superior olive; thalamus
Creator
An entity primarily responsible for making the resource
Beebe Nichole L; Schofield Brett R
Description
An account of the resource
Perineuronal nets (PNs) are aggregates of extracellular matrix molecules that surround some neurons in the brain. While PNs occur widely across many cortical areas, subcortical PNs are especially associated with motor and auditory systems. The auditory system has recently been suggested as an ideal model system for studying PNs and their functions. However, descriptions of PNs in subcortical auditory areas vary, and it is unclear whether the variation reflects species differences or differences in staining techniques. Here, we used two staining techniques (one lectin stain and one antibody stain) to examine PN distribution in the subcortical auditory system of four different species: guinea pigs (Cavia porcellus), mice (Mus musculus, CBA/CaJ strain), Long-Evans rats (Rattus norvegicus), and naked mole-rats (Heterocephalus glaber). We found that some auditory nuclei exhibit dramatic differences in PN distribution among species while other nuclei have consistent PN distributions. We also found that PNs exhibit molecular heterogeneity, and can stain with either marker individually or with both. PNs within a given nucleus can be heterogeneous or homogenous in their staining patterns. We compared PN staining across the frequency axes of tonotopically organized nuclei and among species with different hearing ranges. PNs were distributed non-uniformly across some nuclei, but only rarely did this appear related to the tonotopic axis. PNs were prominent in all four species; we found no systematic relationship between the hearing range and the number, staining patterns or distribution of PNs in the auditory nuclei.
Identifier
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<a href="http://doi.org/10.1002/cne.24383" target="_blank" rel="noreferrer noopener">10.1002/cne.24383</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Beebe Nichole L
Department of Anatomy & Neurobiology
guinea pig
inferior colliculus
mouse
naked mole-rat
NEOMED College of Medicine
plasticity
rat
RRID: AB141637
RRID: AB1500687
RRID: AB2336066
RRID: AB2336874
RRID: AB2336881
RRID: AB90460
Schofield Brett R
superior olive
thalamus
The Journal of comparative neurology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/art.40751" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/art.40751</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Genetic inactivation of ZCCHC6 suppresses IL-6 expression and reduces the severity of experimental osteoarthritis in mice.
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Arthritis & rheumatology (Hoboken, N.J.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-10
Creator
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Ansari Mohammad Y; Khan Nazir M; Ahmad Nashrah; Green Jonathan; Novak Kimberly; Haqqi Tariq M
Description
An account of the resource
OBJECTIVE: Cytokine expression is tightly regulated post-transcriptionally but high levels of IL-6 in osteoarthritis (OA) indicate disruption of regulatory mechanisms. ZCCHC6 enzyme is implicated in post-transcriptional regulation of inflammatory cytokine expression but its role in OA pathogenesis is unknown. Here we studied whether ZCCHC6 directs the expression of IL-6 and influence OA pathogenesis in vivo. METHODS: Human and mouse chondrocytes were stimulated with recombinant IL-1beta. We knocked down the expression of ZCCHC6 in human chondrocytes by siRNAs. IL-6 transcript stability was determined by Actinomycin-D chase and 3'-uridylation of miRNAs was determined by deep sequencing. Zcchc6-/- mice were produced by gene targeting. OA was surgically induced in the knee joints of mice and the disease severity was scored using a semi-quantitative scoring system. RESULTS: ZCCHC6 was markedly upregulated in the damaged cartilage from human OA patients and from wild type mice with surgically-induced OA. Overexpression of ZCCHC6 induced the expression of IL-6 and its knockdown reduced the IL-6 transcript stability and IL-1beta-induced expression in chondrocytes. Reintroduction of Zcchc6 in Zcchc6-/- chondrocytes rescued the IL-1beta-induced
Identifier
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<a href="http://doi.org/10.1002/art.40751" target="_blank" rel="noreferrer noopener">10.1002/art.40751</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Ahmad Nashrah
Ansari Mohammad Y
Arthritis & rheumatology (Hoboken, N.J.)
Department of Anatomy & Neurobiology
Green Jonathan
Haqqi Tariq M
Khan Nazir M
NEOMED College of Medicine
Novak Kimberly
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/ar.24045" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ar.24045</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Getting into Shape: Limb Bone Strength in Perinatal Lemur catta and Propithecus coquereli.
