Browse Items (18 total)
- Tags: Department of Integrative Medical Sciences, 2016
Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice.
Tags: *Lipid Metabolism, 2016, Adiposity, Animals, Carboxylesterase/*metabolism, Carboxylic Ester Hydrolases/genetics/*metabolism, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diabetes Mellitus, Diet, Endoplasmic Reticulum Stress, Energy Metabolism, Experimental/enzymology, Gene Knockdown Techniques, Glucose Tolerance Test, Glucose/metabolism, Hepatocyte Nuclear Factor 4/*metabolism, Hepatology (Baltimore, Md.), High-Fat/adverse effects, Homeostasis, Humans, Inbred C57BL, Jadhav Kavita, Kasumov Takhar, Li Yuanyuan, Lipogenesis, Lipolysis, Liver/enzymology, Male, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*etiology/metabolism, Obesity/enzymology/etiology, Sterol Regulatory Element Binding Protein 1/metabolism, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao
Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice.
Tags: *Intestinal Absorption, 2016, Adorini Luciano, Animals, Bile Acids and Salts/*chemistry, Biological Transport, Cholesterol/*metabolism, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Gonzalez Frank J, Hepatology (Baltimore, Md.), Inbred C57BL, Lee Yoon-Kwang, Li Fei, Mice, NEOMED College of Medicine, Receptors, Xu Jiesi, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao
Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction.
Tags: *Coronary Circulation, *Microcirculation, 2016, Animals, Basic research in cardiology, Bratz Ian N, Capsaicin, Chen Yeong-Renn, Connell Patrick J, Coronary blood flow, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetic Angiopathies/*metabolism, Dick Gregory M, Fahmy Joseph N, Fancher Ibra S, HEK293 Cells, Humans, Hydrogen peroxide, Hydrogen Peroxide/*metabolism, Inbred C57BL, Kang Patrick T, Klarich Brittany, Knockout, Male, Mice, NEOMED College of Medicine, reactive oxygen species, Thodeti Charles K, TRPV Cation Channels/*metabolism, TRPV1
Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage.
Tags: 2016, Animal, Animals, Basic research in cardiology, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Coronary Circulation, Coronary microcirculation, Coronary Vessels/metabolism/*physiopathology, Department of Integrative Medical Sciences, Diabetes, Disease Models, DNA, DNA Damage/physiology, DNA Fragmentation, Dobson James G Jr, Fenton Richard, Guarini Giacinta, Hardwick James P, Kang Patrick T, Kiyooka Takahiko, Kolz Christopher L, Marzilli Mario, Metabolic Syndrome/metabolism/*physiopathology, Mitochondria, Mitochondria/*metabolism, Mitochondrial/*metabolism, NEOMED College of Medicine, Obesity, Ohanyan Vahagn, Oxidative Stress/physiology, Pung Yuh Fen, Rats, Reactive Oxygen Species/metabolism, Shokolenko Inna, Vasodilation/physiology, Wilson Glenn L, Yin Liya, Zucker
Lipopolysaccharide supports maintaining the stemness of CD133(+) hepatoma cells through activation of the NF-kappaB/HIF-1alpha pathway.
