1
40
103
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<a href="http://doi.org/10.14309/01.ajg.0000706532.82398.af" target="_blank" rel="noreferrer noopener">http://doi.org/10.14309/01.ajg.0000706532.82398.af</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S564-S565
Issue
S
Volume
115
ISSN
0002-9270
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February 2021 List
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Department of Pharmaceutical Sciences
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Title
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Role of Markers of Heavy Metal Metabolism in Identification of Hepatic Fibrosis in Patients With Non-Alcoholic Fatty Liver Disease (NAFLD)
Date
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2020
2020-10
Subject
The topic of the resource
Oxidative stress; hepatic fibrosis; non-alcoholic fatty liver disease; Heavy Metals; non-alcoholic steatohepatitis (NASH)
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Aggarwal Manik;Mitchell B;Singh AD;Kasumov T;McCullough A
Description
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INTRODUCTION: Fibrosis & nonalcoholic steatohepatitis (NASH) are important predictors of long term prognosis in patients with non-alcoholic fatty liver disease (NAFLD). Oxidative stress (OS) has been shown to play a central role in progression of NAFLD, & changes in proteins associated with metal homeostasis may exacerbate OS. We investigated relationship of proteins related to transition metal metabolism with fibrosis in NAFLD. METHODS: Adult patients (>18y) who underwent liver biopsy for clinically suspected NAFLD at our institution were included. We retrospectively collected serum levels of ceruloplasmin (Cp), ferritin, iron, & transferrin saturation (Tsat) within 3 months of liver biopsy & calculated Cp/Tsat ratio (CT ratio) & Cp/Ferritin ratio (CF ratio). Histologic features were scored by an experienced pathologist using Non-alcoholic Steatohepatitis Clinical Research Network criteria. Fibrosis was staged as (0 - 4). Independent T test were used to compare the means & receiver operating characteristics (ROC) curves were plotted for assessing area under curve (AUC), sensitivity (Sn) & specificity (Sp). RESULTS: 174 patients were included in final analysis. The mean age of subjects was 48 y. Baseline features are depicted in Table 1. Biopsy proven NASH was seen in 61.5% of liver biopsies. No fibrosis was seen in 29.3% of liver biopsies & Stage 1, 2,3& 4 fibrosis were seen in 29.9%, 10.9%, 14.3% & 15.55% of samples. Mean Tsat was significantly higher (24.41% v/s 38.27%, P < 0.0001) & Cp (mg/dl) (27.82 v/s 24.91, P = 0.03) significantly lower between patients with advanced fibrosis (AF) (3-4) v/s early fibrosis (EF) (0-2). The mean CT ratio was also higher in patients with EF v/s AF (1.54 v/s 1.02, P = 0.01). The mean Tsat of patients with fibrosis v/s without fibrosis was higher (31.4% v/s 21.57% P < 0.005) however mean Cp (mg/dl) values were not significantly different (27.88 v/s 27.58, P = 0.42). The ROC curves show CF ratio (Figure 1) at a cut off of 0.10 had AUC = 0.61 (Sn = 70%, Sp = 52% P = 0.01) to detect any fibrosis & CT ratio (Figure 2) at a cut off 0.86 had AUC = 0.65 (Sn = 69%, Sp = 50% P = 0.002) for differentiating EF v/s AF. CONCLUSION: Our data reveals changes in ceruloplasmin: transferrin system, which decreases the content of toxic ions of Fe2+ in NAFLD. Tsat, Cp, CF ratio & CT ratio are useful non-invasive biomarkers in identifying NAFLD patients with fibrosis. Markers of heavy metal metabolism can spare patients from liver biopsies & can be potential therapeutic targets in future.
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<a href="http://doi.org/10.14309/01.ajg.0000706532.82398.af" target="_blank" rel="noreferrer noopener">10.14309/01.ajg.0000706532.82398.af</a>
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journalArticle
Publisher
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American Journal Of Gastroenterology
2020
Aggarwal Manik
American Journal of Gastroenterology
Department of Pharmaceutical Sciences
February 2021 List
Heavy Metals
hepatic fibrosis
journalArticle
Kasumov T
McCullough A
Mitchell B
NEOMED College of Pharmacy
non-alcoholic steatohepatitis (NASH)
Non-alcoholic Fatty Liver Disease
Oxidative Stress
Singh AD
-
Text
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URL Address
<a href="http://doi.org/10.1111/joa.13381" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/joa.13381</a>
ISSN
1469-7580 0021-8782
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January 2021 List
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Department of Pharmaceutical Sciences
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Title
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Long bone histomorphogenesis of the naked mole-rat: Histodiversity and intraspecific variation.
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Journal of Anatomy
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-12-11
Subject
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bone microstructure; bone modeling; endosteal bone; Heterocephalus glaber; lamellar bone; lamellar-zonal bone; long bone growth; lamellar‐ zonal bone
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Montoya-Sanhueza G; Bennett NC; Oosthuizen MK; Dengler-Crish CM; Chinsamy A
Description
An account of the resource
Lacking fur, living in eusocial colonies and having the longest lifespan of any rodent, makes naked mole-rats (NMRs) rather peculiar mammals. Although they exhibit a high degree of polymorphism, skeletal plasticity are considered a novel model to assess the effects of delayed puberty on the skeletal system, scarce information on their morphogenesis exists. Here, we examined a large ontogenetic sample (n = 76) of subordinate individuals to assess the pattern of bone growth and bone microstructure of fore- and hindlimb bones by using histomorphological techniques. Over 290 undecalcified thin cross-sections from the midshaft of the humerus, ulna, femur, and tibia from pups, juveniles and adults were analyzed with polarized light microscopy. Similar to other fossorial mammals, NMRs exhibited a systematic cortical thickening of their long bones, which clearly indicates a conserved functional adaptation to withstand the mechanical strains imposed during digging, regardless of their chisel-tooth predominance. We describe a high histodiversity of bone matrices and the formation of secondary osteons in NMRs. The bones of pups are extremely thin-walled and grow by periosteal bone formation coupled with considerable expansion of the medullary cavity, a process probably tightly regulated and adapted to optimize the amount of minerals destined for skeletal development, to thus allow the female breeder to produce a higher number of pups, as well as several litters. Subsequent cortical thickening in juveniles involves high amounts of endosteal bone apposition, which contrasts with the bone modeling of other mammals where a periosteal predominance exists. Adults have bone matrices predominantly consisting of parallel-fibered bone and lamellar bone, which indicate intermediate to slow rates of osteogenesis, as well as the development of poorly vascularized lamellar-zonal tissues separated by lines of arrested growth (LAGs) and annuli. These features reflect the low metabolism, low body temperature and slow growth rates reported for this species, as well as indicate a cyclical pattern of osteogenesis. The presence of LAGs in captive individuals was striking and indicates that postnatal osteogenesis and its consequent cortical stratification most likely represents a plesiomorphic thermometabolic strategy among endotherms which has been suggested to be regulated by endogenous rhythms. However, the generalized presence of LAGs in this and other subterranean taxa in the wild, as well as recent investigations on variability of environmental conditions in burrow systems, supports the hypothesis that underground environments experience seasonal fluctuations that may influence the postnatal osteogenesis of animals by limiting the extension of burrow systems during the unfavorable dry seasons and therefore the finding of food resources. Additionally, the intraspecific variation found in the formation of bone tissue matrices and vascularization suggested a high degree of developmental plasticity in NMRs, which may help explaining the polymorphism reported for this species. The results obtained here represent a valuable contribution to understanding the relationship of several aspects involved in the morphogenesis of the skeletal system of a mammal with extraordinary adaptations.