Publisher
An entity responsible for making the resource available
Anatomical record (Hoboken, N.J. : 2007)
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-12
Subject
The topic of the resource
cross-sectional geometry; material properties; ontogeny; quadrupedalism; vertical clinging and leaping
Creator
An entity primarily responsible for making the resource
Young Jesse W; Jankord Kathryn; Saunders Marnie M; Smith Timothy D
Description
An account of the resource
Functional studies of skeletal anatomy are predicated on the fundamental assumption that form will follow function. For instance, previous studies have shown that the femora of specialized leaping primates are more robust than those of more generalized primate quadrupeds. Are such differences solely a plastic response to differential loading patterns during postnatal life, or might they also reflect more canalized developmental mechanisms present at birth? Here, we show that perinatal Lemur catta, an arboreal/terrestrial quadruped, have less robust femora than perinatal Propithecus coquereli, a closely related species specialized for vertical clinging and leaping (a highly unusual locomotor mode in which the hindlimbs are used to launch the animal between vertical tree trunks). These results suggest that functional differences in long bone cross-sectional dimensions are manifest at birth, belying simple interpretations of adult postcranial form as a direct record of loading patterns during postnatal life. Despite these significant differences in bone robusticity, we find that hindlimb bone mineralization, material properties, and measures of whole-bone strength generally overlap in perinatal L. catta and P. coquereli, indicating little differentiation in postcranial maturity at birth despite known differences in the pace of craniodental development between the species. In a broader perspective, our results likely reflect evolution acting during prenatal ontogeny. Even though primates are notable for relatively prolonged gestation and postnatal parental care, neonates are not buffered from selection, perhaps especially in the unpredictable and volatile environment of Madagascar. Anat Rec, 2018. (c) 2018 Wiley Periodicals, Inc.
Identifier
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<a href="http://doi.org/10.1002/ar.24045" target="_blank" rel="noreferrer noopener">10.1002/ar.24045</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Anatomical record (Hoboken, N.J. : 2007)
cross-sectional geometry
Department of Anatomy & Neurobiology
Jankord Kathryn
material properties
NEOMED College of Medicine
ontogeny
quadrupedalism
Saunders Marnie M
Smith Timothy D
vertical clinging and leaping
Young Jesse W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/ar.23991" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ar.23991</a>
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1002/ar.24045" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1002/ar.24045</a>
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Title
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A Comparison of the Cortical Structure of the Bowhead Whale (Balaena mysticetus), a Basal Mysticete, with Other Cetaceans.
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An entity responsible for making the resource available
Anatomical record (Hoboken, N.J. : 2007)
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-10
Subject
The topic of the resource
baleen whale; cytoarchitecture; humpback whale; minke whale; sperm whale
Creator
An entity primarily responsible for making the resource
Raghanti Mary Ann; Wicinski Bridget; Meierovich Rachel; Warda Tahia; Dickstein Dara L; Reidenberg Joy S; Tang Cheuk Y; George John C; Hans Thewissen J G M; Butti Camilla; Hof Patrick R
Description
An account of the resource
Few studies exist of the bowhead whale brain and virtually nothing is known about its cortical cytoarchitecture or how it compares to other cetaceans. Bowhead whales are one of the least encephalized cetaceans and occupy a basal phylogenetic position among mysticetes. Therefore, the bowhead whale is an important specimen for understanding the evolutionary specializations of cetacean brains. Here, we present an overview of the structure and cytoarchitecture of the bowhead whale cerebral cortex gleaned from Nissl-stained sections and magnetic resonance imaging (MRI) in comparison with other mysticetes and odontocetes. In general, the cytoarchitecture of cetacean cortex is consistent in displaying a thin cortex, a thick, prominent layer I, and absence of a granular layer IV. Cell density, composition, and width of layers III, V, and VI vary among cortical regions, and cetacean cortex is cell-sparse relative to that of terrestrial mammals. Notably, all regions of the bowhead cortex possess high numbers of von Economo neurons and fork neurons, with the highest numbers observed at the apex of gyri. The bowhead whale is also distinctive in having a significantly reduced hippocampus that occupies a space below the corpus callosum within the lateral ventricle. Consistent with other balaenids, bowhead whales possess what appears to be a blunted temporal lobe, which is in contrast to the expansive temporal lobes that characterize most odontocetes. The present report demonstrates that many morphological and cytoarchitectural characteristics are conserved among cetaceans, while other features, such as a reduced temporal lobe, may characterize balaenids among mysticetes. Anat Rec, 2018. (c) 2018 Wiley Periodicals, Inc.
