1
40
38
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s40572-017-0143-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s40572-017-0143-2</a>
Pages
192–199
Issue
2
Volume
4
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mechanisms of Gene-Environment Interactions in Parkinson's Disease.
Publisher
An entity responsible for making the resource available
Current environmental health reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-06
Subject
The topic of the resource
*Alpha-synuclein; *ATP13A2; *Gene-Environment Interaction; *Genetic Predisposition to Disease; *Manganese; *Paraquat; *Parkinson Disease; *Parkinson's disease; *Rotenone; Environmental Exposure/*adverse effects; Herbicides/adverse effects; Humans; Insecticides/adverse effects; Mutation/genetics; Paraquat/adverse effects; Risk Factors; Rotenone/adverse effects
Creator
An entity primarily responsible for making the resource
Fleming Sheila M
Description
An account of the resource
PURPOSE OF REVIEW: The purpose of the study was to discuss the main mechanisms associated with environmental and genetic factors that contribute to the development of Parkinson's disease (PD). RECENT FINDINGS: Novel genetic contributors to PD are being identified at a rapid pace in addition to novel environmental factors. The discovery of mutations in alpha-synuclein and leucine-rich repeat kinase 2 causing inherited forms of PD along with epidemiological, in vitro, and in vivo studies identifying herbicides, pesticides, and metals as risk factors have dramatically improved our understanding of mechanisms involved in the development of PD. However, at the same time, these discoveries have also added layers of complexity to the disease. Within the last several years, the genetics associated with PD has dominated the field in many ways; however, the majority of PD cases are likely due to different combinations of environmental exposures and genetic susceptibility. The most common toxicants used to model PD including rotenone, paraquat, and
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s40572-017-0143-2" target="_blank" rel="noreferrer noopener">10.1007/s40572-017-0143-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Alpha-synuclein
*ATP13A2
*Gene-Environment Interaction
*Genetic Predisposition to Disease
*Manganese
*Paraquat
*Parkinson Disease
*Parkinson's disease
*Rotenone
2017
Current environmental health reports
Department of Pharmaceutical Sciences
Environmental Exposure/*adverse effects
Fleming Sheila M
Herbicides/adverse effects
Humans
Insecticides/adverse effects
Mutation/genetics
NEOMED College of Pharmacy
Paraquat/adverse effects
Risk Factors
Rotenone/adverse effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bmcl.2016.11.053" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bmcl.2016.11.053</a>
Pages
303–308
Issue
2
Volume
27
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Structure-activity and in vivo evaluation of a novel lipoprotein lipase (LPL) activator.
Publisher
An entity responsible for making the resource available
Bioorganic & medicinal chemistry letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-01
Subject
The topic of the resource
*Diabetes; *High-fat diet; *Homology modeling; *Hyperlipidemia; *Lipoprotein lipase; *Liver cirrhosis; *Obesity; Animals; Benzeneacetamides/chemical synthesis/chemistry/*pharmacology; Dose-Response Relationship; Drug; Imidazoles/chemical synthesis/chemistry/*pharmacology; Lipoprotein Lipase/*metabolism; Mice; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship
Creator
An entity primarily responsible for making the resource
Geldenhuys Werner J; Caporoso Joel; Leeper Thomas C; Lee Yoon-Kwang; Lin Li; Darvesh Altaf S; Sadana Prabodh
Description
An account of the resource
Elevated triglycerides (TG) contribute towards increased risk for cardiovascular disease. Lipoprotein lipase (LPL) is an enzyme that is responsible for the metabolism of core triglycerides of very-low density lipoproteins (VLDL) and chylomicrons in the vasculature. In this study, we explored the structure-activity relationships of our lead compound (C10d) that we have previously identified as an LPL agonist. We found that the cyclopropyl moiety of C10d is not absolutely necessary for LPL activity. Several substitutions were found to result in loss of LPL activity. The compound C10d was also tested in vivo for its lipid lowering activity. Mice were fed a high-fat diet (HFD) for four months, and treated for one week at 10mg/kg. At this dose, C10d exhibited in vivo biological activity as indicated by lower TG and cholesterol levels as well as reduced body fat content as determined by ECHO-MRI. Furthermore, C10d also reduced the HFD induced fat accumulation in the liver. Our study has provided insights into the structural and functional characteristics of this novel LPL activator.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bmcl.2016.11.053" target="_blank" rel="noreferrer noopener">10.1016/j.bmcl.2016.11.053</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Diabetes
*High-fat diet
*Homology modeling
*Hyperlipidemia
*Lipoprotein lipase
*Liver cirrhosis
*Obesity
2017
Animals
Benzeneacetamides/chemical synthesis/chemistry/*pharmacology
Bioorganic & medicinal chemistry letters
Caporoso Joel
Darvesh Altaf S
Department of Integrative Medical Sciences
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Dose-Response Relationship
Drug
Geldenhuys Werner J
Imidazoles/chemical synthesis/chemistry/*pharmacology
Lee Yoon-Kwang
Leeper Thomas C
Lin Li
Lipoprotein Lipase/*metabolism
Mice
Molecular Docking Simulation
Molecular Structure
NEOMED College of Graduate Studies
NEOMED College of Medicine
NEOMED College of Pharmacy
Sadana Prabodh
Structure-Activity Relationship
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.cptl.2016.08.029" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.cptl.2016.08.029</a>
Pages
20–27
Issue
1
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Identifying motivators and barriers to student completion of instructor evaluations: A multi-faceted, collaborative approach from four colleges of pharmacy.
Publisher
An entity responsible for making the resource available
Currents in pharmacy teaching & learning
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-02
Subject
The topic of the resource
*Attitude of Health Personnel; *Barriers; *Faculty; *Focus group; *Instructor evaluation; *Motivators; *Student; Adult; Education; Educational Measurement/methods/*standards; Faculty/standards; Female; Humans; Male; Middle Aged; Motivation; Ohio; Pharmacy/*methods; Pharmacy/*psychology; Students; Surveys and Questionnaires; Universities/organization & administration
Creator
An entity primarily responsible for making the resource
McAuley James W; Backo Jennifer Lynn; Sobota Kristen Finley; Metzger Anne H; Ulbrich Timothy
Description
An account of the resource
OBJECTIVE: To identify motivators and barriers to pharmacy student completion of instructor evaluations, and to develop potential strategies to improve the evaluation process. METHODS: Completed at four Ohio Colleges of Pharmacy, Phase I consisted of a student/faculty survey and Phase II consisted of joint student/faculty focus groups to discuss Phase I data and to problem solve. RESULTS: In Phase I, the top three student-identified and faculty-perceived motivators to completion of evaluations were to (1) make the course better, (2) earn bonus points, and (3) improve the instructor's teaching. The top three student-identified barriers to completion of evaluations were having to (1) evaluate multiple instructors, (2) complete several evaluations around the same time, and (3) complete lengthy evaluations. Phase II focus groups identified a number of potential ways to enhance the motivators and reduce barriers, including but not limited to making sure faculty convey to students that the feedback they provide is useful and to provide examples of how student feedback has been used to improve their teaching/the course. CONCLUSIONS: Students and faculty identified motivators and barriers to completing instructor evaluations and were willing to work together to improve the process.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.cptl.2016.08.029" target="_blank" rel="noreferrer noopener">10.1016/j.cptl.2016.08.029</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Attitude of Health Personnel
*Barriers
*Faculty
*Focus group
*Instructor evaluation
*Motivators
*Student
2017
Adult
Backo Jennifer Lynn
Currents in pharmacy teaching & learning
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Education
Educational Measurement/methods/*standards
Faculty/standards
Female
Humans
Male
McAuley James W
Metzger Anne H
Middle Aged
Motivation
NEOMED College of Pharmacy
Ohio
Pharmacy/*methods
Pharmacy/*psychology
Sobota Kristen Finley
Students
Surveys and Questionnaires
Ulbrich Timothy
Universities/organization & administration
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.cptl.2017.03.030" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.cptl.2017.03.030</a>
Pages
671–682
Issue
4
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Preparing students for residency interviews through a residency interview boot camp.
Publisher
An entity responsible for making the resource available
Currents in pharmacy teaching & learning
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-07
Subject
The topic of the resource
*Career Mobility; *Internship and Residency; *Interviewing skills; *Mock interview; *Residency training; Adult; Curriculum/trends; Education; Feedback; Female; Humans; interviews; Interviews as Topic/*methods/standards; Male; pharmacy residency; Pharmacy/*psychology; Pharmacy/methods; residency interviews; Students; Workforce
Creator
An entity primarily responsible for making the resource
Ulbrich Timothy R; Boyle Jaclyn A
Description
An account of the resource
BACKGROUND AND PURPOSE: To describe the offering of the residency boot camp activity at one college of pharmacy for students in their fourth professional year. EDUCATIONAL ACTIVITY AND SETTING: Student pharmacists in their final professional year of pharmacy school were invited to participate in a voluntary residency boot camp activity. Originally, the activity consisted of four parts: (1) guidance on preparing for residency interviews; (2) a 1:1 mock interview with a resident, faculty member, residency preceptor or area program director; (3) a review of the student's curriculum vitae (CV) and letter of intent; and (4) a review of the application timeline and process. Based on the feedback, the activity was changed to include five parts: (1) orientation/welcome session, (2) mock interview, (3) case presentation, (4) podium presentation, and (5) a debriefing session on the day's activities and to answer any remaining student questions about the residency application process. In the second offering of the residency boot camp, students were invited to complete a voluntary pre- and post-assessment of their perceived readiness for residency interviews. The activity has evolved based on student feedback to focus predominately on the group and 1:1 interviews. FINDINGS: Since starting the activity in 2013, 14 of the 21 students (67%) from the class of 2014, 16 of the 25 students (64%) from the class of 2015 and 24 of the 26 students (92%) from the class of 2016 that applied for residency training participated in the residency boot camp activity. For the Fall 2014 offering where a survey was conducted, the pre- and post-survey instrument used a Likert Scale, ranging from "strongly disagree" (score of 1) to "strongly agree" (score of "5"). DISCUSSION: and conclusions: Simulated exercises such as a residency boot camp can expose student pharmacists to important interview readiness skills. Student pharmacists involved in this activity demonstrated a perceived positive effect of such activities.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.cptl.2017.03.030" target="_blank" rel="noreferrer noopener">10.1016/j.cptl.2017.03.030</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Career Mobility
*Internship and Residency
*Interviewing skills
*Mock interview
*Residency training
2017
Adult
Boyle Jaclyn A
Currents in pharmacy teaching & learning
Curriculum/trends
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Education
Feedback
Female
Humans
interviews
Interviews as Topic/*methods/standards
Male
NEOMED College of Pharmacy
pharmacy residency
Pharmacy/*psychology
Pharmacy/methods
residency interviews
Students
Ulbrich Timothy R
Workforce
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.cptl.2017.05.002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.cptl.2017.05.002</a>
Pages
750–762
Issue
5
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Toolkit for US colleges/schools of pharmacy to prepare learners for careers in academia.