Tags: *Cancer stem cells, *Lipopolysaccharide, *Plasticity, *Stemness maintenance, *Tumor microenvironment, 2016, AC133 Antigen/genetics/*metabolism, alpha Subunit/genetics/*metabolism, Animals, Antineoplastic Agents – Pharmacodynamics, Antineoplastic Agents/pharmacology, Body Weights and Measures, Cancer letters, Carcinoma, Cell Line, Cell Movement – Drug Effects, Cell Movement/drug effects, Cell Physiology, Cell Physiology – Drug Effects, Cell Proliferation/drug effects, Department of Integrative Medical Sciences, Drug Resistance, Gene Expression Regulation, Genes, Genetic Techniques, Han Zhi-Peng, Hepatocellular, Hepatocellular – Drug Therapy, Hepatocellular – Metabolism, Hepatocellular – Pathology, Hepatocellular/drug therapy/genetics/*metabolism/pathology, Humans, Hypoxia-Inducible Factor 1, Inbred BALB C, Jing Ying-Ying, Lai Fo-Bao, Li Rong, Li Xiao-Yong, Lipopolysaccharides – Pharmacodynamics, Lipopolysaccharides/*pharmacology, Liu Jing-Feng, Liu Wen-Ting, Liver Neoplasms, Liver Neoplasms – Drug Therapy, Liver Neoplasms – Metabolism, Liver Neoplasms – Pathology, Liver Neoplasms/drug therapy/genetics/*metabolism/pathology, Male, Mice, NEOMED College of Medicine, Neoplasm, Neoplasm Invasiveness, Neoplastic, Neoplastic Stem Cells/*drug effects/metabolism/pathology, NF-kappa B – Metabolism, NF-kappa B/*metabolism, Nude, Pan Xiao-Rong, Phenotype, Proteins, Proteins – Metabolism, RNA Interference, Shi Rong-Yu, Signal Transduction – Drug Effects, Signal Transduction/drug effects, Stem Cells – Drug Effects, Stem Cells – Metabolism, Stem Cells – Pathology, Time Factors, Transfection, Tumor Burden, Tumor Microenvironment, Wei Li-Xin, Wu Meng-Chao, Yang Xue, Yu Guo-Feng, Zeng Jian-Xing, Zhang Hang-Jie, Zhang Ping, Zhao Qiu-Dong
Tags: *4-Hydroxynonenal, *Coronary regulation, *Lipid peroxidation, *Post-translational modification, *Protein Processing, *Reactive oxygen species, *Signal Transduction, *TRPV1, 2016, Action Potentials/drug effects, Aldehydes/antagonists & inhibitors/metabolism/*pharmacology, Animal, Animals, Blood Flow Velocity, Bratz Ian N, Calcium Signaling/drug effects, Cappelli Holly C, Capsaicin/*pharmacology, Cardiovascular Agents/*pharmacology, Connell Patrick J, Coronary Circulation/drug effects, Coronary Vessels/metabolism/physiopathology, Cysteine/genetics/metabolism, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus/drug therapy/*metabolism/physiopathology, Disease Models, Fahmy Joseph N, Femoral Artery/metabolism/physiopathology, Free radical biology & medicine, Geldenhuys Werner J, HEK293 Cells, Humans, Inbred C57BL, Lipid Peroxidation, Male, Mice, NEOMED College of Medicine, Patch-Clamp Techniques, Post-Translational, Sinharoy Pritam, Thodeti Charles K, TRPV Cation Channels/genetics/*metabolism, Vasodilation/drug effects
Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3.
Tags: 2016, Al-Azzam Nosayba, Animals, Boyce Joshua A, c-fos, Capillary Permeability, Cell Line, CysLT(1)R, Department of Integrative Medical Sciences, Dinoprostone/*immunology, Duah Ernest, E-prostanoid receptor 3, Edema/immunology, EP3 Subtype/*immunology, extracellular signal-regulated kinase, Humans, Inbred BALB C, Inbred C57BL, Inflammation/immunology, Kondeti Vinay, leukotriene D(4), Leukotriene D4/*immunology, Leukotriene/*immunology, macrophage inflammatory protein 1beta, Mast cells, Mast Cells/*immunology, Mice, NEOMED College of Medicine, Paruchuri Sailaja, prostaglandin D(2), Prostaglandin E, prostaglandin E(2), protein kinase G, Receptors, The Journal of allergy and clinical immunology, Thodeti Charles K, Transgenic, Tumor
Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy.
Tags: 2016, Adapala R K, Animals, Calcium Signaling/genetics, Cappelli H C, Carcinoma, Cell Line, Cell Proliferation/drug effects, Chilian W M, Cisplatin/administration & dosage, Department of Integrative Medical Sciences, Dudley A C, Endothelium, Gene Expression Regulation, Ghosh K, Humans, Ingber D E, Keshamouni V, Klagsbrun M, Leucine/administration & dosage/analogs & derivatives, Lewis Lung/drug therapy/*genetics/pathology, Meszaros J G, Mice, NEOMED College of Medicine, Neoplastic/drug effects, Neovascularization, Oncogene, Paruchuri S, Pathologic/drug therapy/*genetics/pathology, Sulfonamides/administration & dosage, Thodeti C K, Thoppil R J, TRPV Cation Channels/agonists/biosynthesis/*genetics, Tumor, Vascular Endothelial Growth Factor A/genetics, Vascular/drug effects/*pathology
Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4alpha and Protects Against Alcohol- and MCD diet-induced Liver Injury.