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<a href="http://doi.org/10.1111/joa.13381" target="_blank" rel="noreferrer noopener">10.1111/joa.13381</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
Bennett NC
bone microstructure
bone modeling
Chinsamy A
Dengler-Crish CM
Department of Pharmaceutical Sciences
endosteal bone
Heterocephalus glaber
January 2021 List
Journal of anatomy
journalArticle
lamellar bone
lamellar-zonal bone
lamellar‐
long bone growth
Montoya-Sanhueza G
NEOMED College of Pharmacy
Oosthuizen MK
zonal bone
-
Text
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URL Address
<a href="http://doi.org/10.1111/jcpt.13324" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/jcpt.13324</a>
ISSN
1365-2710 0269-4727
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Title
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Prevalence, predictors and trends of opioid prescribing for lower back pain in united states emergency departments.
Publisher
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Journal of Clinical Pharmacy and Therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-12-11
Subject
The topic of the resource
low back pain; opioid; opioid prescribing; pain
Creator
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Walkerly A; Neugebauer RE; Misko B; Shively Danielle; Singh S; Chahda B; Dhanireddy S; King K; Lloyd M; Fosnight S; Costello M; Palladino C; Soric M
Description
An account of the resource
WHAT IS KNOWN AND OBJECTIVE: Current evidence-based guidelines for the treatment of acute low back pain (ALBP) recommend the use of opioid medications only after failure of nonpharmacological therapy, non-steroidal anti-inflammatory drugs and skeletal muscle relaxants and after thorough evaluation of risks and benefits. Despite this recommendation and the state of the opioid epidemic in the United States (US), opioids remain a common drug of choice for ALBP in the emergency department (ED). The purpose of this study was to quantify the prevalence and identify predictors of opioid prescribing for acute lower back pain (ALBP) in emergency departments (EDs) in the United States. METHODS: This was a national, cross-sectional study of the National Hospital Ambulatory Care Survey from 2013-2016. ED visits for patients aged ≥18 years treated for ALBP were included. Patients presenting with specified reasons that an opioid may be indicated were excluded. The primary endpoint was frequency of opioids prescribed. A multivariate logistic regression model identified patient- and provider-level predictors of opioid use. RESULTS AND DISCUSSION: This analysis included 2260 visits for ALBP. Opioids were prescribed in 32.3% of visits. Positive predictors of opioid prescribing were pain score of 7-10 (OR 1.85; 95% CI 1.26-2.70), and patients seen in the Southern (OR 2.53; 95% CI 1.47-4.36) or Western US (OR 2.10; 95% CI 1.19-3.70). Opioids were prescribed less often to patients who received a NSAID or acetaminophen (OR 0.38; 95% CI 0.28-0.52 and OR 0.03; 95% CI 0.01-0.10, respectively). WHAT IS NEW AND CONCLUSION: Opioid prescribing rates for ALBP remain high and the predictors identified demonstrate that this prescribing pattern is not uniformly distributed across the patient and provider characteristics studied.
Identifier
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<a href="http://doi.org/10.1111/jcpt.13324" target="_blank" rel="noreferrer noopener">10.1111/jcpt.13324</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
Chahda B
Costello M
Department of Pharmacy Practice
Dhanireddy S
Fosnight S
January 2021 List
Journal of Clinical Pharmacy and Therapeutics
journalArticle
King K
Lloyd M
Low Back Pain
Misko B
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
NEOMED Student Publications
Neugebauer RE
Opioid
opioid prescribing
Pain
Palladino C
Shively Danielle
Singh S
Soric M
Walkerly A
-
Text
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URL Address
<a href="http://doi.org/10.1097/MJT.0000000000001283" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/MJT.0000000000001283</a>
Volume
Publish Ahead of Print
ISSN
1536-3686 1075-2765
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Title
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Evaluating the impact of glucagon-like peptide-1 receptor agonists on metabolic changes in patients with type 2 diabetes on high-dose insulin.
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American Journal of Therapeutics
Date
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2020
2020-12-29
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Rentsch T; Awad M; Moorman JM; Gothard MD
Description
An account of the resource
BACKGROUND: Studies involving the glucagon-like peptide-1 receptor agonist (GLP-1 RA) liraglutide have shown reductions in hemoglobin A1c (HbA1c), weight, and insulin requirements in patients with type 2 diabetes mellitus (DM2) requiring high-dose insulin therapy. The effect of the class of GLP-1 RAs on these parameters is unknown. DATA SOURCES: A retrospective cohort analysis was conducted in patients with DM2 where a GLP-1 RA was added to high-dose insulin therapy. The primary composite outcome was the change from baseline to 9 months in HbA1c, weight, and insulin dose. RESULTS: GLP-1 RA therapy was associated with a significant reduction in HbA1c from baseline (-0.9%; P = 0.022). Weight and insulin dose were not significantly reduced from baseline. There was a moderate effect of individual agents on these outcomes, but no significant reductions were seen due to the small sample size. LIMITATIONS: Generalizability of these findings may be limited by the characteristics and size of the study population. THERAPEUTIC OPINION: The effect of GLP-1 RA therapy on HbA1c may be attributed to the medication class. The effect of individual agents on weight and insulin requirements needs further investigation.