Publisher
An entity responsible for making the resource available
Currents in pharmacy teaching & learning
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-09
Subject
The topic of the resource
*Academia; *Career; *Student preparation; *Training; Curriculum/trends; Education; Faculty; Humans; Pharmacy/*education/organization & administration; Pharmacy/*methods/organization & administration; Pharmacy/*psychology; Students; Universities/organization & administration/trends; Workforce
Creator
An entity primarily responsible for making the resource
Haines Seena L; Summa Maria A; Peeters Michael J; Dy-Boarman Eliza A; Boyle Jaclyn A; Clifford Kalin M; Willson Megan N
Description
An account of the resource
INTRODUCTION: The objective of this article is to provide an academic toolkit for use by colleges/schools of pharmacy to prepare student pharmacists/residents for academic careers. METHODS: Through the American Association of Colleges of Pharmac (AACP) Section of Pharmacy Practice, the Student Resident Engagement Task Force (SRETF) collated teaching materials used by colleges/schools of pharmacy from a previously reported national survey. The SRETF developed a toolkit for student pharmacists/residents interested in academic pharmacy. RESULTS: Eighteen institutions provided materials; five provided materials describing didactic coursework; over fifteen provided materials for an academia-focused Advanced Pharmacy Practice Experiences (APPE), while one provided materials for an APPE teaching-research elective. SRETF members created a syllabus template and sample lesson plan by integrating submitted resources. Submissions still needed to complete the toolkit include examples of curricular tracks and certificate programs. DISCUSSION AND CONCLUSIONS: Pharmacy faculty vacancies still exist in pharmacy education. Engaging student pharmacists/residents about academia pillars of teaching, scholarship and service is critical for the future success of the academy.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.cptl.2017.05.002" target="_blank" rel="noreferrer noopener">10.1016/j.cptl.2017.05.002</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Academia
*Career
*Student preparation
*Training
2017
Boyle Jaclyn A
Clifford Kalin M
Currents in pharmacy teaching & learning
Curriculum/trends
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Dy-Boarman Eliza A
Education
Faculty
Haines Seena L
Humans
NEOMED College of Pharmacy
Peeters Michael J
Pharmacy/*education/organization & administration
Pharmacy/*methods/organization & administration
Pharmacy/*psychology
Students
Summa Maria A
Universities/organization & administration/trends
Willson Megan N
Workforce
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.drudis.2016.10.007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.drudis.2016.10.007</a>
Pages
352–365
Issue
2
Volume
22
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Emerging strategies of targeting lipoprotein lipase for metabolic and cardiovascular diseases.
Publisher
An entity responsible for making the resource available
Drug Discovery Today
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-02
Subject
The topic of the resource
Animals; Cardiovascular Diseases/drug therapy/*enzymology; Humans; Lipoprotein Lipase/chemistry/*metabolism; Metabolic Diseases/drug therapy/*enzymology
Creator
An entity primarily responsible for making the resource
Geldenhuys Werner J; Lin Li; Darvesh Altaf S; Sadana Prabodh
Description
An account of the resource
Although statins and other pharmacological approaches have improved the management of lipid abnormalities, there exists a need for newer treatment modalities especially for the management of hypertriglyceridemia. Lipoprotein lipase (LPL), by promoting hydrolytic cleavage of the triglyceride core of lipoproteins, is a crucial node in the management of plasma lipid levels. Although LPL expression and activity modulation is observed as a pleiotropic action of some the commonly used lipid lowering drugs, the deliberate development of drugs targeting LPL has not occurred yet. In this review, we present the biology of LPL, highlight the LPL modulation property of currently used drugs and review the novel emerging approaches to target LPL.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.drudis.2016.10.007" target="_blank" rel="noreferrer noopener">10.1016/j.drudis.2016.10.007</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Animals
Cardiovascular Diseases/drug therapy/*enzymology
Darvesh Altaf S
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Drug Discovery Today
Geldenhuys Werner J
Humans
Lin Li
Lipoprotein Lipase/chemistry/*metabolism
Metabolic Diseases/drug therapy/*enzymology
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Sadana Prabodh
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.expneurol.2017.06.020" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.expneurol.2017.06.020</a>
Pages
1–15
Volume
296
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Injury-induced gp130 cytokine signaling in peripheral ganglia is reduced in diabetes mellitus.
Publisher
An entity responsible for making the resource available
Experimental neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-10
Subject
The topic of the resource
*Axon regeneration; *Axotomy; *Diabetes; *Neuropathy; *Peripheral nervous system; Animal; Animals; Antibiotics; Antineoplastic/toxicity; Blood Glucose/drug effects; Body Weight/drug effects; Cytokine Receptor gp130/genetics/*metabolism; Cytokines/metabolism; Diabetes Mellitus; Disease Models; Experimental/chemically induced/complications/*pathology; Fasting/blood; Gene Expression Regulation/*physiology; Hyperalgesia/etiology; Hyperglycemia/etiology; Inbred C57BL; Male; Mice; Nerve Degeneration/*etiology/pathology; Nerve Tissue Proteins/metabolism; Pain Measurement; Signal Transduction/drug effects/*physiology; Streptozocin/toxicity; Superior Cervical Ganglion/drug effects/*metabolism; Sweating/drug effects
Creator
An entity primarily responsible for making the resource
Niemi Jon P; Filous Angela R; DeFrancesco Alicia; Lindborg Jane A; Malhotra Nisha A; Wilson Gina N; Zhou Bowen; Crish Samuel D; Zigmond Richard E
Description
An account of the resource
Neuropathy is a major diabetic complication. While the mechanism of this neuropathy is not well understood, it is believed to result in part from deficient nerve regeneration. Work from our laboratory established that gp130 family of cytokines are induced in animals after axonal injury and are involved in the induction of regeneration-associated genes (RAGs) and in the conditioning lesion response. Here, we examine whether a reduction of cytokine signaling occurs in diabetes. Streptozotocin (STZ) was used to destroy pancreatic beta cells, leading to chronic hyperglycemia. Mice were injected with either low doses of STZ (5x60mg/kg) or a single high dose (1x200mg/kg) and examined after three or one month, respectively. Both low and high dose STZ treatment resulted in sustained hyperglycemia and functional deficits associated with the presence of both sensory and autonomic neuropathy. Diabetic mice displayed significantly reduced intraepidermal nerve fiber density and sudomotor function. Furthermore, low and high dose diabetic mice showed significantly reduced tactile touch sensation measured with Von Frey monofilaments. To look at the regenerative and injury-induced responses in diabetic mice, neurons in both superior cervical ganglia (SCG) and the 4th and 5th lumbar dorsal root ganglia (DRG) were unilaterally axotomized. Both high and low dose diabetic mice displayed significantly less axonal regeneration in the sciatic nerve, when measured in vivo, 48h after crush injury. Significantly reduced induction of two gp130 cytokines, leukemia inhibitory factor and interleukin-6, occurred in diabetic animals in SCG 6h after injury compared to controls. Injury-induced expression of interleukin-6 was also found to be significantly reduced in the DRG at 6h after injury in low and high dose diabetic mice. These effects were accompanied by reduced phosphorylation of signal transducer and activator of transcription 3 (STAT3), a downstream effector of the gp130 signaling pathway. We also found decreased induction of several gp130-dependent RAGs, including galanin and vasoactive intestinal peptide. Together, these data suggest a novel mechanism for the decreased response of diabetic sympathetic and sensory neurons to injury.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.expneurol.2017.06.020" target="_blank" rel="noreferrer noopener">10.1016/j.expneurol.2017.06.020</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Axon regeneration
*Axotomy
*Diabetes
*Neuropathy
*Peripheral nervous system
2017
Animal
Animals
Antibiotics
Antineoplastic/toxicity
Blood Glucose/drug effects
Body Weight/drug effects
Crish Samuel D
Cytokine Receptor gp130/genetics/*metabolism
Cytokines/metabolism
DeFrancesco Alicia
Department of Pharmaceutical Sciences
Diabetes Mellitus
Disease Models
Experimental neurology
Experimental/chemically induced/complications/*pathology
Fasting/blood
Filous Angela R
Gene Expression Regulation/*physiology
Hyperalgesia/etiology
Hyperglycemia/etiology
Inbred C57BL
Lindborg Jane A
Male
Malhotra Nisha A
Mice
NEOMED College of Pharmacy
Nerve Degeneration/*etiology/pathology
Nerve Tissue Proteins/metabolism
Niemi Jon P
Pain Measurement
Signal Transduction/drug effects/*physiology
Streptozocin/toxicity
Superior Cervical Ganglion/drug effects/*metabolism
Sweating/drug effects
Wilson Gina N
Zhou Bowen
Zigmond Richard E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.freeradbiomed.2017.10.373" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.freeradbiomed.2017.10.373</a>
Pages
461–469
Volume
113
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes.
Publisher
An entity responsible for making the resource available
Free radical biology & medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-12
Subject
The topic of the resource
*Ceruloplasmin; *Deamidation; *Heavy water metabolic labeling; *High resolution mass spectrometry; *Iron metabolism; *LC-MS/MS; *Non-enzymatic glycation; *Oxidative stress; *Protein Processing; *Proteome dynamics; *Serotransferrin; *Type 2 diabetes mellitus; Adult; Amino Acid Sequence; Case-Control Studies; Ceruloplasmin/genetics/*metabolism; Deuterium/metabolism; Diabetes Mellitus; Diabetic; Diet; Female; Gene Expression Regulation; Glycated Hemoglobin A/genetics/metabolism; Glycosylation; Humans; Iron/*metabolism; Isotope Labeling; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Post-Translational; Proteolysis; Transferrin/genetics/*metabolism; Type 2/diet therapy/genetics/*metabolism/pathology
Creator
An entity primarily responsible for making the resource
Golizeh Makan; Lee Kwangwon; Ilchenko Serguei; Osme Abdullah; Bena James; Sadygov Rovshan G; Kashyap Sangeeta R; Kasumov Takhar
Description
An account of the resource
Type 2 diabetes mellitus (T2DM) is associated with oxidative stress and perturbed iron metabolism. Serotransferrin (Trf) and ceruloplasmin (Cp) are two key proteins involved in iron metabolism and anti-oxidant defense. Non-enzymatic glycation and oxidative modification of plasma proteins are known to occur under hyperglycemia and oxidative stress. In this study, shotgun proteomics and (2)H2O-based metabolic labeling were used to characterize post-translational modifications and assess the kinetics of Trf and Cp in T2DM patients and matched controls in vivo. Six early lysine (Amadori) and one advanced arginine glycation were detected in Trf. No glycation, but five asparagine deamidations, were found in Cp. T2DM patients had increased fractional catabolic rates of both Trf and Cp that correlated with HbA1c (p \textless 0.05). The glycated Trf population was subject to an even faster degradation compared to the total Trf pool, suggesting that hyperglycemia contributed to an increased Trf degradation in T2DM patients. Enhanced production of Trf and Cp kept their levels stable. The changes in Trf and Cp turnover were associated with increased systemic oxidative stress without any alteration in iron status in T2DM. These findings can help better understand the potential role of altered Trf and Cp metabolism in the pathogenesis of T2DM and other diseases.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.freeradbiomed.2017.10.373" target="_blank" rel="noreferrer noopener">10.1016/j.freeradbiomed.2017.10.373</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Ceruloplasmin
*Deamidation
*Heavy water metabolic labeling
*High resolution mass spectrometry
*Iron metabolism
*LC-MS/MS
*Non-enzymatic glycation
*Oxidative Stress
*Protein Processing
*Proteome dynamics
*Serotransferrin
*Type 2 diabetes mellitus
2017
Adult
Amino Acid Sequence
Bena James
Case-Control Studies
Ceruloplasmin/genetics/*metabolism
Department of Pharmaceutical Sciences
Deuterium/metabolism
Diabetes Mellitus
Diabetic
Diet
Female
Free radical biology & medicine
Gene Expression Regulation
Glycated Hemoglobin A/genetics/metabolism
Glycosylation
Golizeh Makan
Humans
Ilchenko Serguei
Iron/*metabolism
Isotope Labeling
Kashyap Sangeeta R
Kasumov Takhar
Lee Kwangwon
Male
Middle Aged
NEOMED College of Pharmacy
Osme Abdullah
Oxidation-Reduction
Oxidative Stress
Post-Translational
Proteolysis
Sadygov Rovshan G
Transferrin/genetics/*metabolism
Type 2/diet therapy/genetics/*metabolism/pathology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.nbd.2017.08.009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.nbd.2017.08.009</a>
Pages
115–127
Volume
108
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide.
