Browse Items · NEOMED Bibliography Database

RNAseq analysis of hippocampal microglia after kainic acid-induced seizures.

Microglia have been shown to be of critical importance to the progression of temporal lobe epilepsy. However, the broad transcriptional changes that these cells undergo following seizure induction is not well understood. As such, we utilized RNAseq…

ROLE OF SPLICING REGULATOR SLU7 IN ETHANOL-INDUCED INFLAMMATION AND LIVER INJURY

Tags: 2018, Alcoholism-Clinical and Experimental Research, Department of Pharmaceutical Sciences, Journal Article, NEOMED College of Pharmacy, Substance Abuse, You M

Stable isotope-based flux studies in nonalcoholic fatty liver disease.

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is associated with the worldwide epidemics of obesity, diabetes and cardiovascular diseases. NAFLD ranges from benign fat accumulation in the liver (steatosis) to…

Tags: *Citric acid cycle, *Fatty acid oxidation, *Fibrosis, *NAFLD, *Oxidative Stress, *Stable isotopes, 2018, Animals, Department of Pharmaceutical Sciences, Humans, Isotopes/metabolism, Kasumov Takhar, Mass Spectrometry/*methods, McCullough Arthur, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*metabolism, Pharmacology & therapeutics, Previs Stephen

Structural and Functional Rescue of Chronic Metabolically Stressed Optic Nerves through Respiration.

Axon degeneration can arise from metabolic stress, potentially a result of mitochondrial dysfunction or lack of appropriate substrate input. In this study, we investigated whether the metabolic vulnerability observed during optic neuropathy in the…

Tags: 2018, b-hydroxybutyrate, Crish Samuel D, Department of Pharmaceutical Sciences, Gevorgyan Victoria, Harun-Or-Rashid Mohammad, Inman Denise M, Ketogenic diet, NEOMED College of Pharmacy, neural-glial interaction, optic nerve, Palmer Peter G, Pappenhagen Nate, Smith Matthew A, The Journal of neuroscience : the official journal of the Society for Neuroscience, Wilson Gina N

The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6.

Parkinson's disease (PD), the second most common age-related progressive neurodegenerative disorder, is characterized by dopamine depletion and the loss of dopaminergic (DA) neurons with accompanying neuroinflammation. Zonisamide is…

Tags: *gp91(phox), *Microglia, *MPTP, *Na(v)1.6, *Neuroinflammation, *Parkinson's disease, *TNF-alpha, *Voltage-gated sodium channels, *Zonisamide, 2018, Department of Pharmaceutical Sciences, Experimental neurology, Gearing Marla, Hossain Muhammad M, NEOMED College of Pharmacy, Reuhl Kenneth, Richardson Jason R, Weig Blair, Wu Long-Jun

The effect of manganese exposure in Atp13a2-deficient mice.

Loss of function mutations in the P5-ATPase ATP13A2 are associated with Kufor-Rakeb Syndrome and Neuronal Ceroid Lipofuscinosis. While the function of ATP13A2 is unclear, in vitro studies suggest it is a lysosomal protein that interacts with the…

The effect of manganese exposure in Atp13a2-deficient mice.

Loss of function mutations in the P5-ATPase ATP13A2 are associated with Kufor-Rakeb Syndrome and Neuronal Ceroid Lipofuscinosis. While the function of ATP13A2 is unclear, in vitro studies suggest it is a lysosomal protein that interacts with the…

The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor.

BACKGROUND: Neuroinflammation is one of the hallmarks of neurodegenerative diseases, such as Parkinson's disease (PD). Activation of glial cells, including microglia and astrocytes, is a characteristic of the inflammatory response. Glycoprotein…

Tags: 2018, Astrocyte, Boyle Alexa M, Budge Kevin M, CD44, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, GPNMB, Journal of neuroinflammation, Neal Matthew L, NEOMED College of Medicine, NEOMED College of Pharmacy, Neuroinflammation, Parkinson's disease, Richardson Jason R, Safadi Fayez F

Time to get Personal: A Framework for Personalized Targeting of Oxidative Stress in Neurotoxicity and Neurodegenerative Disease.

The annual cost for neurological disorders in the United States was $789 billion in 2014, and with an aging population these numbers are expected to significantly increase in the next 50 years [1]. Neurodegenerative diseases make up a significant…

Tags: 2018, Current opinion in toxicology, Department of Pharmaceutical Sciences, Neal Matthew, NEOMED College of Pharmacy, Richardson Jason R

Transport of a manganese/zinc ethylene-bis-dithiocarbamate fungicide may involve pre-synaptic dopaminergic transporters

Mancozeb (MZ), an organic-metal fungicide used predominantly on vegetables and fruits, has been linked to neurodegeneration and behavioral disruptions in a variety of organisms, including humans. Both gamma-aminobutyric acid and dopamine neurons…

Using the Practice Advancement Initiative to expand pharmacy student involvement.

The article discusses the feasibility of developing focused education for pharmacy students on the American Society of Health-System Pharmacists Practice Advancement Initiative (PAI). The article gives examples of PAI activities in which students can…

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