Browse Items (51 total)
- Tags: Department of Pharmaceutical Sciences, 2018
Ahr And Cyp1a2 Genotypes Both Affect Susceptibility To Motor Deficits Following Gestational And Lactational Exposure To Polychlorinated Biphenyls
Tags: 2018, Aryl hydrocarbon receptor, Cerebellum, Colter B T, Curran C P, CYP1A2, Department of Pharmaceutical Sciences, developmental exposure, dioxin-like compounds, dopamine concentrations, Fleming S M, Fowler J P, Garber H F, Harding G D, Hooven M K, Howes A A, in-utero, Infante S K, Lang A L, MacDougall M C, Motor function, NEOMED College of Pharmacy, Neurosciences & Neurology, Neurotoxicology, Nigrostriatal pathways, parkinsons-disease, pcb exposure, perinatal exposure, Pharmacology & Pharmacy, Polychlorinated biphenyls, prenatal exposure, Risk Assessment, school-age, Stegman M, Taylor K R, Toxicology
Transport of a manganese/zinc ethylene-bis-dithiocarbamate fungicide may involve pre-synaptic dopaminergic transporters
Tags: 2018, antidepressant, Bailey A, Barnett R, C. elegans, caenorhabditis-elegans, Corona C, costa-rica, degeneration, Department of Pharmaceutical Sciences, exposure, Fitsanakis V A, Frye R, infants environmental-health, Journal Article or Conference Abstract Publication, leads, Mancozeb, Manzate, Mn/Zn ethylene-bis-dithiocarbamate, Montgomery K, NEOMED College of Pharmacy, Neurosciences & Neurology, Neurotoxicology and teratology, Neurotransmitter transporters, NEUROTRANSMITTERS, parkinsons-disease, pregnant-women, Toxicology
Chronic exposure to a glyphosate-containing pesticide leads to mitochondrial dysfunction and increased reactive oxygen species production in Caenorhabditis elegans
Tags: 2018, 6-ohda, alzheimers-disease, Bailey D C, Brain, Burchfield S L, C. elegans, complex-i, degeneration, Denney R D, Department of Pharmaceutical Sciences, Environmental Sciences & Ecology, Environmental toxicology and pharmacology, Fitsanakis V A, Glyphosate, Herbicide, Hydrogen peroxide, Journal Article or Conference Abstract Publication, mechanisms, Mitochondrial inhibition, Negga R, NEOMED College of Pharmacy, Neurodegenerative Diseases, Oxidative Stress, parkinsons-disease, Pharmacology & Pharmacy, Pressley A S, Reactive oxygen, Snapp I B, SPECIES, Todt C E, Toxicology, Traynor W L
d2ome, Software for in Vivo Protein Turnover Analysis Using Heavy Water Labeling and LC-MS, Reveals Alterations of Hepatic Proteome Dynamics in a Mouse Model of NAFLD
Tags: 2018, 40S ribosomal proteins, algorithm, amino-acids, Avva J, Biochemistry & Molecular Biology, Borzou A, Department of Pharmaceutical Sciences, DNA, Ilchenko S, in vivo protein turnover, isotopomer, Journal Article, Journal of proteome research, Kasumov T, Lee K, Mass spectrometry, metabolic labeling, NAFLD, NEOMED College of Pharmacy, nonlinear least-squares modeling, peak detection and integration, proliferation, protein half-life, Proteome dynamics, proteostasis, quantification, Rahman M, rates, respiratory-chain, Sadygov R G, Steatosis, UPR
Nodes of Ranvier in Glaucoma.
Tags: *Axonopathy, *axons, *neurodegeneration, *neurofilament, *node of Ranvier, *superior colliculus, 2018, Action Potentials, Animals, Axons/pathology, Crish S D, Cytoskeleton/pathology, Dengler-Crish Christine M, Department of Pharmaceutical Sciences, Female, Glaucoma/metabolism/pathology/*physiopathology, Inbred C57BL, Male, Meier J, Mice, NEOMED College of Pharmacy, Neuroscience, Optic Nerve/metabolism/pathology, Plyler E S, Ranvier's Nodes/*physiology/ultrastructure, Smith M A, Transgenic, Visual Pathways/metabolism/*physiopathology/ultrastructure, Voltage-Gated Sodium Channels/metabolism
The effect of manganese exposure in Atp13a2-deficient mice.