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<a href="http://doi.org/10.1097/MJT.0000000000001283" target="_blank" rel="noreferrer noopener">10.1097/MJT.0000000000001283</a>
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journalArticle
2020
American journal of therapeutics
Awad M
Department of Pharmacy Practice
Gothard MD
January 2021 List
journalArticle
Moorman JM
NEOMED College of Pharmacy
Rentsch T
-
Text
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URL Address
<a href="http://doi.org/10.1002/cne.25101" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/cne.25101</a>
ISSN
1096-9861 0021-9967
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January 2021 List
NEOMED College
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Department of Pharmaceutical Sciences
Department of Anatomy & Neurobiology
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Title
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A comparative analysis of cone photoreceptor morphology in bowhead and beluga whales.
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The Journal of Comparative Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-12-30
Subject
The topic of the resource
cone photoreceptor; magnetosensation; mysticetes; odontocetes; retina
Creator
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Smith MA; Waugh DA; McBurney DL; George JC; Suydam RS; Thewissen JGM; Crish SD
Description
An account of the resource
The cetacean visual system is a product of selection pressures favoring underwater vision, yet relatively little is known about it across taxa. Previous studies report several mutations in the opsin genetic sequence in cetaceans, suggesting the evolutionary complete or partial loss of retinal cone photoreceptor function in mysticete and odontocete lineages, respectively. Despite this, limited anatomical evidence suggests cone structures are partially maintained but with absent outer and inner segments in the bowhead retina. The functional consequence and anatomical distributions associated with these unique cone morphologies remain unclear. The current study further investigates the morphology and distribution of cone photoreceptors in the bowhead whale and beluga retina and evaluates the potential functional capacity of these cells' alternative to photoreception. Refined histological and advanced microscopic techniques revealed two additional cone morphologies in the bowhead and beluga retina that have not been previously described. Two proteins involved in magnetosensation were present in these cone structures suggesting the possibility for an alternative functional role in responding to changes in geomagnetic fields. These findings highlight a revised understanding of the unique evolution of cone and gross retinal anatomy in cetaceans, and provide prefatory evidence of potential functional reassignment of these cells.
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<a href="http://doi.org/10.1002/cne.25101" target="_blank" rel="noreferrer noopener">10.1002/cne.25101</a>
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journalArticle
2020
cone photoreceptor
Crish SD
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
George JC
January 2021 List
journalArticle
magnetosensation
McBurney DL
mysticetes
NEOMED College of Medicine
NEOMED College of Pharmacy
odontocetes
retina
Smith MA
Suydam RS
The Journal of comparative neurology
Thewissen JGM
Waugh DA
-
Text
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<a href="http://doi.org/10.3390/metabo10110474" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/metabo10110474</a>
Issue
11
Volume
10
ISSN
2218-1989 2218-1989 2218-1989
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December 2020 List
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NEOMED College of Pharmacy
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Department of Pharmaceutical Sciences
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Title
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Isotope Fractionation during Gas Chromatography Can Enhance Mass Spectrometry-Based Measures of (2)H-Labeling of Small Molecules.
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Metabolites
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-11-20
Subject
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stable isotopes; data integration; gas chromatography-mass spectrometry; isotope fractionation; metabolic flux; Savitzky-Golay
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Downes DP; Kasumov T; Daurio NA; Wood NB; Previs MJ; Sheth PR; McLaren DG; Previs SF
Description
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Stable isotope tracers can be used to quantify the activity of metabolic pathways. Specifically, (2)H-water is quite versatile, and its incorporation into various products can enable measurements of carbohydrate, lipid, protein and nucleic acid kinetics. However, since there are limits on how much (2)H-water can be administered and since some metabolic processes may be slow, it is possible that one may be challenged with measuring small changes in isotopic enrichment. We demonstrate an advantage of the isotope fractionation that occurs during gas chromatography, namely, setting tightly bounded integration regions yields a powerful approach for determining isotope ratios. We determined how the degree of isotope fractionation, chromatographic peak width and mass spectrometer dwell time can increase the apparent isotope labeling. Relatively simple changes in the logic surrounding data acquisition and processing can enhance gas chromatography-mass spectrometry measures of low levels of (2)H-labeling, this is especially useful when asymmetrical peaks are recorded at low signal:background. Although we have largely focused attention on alanine (which is of interest in studies of protein synthesis), it should be possible to extend the concepts to other analytes and/or hardware configurations.