Publisher
An entity responsible for making the resource available
Neurobiology of disease
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-12
Subject
The topic of the resource
Animals; Astrocytes/immunology/pathology; Cell Death/physiology; Corpus Striatum/immunology/pathology; Cytokines/metabolism; Disease Progression; Dopaminergic Neurons/*immunology/pathology; Inbred C57BL; Inflammation/pathology/physiopathology; Lipopolysaccharides/*toxicity; Male; Messenger/metabolism; Mice; Microglia/*immunology/pathology; Nerve Degeneration/*immunology/pathology; Neurodegenerative Diseases/immunology/pathology; Neuroimmunomodulation/physiology; Random Allocation; RNA; Time Factors
Creator
An entity primarily responsible for making the resource
Beier Eric E; Neal Matthew; Alam Gelerah; Edler Melissa; Wu Long-Jun; Richardson Jason R
Description
An account of the resource
Inflammation arising from central and/or peripheral sources contributes to the pathogenesis of multiple neurodegenerative diseases including Parkinson's disease (PD). Emerging data suggest that differential activation of glia could lead to the pathogenesis and progression of PD. Here, we sought to determine the relationship between lipopolysaccharide (LPS) treatment, loss of dopaminergic neurons and differential activation of glia. Using a model of repeated injections with LPS (1mg/kg, i.p. for 4days), we found that LPS induced a 34% loss of dopamine neurons in the substantia nigra 19days after initiation of treatment, but no further cell loss was observed at 36days. LPS induced a strong pro-inflammatory response with increased mRNA expression of pro-inflammatory markers, including tumor necrosis factor-alpha (4.8-fold), inducible nitric oxide synthase (2.0-fold), interleukin-1 beta (8.9-fold), interleukin-6 (10.7-fold), and robust glial activation were observed at 1day after final dose of LPS. These pro-inflammatory genes were then reduced at 19days after treatment, when there was a rise in the anti-inflammatory genes Ym1 (1.8-fold) and arginase-1 (2.6-fold). Additionally, 36days after the last LPS injection there was a significant increase in interleukin-10 (2.1-fold) expression. The qPCR data results were supported by protein data, including cytokine measurements, western blotting, and immunofluorescence in brain microglia. Taken together, these data demonstrate that progressive neurodegeneration in the substantia nigra following LPS is likely arrested by microglia shifting to an anti-inflammatory phenotype. Thus, strategies to promote resolution of neuroinflammation may be a promising avenue to slow the progressive loss of dopamine neurons in PD.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.nbd.2017.08.009" target="_blank" rel="noreferrer noopener">10.1016/j.nbd.2017.08.009</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Alam Gelerah
Animals
Astrocytes/immunology/pathology
Beier Eric E
Cell Death/physiology
Corpus Striatum/immunology/pathology
Cytokines/metabolism
Department of Pharmaceutical Sciences
Disease Progression
Dopaminergic Neurons/*immunology/pathology
Edler Melissa
Inbred C57BL
Inflammation/pathology/physiopathology
Lipopolysaccharides/*toxicity
Male
Messenger/metabolism
Mice
Microglia/*immunology/pathology
Neal Matthew
NEOMED College of Pharmacy
Nerve Degeneration/*immunology/pathology
Neurobiology of disease
Neurodegenerative Diseases/immunology/pathology
Neuroimmunomodulation/physiology
Random Allocation
Richardson Jason R
RNA
Time Factors
Wu Long-Jun
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuro.2016.04.002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuro.2016.04.002</a>
Pages
274–279
Volume
60
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Developmental pyrethroid exposure causes long-term decreases of neuronal sodium channel expression.
Publisher
An entity responsible for making the resource available
Neurotoxicology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-05
Subject
The topic of the resource
Animals; BDNF; Brain-Derived Neurotrophic Factor/metabolism; Cerebral Cortex/*drug effects/growth & development/metabolism; Corpus Striatum/*drug effects/growth & development/metabolism; Deltamethrin; Female; Inbred C57BL; Insecticides/*toxicity; Male; Messenger/metabolism; Mice; Neurodevelopmental; Neurons/*drug effects/metabolism; Nitriles/*toxicity; Pregnancy; Prenatal Exposure Delayed Effects/*metabolism; Pyrethrins/*toxicity; Pyrethroid; RNA; Sodium channel; Voltage-Gated Sodium Channels/*metabolism
Creator
An entity primarily responsible for making the resource
Magby Jason P; Richardson Jason R
Description
An account of the resource
Pyrethroid insecticide use has increased over recent years because of their low to moderate acute toxicity in mammals. However, there is increasing concern over the potential detrimental effects of pyrethroids on developing animals. Most recently, we have shown that developmental exposure to deltamethrin results in long-term neurobehavioral effects. Pyrethroids exert their toxicity by acting on the voltage-gated sodium channel (Nav), delaying channel inactivation and causing hyperexcitability in the nervous system. Previous in vitro studies found that exposure to agents that increase Na(+) influx, including deltamethrin decreased Nav mRNA expression. However, it is unknown whether this occurs in vivo. To determine whether developmental pyrethroid exposure decreases Nav mRNA expression, pregnant mice were exposed to the pyrethroid deltamethrin (0 or 3mg/kg) every three days throughout gestation and lactation. Nav mRNA expression was measured in the striatum and cortex of the offspring at 10-11 months of age, a time at which behavioral abnormalities were still observed. Developmental exposure to deltamethrin decreased expression of Nav mRNA in a region- and isoform-specific fashion by 24-50%. Deltamethrin exposure also resulted in the persistent down-regulation of brain-derived neurotrophic factor (Bdnf) in the striatum by 66% but not in the cortex, suggesting a plausible mechanism for some of the associated behavioral effects observed previously. Taken together these data suggest that developmental deltamethrin exposure results in persistent deficits in Nav and BDNF mRNA expression that may contribute to long-term behavioral deficits.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuro.2016.04.002" target="_blank" rel="noreferrer noopener">10.1016/j.neuro.2016.04.002</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Animals
BDNF
Brain-Derived Neurotrophic Factor/metabolism
Cerebral Cortex/*drug effects/growth & development/metabolism
Corpus Striatum/*drug effects/growth & development/metabolism
Deltamethrin
Department of Pharmaceutical Sciences
Female
Inbred C57BL
Insecticides/*toxicity
Magby Jason P
Male
Messenger/metabolism
Mice
NEOMED College of Pharmacy
Neurodevelopmental
Neurons/*drug effects/metabolism
Neurotoxicology
Nitriles/*toxicity
Pregnancy
Prenatal Exposure Delayed Effects/*metabolism
Pyrethrins/*toxicity
Pyrethroid
Richardson Jason R
RNA
Sodium channel
Voltage-Gated Sodium Channels/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuro.2017.03.008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuro.2017.03.008</a>
Pages
99–106
Volume
60
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron loss.
Publisher
An entity responsible for making the resource available
Neurotoxicology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-05
Subject
The topic of the resource
1-Methyl-4-phenyl-1; 2; 3; 6-tetrahydropyridine/*administration & dosage; Animals; Catecholamines/metabolism; Cell Count; Corpus Striatum/*drug effects/metabolism; Dopamine; Dopamine transporter; Dopaminergic Neurons/*drug effects/metabolism; Inbred C57BL; Male; Mice; MPTP; MPTP Poisoning; Parkinsonian Disorders/*metabolism/*pathology; Stereology; Substantia Nigra/*drug effects/metabolism; Tyrosine 3-Monooxygenase/*metabolism; Tyrosine hydroxylase; Vesicular monoamine transporter
Creator
An entity primarily responsible for making the resource
Alam Gelareh; Edler Melissa; Burchfield Shelbie L; Richardson Jason R
Description
An account of the resource
Parkinson's disease (PD) is the second most common age-related neurodegenerative disease. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a prototypical neurotoxicant used in mice to mimic primary features of PD pathology including striatal dopamine depletion and dopamine neuron loss in the substantia nigra pars compacta (SNc). In the literature, there are several experimental paradigms involving multiple doses of MPTP that are used to elicit dopamine neuron loss. However, a recent study reported that a single low dose caused significant loss of dopamine neurons. Here, we determined the effect of a single intraperitoneal injection of one of three doses of MPTP (0.1, 2 and 20mg/kg) on dopamine neurons, labeled by tyrosine hydroxylase (TH(+)), and total neuron number (Nissl(+)) in the SNc using unbiased stereological counting. Data reveal a significant loss of neurons in the SNc (TH(+) and Nissl(+)) only in the group treated with 20mg/kg MPTP. Groups treated with lower dose of MPTP (0.1 and 2mg/kg) only showed significant loss of TH(+) neurons rather than TH(+) and Nissl(+) neurons. Striatal dopamine levels were decreased in the groups treated with 2 and 20mg/kg MPTP and striatal terminal markers including, TH and the dopamine transporter (DAT), were only decreased in the groups treated with 20mg/kg MPTP. These data demonstrate that lower doses of MPTP likely result in loss of TH expression rather than actual dopamine neuron loss in the SN. This finding reinforces the need to measure both total neuron number along with TH(+) cells in determining dopamine neuron loss.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuro.2017.03.008" target="_blank" rel="noreferrer noopener">10.1016/j.neuro.2017.03.008</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1-Methyl-4-phenyl-1
2
2017
3
6-tetrahydropyridine/*administration & dosage
Alam Gelareh
Animals
Burchfield Shelbie L
Catecholamines/metabolism
Cell Count
Corpus Striatum/*drug effects/metabolism
Department of Pharmaceutical Sciences
Dopamine
Dopamine transporter
Dopaminergic Neurons/*drug effects/metabolism
Edler Melissa
Inbred C57BL
Male
Mice
MPTP
MPTP Poisoning
NEOMED College of Pharmacy
Neurotoxicology
Parkinsonian Disorders/*metabolism/*pathology
Richardson Jason R
Stereology
Substantia Nigra/*drug effects/metabolism
Tyrosine 3-Monooxygenase/*metabolism
Tyrosine hydroxylase
Vesicular monoamine transporter
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuropharm.2017.07.020" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuropharm.2017.07.020</a>
Pages
189–196
Volume
125
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1.