Tags: *Alpha-synuclein, *Lipofuscin, *Manganese, *Parkinson's disease, *Sensorimotor function, 2018, Adenosine Triphosphatases/genetics/*metabolism, Aga Diana S, alpha-Synuclein/metabolism, Animal, Animals, Behavior, Brain/*drug effects/*metabolism, Department of Pharmaceutical Sciences, Ekhator Osunde R, Female, Fleming Sheila M, Holden John G, Inbred C57BL, Karkare Swagata, Knockout, Lemkuhl Andrew, Linn Stephen C, Liou Benjamin, Male, Manganese/metabolism/*toxicity, Membrane Proteins/genetics/*metabolism, Mice, Motor Activity, Mullin Elizabeth J, NEOMED College of Pharmacy, Neurotoxicology, Pamphile Shanta, Roth Jerome A, Santiago Nicholas A, Schultheis Patrick J, Shull Gary E, Sun Ying
Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR.
Tags: *Atherosclerosis, *Farnesoid X receptor, *NAFLD, *Obesity, *TGR5, 2018, Adorini Luciano, Animals, Bile Acids and Salts/pharmacology/*therapeutic use, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diet, G-Protein-Coupled/*agonists, Hep G2 Cells, High-Fat/adverse effects, Humans, Hypercholesterolemia/*drug therapy/etiology/metabolism, Inbred C57BL, Jadhav Kavita, Kasumov Takhar, Lee Yoon Kwang, Li Yuanyuan, Male, Mice, Molecular metabolism, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*drug therapy/etiology/metabolism, Obesity/*drug therapy/etiology/metabolism, Receptors, Xu Jiesi, Xu Yang, Xu Yanyong, Yin Liya, Zhang Yanqiao, Zhu Yingdong
Using the Practice Advancement Initiative to expand pharmacy student involvement.
Tags: 2018, Ambulatory Care, American Journal of Health-System Pharmacy, Boyle Jaclyn, Cavanaugh Teresa M, collaboration, Curriculum, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Leaders, Medical Organizations, NEOMED College of Pharmacy, Patient Care, Pharmaceutical, Pharmacist Attitudes, Pharmacy – Psychosocial Factors, Pharmacy Service, Professional development, Professional Role, Self Assessment, STRATEGIC planning, Students, Technology, Vest Tyler A, Work Environment
Endocrine Adiponectin-FGF15/19 Axis in Ethanol-Induced Inflammation and Alcoholic Liver Injury.
Structural and Functional Rescue of Chronic Metabolically Stressed Optic Nerves through Respiration.
Tags: 2018, b-hydroxybutyrate, Crish Samuel D, Department of Pharmaceutical Sciences, Gevorgyan Victoria, Harun-Or-Rashid Mohammad, Inman Denise M, Ketogenic diet, NEOMED College of Pharmacy, neural-glial interaction, optic nerve, Palmer Peter G, Pappenhagen Nate, Smith Matthew A, The Journal of neuroscience : the official journal of the Society for Neuroscience, Wilson Gina N
Glycation Reduces the Stability of ApoAI and Increases HDL Dysfunction in Diet-Controlled Type 2 Diabetes.
Tags: 2018, Adult, Aged, Animal Studies, Animals, Apolipoprotein A-I/blood/*metabolism, Apolipoproteins – Blood, Apolipoproteins – Metabolism, Bena James, Biochemical Phenomena, Case Control Studies, Case-Control Studies, Cells, Comparative Studies, Cultured, Department of Pharmaceutical Sciences, Diabetes Mellitus, Diet, Dyslipidemias/complications/diet therapy/*metabolism, Evaluation Research, Female, Funding Source, Glycosylation, Golizeh Makan, HDL – Metabolism, HDL/*metabolism, Human, Humans, Hyperglycemia – Complications, Hyperglycemia – Diet Therapy, Hyperglycemia – Metabolism, Hyperglycemia/complications/diet therapy/*metabolism, Hyperlipidemia – Complications, Hyperlipidemia – Diet Therapy, Hyperlipidemia – Metabolism, Ilchenko Serguei, Kashyap Sangeeta R, Kasumov Takhar, Lee Kwangwon, Lipoproteins, Male, Mice, Middle Age, Middle Aged, Multicenter Studies, NEOMED College of Pharmacy, Osme Abdullah, Previs Stephen F, Protein Stability, Smith Jonathan D, The Journal of clinical endocrinology and metabolism, Type 2 – Complications, Type 2 – Diet Therapy, Type 2 – Metabolism, Type 2/complications/*diet therapy/metabolism, Validation Studies, Wang Shuhui
RNAseq analysis of hippocampal microglia after kainic acid-induced seizures.