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<a href="http://doi.org/10.3390/metabo10110474" target="_blank" rel="noreferrer noopener">10.3390/metabo10110474</a>
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journalArticle
2020
data integration
Daurio NA
December 2020 List
Department of Pharmaceutical Sciences
Downes DP
gas chromatography-mass spectrometry
isotope fractionation
journalArticle
Kasumov T
McLaren DG
metabolic flux
metabolites
NEOMED College of Pharmacy
Previs MJ
Previs SF
Savitzky-Golay
Sheth PR
Stable isotopes
Wood NB
-
Text
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener">http://doi.org/</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S224-S225
Issue
1, SI
Volume
35
ISSN
0885-3185
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October 2020 List
NEOMED College
NEOMED College of Pharmacy
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Department of Pharmaceutical Sciences
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Title
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Intrastriatal injection of alpha-synuclein preformed fibrils results in cognitive dysfunction and L-DOPA reversible sensorimotor impairments in rats
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Movement Disorders
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-09
Creator
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Fleming S;Patterson J;Yan L;Kemp C;Miller K;Stoll A;Duffy M;Herman D;Lipton J;Luk K;Goudreau J;Sortwell C
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener"></a>
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journalArticle
2020
Department of Pharmaceutical Sciences
Duffy M
Fleming S
Goudreau J
Herman D
journalArticle
Kemp C
Lipton J
Luk K
Miller K
MOVEMENT disorders
NEOMED College of Pharmacy
October 2020 List
Patterson J
Sortwell C
Stoll A
Yan L
-
Text
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener">http://doi.org/</a>
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Pages
324A
Issue
1
Volume
72
ISSN
0270-9139
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October 2020 List
NEOMED College
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Department of Pharmaceutical Sciences
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Title
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Effect of a high fat "western type" diet on dynamics of hepatic acetylated mitochondrial proteins in a mouse model of NAFLD
Publisher
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Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-11
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Kasumov T;Arias-Alvarado A;Aghayev M;Ilchenko S;McCullough AJ
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener"></a>
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journalArticle
2020
Aghayev M
Arias-Alvarado A
Department of Pharmaceutical Sciences
Hepatology
Ilchenko S
journalArticle
Kasumov T
McCullough AJ
NEOMED College of Pharmacy
October 2020 List
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener">http://doi.org/</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
229A-230A
Issue
1
Volume
72
ISSN
0270-9139
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October 2020 List
NEOMED College
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Department of Interative Medical Sciences
Department of Pharmaceutical Sciences
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Title
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The role of the bile acid receptor TGR5 in Alzheimer's Disease
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Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-11
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Ferrell JM;Boehme S;Gilliland T;Lin Li;Dengler-Crish CM;Takahashi S;Gonzalez FJ;Chiang JYL
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener"></a>
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journalArticle
2020
Boehme S
Chiang JYL
Dengler-Crish CM
Department of Integrative Medical Sciences
Department of Pharmaceutical Sciences
Ferrell JM
Gilliland T
Gonzalez FJ
Hepatology
journalArticle
Lin Li
NEOMED College of Medicine
NEOMED College of Pharmacy
October 2020 List
Takahashi S
-
Text
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URL Address
<a href="http://doi.org/10.3390/ijms21207472" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/ijms21207472</a>
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Issue
20
Volume
21
ISSN
1422-0067 1422-0067
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NEOMED College
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Department of Pharmacy Practice
Department of Pharmaceutical Sciences
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Title
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Early pro-inflammatory remodeling of HDL proteome in a model of diet-induced obesity: 2H2O-metabolic labeling-based kinetic approach.
Publisher
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International Journal of Molecular Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-10-10
Subject
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inflammation; NAFLD; proteome dynamics; dyslipidemia; insulin resistance; diet-induced obesity; acute-phase proteins; high-density lipoprotein; high-fat diet
Creator
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Sadana P;Lin Li;Aghayev M;Ilchenko S;Kasumov T
Description
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Mice fed a high-fat diet for 12 weeks or longer develop hyperglycemia, insulin resistance, dyslipidemia, and fatty liver. Additionally, a high-fat diet induces inflammation that remodels and affects the anti-inflammatory and antiatherogenic property of the high-density lipoprotein (HDL). However, the precise time course of metabolic disease progression and HDL remodeling remains unclear. Short-term (four weeks) high-fat feeding (60% fat calories) was performed in wild-type male C57BL/6J mice to gain insights into the early metabolic disease processes in conjunction with a HDL proteome dynamics analysis using a heavy water metabolic labeling approach. The high-fat diet-fed mice developed hyperglycemia, impaired glucose tolerance, hypercholesterolemia without hypertriglyceridemia or hepatic steatosis. A plasma HDL proteome dynamics analysis revealed increased turnover rates (and reduced half-lives) of several acute-phase response proteins involved in innate immunity, including complement C3 (12.77 ± 0.81 vs. 9.98 ± 1.20 h, p < 0.005), complement factor B (12.71 ± 1.01 vs. 10.85 ± 1.04 h, p < 0.05), complement Factor H (19.60 ± 1.84 vs. 16.80 ± 1.58 h, p < 0.05), and complement factor I (25.25 ± 1.29 vs. 19.88 ± 1.50 h, p < 0.005). Our findings suggest that an early immune response-induced inflammatory remodeling of the plasma HDL proteome precedes the diet-induced steatosis and dyslipidemia.
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<a href="http://doi.org/10.3390/ijms21207472" target="_blank" rel="noreferrer noopener">10.3390/ijms21207472</a>
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journalArticle
2020
acute-phase proteins
Aghayev M
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
diet-induced obesity
dyslipidemia
high-density lipoprotein
High-fat diet
Ilchenko S
Inflammation
Insulin Resistance
International journal of molecular sciences
journalArticle
Kasumov T
Lin Li
NAFLD
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
October 2020 List
Proteome dynamics
Sadana P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/03008207.2020.1828380" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/03008207.2020.1828380</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-14
ISSN
1607-8438 0300-8207
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Title
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A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes.
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Connective Tissue Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-10-12
Subject
The topic of the resource
gene regulation; chondrogenesis; extracellular matrix; chondrocyte; ZCCHC5/RTL3; RTL3; ZCCHC5
Creator
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Ball HC;Ansari M Y;Ahmad N;Novak K;Haqqi TM
Description
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PURPOSE: Transposable elements are known to remodel gene structure and provide a known source of genetic variation. Retrotransposon gag-like-3 (RTL3) is a mammalian retrotransposon-derived transcript (MART) whose function in the skeletal tissue is unknown. This study aimed to elucidate the biological significance of RTL3 in chondrogenesis and type-II collagen (COL2A1) gene expression in chondrocytes. MATERIALS AND METHODS: Expression of RTL3, SOX-9 and COL2A1 mRNAs was determined by TaqMan assays and the protein expression by immunoblotting. RTL3 and Sox-9 depletion in human chondrocytes was achieved using validated siRNAs. An RTL3 mutant (∆RTL3) lacking the zinc finger domain was created using in vitro mutagenesis. Forced expression of RTL3, ∆RTL3, and SOX-9 was achieved using CMV promoter containing expression plasmids. CRISPR-Cas9 was utilized to delete Rtl3 and create a stable ATDC5(Rlt3-/-) cell line. Matrix deposition and Col2a1 quantification during chondrogenesis were determined by Alcian blue staining and Sircol™ Soluble Collagen Assay, respectively. RESULTS: RTL3 is not ubiquitously expressed but showed strong expression in cartilage, chondrocytes and synoviocytes but not in muscle, brain, or other tissues analyzed. Loss-of-function and gain-of-function studies demonstrated a critical role of RTL3 in the regulation of SOX-9 and COL2A1 expression and matrix synthesis during chondrogenesis. Both RTL3 and SOX-9 displayed co-regulated expression in chondrocytes. Gene regulatory activity of RTL3 requires the c-terminal CCHC zinc-finger binding domain. CONCLUSIONS: Our results identify a novel regulatory mechanism of COL2A1 expression in chondrocytes that may help to further understand the skeletal development and the pathogenesis of diseases with altered COL2A1 expression.