Publisher
An entity responsible for making the resource available
Neuropharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-10
Subject
The topic of the resource
Acetylation/drug effects; Animals; Butyrates/pharmacology; Cell Line; Cell Survival/drug effects; Dopamine Plasma Membrane Transport Proteins/*metabolism; Dopamine transporter; Dopaminergic Neurons/cytology/drug effects/metabolism; Dose-Response Relationship; Drug; Epigenesis; Epigenetics; Genetic; Genetic/drug effects; Group A; HDAC; Histone deacetylase; Histone Deacetylase Inhibitors/*pharmacology; Histone Deacetylases/metabolism; Histones/*drug effects/metabolism; Homeodomain Proteins/metabolism; Hydroxamic Acids/pharmacology; Member 2/*metabolism; Messenger/metabolism; Nuclear Receptor Subfamily 4; Nurr1; Pitx3; Promoter Regions; Rats; RNA; Transcription Factors/metabolism; Valproate; Valproic Acid/*pharmacology
Creator
An entity primarily responsible for making the resource
Green Ashley L; Zhan Le; Eid Aseel; Zarbl Helmut; Guo Grace L; Richardson Jason R
Description
An account of the resource
The dopamine transporter (DAT) is the key regulator of dopaminergic transmission and is a target of several xenobiotics, including pesticides and pharmacological agents. Previously, we identified a prominent role for histone deacetylases in the regulation of DAT expression. Here, we utilized a rat dopaminergic cell line (N27) to probe the responsiveness of DAT mRNA expression to inhibitors of histone acetylation. Inhibition of histone deacetylases (HDACs) by valproate, butyrate and Trichostatin A led to a 3-10-fold increase in DAT mRNA expression, a 50% increase in protein levels, which were accompanied by increased H3 acetylation levels. To confirm the mechanism of valproate-mediated increase in DAT mRNA, chromatin immunoprecipitation (ChIP) assays were used and demonstrated a significant increase in enrichment of acetylation of histone 3 on lysines 9 and 14 (H3K9/K14ac) in the DAT promoter. Expression of Nurr1 and Pitx3, key regulators of DAT expression, were increased following valproate treatment and Nurr1 binding was enriched in the DAT promoter. Together, these results indicate that histone acetylation and subsequent enhancement of transcription factor binding are plausible mechanisms for DAT regulation by valproate and, perhaps, by other xenobiotics.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuropharm.2017.07.020" target="_blank" rel="noreferrer noopener">10.1016/j.neuropharm.2017.07.020</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Acetylation/drug effects
Animals
Butyrates/pharmacology
Cell Line
Cell Survival/drug effects
Department of Pharmaceutical Sciences
Dopamine Plasma Membrane Transport Proteins/*metabolism
Dopamine transporter
Dopaminergic Neurons/cytology/drug effects/metabolism
Dose-Response Relationship
Drug
Eid Aseel
Epigenesis
Epigenetics
Genetic
Genetic/drug effects
Green Ashley L
Group A
Guo Grace L
HDAC
Histone deacetylase
Histone Deacetylase Inhibitors/*pharmacology
Histone Deacetylases/metabolism
Histones/*drug effects/metabolism
Homeodomain Proteins/metabolism
Hydroxamic Acids/pharmacology
Member 2/*metabolism
Messenger/metabolism
NEOMED College of Pharmacy
Neuropharmacology
Nuclear Receptor Subfamily 4
Nurr1
Pitx3
Promoter Regions
Rats
Richardson Jason R
RNA
Transcription Factors/metabolism
Valproate
Valproic Acid/*pharmacology
Zarbl Helmut
Zhan Le
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/acschemneuro.7b00287" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/acschemneuro.7b00287</a>
Pages
2759–2765
Issue
12
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype.
Publisher
An entity responsible for making the resource available
ACS chemical neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-12
Subject
The topic of the resource
*aging; *Disease Models; *drug discovery; *mitochondrial dysfunction; *mitoNEET; Animal; Animals; Corpus Striatum/*metabolism/*pathology; Inbred C57BL; Iron-Binding Proteins/genetics/*metabolism; Knockout; Male; Membrane Proteins/genetics/*metabolism; Mice; Mitochondria/*metabolism/*pathology; Parkinson Disease/*metabolism/pathology
Creator
An entity primarily responsible for making the resource
Geldenhuys Werner J; Benkovic Stanley A; Lin Li; Yonutas Heather M; Crish Samuel D; Sullivan Patrick G; Darvesh Altaf S; Brown Candice M; Richardson Jason R
Description
An account of the resource
Mitochondrial dysfunction is thought to play a significant role in neurodegeneration observed in Parkinson's disease (PD), yet the mechanisms underlying this pathology remain unclear. Here, we demonstrate that loss of mitoNEET (CISD1), an iron-sulfur containing protein that regulates mitochondrial bioenergetics, results in mitochondrial dysfunction and loss of striatal dopamine and tyrosine hydroxylase. Mitochondria isolated from mice lacking mitoNEET were dysfunctional as revealed by elevated reactive oxygen species (ROS) and reduced capacity to produce ATP. Gait analysis revealed a shortened stride length and decreased rotarod performance in knockout mice, consistent with the loss of striatal dopamine. Together, these data suggest that mitoNEET KO mice exhibit many of the characteristics of early neurodegeneration in PD and may provide a novel drug discovery platform to evaluate compounds for enhancing mitochondrial function in neurodegenerative disorders.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/acschemneuro.7b00287" target="_blank" rel="noreferrer noopener">10.1021/acschemneuro.7b00287</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Aging
*Disease Models
*drug discovery
*mitochondrial dysfunction
*mitoNEET
2017
ACS chemical neuroscience
Animal
Animals
Benkovic Stanley A
Brown Candice M
Corpus Striatum/*metabolism/*pathology
Crish Samuel D
Darvesh Altaf S
Department of Pharmaceutical Sciences
Geldenhuys Werner J
Inbred C57BL
Iron-Binding Proteins/genetics/*metabolism
Knockout
Lin Li
Male
Membrane Proteins/genetics/*metabolism
Mice
Mitochondria/*metabolism/*pathology
NEOMED College of Pharmacy
Parkinson Disease/*metabolism/pathology
Richardson Jason R
Sullivan Patrick G
Yonutas Heather M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/toxsci/kfw187" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/toxsci/kfw187</a>
Pages
112–123
Issue
1
Volume
155
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pyrethroid Insecticides Directly Activate Microglia Through Interaction With Voltage-Gated Sodium Channels.
Publisher
An entity responsible for making the resource available
Toxicological sciences : an official journal of the Society of Toxicology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-01
Subject
The topic of the resource
*deltamethrin; *intracellular sodium.; *microglia; *neurodegeneration; *neuroinflammation; *permethrin; *pyrethroids; *tetrodotoxin; *tumor necrosis factor; *voltage-gated sodium channels; Animals; Cell Line; Dose-Response Relationship; Drug; Inbred C57BL; Insecticides/*toxicity; Ion Channel Gating/*drug effects; Mice; Microglia/*drug effects/metabolism; Pyrethrins/*toxicity; Sodium Channels/*drug effects; Transformed; Tumor Necrosis Factor-alpha/metabolism
Creator
An entity primarily responsible for making the resource
Hossain Muhammad M; Liu Jason; Richardson Jason R
Description
An account of the resource
Microglia are considered to be the resident immune cells of the central nervous system and contribute significantly to ongoing neuroinflammation in a variety of neurodegenerative diseases. Recently, we and others identified that voltage-gated sodium channels (VGSC) are present on microglia cells and contribute to excessive accumulation of intracellular Na(+ )and release of major pro-inflammatory cytokine tumor necrosis factor alpha (TNF-alpha). Based on this finding and the fact that pyrethroid pesticides act on VGSC, we hypothesized that exposure of microglia to the pyrethroid pesticides, permethrin and deltamethrin, would activate microglia and increase the release of TNF-alpha. BV2 cells or primary microglia were treated with 0-5 microM deltamethrin or permethrin in the presence or absence of tetrodotoxin (TTX), a VGSC blocker for 24-48 h. Both pyrethroids caused a rapid Na(+ )influx and increased accumulation of intracellular sodium [(Na(+))i] in the microglia in a dose- and time-dependent manner, which was significantly reduced by TTX. Furthermore, deltamethrin and permethrin increased the release of TNF-alpha in a dose- and time-dependent manner, which was significantly reduced by pre-treatment of cells with TTX. These results demonstrate that pyrethroid pesticides may directly activate microglial cells through their interaction with microglial VGSC. Because neuroinflammation plays a key role in many neurodegenerative diseases, these data provide an additional mechanism by which exposure to pyrethroid insecticides may contribute to neurodegeneration.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/toxsci/kfw187" target="_blank" rel="noreferrer noopener">10.1093/toxsci/kfw187</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*deltamethrin
*intracellular sodium.
*Microglia
*neurodegeneration
*Neuroinflammation
*permethrin
*pyrethroids
*tetrodotoxin
*tumor necrosis factor
*Voltage-gated sodium channels
2017
Animals
Cell Line
Department of Pharmaceutical Sciences
Dose-Response Relationship
Drug
Hossain Muhammad M
Inbred C57BL
Insecticides/*toxicity
Ion Channel Gating/*drug effects
Liu Jason
Mice
Microglia/*drug effects/metabolism
NEOMED College of Pharmacy
Pyrethrins/*toxicity
Richardson Jason R
Sodium Channels/*drug effects
Toxicological sciences : an official journal of the Society of Toxicology
Transformed
Tumor Necrosis Factor-alpha/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1124/jpet.117.241091" target="_blank" rel="noreferrer noopener">http://doi.org/10.1124/jpet.117.241091</a>
Pages
80–91
Issue
1
Volume
363
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Enhancing Studies of Pharmacodynamic Mechanisms via Measurements of Metabolic Flux: Fundamental Concepts and Guiding Principles for Using Stable Isotope Tracers.