Tags: 2018, Animals, Bosco Dale B, Department of Pharmaceutical Sciences, Eyo Ukpong B, Feng Lijie, Gene Expression Profiling, Gene Ontology, Hippocampus/*pathology, Huang Jun, Immunity, Interferon-beta/metabolism, Kainic Acid, Mice, Microglia/*metabolism/*pathology, Molecular brain, NEOMED College of Pharmacy, Peng Jiyun, Richardson Jason R, RNA/*methods, Seizures/*chemically induced, Sequence Analysis, Signal Transduction/genetics, Tang Ke, Up-Regulation/genetics, Wang Hui, Wu Gongxiong, Wu Long-Jun, Xu Zhiyan, Yan Cheng, Zheng Jiaying
Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma.
Tags: 2018, AMP-activated protein kinase, AMP-Activated Protein Kinases/*metabolism, Animal, Animals, Biological, Calcium Binding Proteins – Metabolism, Calcium-Binding Proteins/metabolism, Cells – Drug Effects, Cells – Pathology, Department of Pharmaceutical Sciences, Diet, Disease Models, Eye Proteins/genetics, Female, G-Protein-Coupled – Metabolism, G-Protein-Coupled/*metabolism, Glaucoma, Glaucoma – Complications, Glaucoma – Pathology, Glaucoma/*complications/pathology, Harun-Or-Rashid Mohammad, Impact of Events Scale, Inbred DBA, Inflammation – Etiology, Inflammation – Prevention and Control, Inflammation hydroxycarboxylic acid receptor, Inflammation/*etiology/*prevention & control, Inman Denise M, Journal of neuroinflammation, Ketogenic diet, Ketogenic/methods, Male, Membrane Glycoproteins, Membrane Glycoproteins/genetics, Mice, Microfilament Proteins – Metabolism, Microfilament Proteins/metabolism, Microglia/drug effects/pathology, Models, Mutation, Mutation/genetics, NEOMED College of Pharmacy, Neuroprotection/drug effects/*physiology, NLR Family, Optic Nerve – Pathology, Optic Nerve/pathology, Phosphotransferases – Metabolism, Proteins, Pyrin Domain-Containing 3 Protein/genetics/metabolism, Receptors, Retina – Drug Effects, Retina – Pathology, Retinal Ganglion Cells/drug effects/*pathology, Transgenic
Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy.
Tags: 2018, Alzheimer's disease, Animal, Animals, Antigens, Bemiller Shane M, Bhaskar Kiran, Biological, Calcium Binding Proteins – Metabolism, Calcium-Binding Proteins/metabolism, Cannon Judy L, Cardona Astrid E, Cells – Drug Effects, Cells – Metabolism, Cells – Pathology, Chemokine CX3CL1/*genetics/metabolism, Cognition Disorders – Etiology, Cognition Disorders/etiology, Crish Samuel D, CX3CL1, CX3CR1, Cytokines, Cytokines – Metabolism, Cytokines/metabolism, Department of Pharmaceutical Sciences, Differentiation/genetics/metabolism, Disease Models, Formica Shane V, Gene Expression Regulation/drug effects/*genetics, Genes, Genes – Drug Effects, Journal of neuroinflammation, Jung Steffen, Kim Ki-Wook, Kokiko-Cochran Olga N, Lamb Bruce T, Learning, Lipopolysaccharides, Lipopolysaccharides/toxicity, Maphis Nicole M, Maze Learning, Mice, Microfilament Proteins – Metabolism, Microfilament Proteins/metabolism, Microglia, Microglia/drug effects/*metabolism/pathology, Miller Crystal M, Models, Mutation, Mutation/genetics, NEOMED College of Pharmacy, Nerve Tissue Proteins, Nerve Tissue Proteins – Metabolism, Neurodegenerative Diseases, Neurodegenerative Diseases – Complications, Neurodegenerative Diseases – Pathology, Neuroinflammation, Surface, Surface – Metabolism, Tau, tau Proteins/genetics/metabolism, Tauopathies, Tauopathies/complications/genetics/*pathology, Transgenic, Wilson Gina N, Xu Guixiang
The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor.