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<a href="http://doi.org/10.1080/03008207.2020.1828380" target="_blank" rel="noreferrer noopener">10.1080/03008207.2020.1828380</a>
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The file format, physical medium, or dimensions of the resource
journalArticle
2020
Ahmad N
Ansari M Y
Ball HC
chondrocyte
chondrogenesis
Connective tissue research
Department of Anatomy & Neurobiology
Department of Pharmacy Practice
Extracellular Matrix
Gene Regulation
Haqqi TM
journalArticle
NEOMED College of Medicine
NEOMED College of Pharmacy
NEOMED Student Publications
Novak K
October 2020 List
RTL3
ZCCHC5
ZCCHC5/RTL3
-
Text
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URL Address
<a href="http://doi.org/10.1155/2020/8856022" target="_blank" rel="noreferrer noopener">http://doi.org/10.1155/2020/8856022</a>
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Pages
8856022
Volume
2020
ISSN
2090-6501 2090-651X 2090-651X
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October 2020 List
NEOMED College
NEOMED College of Medicine
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Department of Internal Medicine
Department of Pharmacy Practice
Affiliated Hospital
Cleveland Clinic Akron General Hospital
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Title
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Critical low catastrophe: a case report of treatment-refractory hypoglycemia following overdose of long-acting insulin.
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Case Reports in Endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
1905-07
Subject
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BLOOD sugar; DEXTROSE; HYPOGLYCEMIA; INSULIN; INSULINOMA; PARENTERAL infusions
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Sandooja R;Moorman JM;Priyadarshini KM;Detoya K
Description
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Overdose of long-acting insulin can cause unpredictable hypoglycemia for prolonged periods of time. The initial treatment of hypoglycemia includes oral carbohydrate intake as able and/or parenteral dextrose infusion. Refractory hypoglycemia following these interventions presents a clinical challenge in the absence of clear guidelines for management. Octreotide has sometimes been used, but its use is generally limited to sulfonylurea overdose. In this case report, we present a case of refractory hypoglycemia following an overdose of 900 units of long-acting insulin glargine that failed to respond to usual modes of therapy mentioned above. Stress-dose corticosteroids were then initiated, followed by subsequent improvement in IV dextrose and glucagon requirements and blood glucose levels. Hence, corticosteroids may serve as an adjunctive therapy in managing hypoglycemia and can be considered earlier in the course of treatment in patients with refractory hypoglycemia to prevent volume overload, especially when large volumes of dextrose infusions are required.
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<a href="http://doi.org/10.1155/2020/8856022" target="_blank" rel="noreferrer noopener">10.1155/2020/8856022</a>
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journalArticle
2020
BLOOD sugar
Case Reports in Endocrinology
Cleveland Clinic Akron General Hospital
Department of Internal Medicine
Department of Pharmacy Practice
Detoya K
DEXTROSE
hypoglycemia
insulin
INSULINOMA
journalArticle
Moorman JM
NEOMED College of Medicine
NEOMED College of Pharmacy
October 2020 List
PARENTERAL infusions
Priyadarshini KM
Sandooja R
-
Text
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URL Address
<a href="http://doi.org/10.1002/jcp.30116" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jcp.30116</a>
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ISSN
1097-4652 0021-9541
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October 2020 List
NEOMED College
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Department of Integrative Medical Sciences
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Department of Pharmaceutical Sciences
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Title
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Transient receptor potential vanilloid 4 channel deletion regulates pathological but not developmental retinal angiogenesis.
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Journal of Cellular Physiology
Date
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2020
2020-10-20
Subject
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neovascularization; TRPV4; mechanotransduction; ECM stiffness; human retinal endothelial cells
Creator
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Cappelli HC;Guarino BD;Kanugula AK;Adapala R K;Perera V;Smith MA;Paruchuri S;Thodeti CK
Description
An account of the resource
Transient receptor potential vanilloid 4 (TRPV4) channels are mechanosensitive ion channels that regulate systemic endothelial cell (EC) functions such as vasodilation, permeability, and angiogenesis. TRPV4 is expressed in retinal ganglion cells, Müller glia, pigment epithelium, microvascular ECs, and modulates cell volume regulation, calcium homeostasis, and survival. TRPV4-mediated physiological or pathological retinal angiogenesis remains poorly understood. Here, we demonstrate that TRPV4 is expressed, functional, and mechanosensitive in retinal ECs. The genetic deletion of TRPV4 did not affect postnatal developmental angiogenesis but increased pathological neovascularization in response to oxygen-induced retinopathy (OIR). Retinal vessels from TRPV4 knockout mice subjected to OIR exhibited neovascular tufts that projected into the vitreous humor and displayed reduced pericyte coverage compared with wild-type mice. These results suggest that TRPV4 is a regulator of retinal angiogenesis, its deletion augments pathological retinal angiogenesis, and that TRPV4 could be a novel target for the development of therapies against neovascular ocular diseases.