Publisher
An entity responsible for making the resource available
The Journal of pharmacology and experimental therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-10
Subject
The topic of the resource
Animals; Drug Discovery/*methods; Humans; Isotope Labeling; Isotopes/chemistry; Metabolic Flux Analysis/*methods; Water/chemistry/metabolism
Creator
An entity primarily responsible for making the resource
Daurio Natalie A; Wang Sheng-Ping; Chen Ying; Zhou Haihong; McLaren David G; Roddy Thomas P; Johns Douglas G; Milot Denise; Kasumov Takhar; Erion Mark D; Kelley David E; Previs Stephen F
Description
An account of the resource
Drug discovery and development efforts are largely based around a common expectation, namely, that direct or indirect action on a cellular process (e.g., statin-mediated enzyme inhibition or insulin-stimulated receptor activation) will have a beneficial impact on physiologic homeostasis. To expand on this, one could argue that virtually all pharmacologic interventions attempt to influence the flow of "traffic" in a biochemical network, irrespective of disease or modality. Since stable isotope tracer kinetic methods provide a measure of traffic flow (i.e., metabolic flux), their inclusion in study designs can yield novel information regarding pathway biology; the application of such methods requires the integration of knowledge in physiology, analytical chemistry, and mathematical modeling. Herein, we review the fundamental concepts that surround the use of tracer kinetics, define basic terms, and outline guiding principles via theoretical and experimental problems. Specifically, one needs to 1) recognize the types of biochemical events that change isotopic enrichments, 2) appreciate the distinction between fractional turnover and flux rate, and 3) be aware of the subtle differences between tracer kinetics and pharmacokinetics. We hope investigators can use the framework presented here to develop applications that address their specific questions surrounding biochemical flux, and thereby gain insight into the pathophysiology of disease states, and examine pharmacodynamic mechanisms.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1124/jpet.117.241091" target="_blank" rel="noreferrer noopener">10.1124/jpet.117.241091</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Animals
Chen Ying
Daurio Natalie A
Department of Pharmaceutical Sciences
Drug Discovery/*methods
Erion Mark D
Humans
Isotope Labeling
Isotopes/chemistry
Johns Douglas G
Kasumov Takhar
Kelley David E
McLaren David G
Metabolic Flux Analysis/*methods
Milot Denise
NEOMED College of Pharmacy
Previs Stephen F
Roddy Thomas P
The Journal of pharmacology and experimental therapeutics
Wang Sheng-Ping
Water/chemistry/metabolism
Zhou Haihong
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1136/gutjnl-2016-311861" target="_blank" rel="noreferrer noopener">http://doi.org/10.1136/gutjnl-2016-311861</a>
Pages
705–715
Issue
4
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the
Publisher
An entity responsible for making the resource available
Gut
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-04
Subject
The topic of the resource
*CYTOKINES; *ETHANOL; *FATTY LIVER; *INFLAMMATION; *LEUKOCYTES; Adult; Alanine Transaminase/blood; Alcoholic/genetics/*metabolism/pathology; Alcoholism/*blood/complications; Animals; Aspartate Aminotransferases/blood; Bilirubin/blood; Binge Drinking/*blood/complications; Case-Control Studies; Central Nervous System Depressants/administration & dosage; Down-Regulation; Ethanol/administration & dosage; Female; Humans; Inbred C57BL; Interleukin-6/genetics/metabolism; Liver Diseases; Male; Mice; MicroRNAs/*blood/*genetics; Middle Aged; NADPH Oxidases/genetics/metabolism; Neutrophils/*metabolism; Reactive Oxygen Species/metabolism; Up-Regulation; Young Adult
Creator
An entity primarily responsible for making the resource
Li Man; He Yong; Zhou Zhou; Ramirez Teresa; Gao Yueqiu; Gao Yanhang; Ross Ruth A; Cao Haixia; Cai Yan; Xu Ming-Jiang; Feng Dechun; Zhang Ping; Liangpunsakul Suthat; Gao Bin
Description
An account of the resource
OBJECTIVES: Chronic-plus-binge ethanol feeding activates neutrophils and exacerbates liver injury in mice. This study investigates how recent excessive drinking affects peripheral neutrophils and liver injury in alcoholics, and how miR-223, one of the most abundant microRNAs (miRNAs) in neutrophils, modulates neutrophil function and liver injury in ethanol-fed mice. DESIGNS: Three hundred alcoholics with (n=140) or without (n=160) recent excessive drinking and 45 healthy controls were enrolled. Mice were fed an ethanol diet for 10 days followed by a single binge of ethanol. RESULTS: Compared with healthy controls or alcoholics without recent drinking, alcoholics with recent excessive drinking had higher levels of circulating neutrophils, which correlated with serum levels of alanine transaminase (ALT) and aspartate transaminase (AST). miRNA array analysis revealed that alcoholics had elevated serum miR-223 levels compared with healthy controls. In chronic-plus-binge ethanol feeding mouse model, the levels of miR-223 were increased in both serum and neutrophils. Genetic deletion of the miR-223 gene exacerbated ethanol-induced hepatic injury, neutrophil infiltration, reactive oxygen species (ROS) and upregulated hepatic expression of interleukin (IL)-6 and phagocytic oxidase (phox) p47(phox). Mechanistic studies revealed that miR-223 directly inhibited IL-6 expression and subsequently inhibited p47(phox) expression in neutrophils. Deletion of the p47(phox) gene ameliorated ethanol-induced liver injury and ROS production by neutrophils. Finally, miR-223 expression was downregulated, while IL-6 and p47(phox) expression were upregulated in peripheral blood neutrophils from alcoholics compared with healthy controls. CONCLUSIONS: miR-223 is an important regulator to block neutrophil infiltration in alcoholic liver disease and could be a novel therapeutic target for the treatment of this malady.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1136/gutjnl-2016-311861" target="_blank" rel="noreferrer noopener">10.1136/gutjnl-2016-311861</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*CYTOKINES
*ETHANOL
*FATTY LIVER
*Inflammation
*LEUKOCYTES
2017
Adult
Alanine Transaminase/blood
Alcoholic/genetics/*metabolism/pathology
Alcoholism/*blood/complications
Animals
Aspartate Aminotransferases/blood
Bilirubin/blood
Binge Drinking/*blood/complications
Cai Yan
Cao Haixia
Case-Control Studies
Central Nervous System Depressants/administration & dosage
Department of Integrative Medical Sciences
Department of Pharmaceutical Sciences
Down-Regulation
Ethanol/administration & dosage
Female
Feng Dechun
Gao Bin
Gao Yanhang
Gao Yueqiu
Gut
He Yong
Humans
Inbred C57BL
Interleukin-6/genetics/metabolism
Li Man
Liangpunsakul Suthat
Liver Diseases
Male
Mice
MicroRNAs/*blood/*genetics
Middle Aged
NADPH Oxidases/genetics/metabolism
NEOMED College of Medicine
NEOMED College of Pharmacy
Neutrophils/*metabolism
Ramirez Teresa
Reactive Oxygen Species/metabolism
Ross Ruth A
Up-Regulation
Xu Ming-Jiang
Young Adult
Zhang Ping
Zhou Zhou
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/0897190015621813" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/0897190015621813</a>
Pages
89–93
Issue
1
Volume
30
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Impact of Tranexamic Acid in Total Knee and Total Hip Replacement.
Publisher
An entity responsible for making the resource available
Journal of pharmacy practice
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-02
Subject
The topic of the resource
Aged; Antifibrinolytic Agents/adverse effects/therapeutic use; Arthroplasty; Blood Transfusion; Blood Transfusion/statistics & numerical data; Case-Control Studies; Descriptive Statistics; Female; Hemoglobins – Analysis; Hemoglobins/metabolism; Hip; Hip/*methods; Human; Humans; Knee; Knee/*methods; Length of Stay – Evaluation; Length of Stay/statistics & numerical data; Male; Outcome Assessment; Replacement; Retrospective Design; Retrospective Studies; total hip replacement; total knee replacement; tranexamic acid; Tranexamic Acid – Administration and Dosage; Tranexamic Acid/adverse effects/*therapeutic use; Venous Thromboembolism – Risk Factors; Venous Thromboembolism/epidemiology
Creator
An entity primarily responsible for making the resource
Boyle Jaclyn A; Soric Mate M
Description
An account of the resource
OBJECTIVE: To evaluate the net clinical benefit of tranexamic acid use in patients undergoing total knee or total hip replacement. METHODS: This is a retrospective study of patients undergoing total knee or total hip replacement. The primary outcome was the net clinical benefit of tranexamic acid use. Secondary outcomes included length of stay, incidence of venous thromboembolism, change in hemoglobin, and number of units of blood transfused. RESULTS: Four hundred and six patients were screened for inclusion and 327 patients met inclusion criteria; 174 patients received tranexamic acid versus 153 patients who received usual care. Tranexamic acid demonstrated a positive net clinical benefit versus usual care (40.8% vs 13.7%, P \textless .01) but did not affect length of stay (3.39 vs 3.37 days, respectively, P = .76). Venous thromboembolism was comparable between groups (2.3% vs 0.7%, P = .38). Average change in hemoglobin and need for transfusion were lower in the treatment group versus the usual care group, respectively (3.46 vs 4.26 mg/dL, P \textless .01). CONCLUSION: Tranexamic acid demonstrated a significant benefit in decreasing change in hemoglobin as well as the need for blood transfusion with no increase in the risk of venous thromboembolism in patients undergoing total knee or total hip replacement.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/0897190015621813" target="_blank" rel="noreferrer noopener">10.1177/0897190015621813</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Aged
Antifibrinolytic Agents/adverse effects/therapeutic use
Arthroplasty
Blood Transfusion
Blood Transfusion/statistics & numerical data
Boyle Jaclyn A
Case-Control Studies
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Descriptive Statistics
Female
Hemoglobins – Analysis
Hemoglobins/metabolism
Hip
Hip/*methods
Human
Humans
Journal of pharmacy practice
Knee
Knee/*methods
Length of Stay – Evaluation
Length of Stay/statistics & numerical data
Male
NEOMED College of Pharmacy
Outcome Assessment
Replacement
Retrospective Design
Retrospective Studies
Soric Mate M
total hip replacement
total knee replacement
tranexamic acid
Tranexamic Acid – Administration and Dosage
Tranexamic Acid/adverse effects/*therapeutic use
Venous Thromboembolism – Risk Factors
Venous Thromboembolism/epidemiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/0897190016665541" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/0897190016665541</a>
Pages
506–515
Issue
5
Volume
30
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Patient Awareness and Expectations of Pharmacist Services During Hospital Stay.
Publisher
An entity responsible for making the resource available
Journal of pharmacy practice
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-10
Subject
The topic of the resource
*Anticipation; *Awareness; *Health Knowledge; 80 and over; Adolescent; Adult; Aged; Attitudes; Descriptive Statistics; Female; Health Services Accessibility; hospital; Hospital/methods/*statistics & numerical data; Human; Humans; Inpatients; Inpatients/*psychology; Male; marketing; Marketing/methods; Middle Aged; Patient Attitudes; patient awareness; Patient Education; patient expectations; Pharmacists/*statistics & numerical data; Pharmacy Service; pharmacy services; Practice; Pretest-Posttest Design; Professional Role; Professional-Patient Relations; Psychological; Social Marketing; Summated Rating Scaling; Surveys; Surveys and Questionnaires; United States; Young Adult
Creator
An entity primarily responsible for making the resource
King Philip K; Martin Steven J; Betka Eric M
Description
An account of the resource
BACKGROUND: There are insufficient data in the United States regarding patient awareness and expectations of hospital pharmacist availability and services. OBJECTIVE: The objective of this research is to assess patient awareness and expectations of hospital pharmacist services and to determine whether a marketing campaign for pharmacist services increases patient awareness and expectations. METHODS: Eligible inpatients were surveyed before and after implementation of a hospital-wide pharmacist services marketing campaign (12 items; Likert scale of 1 [strongly disagree] to 4 [strongly agree]; maximum total score of 48) regarding awareness of pharmacist services. The primary outcome was the change in median total survey scores from baseline. Other outcomes included the frequency of patient requests for pharmacists. RESULTS: Similar numbers of patients completed the survey before and after the campaign (intervention, n = 140, vs control, n = 147). Awareness of pharmacist availability and services was increased (41 [interquartile ranges, IQRs: 36-46] vs 37 [IQR 31-43]; P \textless .001). Patients were 7 times more likely to request a pharmacist following the marketing campaign implementation. CONCLUSION: Awareness among inpatients of pharmacist services is low. Marketing pharmacist availability and services to patients in the hospital improves awareness and expectations for pharmacist-provided care and increases the frequency of patient-initiated interaction between pharmacists and patients. This could improve patient outcomes as pharmacists become more integrally involved in direct patient care.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/0897190016665541" target="_blank" rel="noreferrer noopener">10.1177/0897190016665541</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Anticipation
*Awareness
*Health Knowledge
2017
80 and over
Adolescent
Adult
Aged
Attitudes
Betka Eric M
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Descriptive Statistics
Female
Health Services Accessibility
Hospital
Hospital/methods/*statistics & numerical data
Human
Humans
Inpatients
Inpatients/*psychology
Journal of pharmacy practice
King Philip K
Male
Marketing
Marketing/methods
Martin Steven J
Middle Aged
NEOMED College of Pharmacy
Patient Attitudes
patient awareness
Patient Education
patient expectations
Pharmacists/*statistics & numerical data
Pharmacy Service
pharmacy services
Practice
Pretest-Posttest Design
Professional Role
Professional-Patient Relations
Psychological
Social Marketing
Summated Rating Scaling
Surveys
Surveys and Questionnaires
United States
Young Adult
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1186/s13024-017-0216-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1186/s13024-017-0216-6</a>
Pages
74–74
Issue
1
Volume
12
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.