Tags: 2018, Astrocyte, Boyle Alexa M, Budge Kevin M, CD44, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, GPNMB, Journal of neuroinflammation, Neal Matthew L, NEOMED College of Medicine, NEOMED College of Pharmacy, Neuroinflammation, Parkinson's disease, Richardson Jason R, Safadi Fayez F
Evidence of Oropharyngeal Dysfunction in Feeding in the Rat Rotenone Model of Parkinson's Disease.
Tags: 2018, Animal Studies, Deglutition – Drug Effects, Deglutition disorders, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Eating – Drug Effects, Feeding Methods, German Rebecca Z, Gould François D H, Gross Andrew, Isoflavones – Administration and Dosage, Isoflavones – Pharmacodynamics, Mastication, NEOMED College of Medicine, NEOMED College of Pharmacy, Oropharynx – Pathology, Parkinson Disease, Parkinson's disease, Phenotype, Rats, Richardson Jason R
Quantifying ceramide kinetics in vivo using stable isotope tracers and LC-MS/MS.
Tags: 2018, American journal of physiology. Endocrinology and metabolism, Berejnaia Olga, Chen Ying, Daurio Natalie A, Department of Pharmaceutical Sciences, dyslipidemia, Insulin Resistance, Kasumov Takhar, Kelley David E, Kinetics, lipid turnover, Liu Jinqi, Mass spectrometry, Mayoral Rafael, McLaren David G, NEOMED College of Pharmacy, Petrov Aleksandr, Previs Stephen F, Wang Sheng-Ping, Yin Wu, Zhang Guo-Fang
Interprofessional education model for geriatric falls risk assessment and prevention.
Tags: 2018, BMJ open quality, Brown Diane K, College of Medicine, Department of Family & Community Medicine, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Drost Jenifer C, Fleming Eileen, Fosnight Sue, Hazelett Susan, Hovland Cynthia A, Kropp Denise J, McQuown Colleen, Morgan Abigail, NEOMED College of Medicine, NEOMED College of Pharmacy, Niederriter Joan E, Ortiz Figueroa Fabiana, Patton Rikki, Scott Edward Demond, Steiner Richard P, Whitford Maureen
Mineralocorticoid Receptor Antagonist Utilization in a Nationally Representative Heart Failure With Reduced Ejection Fraction Outpatient Population: A Cross-Sectional Study.
Preparation of emulsifying wax/glyceryl monooleate nanoparticles and evaluation as a delivery system for repurposing simvastatin in bone regeneration.
Tags: 2018, Animals, Bone, Bone Regeneration/*drug effects/physiology, Czech Tori, Department of Pharmaceutical Sciences, Drug delivery, Drug Delivery Systems/*methods, Drug development and industrial pharmacy, Drug Evaluation, Drug Repositioning/methods, Emulsifying Agents/administration & dosage/*chemical synthesis, Eskinazi-Budge Aaron, Glycerides/administration & dosage/*chemical synthesis, Kunzler James, Manickavasagam Dharani, Mice, nanoemulsions, Nanoparticles, Nanoparticles/administration & dosage/*chemistry, NEOMED College of Pharmacy, Novak Kimberly, Osteoblasts, Osteoblasts/drug effects/physiology, Osteoclasts, Oyewumi Moses O, Preclinical/methods, RAW 264.7 Cells, Simvastatin/administration & dosage/*chemical synthesis, Waxes/chemical synthesis/pharmacology
Hepatic Mitochondrial Defects in a Nonalcoholic Fatty Liver Disease Mouse Model Are Associated with Increased Degradation of Oxidative Phosphorylation Subunits.
Tags: 2018, Allende Daniela, Borzou Ahmad, Dasarathy Srinivasan, Department of Pharmaceutical Sciences, Energy Metabolism, Haddad Andrew, Heavy water, Ilchenko Sergei, Kasumov Takhar, Kim Chunki, Lee Kwangwon, Mass spectrometry, McCullough Arthur, metabolic labeling, Mitochondria function or biology, Molecular & cellular proteomics : MCP, NEOMED College of Pharmacy, Osme Abdullah, oxidative phosphorylation, Oxidative Stress, Protein Degradation, Protein Turnover, Sadygov Rovshan G
d2ome, Software for in Vivo Protein Turnover Analysis Using Heavy Water Labeling and LC-MS, Reveals Alterations of Hepatic Proteome Dynamics in a Mouse Model of NAFLD.