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<a href="http://doi.org/10.1002/jcp.30116" target="_blank" rel="noreferrer noopener">10.1002/jcp.30116</a>
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journalArticle
2020
Adapala R K
Cappelli HC
Department of Integrative Medical Sciences
Department of Pharmaceutical Sciences
ECM stiffness
Guarino BD
human retinal endothelial cells
Journal of cellular physiology
journalArticle
Kanugula AK
Mechanotransduction
NEOMED College of Medicine
NEOMED College of Medicine Postdoc
NEOMED College of Medicine Student
NEOMED College of Pharmacy
NEOMED Postdoc Publications
NEOMED Student Publications
Neovascularization
October 2020 List
Paruchuri S
Perera V
Smith MA
Thodeti CK
TRPV4
-
Text
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URL Address
<a href="http://doi.org/10.1096/fasebj.2020.34.s1.09750" target="_blank" rel="noreferrer noopener">http://doi.org/10.1096/fasebj.2020.34.s1.09750</a>
Issue
1
Volume
34
ISSN
0892-6638
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Department of Pharmaceutical Science
Department of Anatomy & Neurobiology
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L-plastin, a novel regulator of microglial activation in parkinsons disease
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Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Creator
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Budge K;Richardson JR;Safadi F
Description
An account of the resource
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease worldwide behind Alzheimer’s disease. One prominent feature of PD is the marked loss of dopaminergic and motor dysfunction. Currently, there are no therapies to effectively slow disease progression. Neuroinflammation is a major contributing factor in neurodegeneration diseases including PD. Microglia, a type of glial cell, are primary regulators of neuroinflammation and these cells are capable of assuming activation states ranging from inflammatory to anti‐inflammatory and reparative. Thus methods to combat microglial inflammation or promote microglial anti‐inflammatory and reparative effects show promise as treatments to slow neurodegeneration. L‐plastin (LPL) is an acting bundling protein and other research has shown that LPL plays a role in osteoclast function, T‐cell activation, and it may be involved in the NLRP3 inflammasome activation in macrophages. It has been shown in osteoclasts, that LPL phosphorylation at serine 5 plays a role in sealing zone formation. Using a peptide inhibitor to block phosphorylation of serine 5 on LPL prevented sealing zone formation and inhibited osteoclast‐mediated bone resorption. Given the evidence that LPL may play a role in inflammasome activation in macrophages, we investigated if LPL may play a role in microglial activation. To assess the function of LPL in the microglial inflammatory response, we utilized qPCR, Western blot, and immunofluorescence techniques. We show here that lipopolysaccharide (LPS) treatment induces LPL phosphorylation at serine 5, as well as increased Lcp1 mRNA expression. Furthermore, using a TAT‐fused peptidomimetic inhibitor of LPL phosphorylation significantly reduced LPS‐induced inflammatory gene (Il‐1b, Il‐6, Tnfa) expression. For this study, an acute 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) mouse model was also used. Male (10‐week‐old) C57BL/6N mice were treated with four injections (one every two hours) of either saline or 15mg/kg of MPTP. Mice were then sacrificed two days after the last injection and striatum and hindbrain were isolated. Two days after MPTP treatment is when peak inflammation occurs in the brain. We found that Lcp1 mRNA expression was significantly increased in the striatum of MPTP‐treated mice compared to saline‐treated mice. These results suggest that LPL may play a role in the microglial inflammatory response, and that LPL inhibition may be a novel way to combat neuroinflammation and neurodegeneration. We are currently staining for phosphorylated LPL in the microglia of MPTP treated mice. Furthermore, we have obtained LPL KO mice to assess the in vivo function of LPL in mouse models of PD.
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<a href="http://doi.org/10.1096/fasebj.2020.34.s1.09750" target="_blank" rel="noreferrer noopener">10.1096/fasebj.2020.34.s1.09750</a>
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journalArticle
2020
Budge K
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Faseb Journal
journalArticle
NEOMED College of Medicine
NEOMED College of Pharmacy
Richardson JR
Safadi F
September 2020 List
-
Text
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URL Address
<a href="http://doi.org/10.1093/toxsci/kfaa144" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/toxsci/kfaa144</a>
ISSN
1096-0929
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September 2020 List
NEOMED College
NEOMED College of Pharmacy
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NEOMED Student Publications
Department of Pharmaceutical Sciences
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Title
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Deltamethrin exposure inhibits adult hippocampal neurogenesis and causes deficits in learning and memory in mice.
Publisher
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Toxicological Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-09-25
Subject
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mice; pyrethroid; cognition; adult neurogenesis
Creator
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Hossain MM;Belkadi A;Al-Haddad S;Richardson JR
Description
An account of the resource
Deficits in learning and memory are often associated with disruption of hippocampal neurogenesis, which is regulated by numerous processes, including precursor cell proliferation, survival, migration, and differentiation to mature neurons. Recent studies demonstrate that adult born neurons in the dentate gyrus (DG) in the hippocampus can functionally integrate into the existing neuronal circuitry and contribute to hippocampal-dependent learning and memory. Here, we demonstrate that relatively short-term deltamethrin exposure (3 mg/kg every 3 days for 1 month) inhibits adult hippocampal neurogenesis and causes deficits in learning and memory in mice. Hippocampal-dependent cognitive functions were evaluated using two independent hippocampal-dependent behavioural tests, the novel object recognition task and Morris water maze. We found that deltamethrin-treated mice exhibited profound deficits in novel object recognition and learning and memory in water maze. Deltamethrin exposure significantly decreased bromodeoxyuridine (BrdU)-positive cells (39%) and Ki67+ cells (47%) in the dentate gyrus (DG) of the hippocampus, indicating decreased cellular proliferation. In addition, deltamethrin-treated mice exhibited a 44% decrease in nestin-expressing neural progenitor cells and a 38% reduction in the expression of doublecortin (DCX), an early neuronal differentiation marker. Furthermore, deltamethrin exposed mice exhibited a 25% reduction in total number of granule cells in the DG. These findings indicate that relatively short-term exposure to deltamethrin causes significant deficits in hippocampal neurogenesis that is associated with impaired learning and memory. (© The Author(s) 2020. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/toxsci/kfaa144" target="_blank" rel="noreferrer noopener">10.1093/toxsci/kfaa144</a>
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journalArticle
2020
adult neurogenesis
Al-Haddad S
Belkadi A
Cognition
Department of Pharmaceutical Sciences
Hossain MM
journalArticle
Mice
NEOMED College of Pharmacy
NEOMED Student Publications
Pyrethroid
Richardson JR
September 2020 List
Toxicological Sciences
-
Text
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<a href="http://doi.org/10.1021/acschembio.0c00380" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/acschembio.0c00380</a>
ISSN
1554-8937
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September 2020 List
NEOMED College
NEOMED College of Pharmacy
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Department of Pharmaceutical Sciences
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Examining targeted protein degradation from physiological and analytical perspectives: Enabling translation between cells and subjects.
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ACS Chemical Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-09-30
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Daurio NA;Zhou H;Chen Y;Sheth PR;Imbriglio JE;McLaren DG;Tawa P;Rachdaoui N;Previs MJ;Kasumov T;O'Neil J;Previs SF
Description
An account of the resource
The ability to target specific proteins for degradation may open a new door toward developing therapeutics. Although effort in chemistry is essential for advancing this modality, i.e., one needs to generate proteolysis targeting chimeras (bifunctional molecules, also referred to as PROTACS) or "molecular glues" to accelerate protein degradation, we suspect that investigations could also benefit by directing attention toward physiological regulation surrounding protein homeostasis, including the methods that can be used to examine changes in protein kinetics. This perspective will first consider some metabolic scenarios that might be of importance when one aims to change protein abundance by increasing protein degradation. Specifically, could protein turnover impact the apparent outcome? We will then outline how to study protein dynamics by coupling stable isotope tracer methods with mass spectrometry-based detection; since the experimental conditions could have a dramatic effect on protein turnover, special attention is directed toward the application of methods for quantifying protein kinetics using in vitro and in vivo models. Our goal is to present key concepts that should enable mechanistically informed studies which test targeted protein degradation strategies.