Publisher
An entity responsible for making the resource available
Molecular neurodegeneration
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-10
Subject
The topic of the resource
*Alzheimers disease; *Immunity; *Inflammation; *Tauopathy; *TREM2; Animal; Animals; Disease Models; Humans; Immunologic/*deficiency; Inbred C57BL; Membrane Glycoproteins/*deficiency; Mice; Microglia/metabolism; Protein Kinases/*metabolism; Receptors; Signal Transduction/physiology; tau Proteins/*metabolism; Tauopathies/metabolism/*pathology; Transgenic
Creator
An entity primarily responsible for making the resource
Bemiller Shane M; McCray Tyler J; Allan Kevin; Formica Shane V; Xu Guixiang; Wilson Gina; Kokiko-Cochran Olga N; Crish Samuel D; Lasagna-Reeves Cristian A; Ransohoff Richard M; Landreth Gary E; Lamb Bruce T
Description
An account of the resource
BACKGROUND: Genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) confer increased risk of developing late-onset Alzheimer's Disease (LOAD) and other neurodegenerative disorders. Recent studies provided insight into the multifaceted roles of TREM2 in regulating extracellular beta-amyloid (Abeta) pathology, myeloid cell accumulation, and inflammation observed in AD, yet little is known regarding the role of TREM2 in regulating intracellular microtubule associated protein tau (MAPT; tau) pathology in neurodegenerative diseases and in AD, in particular. RESULTS: Here we report that TREM2 deficiency leads to accelerated and exacerbated hyperphosphorylation and aggregation of tau in a humanized mouse model of tauopathy. TREM2 deficiency also results, indirectly, in dramatic widespread dysregulation of neuronal stress kinase pathways. CONCLUSIONS: Our results suggest that deficiency of microglial TREM2 leads to heightened tau pathology coupled with widespread increases in activated neuronal stress kinases. These findings offer new insight into the complex, multiple roles of TREM2 in regulating Abeta and tau pathologies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1186/s13024-017-0216-6" target="_blank" rel="noreferrer noopener">10.1186/s13024-017-0216-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Alzheimers disease
*Immunity
*Inflammation
*Tauopathy
*TREM2
2017
Allan Kevin
Animal
Animals
Bemiller Shane M
Crish Samuel D
Department of Pharmaceutical Sciences
Disease Models
Formica Shane V
Humans
Immunologic/*deficiency
Inbred C57BL
Kokiko-Cochran Olga N
Lamb Bruce T
Landreth Gary E
Lasagna-Reeves Cristian A
McCray Tyler J
Membrane Glycoproteins/*deficiency
Mice
Microglia/metabolism
Molecular neurodegeneration
NEOMED College of Pharmacy
Protein Kinases/*metabolism
Ransohoff Richard M
Receptors
Signal Transduction/physiology
tau Proteins/*metabolism
Tauopathies/metabolism/*pathology
Transgenic
Wilson Gina
Xu Guixiang
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1186/s13148-017-0416-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1186/s13148-017-0416-5</a>
Pages
117–117
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Turnover of histones and histone variants in postnatal rat brain: effects of alcohol exposure.
Publisher
An entity responsible for making the resource available
Clinical epigenetics
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
1905-07
Subject
The topic of the resource
*2H2O-labeling; *Brain; *Genetic Variation; *Histone; *Mass spectrometry; *Post-translational modifications; *Postnatal alcohol exposure; *Turnover; Acetylation; Animal; Animals; Cell Proliferation; Disease Models; DNA Damage; Epigenesis; Female; Fetal Alcohol Spectrum Disorders/genetics/*metabolism; Genetic; Histones/*genetics/*metabolism; Humans; Post-Translational; Pregnancy; Protein Processing; Proteomics/*methods; Rats; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Rachdaoui Nadia; Li Ling; Willard Belinda; Kasumov Takhar; Previs Stephen; Sarkar Dipak
Description
An account of the resource
BACKGROUND: Alcohol consumption during pregnancy is a significant public health problem and can result in a continuum of adverse outcomes to the fetus known as fetal alcohol spectrum disorders (FASD). Subjects with FASD show significant neurological deficits, ranging from microencephaly, neurobehavioral, and mental health problems to poor social adjustment and stress tolerance. Neurons are particularly sensitive to alcohol exposure. The neurotoxic action of alcohol, i.e., through ROS production, induces DNA damage and neuronal cell death by apoptosis. In addition, epigenetics, including DNA methylation, histone posttranslational modifications (PTMs), and non-coding RNA, play an important role in the neuropathology of FASD. However, little is known about the temporal dynamics and kinetics of histones and their PTMs in FASD. RESULTS: We examined the effects of postnatal alcohol exposure (PAE), an animal model of human third-trimester equivalent, on the kinetics of various histone proteins in two distinct brain regions, the frontal cortex, and the hypothalamus, using in vivo (2)H2O-labeling combined with mass spectrometry-based proteomics. We show that histones have long half-lives that are in the order of days. We also show that H3.3 and H2Az histone variants have faster turnovers than canonical histones and that acetylated histones, in general, have a faster turnover than unmodified and methylated histones. Our work is the first to show that PAE induces a differential reduction in turnover rates of histones in both brain regions studied. These alterations in histone turnover were associated with increased DNA damage and decreased cell proliferation in postnatal rat brain. CONCLUSION: Alterations in histone turnover might interfere with histone deposition and chromatin stability, resulting in deregulated cell-specific gene expression and therefore contribute to the development of the neurological disorders associated with FASD. Using in vivo (2)H2O-labeling and mass spectrometry-based proteomics might help in the understanding of histone turnover following alcohol exposure and could be of great importance in enabling researchers to identify novel targets and/or biomarkers for the prevention and management of fetal alcohol spectrum disorders.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1186/s13148-017-0416-5" target="_blank" rel="noreferrer noopener">10.1186/s13148-017-0416-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*2H2O-labeling
*Brain
*Genetic Variation
*Histone
*Mass spectrometry
*Post-translational modifications
*Postnatal alcohol exposure
*Turnover
2017
Acetylation
Animal
Animals
Cell Proliferation
Clinical epigenetics
Department of Pharmaceutical Sciences
Disease Models
DNA Damage
Epigenesis
Female
Fetal Alcohol Spectrum Disorders/genetics/*metabolism
Genetic
Histones/*genetics/*metabolism
Humans
Kasumov Takhar
Li Ling
NEOMED College of Pharmacy
Post-Translational
Pregnancy
Previs Stephen
Protein Processing
Proteomics/*methods
Rachdaoui Nadia
Rats
Sarkar Dipak
Sprague-Dawley
Willard Belinda
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1208/s12248-017-0176-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1208/s12248-017-0176-3</a>
Pages
18–18
Issue
1
Volume
20
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Therapeutic Delivery of Simvastatin Loaded in PLA-PEG Polymersomes Resulted in Amplification of Anti-inflammatory Effects in Activated Microglia.
Publisher
An entity responsible for making the resource available
The AAPS journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-12
Subject
The topic of the resource
*Drug Delivery Systems; *inflammation; *microglia; *neuroprotection; *polymersomes; *simvastatin; Animals; Anti-Inflammatory Agents/*pharmacology; Inbred BALB C; Interleukin-6/antagonists & inhibitors/biosynthesis; Lactates/*administration & dosage; Mice; Microglia/*drug effects; Nitric Oxide/antagonists & inhibitors/biosynthesis; Polyethylene Glycols/*administration & dosage; Simvastatin/*administration & dosage/pharmacology; Tumor Necrosis Factor-alpha/antagonists & inhibitors/biosynthesis
Creator
An entity primarily responsible for making the resource
Manickavasagam Dharani; Novak Kimberly; Oyewumi Moses O
Description
An account of the resource
Simvastatin (Sim), a lipid-lowering drug has been studied in chronic neuroinflammation associated with degenerative brain disorders due to its potential protective properties against inflammatory reaction, oxidative damage, neuronal dysfunction, and death. Meanwhile, potential application of Sim in neuroinflammation will require a suitable delivery system that can overcome notable challenges pertaining to poor blood-brain barrier (BBB) permeability and side/off-target effects. Herein, we engineered and characterized nano-sized polymersomes loaded with Sim (Sim-Ps) using PEG-PdLLA (methoxy polyethylene glycol-poly(D,L) lactic acid) diblock co-polymers. Studies in BV2 microglia indicated that Sim-Ps was superior to Sim alone in suppressing nitric oxide (NO) and proinflammatory cytokines (interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) secretion against LPS activation. The effectiveness of Sim-Ps as compared with Sim alone, in attenuating NO and cytokine production by activated BV2 cells can be attributed to (a) colloidal stability of the delivery platform, (b) protracted release of biologically active Sim, and (c) particulate internalization coupled with enhanced Sim exposure to BV2 cells. Intranasal delivery in BALB/c mice demonstrated enhanced brain distribution with increasing time after administration. Overall data demonstrated suitability of PEG-PdLLA polymersomes in Sim delivery for potential application in treating neuroinflammation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1208/s12248-017-0176-3" target="_blank" rel="noreferrer noopener">10.1208/s12248-017-0176-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Drug Delivery Systems
*Inflammation
*Microglia
*neuroprotection
*polymersomes
*simvastatin
2017
Animals
Anti-Inflammatory Agents/*pharmacology
Department of Pharmaceutical Sciences
Inbred BALB C
Interleukin-6/antagonists & inhibitors/biosynthesis
Lactates/*administration & dosage
Manickavasagam Dharani
Mice
Microglia/*drug effects
NEOMED College of Pharmacy
Nitric Oxide/antagonists & inhibitors/biosynthesis
Novak Kimberly
Oyewumi Moses O
Polyethylene Glycols/*administration & dosage
Simvastatin/*administration & dosage/pharmacology
The AAPS journal
Tumor Necrosis Factor-alpha/antagonists & inhibitors/biosynthesis
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2146/ajhp170082" target="_blank" rel="noreferrer noopener">http://doi.org/10.2146/ajhp170082</a>
Pages
1528–1531
Issue
19
Volume
74
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Is the Public Service Loan Forgiveness program right for you?
Publisher
An entity responsible for making the resource available
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-10
Subject
The topic of the resource
United States; debt; loan forgiveness; loan repayment; student loan; Program Evaluation; Training Support; Financial – United States
Creator
An entity primarily responsible for making the resource
Notareschi Vincent; Ulbrich Timothy R
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2146/ajhp170082" target="_blank" rel="noreferrer noopener">10.2146/ajhp170082</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
debt
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Financial – United States
loan forgiveness
loan repayment
NEOMED College of Pharmacy
Notareschi Vincent
Program Evaluation
student loan
Training Support
Ulbrich Timothy R
United States
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2174/1874467208666150817112109" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/1874467208666150817112109</a>
Pages
226–236
Issue
3
Volume
10
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
Publisher
An entity responsible for making the resource available
Current molecular pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
1905-7
Subject
The topic of the resource
Humans; Animals; AMP-Activated Protein Kinases/metabolism; Signal Transduction; Lipid Metabolism; Fatty Liver; Liver/metabolism; lipid metabolism; alcoholic fatty liver disease; inflammation; Lipin-1; signal transduction; transcriptional regulators; Phosphatidate Phosphatase/*metabolism; Inflammation/metabolism; Ethanol/chemistry/*metabolism; Sirtuin 1/metabolism; Alcoholic/*metabolism/pathology
Creator
An entity primarily responsible for making the resource
You Min; Jogasuria Alvin; Lee Kwangwon; Wu Jiashin; Zhang Yanqiao; Lee Yoon-Kwang; Sadana Prabodh
Description
An account of the resource
Lipin-1, a mammalian phosphatidic acid phosphatase (PAP), is a bi-functional molecule involved in various signaling pathways via its function as a PAP enzyme in the triglyceride synthesis pathway and in the nucleus as a transcriptional co-regulator. In the liver, lipin-1 is known to play a vital role in controlling the lipid metabolism and inflammation process at multiple regulatory levels. Alcoholic fatty liver disease (AFLD) is one of the earliest forms of liver injury and approximately 8-20% of patients with simple steatosis can develop into more severe forms of liver injury, including steatohepatitis, fibrosis/ cirrhosis, and eventually hepatocellular carcinoma (HCC). The signal transduction mechanisms for alcohol-induced detrimental effects in liver involves alteration of complex and multiple signaling pathways largely governed by a central and upstream signaling system, namely, sirtuin 1 (SIRT1)-AMP activated kinase (AMPK) axis. Emerging evidence suggests a pivotal role of lipin-1 as a crucial downstream regulator of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2174/1874467208666150817112109" target="_blank" rel="noreferrer noopener">10.2174/1874467208666150817112109</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
alcoholic fatty liver disease
Alcoholic/*metabolism/pathology
AMP-Activated Protein Kinases/metabolism
Animals
Current molecular pharmacology
Department of Integrative Medical Sciences
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Ethanol/chemistry/*metabolism
Fatty Liver
Humans
Inflammation
Inflammation/metabolism
Jogasuria Alvin
Lee Kwangwon
Lee Yoon-Kwang
Lipid Metabolism
Lipin-1
Liver/metabolism
NEOMED College of Graduate Studies
NEOMED College of Medicine
NEOMED College of Pharmacy
Phosphatidate Phosphatase/*metabolism
Sadana Prabodh
Signal Transduction
Sirtuin 1/metabolism
transcriptional regulators
Wu Jiashin
You Min
Zhang Yanqiao
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3233/JAD-160658" target="_blank" rel="noreferrer noopener">http://doi.org/10.3233/JAD-160658</a>
Pages
1605–1619
Issue
4
Volume
55
Dublin Core
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Title
A name given to the resource
Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease.