Tags: 2018, 40S ribosomal proteins, Avva Jayant, Borzou Ahmad, Department of Pharmaceutical Sciences, Ilchenko Sergei, in vivo protein turnover, isotopomer quantification, Journal of proteome research, Kasumov Takhar, Lee Kwangwon, metabolic labeling, NAFLD, NEOMED College of Pharmacy, nonlinear least-squares modeling, peak detection and integration, protein half-life, Proteome dynamics, Rahman Mahbubur, Sadygov Rovshan G, UPR
Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase.
Tags: 2018, Aleksunes Lauren M, Cytochrome b5, Department of Pharmaceutical Sciences, Free radicals, Fussell Karma C, Heck Diane E, Jan Yi-Hua, Laskin Debra L, Laskin Jeffrey D, Mishin Vladimir, NEOMED College of Pharmacy, reactive oxygen species, Redox cycling, Richardson Jason R, Szilagyi John T, Toxicology and applied pharmacology, Wang Yun, Yang Shaojun
Stable isotope-based flux studies in nonalcoholic fatty liver disease.
Tags: *Citric acid cycle, *Fatty acid oxidation, *Fibrosis, *NAFLD, *Oxidative Stress, *Stable isotopes, 2018, Animals, Department of Pharmaceutical Sciences, Humans, Isotopes/metabolism, Kasumov Takhar, Mass Spectrometry/*methods, McCullough Arthur, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*metabolism, Pharmacology & therapeutics, Previs Stephen
Nodes of Ranvier in Glaucoma.
Evidence of Wnt/beta-catenin alterations in brain and bone of a tauopathy mouse model of Alzheimer's disease.
Tags: *Alzheimer's disease, *Beta catenin, *Bone mineral density, *neurodegeneration, *Tauopathy, *Wnt proteins, *Wnt Signaling Pathway, 2018, Alzheimer Disease/*genetics/*metabolism, Animal, Animals, Ball Hope C, beta Catenin/metabolism, Bone and Bones/*metabolism, Bone Density, Bone Remodeling/genetics, Brain/*metabolism, Cooper Lisa Noelle, Dengler-Crish Christine M, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Disease Models, Female, Gene Expression, Lin Li, Male, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Neurobiology of aging, Novak Kimberly M, Osteogenesis/genetics, Osteoporosis/etiology/genetics, tau Proteins/*metabolism, Tauopathies/genetics/*metabolism, Wnt Proteins/metabolism
The effect of manganese exposure in Atp13a2-deficient mice.
Tags: *Alpha-synuclein, *Lipofuscin, *Manganese, *Mice, *Parkinson's disease, *Sensorimotor function, 2018, Aga Diana S, Department of Pharmaceutical Sciences, Ekhator Osunde R, Fleming Sheila M, Holden John G, Karkare Swagata, Lemkuhl Andrew, Linn Stephen C, Liou Benjamin, Mullin Elizabeth J, NEOMED College of Pharmacy, Neurotoxicology, Pamphile Shanta, Roth Jerome A, Santiago Nicholas A, Schultheis Patrick J, Shull Gary E, Sun Ying
Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR.
Tags: *Atherosclerosis, *Farnesoid X receptor, *NAFLD, *Obesity, *TGR5, 2018, Adorini Luciano, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Jadhav Kavita, Kasumov Takhar, Lee Yoon-Kwang, Li Yuanyuan, Molecular metabolism, NEOMED College of Medicine, NEOMED College of Pharmacy, Xu Jiesi, Xu Yang, Xu Yanyong, Yin Liya, Zhang Yanqiao, Zhu Yingdong
Detection of single mRNAs in individual cells of the auditory system.
Tags: 2018, Bao Jianxin, Chen Yingying, Cochlea, Crish Samuel D, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Hearing research, Immunohistochemistry, Inner hair cell, Lei Debin, Nelson Charlie N, Nelson Jovitha, NEOMED College of Medicine, NEOMED College of Pharmacy, Outer hair cell, Salehi Pezhman, Single-molecule fluorescence in situ hybridization, Spiral ganglion neuron, Zuo Hongyan