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<a href="http://doi.org/10.1021/acschembio.0c00380" target="_blank" rel="noreferrer noopener">10.1021/acschembio.0c00380</a>
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journalArticle
2020
Acs Chemical Biology
Chen Y
Daurio NA
Department of Pharmaceutical Sciences
Imbriglio JE
journalArticle
Kasumov T
McLaren DG
NEOMED College of Pharmacy
O'Neil J
Previs MJ
Previs SF
Rachdaoui N
September 2020 List
Sheth PR
Tawa P
Zhou H
-
Text
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URL Address
<a href="http://doi.org/10.1097/mjt.0000000000001274" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/mjt.0000000000001274</a>
ISSN
1075-2765
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NEOMED College
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Department of Pharmacy Practice
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Title
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Utilization of high-intensity statins in patients at risk for cardiovascular events: A national cross-sectional study
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American Journal Of Therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-10-01
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Moorman JM;Jaclyn B;Leah B;Dugan SE;Lukas E;Gustafson K;Hartzler C;Nathan H;Joshi D;King C;King K;King PK;Pesce A;Prabodh S;Harold S III;Toth J;Unruh A;Walkerly A
Description
An account of the resource
BACKGROUND:: The 2013 American College of Cardiology/American Heart Association cholesterol guidelines, which identified four groups of patients at risk for atherosclerotic cardiovascular disease events, departed from the target-based approach to managing cholesterol. The impact of these guidelines on high-intensity statin use across the United States is unclear. STUDY QUESTION:: The primary objective was to evaluate the rate of high-intensity potential (HIP) statin use before and after the 2013 guidelines. The secondary objective was to identify predictors of HIP statin use within the study population. STUDY DESIGN:: A national cross-sectional study was conducted using data from the National Ambulatory Medical Care Survey. Office visits involving patients aged 21–75 years where criteria for HIP statin therapy were met were included. Visits involving pregnant patients were excluded. MEASURES AND OUTCOMES:: Prescribing trends of HIP statins were measured from National Ambulatory Medical Care Survey data before and after the 2013 guidelines. Multivariate logistic regression identified variables associated with prescribing HIP statins. RESULTS:: A total of 48,884 visits were included, representing more than 940 million office visits nationally. HIP statins were listed in 9.5% and 16.5% of visits before and after 2013, respectively (odds ratio [OR] 1.88; 95% confidence interval [CI] 1.62–2.20). The strongest predictors of HIP statin use were antihypertensive use (OR 5.38, 95% CI 4.67–6.20), comorbid hyperlipidemia (OR 2.93, 95% CI 2.62–3.29), Black race (OR 0.63, 95% CI 0.49–0.81), and Hispanic ethnicity (OR 0.65, 95% CI 0.52–0.80). CONCLUSIONS:: Prescribing rates for HIP statins increased after the release of the 2013 guidelines. The prescribing rates were lower than expected, especially in Black and Hispanic patients. These observations signify opportunities to improve the quality of care for patients who are at risk for atherosclerotic cardiovascular disease events in the United States.
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<a href="http://doi.org/10.1097/mjt.0000000000001274" target="_blank" rel="noreferrer noopener">10.1097/mjt.0000000000001274</a>
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journalArticle
2020
American journal of therapeutics
Department of Pharmacy Practice
Dugan SE
Gustafson K
Harold S III
Hartzler C
Jaclyn B
Joshi D
journalArticle
King C
King K
King PK
Leah B
Lukas E
Moorman JM
Nathan H
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
NEOMED Student Publications
Pesce A
Prabodh S
September 2020 List
Toth J
Unruh A
Walkerly A
-
Text
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URL Address
<a href="http://doi.org/10.1176/appi.ps.202000140" target="_blank" rel="noreferrer noopener">http://doi.org/10.1176/appi.ps.202000140</a>
Pages
941-946
Issue
9
Volume
71
ISSN
1075-2730
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NEOMED College
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Department of Psychiatry
Department of Pharmacy Practice
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Title
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Informed consent: A policy prescription for communicating benefit and risk in state medical marijuana programs
Publisher
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Psychiatric Services
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-09-01
Subject
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Drug-Related Side Effects and Adverse Reactions; Cannabis; Information Dissemination; Marijuana Use; Medical Marijuana; Policy Making
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Messamore E;Dugan SE
Description
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In creating medical marijuana laws, state governments signal to the public that marijuana can safely and effectively treat a wide range of diseases. In many cases, these state approvals overestimate the benefits of marijuana and understate the risks. After a comprehensive review of the medical literature, the National Academies of Sciences, Engineering, and Medicine identified six medical benefits from marijuana that were supported with at least a moderate level of medical evidence and 14 potential health hazards. In contrast, the average state medical marijuana program lists 18 medical benefits, and 24 state medical marijuana program websites say nothing about possible risks. Medication approval processes through the federal government traditionally require independent analysis of data from well-designed clinical trials that measure the effectiveness and capture the risks of adverse effects from specific doses of the medicine. These considerations are generally missing from state approvals of medical marijuana. The power to declare something to be a legitimate medicine comes with the responsibility to provide information that people need to use the medicine wisely. The authors recommend that states that declare marijuana to be a medicine should inform the public about the quality of medical evidence behind each approved use and publicize all scientifically credible risks.
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<a href="http://doi.org/10.1176/appi.ps.202000140" target="_blank" rel="noreferrer noopener">10.1176/appi.ps.202000140</a>
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journalArticle
2020
Cannabis
Department of Pharmacy Practice
Department of Psychiatry
Drug-Related Side Effects and Adverse Reactions
Dugan SE
Information Dissemination
journalArticle
Marijuana Use
Medical Marijuana
Messamore E
NEOMED College of Medicine
NEOMED College of Pharmacy
Policy Making
Psychiatric Services
September 2020 List
-
Text
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URL Address
<a href="http://doi.org/10.1016/j.nbd.2020.104947" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.nbd.2020.104947</a>
Pages
N.PAG-N.PAG
Volume
141
ISSN
9699961
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August 2020 List
NEOMED College
NEOMED College of Pharmacy
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Department of Pharmaceutical Sciences
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Title
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Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits.