Publisher
An entity responsible for making the resource available
Journal of Alzheimer's disease : JAD
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
1905-07
Subject
The topic of the resource
Female; Male; Animals; Mice; *Alzheimer's disease; Body Weight; Body Composition; Age Factors; Body Weight/genetics; Phosphorylation; Bone Density/*physiology; *Alzheimer Disease/complications/genetics/pathology; *bone density; *microtubule-associated protein; *serotonin; *tau proteins; *tauopathies; Body Composition/genetics; Bone Diseases/*etiology; Dorsal Raphe Nucleus/*pathology; Neurons/metabolism/pathology; Serotonin/*metabolism; tau Proteins/*genetics/metabolism; Tauopathies/complications/genetics; Tryptophan Hydroxylase/metabolism; Biological; Models; Inbred C57BL; Animal; Disease Models; Transgenic; Nerve Tissue Proteins; Neurodegenerative Diseases; Animal Studies; Alzheimer's Disease; Bone Density – Physiology; Nerve Tissue Proteins – Metabolism; Neurodegenerative Diseases – Complications; Alzheimer's Disease – Complications; Alzheimer's Disease – Pathology; Bone Diseases – Etiology; Brain Stem – Pathology; Neurons – Metabolism; Neurons – Pathology; Oxidoreductases – Metabolism; Serotonin – Metabolism
Creator
An entity primarily responsible for making the resource
Dengler-Crish Christine M; Smith Matthew A; Wilson Gina N
Description
An account of the resource
Reduced bone mineral density (BMD) and its clinical sequelae, osteoporosis, occur at a much greater rate in patients with Alzheimer's disease (AD), often emerging early in the disease before significant cognitive decline is seen. Reduced BMD translates to increased bone fracture risk, decreased quality of life, and increased mortality for AD patients. However, the mechanism responsible for this observation is unclear. We hypothesize that bone loss is an additional component of an AD prodrome-changes that emerge prior to dementia and are mediated by dysfunction of the central serotonergic pathways. We characterized the skeletal phenotype of htau mice that express human forms of the microtubule-associated protein tau that become pathologically hyperphosphorylated in AD. Using radiographic densitometry, we measured BMD in female and male htau mice from 2-6 months of age-time-points prior to the presence of significant tauopathy in the hippocampal/entorhinal regions characteristic of this model. We found a significantly reduced BMD phenotype in htau mice that was most pronounced in males. Using western blotting and immunofluorescence, we showed overall reduced tryptophan hydroxylase (TPH) protein in htau brainstem and a 70% reduction in
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3233/JAD-160658" target="_blank" rel="noreferrer noopener">10.3233/JAD-160658</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Alzheimer Disease/complications/genetics/pathology
*Alzheimer's disease
*bone density
*microtubule-associated protein
*serotonin
*tau proteins
*tauopathies
2017
Age Factors
Alzheimer's disease
Alzheimer's Disease – Complications
Alzheimer's Disease – Pathology
Animal
Animal Studies
Animals
Biological
Body Composition
Body Composition/genetics
Body Weight
Body Weight/genetics
Bone Density – Physiology
Bone Density/*physiology
Bone Diseases – Etiology
Bone Diseases/*etiology
Brain Stem – Pathology
Dengler-Crish Christine M
Department of Pharmaceutical Sciences
Disease Models
Dorsal Raphe Nucleus/*pathology
Female
Inbred C57BL
Journal of Alzheimer's disease : JAD
Male
Mice
Models
NEOMED College of Pharmacy
Nerve Tissue Proteins
Nerve Tissue Proteins – Metabolism
Neurodegenerative Diseases
Neurodegenerative Diseases – Complications
Neurons – Metabolism
Neurons – Pathology
Neurons/metabolism/pathology
Oxidoreductases – Metabolism
Phosphorylation
Serotonin – Metabolism
Serotonin/*metabolism
Smith Matthew A
tau Proteins/*genetics/metabolism
Tauopathies/complications/genetics
Transgenic
Tryptophan Hydroxylase/metabolism
Wilson Gina N
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.5688/ajpe8116" target="_blank" rel="noreferrer noopener">http://doi.org/10.5688/ajpe8116</a>
Pages
6–6
Issue
1
Volume
81
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Methods Used by Colleges and Schools of Pharmacy to Prepare Student Pharmacists for Careers in Academia.
Publisher
An entity responsible for making the resource available
American journal of pharmaceutical education
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-02
Subject
The topic of the resource
Humans; United States; Surveys and Questionnaires; Curriculum; Societies; *Career Choice; academia; Attitude of Health Personnel; career; Pharmacists; student preparation; training; Education; *Students; Schools; Faculty; Graduate; Pharmacy/*methods; Pharmaceutical; Pharmacy; Pharmacy/*organization & administration
Creator
An entity primarily responsible for making the resource
Haines Seena L; Dy-Boarman Eliza A; Clifford Kalin M; Summa Maria A; Willson Megan N; Boyle Jaclyn A; Peeters Michael J
Description
An account of the resource
Objective. To identify the methods used by US colleges and schools of pharmacy to prepare student pharmacists for academic careers. Method. An 18-item survey instrument was developed and distributed to US colleges and schools of pharmacy. Representatives were asked about faculty responsibilities, experiences in academia currently offered to student pharmacists, and representatives' perception of their student pharmacists' preparedness for careers in academia, including barriers in current programming. Results. Representatives from 96 colleges/schools responded. The vast majority (96%) provided academia-focused advanced pharmacy practice experiences (APPEs), 40% provided didactic coursework in academia, 28% offered a longitudinal research track, and 42% offered academia-focused independent studies. Teaching methods and creating learning objectives were the most common pedagogical content, while assessment activities were diverse. Time was the most prevalent barrier to providing training for academic careers; however, degree of student pharmacist interest, faculty inexperience, and lack of leadership support were also commonly reported. Conclusions: Colleges and schools of pharmacy vary in the extent to which they prepare student pharmacists for careers in academia. Advanced pharmacy practice experiences were the most common method of training offered. Standardization of training for academia may better promote this career path to student pharmacists.
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<a href="http://doi.org/10.5688/ajpe8116" target="_blank" rel="noreferrer noopener">10.5688/ajpe8116</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Career Choice
*Students
2017
Academia
American journal of pharmaceutical education
Attitude of Health Personnel
Boyle Jaclyn A
Career
Clifford Kalin M
Curriculum
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Dy-Boarman Eliza A
Education
Faculty
Graduate
Haines Seena L
Humans
NEOMED College of Pharmacy
Peeters Michael J
Pharmaceutical
Pharmacists
Pharmacy
Pharmacy/*methods
Pharmacy/*organization & administration
Schools
Societies
Student preparation
Summa Maria A
Surveys and Questionnaires
Training
United States
Willson Megan N
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.5688/ajpe816101" target="_blank" rel="noreferrer noopener">http://doi.org/10.5688/ajpe816101</a>
Pages
101–101
Issue
6
Volume
81
Dublin Core
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Title
A name given to the resource
It's Time to Broaden the Conversation About the Student Debt Crisis Beyond Rising Tuition Costs.
Publisher
An entity responsible for making the resource available
American journal of pharmaceutical education
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-08
Subject
The topic of the resource
Humans; Income; *debt; *personal finance; *student loans; Pharmacists/economics; Students; Education; Pharmacy; Pharmacy/*economics
Creator
An entity primarily responsible for making the resource
Ulbrich Timothy R; Kirk Loren M
Identifier
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<a href="http://doi.org/10.5688/ajpe816101" target="_blank" rel="noreferrer noopener">10.5688/ajpe816101</a>
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*debt
*personal finance
*student loans
2017
American journal of pharmaceutical education
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Education
Humans
Income
Kirk Loren M
NEOMED College of Pharmacy
Pharmacists/economics
Pharmacy
Pharmacy/*economics
Students
Ulbrich Timothy R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.5688/ajpe8175990" target="_blank" rel="noreferrer noopener">http://doi.org/10.5688/ajpe8175990</a>
Pages
5990–5990
Issue
7
Volume
81
Dublin Core
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Title
A name given to the resource
Evaluating the Changing Financial Burdens for Graduating Pharmacists.
Publisher
An entity responsible for making the resource available
American journal of pharmaceutical education
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-09
Subject
The topic of the resource
Humans; Career Choice; Income; new practitioners; personal finance; Pharmacists/*economics; Salaries and Fringe Benefits/economics; student debt; Training Support/*economics; Students; Education; Schools; Pharmacy; Pharmacy/*economics
Creator
An entity primarily responsible for making the resource
Mattingly T Joseph 2nd; Ulbrich Timothy R
Description
An account of the resource
Objective. To compare new practitioners in 2009 and 2014 by modeling net income from available salary, expenditure, and student loan data. Methods. A Monte Carlo simulation with probabilistic sensitivity analysis was conducted to model net income for graduating pharmacists in 2009 and 2014. Mean and standard deviations were recorded for each model parameter. Student t-tests were used to compare the mean differences between 2009 and 2014 cohorts. Results. Pharmacist salary and disposable income were higher on average in 2014 compared with 2009. Consumer expenditures were higher in 2014, offsetting the higher salary resulting in a 2014 discretionary income that was less than in 2009 [95% CI: -$2,336, -$1,587]. Net income decreased from 2009 to 2014 for all pharmacy school types. Conclusion. Regardless of loan payment strategy, net incomes for pharmacists graduating from public and private institutions were less in 2014 compared with 2009.
Identifier
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<a href="http://doi.org/10.5688/ajpe8175990" target="_blank" rel="noreferrer noopener">10.5688/ajpe8175990</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
American journal of pharmaceutical education
Career Choice
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Education
Humans
Income
Mattingly T Joseph 2nd
NEOMED College of Pharmacy
new practitioners
personal finance
Pharmacists/*economics
Pharmacy
Pharmacy/*economics
Salaries and Fringe Benefits/economics
Schools
student debt
Students
Training Support/*economics
Ulbrich Timothy R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.alcohol.2017.02.333" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.alcohol.2017.02.333</a>
Pages
238–238
Volume
60
Dublin Core
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Title
A name given to the resource
Nicotinamide adenine einucleotide reverses hepatic molecular chaperones abnormalities and alleviates experimental alcoholic steatohepatitis in mice.
Publisher
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Alcohol
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-05
Creator
An entity primarily responsible for making the resource
Han Y; Kim C; Jogasuria A; Hu X; Wang J; Shen H; Wu J; You M
Identifier
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<a href="http://doi.org/10.1016/j.alcohol.2017.02.333" target="_blank" rel="noreferrer noopener">10.1016/j.alcohol.2017.02.333</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Alcohol
Department of Pharmaceutical Sciences
Han Y
Hu X
Jogasuria A
Kim C
NEOMED College of Pharmacy
Shen H
Wang J
Wu J
You M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jacl.2017.04.100" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jacl.2017.04.100</a>
Pages
832–834
Issue
3
Volume
11
Dublin Core
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Title
A name given to the resource
Development of Small Molecule Screening Assay for Modulation of Lipoprotein Lipase activity Using Hepatocyte Secretome.