Tags: 2016, Alcoholic/*pathology, Alcohols/*toxicity, Animals, Carboxylic Ester Hydrolases/*metabolism, Chemical and Drug Induced Liver Injury/*pathology, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diet/*adverse effects, Fatty Liver, Gene Expression Regulation, Genetic, Hepatocyte Nuclear Factor 4/*metabolism, Hepatocytes/metabolism, Humans, Inbred C57BL, Jadhav Kavita, Knockout, Li Yuanyuan, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Promoter Regions, Protein Binding, Scientific reports, Xu Jiesi, Xu Yang, Yin Liya, You Min, Zhang Yanqiao
Anti-atherogenic effect of trivalent chromium-loaded CPMV nanoparticles in human aortic smooth muscle cells under hyperglycemic conditions in vitro.
Tags: *Comovirus, 2016, Aorta/*metabolism, Atherosclerosis/*drug therapy/therapy, Azo Compounds/chemistry, Cell Proliferation, Cells, Chlorides/*chemistry, Chromium Compounds/*chemistry, Cultured, Cytokines/metabolism, Czech Tori, Department of Integrative Medical Sciences, Drug Delivery Systems, Electron, Fluorescence, Ganguly Rituparna, Glucose/chemistry, Humans, Hyperglycemia/*metabolism, Lipids/chemistry, Microscopy, Myer Ashley B, Myocytes, Nanoparticles/chemistry, Nanoscale, NEOMED College of Medicine, NF-kappa B/metabolism, Proliferating Cell Nuclear Antigen/chemistry, Raman Priya, Sahu Soumyadip, Smooth Muscle/*metabolism, Spectrophotometry, Steinmetz Nicole F, Transforming Growth Factor beta/metabolism, Transmission, Ultraviolet, Wen Amy M
Ecotropic Murine Leukemia Virus Infection of Glial Progenitors Interferes with Oligodendrocyte Differentiation: Implications for Neurovirulence.
Tags: 2016, 3T3 Cells, Animals, Cardona Sandra M, Cell Line, Cell Proliferation, Cell Survival, Department of Integrative Medical Sciences, Dunphy Jaclyn M, env/biosynthesis, Female, Gene Products, Journal of virology, Leukemia Virus, Li Ying, Lynch Connor R, Lynch William P, Macklin Wendy B, Male, Mice, Motor Neuron Disease/*virology, Murine/*pathogenicity, NEOMED College of Medicine, Neural Stem Cells/*virology, Neurogenesis/*physiology, Neuroglia/*virology, Oligodendroglia/cytology/virology, Pedraza Carlos E, Retroviridae Infections/*complications, Transgenic
Leptin augments recruitment of IRF-1 and CREB to thrombospondin-1 gene promoter in vascular smooth muscle cells in vitro.
Tags: *cAMP response element-binding protein, *interferon regulatory factor-1, *leptin, *thrombospondin-1, *Transcription, *vascular smooth muscle cells, 2016, American journal of physiology. Cell physiology, Binding Sites/genetics, Cells, Chromatin Immunoprecipitation/methods, Cultured, Cyclic AMP Response Element-Binding Protein/*metabolism, Department of Integrative Medical Sciences, Ganguly Rituparna, Gene Expression Regulation/genetics, Genetic/genetics, Humans, Interferon Regulatory Factor-1/*metabolism, Leptin/*metabolism, Muscle, Mutagenesis, Myocytes, NEOMED College of Medicine, Promoter Regions, Raman Priya, Response Elements/genetics, Sahu Soumyadip, Site-Directed/methods, Smooth, Smooth Muscle/*metabolism, Thrombospondin 1/*genetics/*metabolism, Transcription, Transcriptional Activation/genetics, Transfection/methods, Up-Regulation/genetics, Vascular/*metabolism
Tags: *acetaldehyde dehydrogenase, *alcoholic fatty liver disease, *Inflammation, *small heterodimer partner, 2016, Acetates/blood, Alcoholic/genetics/*metabolism, Aldehyde Dehydrogenase, American journal of physiology. Gastrointestinal and liver physiology, Animals, Cytoplasmic and Nuclear/deficiency/*genetics/metabolism, Department of Integrative Medical Sciences, Ethanol/blood/*metabolism/toxicity, Inbred C57BL, Lee Mikang, Lee Yoon-Kwang, Lipid Peroxidation, Liver Diseases, Liver/drug effects/metabolism, Male, Mice, Mifflin Ryan, Mitochondrial/genetics/metabolism, NEOMED College of Medicine, Park Jung Eun, PPAR gamma/genetics/metabolism, Receptors
Early upregulation of myocardial CXCR4 expression is critical for dimethyloxalylglycine-induced cardiac improvement in acute myocardial infarction.