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<a href="http://doi.org/10.1002/ar.23991" target="_blank" rel="noreferrer noopener">10.1002/ar.23991</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Anatomical record (Hoboken, N.J. : 2007)
Baleen whale
Butti Camilla
cytoarchitecture
Department of Anatomy & Neurobiology
Dickstein Dara L
George John C
Hans Thewissen J G M
Hof Patrick R
humpback whale
Meierovich Rachel
minke whale
NEOMED College of Medicine
Raghanti Mary Ann
Reidenberg Joy S
sperm whale
Tang Cheuk Y
Warda Tahia
Wicinski Bridget
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/ar.23693" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ar.23693</a>
Pages
77–87
Issue
1
Volume
301
Dublin Core
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Title
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Ontogeny of the Orbital Glands and Their Environs in the Pantropical Spotted Dolphin (Stenella attenuata: Delphinidae).
Publisher
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Anatomical record (Hoboken, N.J. : 2007)
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-01
Subject
The topic of the resource
Animals; cetacean; Fossils/anatomy & histology; Harderian Gland/*embryology; Morphogenesis/*physiology; Nasal Cavity/embryology; nasolacrimal duct; Nasolacrimal Duct/*embryology; ontogeny; Orbit/embryology; orbital glands; Stenella/*embryology
Creator
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Rehorek Susan J; Hillenius Willem J; Lovano Denise M; Thewissen J G M
Description
An account of the resource
The nasolacrimal duct (NLD) connects the orbital (often associated with the Deep Anterior Orbital gland: DAOG, a.k.a. Harderian gland) and nasal regions in many tetrapods. Adult cetaceans are usually said to lack an NLD, and there is little agreement in the literature concerning the identity of their orbital glands, which may reflect conflicting definitions rather than taxonomic variation. In this study, we examined an embryological series of the pantropical spotted dolphin (Stenella attenuata), and report numerous divergences from other tetrapods. Underdeveloped eyelids and a few ventral orbital glands are present by late Stage (S) 17. By S 19, circumorbital conjunctival glands are present. In S 20, these conjunctival glands have proliferated, eyelids (and scattered palpebral glands) have formed, and a duct similar to the NLD has appeared. Subsequently, both the palpebral glands and the NLD are progressively reduced by S 22, even as the conjunctival glands exhibit regional growth. In most tetrapods examined, the ontogeny of the NLD follows a series of three stages: Inception of NLD, Connection of orbit and nasal cavity by the NLD and Ossification (i.e., formation of the bony canal surrounding the NLD, emerging into the orbit via the lacrimal foramen in the lacrimal bone). In contrast, the dolphin NLD originates at the same time as the lacrimal bone, and a lacrimal foramen fails to develop. The cetacean fossil record shows that a lacrimal foramen was present in the earliest ancestral amphibious, freshwater forms, but was soon lost as the lineage invaded the oceans. Anat Rec, 2017. (c) 2017 Wiley Periodicals, Inc. Anat Rec, 301:77-87, 2018. (c) 2017 Wiley Periodicals, Inc.
Identifier
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<a href="http://doi.org/10.1002/ar.23693" target="_blank" rel="noreferrer noopener">10.1002/ar.23693</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Anatomical record (Hoboken, N.J. : 2007)
Animals
Cetacean
Department of Anatomy & Neurobiology
Fossils/anatomy & histology
Harderian Gland/*embryology
Hillenius Willem J
Lovano Denise M
Morphogenesis/*physiology
Nasal Cavity/embryology
nasolacrimal duct
Nasolacrimal Duct/*embryology
NEOMED College of Medicine
ontogeny
Orbit/embryology
orbital glands
Rehorek Susan J
Stenella/*embryology
Thewissen J G M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/ajpa.23686" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ajpa.23686</a>
Pages
569–584
Issue
3
Volume
167
Dublin Core
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Title
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A user's guide for the quantitative analysis of substrate characteristics and locomotor kinematics in free-ranging primates.
Publisher
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American journal of physical anthropology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-11
Subject
The topic of the resource
branch diameter; compliance; gait; orientation; quadrupedalism
Creator
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Dunham Noah T; McNamara Allison; Shapiro Liza; Hieronymus Tobin; Young Jesse W
Description
An account of the resource
OBJECTIVES: Laboratory studies have yielded important insights into primate locomotor mechanics. Nevertheless, laboratory studies fail to capture the range of ecological and structural variation encountered by free-ranging primates. We present techniques for collecting kinematic data on wild primates using consumer grade high-speed cameras and demonstrate novel methods for quantifying metric variation in arboreal substrates. MATERIALS AND METHODS: These methods were developed and applied to our research examining platyrrhine substrate use and locomotion at the Tiputini Biodiversity Station, Ecuador. Modified GoPro cameras equipped with varifocal zoom lenses provided high-resolution footage (1080 p.; 120 fps) suitable for digitizing gait events. We tested two methods for remotely measuring branch diameter: the parallel laser method and the distance meter photogrammetric method. A forestry-grade laser rangefinder was used to quantify substrate angle and a force gauge was used to measure substrate compliance. We also introduce GaitKeeper, a graphical user interface for MATLAB, designed for coding quadrupedal gait. RESULTS: Parallel laser and distance meter methods provided accurate estimations of substrate diameter (percent error: 3.1-4.5%). The laser rangefinder yielded accurate estimations of substrate orientation (mean error = 2.5 degrees ). Compliance values varied tremendously among substrates but were largely explained by substrate diameter, substrate length, and distance of measurement point from trunk. On average, larger primates used relatively small substrates and traveled higher in the canopy. DISCUSSION: Ultimately, these methods will help researchers identify more precisely how primate gait kinematics respond to the complexity of arboreal habitats, furthering our understanding of the adaptive context in which primate quadrupedalism evolved.