Publisher
An entity responsible for making the resource available
Journal of Clinical Lipidology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-05
Subject
The topic of the resource
Lipoproteins; Health Screening; Lipase
Creator
An entity primarily responsible for making the resource
Venkatesh Sahana; Sadana Prabodh; Lin Li
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jacl.2017.04.100" target="_blank" rel="noreferrer noopener">10.1016/j.jacl.2017.04.100</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Health Screening
Journal of Clinical Lipidology
Lin Li
Lipase
Lipoproteins
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Sadana Prabodh
Venkatesh Sahana
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1166/jnn.2017.13449" target="_blank" rel="noreferrer noopener">http://doi.org/10.1166/jnn.2017.13449</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
4867-4881
Issue
7
Volume
17
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Title
A name given to the resource
Engineering Alkoxyphenacyl-Polycarbonate Nanoparticles for Potential Application in Near-Infrared Light-Modulated Drug Delivery via Photon Up-Conversion Process
Publisher
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Journal of Nanoscience and Nanotechnology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-07
Subject
The topic of the resource
800 nm; alkoxylphenacyl-based polycarbonates; biocompatibility; Chemistry; Doxorubicin; Drug Release; luminescence; Materials Science; mesoporous-silica; nanocrystals; Nanotechnology; Near-Infrared Light; photodynamic therapy; Physics; release; Science & Technology - Other Topics; Stimuli-Responsive; upconverting nanoparticles; uv
Creator
An entity primarily responsible for making the resource
Wehrung D; Chamsaz E A; Andrews J H; Joy A; Oyewumi M O
Description
An account of the resource
Photoresponsive delivery systems that are activated by high energy photo-triggers have been accorded much attention because of the capability to achieve reliable photoreactions at short irradiation times. However, the application of a high energy photo-trigger (UV light) is not clinically viable. Meanwhile, the process of photon-upconversion is an effective strategy to generate a high energy photo-trigger (in-situ) through exposure to clinically relevant near-infrared (NIR) light. In this regard, we synthesized photon upconverting nanocrystals (UCNCs) that were subsequently loaded into photoresponsive nanoparticles (NPs) that were prepared using alkoxyphenacyl-based polycarbonate homopolymer (UCNC-APP-NPs). UCNC loading affected resultant NP size, size distribution, colloidal stability but not the zeta potential. The efficiency of NIR-modulated drug delivery was impacted by the heterogenetic nature of the resultant UCNC-APP-NPs which was plausibly formed through a combination of UCNC entrapment within the polymeric NP matrix and nucleation of polymer coating on the surface of the UCNCs. The biocompatibility of UCNC-APP-NPs was demonstrated through cytotoxicity, macrophage activation, and red blood cell lysis assays. Studies in tumor-bearing (nu/nu) athymic mice showed a negligible distribution of UCNC-APP-NPs to reticuloendothelial tissues. Further, distribution of UCNC-APP-NPs to various tissues was in the order (highest to lowest): Lungs> Tumor > Kidneys > Liver > Spleen> Brain > Blood > Heart. In all, the work highlighted some important factors that may influence the effectiveness, reproducibility and biocompatibility of drug delivery systems that operate on the process of photon-upconversion.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1166/jnn.2017.13449" target="_blank" rel="noreferrer noopener">10.1166/jnn.2017.13449</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2017
800 nm
alkoxylphenacyl-based polycarbonates
Andrews J H
Biocompatibility
Chamsaz E A
Chemistry
Department of Pharmaceutical Sciences
Doxorubicin
Drug Release
Journal Article
Journal of nanoscience and nanotechnology
Joy A
luminescence
Materials Science
mesoporous-silica
nanocrystals
Nanotechnology
Near-Infrared Light
NEOMED College of Pharmacy
Oyewumi M O
photodynamic therapy
Physics
release
Science & Technology - Other Topics
Stimuli-responsive
upconverting nanoparticles
uv
Wehrung D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1041A-1042A
Volume
66
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Dublin Core
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Title
A name given to the resource
Role of Intestine-Specific Sirt1 in the Protective Action of Salvianolic Acid B against Ethanol-Induced Inflammation and Liver Injury in Mice
Publisher
An entity responsible for making the resource available
Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-10
Subject
The topic of the resource
Gastroenterology & Hepatology
Creator
An entity primarily responsible for making the resource
Shen H; Kainrad N; Jogasuria A; Kim C; Han Y; Zhou Z; Wang J Y; Wu J S; Zhang J C; You M
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2017
Department of Pharmaceutical Sciences
Gastroenterology & Hepatology
Han Y
Hepatology
Jogasuria A
Journal Article
Kainrad N
Kim C
NEOMED College of Pharmacy
Shen H
Wang J Y
Wu J S
You M
Zhang J C
Zhou Z
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
52
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Title
A name given to the resource
MITONEET DEFICIENCY STIMULATES ENDOCRINE ADIPONECTIN-FGF15/ 19 SIGNALING AND ALLEVIATES ALCOHOLIC STEATOHEPATITIS IN MICE
Publisher
An entity responsible for making the resource available
Alcohol and Alcoholism
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-10
Subject
The topic of the resource
Substance Abuse
Creator
An entity primarily responsible for making the resource
You M
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2017
Alcohol and Alcoholism
Department of Pharmaceutical Sciences
Journal Article
NEOMED College of Pharmacy
Substance Abuse
You M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fnins.2017.00146" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fnins.2017.00146</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
19-19
Volume
11
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Title
A name given to the resource
Metabolic Vulnerability In The Neurodegenerative Disease Glaucoma
Publisher
An entity responsible for making the resource available
Frontiers in Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-03
Subject
The topic of the resource
amyotrophic-lateral-sclerosis; axon; axonopathy; glucose-transporter glut3; glycogen-synthase kinase-3; lactate; Mitochondria; monocarboxylate transporters; mouse white-matter; neuron lactate-shuttle; neuropathy; Neurosciences & Neurology; optic; optic-nerve head; retinal ganglion-cells; self-destruction; slow wallerian degeneration; Wallerian degeneration
Creator
An entity primarily responsible for making the resource
Inman D M; Harun-Or-Rashid M
Description
An account of the resource
Axons can be several orders of magnitude longer than neural somas, presenting logistical difficulties in cargo trafficking and structural maintenance. Keeping the axon compartment well supplied with energy also presents a considerable challenge; even seemingly subtle modifications of metabolism can result in functional deficits and degeneration. Axons require a great deal of energy, up to 70% of all energy used by a neuron, just to maintain the resting membrane potential. Axonal energy, in the form of ATP, is generated primarily through oxidative phosphorylation in the mitochondria. In addition, glial cells contribute metabolic intermediates to axons at moments of high activity or according to need. Recent evidence suggests energy disruption is an early contributor to pathology in a wide variety of neurodegenerative disorders characterized by axonopathy. However, the degree to which the energy disruption is intrinsic to the axon vs. associated glia is not clear. This paper will review the role of energy availability and utilization in axon degeneration in glaucoma, a chronic axonopathy of the retinal projection.
Identifier
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<a href="http://doi.org/10.3389/fnins.2017.00146" target="_blank" rel="noreferrer noopener">10.3389/fnins.2017.00146</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2017
amyotrophic-lateral-sclerosis
axon
Axonopathy
Department of Pharmaceutical Sciences
Frontiers in neuroscience
glucose-transporter glut3
glycogen-synthase kinase-3
Harun-Or-Rashid M
Inman D M
Journal Article or Conference Abstract Publication
lactate
Mitochondria
monocarboxylate transporters
mouse white-matter
NEOMED College of Pharmacy
neuron lactate-shuttle
Neuropathy
Neurosciences & Neurology
optic
optic-nerve head
retinal ganglion-cells
self-destruction
slow wallerian degeneration
Wallerian degeneration
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
E146-E147
Issue
12
Volume
37
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Aldosterone Antagonist Utilization In A Nationally Representative Heart Failure With Reduced Ejection Fraction Outpatient Population: Prevalence And Predictors
Publisher
An entity responsible for making the resource available
Pharmacotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-12
Subject
The topic of the resource
Pharmacology & Pharmacy
Creator
An entity primarily responsible for making the resource
Joyner K; Soric M; Boyle J; Moorman J; Fredrickson M E; Turosky J
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2017
Boyle J
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Fredrickson M E
Journal Article or Conference Abstract Publication
Joyner K
Moorman J
NEOMED College of Pharmacy
Pharmacology & Pharmacy
Pharmacotherapy
Soric M
Turosky J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
37
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Role Of Amadori-glycation In High Density Lipoprotein Dysfunction And Oxidative Stress In Patients With Diabetes
Publisher
An entity responsible for making the resource available
Arteriosclerosis Thrombosis and Vascular Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-05
Subject
The topic of the resource
Apolipoproteins; Atherosclerosis; Cardiovascular System & Cardiology; Hematology; Insulin resistance
Creator
An entity primarily responsible for making the resource
Kasumov T; Golizeh M; Lee K; Ilchenko S; Wang S H; Smith J; Kashyap S
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2017
Apolipoproteins
Arteriosclerosis Thrombosis and Vascular Biology
Atherosclerosis
Cardiovascular System & Cardiology
Department of Pharmaceutical Sciences
Golizeh M
Hematology
Ilchenko S
Insulin Resistance
Journal Article or Conference Abstract Publication
Kashyap S
Kasumov T
Lee K
NEOMED College of Pharmacy
Smith J
Wang S H
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1082A-1083A
Volume
66
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Transferrin And Ceruloplasmin Kinetics Discriminate Simple Steatosis From Nonalcoholic Steatohepatitis
Publisher
An entity responsible for making the resource available
Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-10
Subject
The topic of the resource
Gastroenterology & Hepatology
Creator
An entity primarily responsible for making the resource
Kasumov T; Lee K; Osme A; Kalinina I; Dasarathy J; Dasarathy S; McCullough A J
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2017
Dasarathy J
Dasarathy S
Department of Pharmaceutical Sciences
Gastroenterology & Hepatology
Hepatology
Journal Article or Conference Abstract Publication
Kalinina I
Kasumov T
Lee K
McCullough A J
NEOMED College of Pharmacy
Osme A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
272A-272A
Volume
41
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Myeloid Cell-specific Sirt1 Deficiency Exacerbates Alcoholic Steatohepatitis Via Amplifying Neutrophilic Inflammation In Mice
Publisher
An entity responsible for making the resource available
Alcoholism-Clinical and Experimental Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-06
Subject
The topic of the resource
Substance Abuse
Creator
An entity primarily responsible for making the resource
Kim C; Shi X; Han Y; Jogasuria A; Wang J; Wu J; Zhang P; You M
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2017
Alcoholism-Clinical and Experimental Research
Department of Pharmaceutical Sciences
Han Y
Jogasuria A
Journal Article or Conference Abstract Publication
Kim C
NEOMED College of Pharmacy
Shi X
Substance Abuse
Wang J
Wu J
You M
Zhang P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
37
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inhibition Of Angiopoietin-like 3 Expression Is A Potential Mechanism Of Activation Of Lipoprotein Lipase And Of Lipid Lowering By Metformin
Publisher
An entity responsible for making the resource available
Arteriosclerosis Thrombosis and Vascular Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-05
Subject
The topic of the resource
Cardiovascular System & Cardiology; Drugs; Hematology; Hyperlipidemia; Lipases
Creator
An entity primarily responsible for making the resource
Lin L; Burke J R; Geldenhuys W J; Sadana P
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2017
Arteriosclerosis Thrombosis and Vascular Biology
Burke J R
Cardiovascular System & Cardiology
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Drugs
Geldenhuys W J
Hematology
Hyperlipidemia
Journal Article or Conference Abstract Publication
Lin L
Lipases
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Sadana P