Tags: 2016, alpha Subunit/metabolism, American journal of physiology. Heart and circulatory physiology, Amino Acids, Animal, Animals, Apoptosis/drug effects, Cardiotonic Agents/*pharmacology, Cell Hypoxia, Cell Line, Chilian William M, CXCR4/deficiency/genetics/*metabolism, Department of Integrative Medical Sciences, Dicarboxylic/*pharmacology, Disease Models, Dong Feng, Enzyme Inhibitors/pharmacology, Forudi Farhad, hypoxia, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor-Proline Dioxygenases/antagonists & inhibitors/metabolism, Inbred C57BL, Kiedrowski Matthew, Knockout, Left/*drug effects, Mayorga Mari, Mice, myocardial infarction, Myocardial Infarction/*drug therapy/genetics/metabolism/pathology/physiopathology, Myocardium/*metabolism/pathology, NEOMED College of Medicine, Penn Marc S, Rats, Receptors, Recovery of Function, Shamhart Patricia, Signal Transduction/drug effects, stem cells, Stem Cells/drug effects/metabolism, Stroke Volume/drug effects, Time Factors, Up-Regulation, Ventricular Function, Weber Kristal
Cholesterol 7alpha-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.
Tags: *bile acids and salt/metabolism, *cholesterol/diet, *Lipids, *Liver, 2016, Animal, Animals, Bile Acids and Salts/genetics/metabolism, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cholesterol/*metabolism, Department of Integrative Medical Sciences, Diet, Disease Models, Exhalation/genetics, Ferrell Jessica M, Glucose/metabolism, High-Fat, Homeostasis, Humans, Journal of lipid research, Li Feng, Lipid Metabolism/genetics, Liver/enzymology/pathology, Metabolic Diseases/*genetics/metabolism, Mice, NEOMED College of Medicine
Cholesteryl ester transfer protein alters liver and plasma triglyceride metabolism through two liver networks in female mice.
Tags: *estrogen, *estrogen receptor alpha, *lipid and lipoprotein metabolism, *small heterodimer partner, *triglycerides, *very low density lipoprotein, 2016, Animals, Cholesterol Ester Transfer Proteins/*physiology, Department of Integrative Medical Sciences, Estrogen Receptor alpha/metabolism, Estrogens/physiology, Female, Inbred C57BL, Journal of lipid research, Le Thao D, Lee Yoon-Kwang, Lipid Metabolism, Liver/*metabolism, Metabolic Networks and Pathways, Mice, NEOMED College of Medicine, Oxidation-Reduction, Palmisano Brian T, Stafford John M, Transgenic, Triglycerides/biosynthesis/*blood, Zhu Lin
Cholesterol 7alpha-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis.
Tags: *bile acid, *Cholesterol 7-alpha-Hydroxylase/genetics/metabolism, *Farnesoid X receptor, *Homeostasis, *Liver Cirrhosis/chemically induced/enzymology/genetics/prevention & control, *Liver/enzymology/pathology, *nuclear receptor, *Takeda G protein-coupled receptor 5, 2016, Animals, Boehme Shannon, Chiang John Y L, Cholesterol/genetics/*metabolism, Department of Integrative Medical Sciences, G-Protein-Coupled/genetics/metabolism, Hep G2 Cells, Humans, Journal of lipid research, Knockout, Liu Hailiang, Mice, NEOMED College of Medicine, NF-kappa B/genetics/metabolism, Oxidative Stress, Pathak Preeti, Receptors, Tumor Necrosis Factor-alpha/genetics/metabolism
Tags: 2016, Adapala Ravi K, Animals, Cappelli Holly C, Carcinoma, Cell Movement/physiology, Department of Integrative Medical Sciences, endothelial cell, Endothelial Cells/metabolism/pathology, Inbred C57BL, Kanugula Anantha K, Knockout, Lewis Lung/metabolism/*pathology, Mechanotransduction, Mice, NEOMED College of Medicine, Neovascularization, Oncotarget, Paruchuri Sailaja, Pathologic/*metabolism/pathology, rho-Associated Kinases/*metabolism, Rho/Rho kinase, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/*metabolism, TRPV4, tumor angiogenesis