Identifier
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<a href="http://doi.org/10.1002/ajpa.23686" target="_blank" rel="noreferrer noopener">10.1002/ajpa.23686</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
American journal of physical anthropology
branch diameter
Compliance
Department of Anatomy & Neurobiology
Dunham Noah T
Gait
Hieronymus Tobin
McNamara Allison
NEOMED College of Medicine
Orientation
quadrupedalism
Shapiro Liza
Young Jesse W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/ajpa.23388" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ajpa.23388</a>
Pages
37–71
Volume
165 Suppl 65
Dublin Core
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Title
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Developments in development: What have we learned from primate locomotor ontogeny?
Publisher
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American journal of physical anthropology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-01
Subject
The topic of the resource
*allometry; *gait mechanics; *life history; *locomotor independence; *ontogeny; Animals; Anthropology; Biomechanical Phenomena/*physiology; Bone and Bones/physiology; Female; Gait/*physiology; Hand Strength/physiology; Humans; Locomotion/*physiology; Male; Phylogeny; Physical; Primates/*physiology
Creator
An entity primarily responsible for making the resource
Young Jesse W; Shapiro Liza J
Description
An account of the resource
The importance of locomotion to evolutionary fitness has led to extensive study of primate locomotor behavior, morphology and ecology. Most previous research has focused on adult primates, but in the last few decades, increased attention to locomotor development has provided new insights toward our broader understanding of primate adaptation and evolution. Here, we review the contributions of this body of work from three basic perspectives. First, we assess possible determinants on the timing of locomotor independence, an important life history event. Significant influences on timing of locomotor independence include adult female body mass, age at weaning, and especially relative brain size, a significant predictor of other primate life history variables. Additionally, we found significant phylogenetic differences in the timing of locomotor independence, even accounting for these influences. Second, we discuss how structural aspects of primate growth may enhance the locomotor performance and safety of young primates, despite their inherent neuromotor and musculoskeletal limitations. For example, compared to adults, growing primates have greater muscle mechanical advantage, greater bone robusticity, and larger extremities with relatively long digits. Third, focusing on primate quadrupedalism, we provide examples that illustrate how ontogenetic transitions in morphology and locomotion can serve as a model system for testing broader principles underlying primate locomotor biomechanics. This approach has led to a better understanding of the key features that contribute to primates' stride characteristics, gait patterns, limb force distribution, and limb postures. We have learned a great deal from the study of locomotor ontogeny, but there is much left to explore. We conclude by offering guidelines for future research, both in the laboratory and the field.
Identifier
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<a href="http://doi.org/10.1002/ajpa.23388" target="_blank" rel="noreferrer noopener">10.1002/ajpa.23388</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*allometry
*gait mechanics
*life history
*locomotor independence
*ontogeny
2018
American journal of physical anthropology
Animals
Anthropology
Biomechanical Phenomena/*physiology
Bone and Bones/physiology
Department of Anatomy & Neurobiology
Female
Gait/*physiology
Hand Strength/physiology
Humans
Locomotion/*physiology
Male
NEOMED College of Medicine
Phylogeny
Physical
Primates/*physiology
Shapiro Liza J
Young Jesse W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/ajpa.23331" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ajpa.23331</a>
Pages
65–76
Issue
1
Volume
165
Dublin Core
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Title
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Behavioral implications of ontogenetic changes in intrinsic hand and foot proportions in olive baboons (Papio Anubis).
Publisher
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American journal of physical anthropology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-01
Subject
The topic of the resource
*allometry; *early performance; *Foot/anatomy & histology/physiology; *grasping; *Hand/anatomy & histology/physiology; *locomotor development; *Papio anubis/anatomy & histology/physiology; *primate evolution; Animals; Anthropology; Female; Hand Strength/physiology; Locomotion; Male; Models; Physical; Statistical
Creator
An entity primarily responsible for making the resource
Druelle Francois; Young Jesse; Berillon Gilles
Description
An account of the resource
OBJECTIVES: Relatively long digits are considered to enhance grasping performance in primates. We tested whether growth-related changes in intrinsic hand and foot proportions may have behavioral implications for growing animals, by examining whether ontogenetic changes in digital proportions are related to variation in voluntary grasping behaviors in baboons. MATERIALS AND METHODS: Longitudinal morphological and behavioral data were collected on 6 captive olive baboons (Papio anubis) as they aged from 5 to 22 months. The length of digits and metapodials, measured from radiographs, were used to calculate phalangeal indices (i.e., PIs: summed length of non-distal phalanges relative to corresponding metapodial length). We also examined the allometric scaling of digital bones relative to body mass. We observed baboon positional behaviors over a 15-day period following the radiographic sessions, quantifying the frequency of forelimb and hindlimb grasping behaviors. RESULTS: PIs for all digits declined during growth, a result of the differential scaling of metapodials (which scaled to body mass with isometry) versus phalanges (which scaled with negative allometry). The incidence of forelimb and hindlimb grasping behaviors declined with age. Though we found no relationship between forelimb grasping and hand proportions, the incidence of hindlimb grasping was directly correlated with postaxial digit PIs. DISCUSSION: Only changes in the intrinsic proportions of the pedal digits are associated with variation in grasping activity in growing baboons. This finding accords previous biomechanical and neuroanatomical studies showing distinct functional roles for the hands and feet during primate locomotion, and has important implications for reconstructing primate locomotor evolution.
Identifier
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<a href="http://doi.org/10.1002/ajpa.23331" target="_blank" rel="noreferrer noopener">10.1002/ajpa.23331</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*allometry
*early performance
*Foot/anatomy & histology/physiology
*grasping
*Hand/anatomy & histology/physiology
*locomotor development
*Papio anubis/anatomy & histology/physiology
*primate evolution
2018
American journal of physical anthropology
Animals
Anthropology
Berillon Gilles
Department of Anatomy & Neurobiology
Druelle Francois
Female
Hand Strength/physiology
Locomotion
Male
Models
NEOMED College of Medicine
Physical
Statistical
Young Jesse
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/ajp.22878" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ajp.22878</a>
Pages
e22878–e22878
Issue
7
Volume
80
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Nutrient intake and balancing among female Colobus angolensis palliatus inhabiting structurally distinct forest areas: Effects of group, season, and reproductive state.
Publisher
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American journal of primatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-07
Subject
The topic of the resource
diet; foraging; geometric framework; nutritional geometry
Creator
An entity primarily responsible for making the resource
Dunham Noah T; Rodriguez-Saona Luis E
Description
An account of the resource
Understanding intraspecific behavioral and dietary variation is critical for assessing primate populations' abilities to persist in habitats characterized by increasing anthropogenic disturbances. While it is evident that some species exhibit considerable dietary flexibility (in terms of species-specific plant parts) in relation to habitat disturbance, it is unclear if primates are characterized by similar variation and flexibility regarding nutrient intake. This study examined the effects of group, season, and reproductive state on nutrient intake and balancing in adult female Colobus angolensis palliatus in the Diani Forest, Kenya. During July 2014 to December 2015, estimates of nutrient intake were recorded for eight females from three groups inhabiting structurally and ecologically distinct forest areas differing in tree species composition and density. There were differences in metabolizable energy (ME) and macronutrient intakes among groups, seasons, and reproductive states. Most notably, females inhabiting one of the more disturbed forest areas consumed less ME and macronutrients compared to females in the more intact forest area. Contrary to prediction, females in early lactation consumed significantly less ME and macronutrients compared to non-lactating and late lactation females. Despite differences in macronutrient intake, the relative contribution of macronutrients to ME were generally more conservative among groups, seasons, and reproductive states. Average daily intake ratios of non-protein energy to available protein ranged from approximately 3.5:1-4.3:1 among groups. These results indicate that female C. a. palliatus demonstrate a consistent nutrient balancing strategy despite significant intergroup differences in consumption of species-specific plant parts. Data from additional colobine species inhabiting different forest types are required to assess the extent to which nutrient balancing is constrained by phylogeny or is more flexible to local ecological conditions.
Identifier
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<a href="http://doi.org/10.1002/ajp.22878" target="_blank" rel="noreferrer noopener">10.1002/ajp.22878</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
American journal of primatology
Department of Anatomy & Neurobiology
Diet
Dunham Noah T
foraging
geometric framework
NEOMED College of Medicine
nutritional geometry
Rodriguez-Saona Luis E