Publisher
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Neurobiology of Disease
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-07-15
Subject
The topic of the resource
Sex differences; Neuroinflammation; Parkinson's; Neurotoxicity; Pesticide; PARKINSON'S disease; SUBSTANTIA nigra; Synuclein; CORN oil; ORGANOCHLORINE pesticides; SALINE injections
Creator
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Gezer AO; Kochmanski J; VanOeveren SE; Cole-Strauss A; Kemp CJ; Patterson JR; Miller KM; Kuhn NC; Herman DE; McIntire A; Lipton JW; Luk KC; Fleming SM; Sortwell CE; Bernstein AI
Description
An account of the resource
Human and animal studies have shown that exposure to the organochlorine pesticide dieldrin is associated with increased risk of Parkinson's disease (PD). Previous work showed that developmental dieldrin exposure increased neuronal susceptibility to MPTP toxicity in male C57BL/6 mice, possibly via changes in dopamine (DA) packaging and turnover. However, the relevance of the MPTP model to PD pathophysiology has been questioned. We therefore studied dieldrin-induced neurotoxicity in the α-synuclein (α-syn)-preformed fibril (PFF) model, which better reflects the α-syn pathology and toxicity observed in PD pathogenesis. Specifically, we used a "two-hit" model to determine whether developmental dieldrin exposure increases susceptibility to α-syn PFF-induced synucleinopathy. Dams were fed either dieldrin (0.3 mg/kg, every 3–4 days) or vehicle corn oil starting 1 month prior to breeding and continuing through weaning of pups at postnatal day 22. At 12 weeks of age, male and female offspring received intrastriatal α-syn PFF or control saline injections. Consistent with the male-specific increased susceptibility to MPTP, our results demonstrate that developmental dieldrin exposure exacerbates PFF-induced toxicity in male mice only. Specifically, in male offspring, dieldrin exacerbated PFF-induced motor deficits on the challenging beam and increased DA turnover in the striatum 6 months after PFF injection. However, male offspring showed neither exacerbation of phosphorylated α-syn aggregation (pSyn) in the substantia nigra (SN) at 1 or 2 months post-PFF injection, nor exacerbation of PFF-induced TH and NeuN loss in the SN 6 months post-PFF injection. Collectively, these data indicate that developmental dieldrin exposure produces a male-specific exacerbation of synucleinopathy-induced behavioral and biochemical deficits. This sex-specific result is consistent with both previous work in the MPTP model, our previously reported sex-specific effects of this exposure paradigm on the male and female epigenome, and the higher prevalence and more severe course of PD in males. The novel two-hit environmental toxicant/PFF exposure paradigm established in this project can be used to explore the mechanisms by which other PD-related exposures alter neuronal vulnerability to synucleinopathy in sporadic PD. Unlabelled Image • Developmental dieldrin exposure increases α- syn -PFF-induced motor deficits. • Developmental dieldrin exposure increases PFF-induced deficits in DA handling. • Developmental dieldrin exposure does not affect PFF-induced loss of nigral neurons. • This is a novel paradigm modeling how environmental factors increase risk of PD. • Female mice show PFF-induced pathology, but no PFF-induced motor deficits. [ABSTRACT FROM AUTHOR]
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<a href="http://doi.org/10.1016/j.nbd.2020.104947" target="_blank" rel="noreferrer noopener">10.1016/j.nbd.2020.104947</a>
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journalArticle
2020
August 2020 List
Bernstein AI
Cole-Strauss A
CORN oil
Department of Pharmaceutical Sciences
Fleming SM
Gezer AO
Herman DE
journalArticle
Kemp CJ
Kochmanski J
Kuhn NC
Lipton JW
Luk KC
McIntire A
Miller KM
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
NEOMED Student Publications
Neurobiology of disease
Neuroinflammation
Neurotoxicity
ORGANOCHLORINE pesticides
Parkinson's
Parkinson's disease
Patterson JR
Pesticide
SALINE injections
Sex differences
Sortwell CE
SUBSTANTIA nigra
Synuclein
VanOeveren SE
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.18549/PharmPract.2020.3.1928" target="_blank" rel="noreferrer noopener">http://doi.org/10.18549/PharmPract.2020.3.1928</a>
Pages
1928
Issue
3
Volume
18
ISSN
1885-642X 1886-3655 1885-642X
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August 2020 List
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
NEOMED Student Publications
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Title
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The role of the community pharmacist in veterinary patient care: A cross-sectional study of pharmacist and veterinarian viewpoints.
Publisher
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Pharmacy Practice
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-09
Subject
The topic of the resource
United States; Surveys and Questionnaires; Professional Role; Pharmacists; Counseling; Drug Compounding; Intersectoral Collaboration; Pharmacies; Veterinarians
Creator
An entity primarily responsible for making the resource
Fredrickson ME; Terlizzi H; Horne RL; Dannemiller S
Description
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BACKGROUND: The role of the community pharmacist is rapidly expanding to encompass the care of veterinary patients in the United States of America This change makes it imperative for pharmacists and veterinarians who practice in community settings to establish mutual agreement on the roles of pharmacists in the care of these patients. OBJECTIVE: To examine community-based pharmacist and veterinarian viewpoints on interprofessional collaboration and the role of the community pharmacist in veterinary patient care. METHODS: Cross-sectional surveys were sent to pharmacists and veterinarians who practice in a community setting in Ohio. Surveys collected demographic information and addressed the following themes: attitudes toward collaboration, perceived roles of the pharmacist, expectations of the pharmacist, and previous collaborative experiences. A chi-square test was used for statistical analysis. RESULTS: In total, 357 pharmacists and 232 veterinarians participated in the study. Both professions agreed that pharmacist-veterinarian collaboration is important in order to optimize veterinary patient care (chi-square (1, N=589)=7.7, p=0.006). Overall, veterinarians were more likely to identify an important role of the community pharmacist to be compounding medications (chi-square (1, N=589)=26.7, p<0.001) compared to counseling pet owners (chi-square (1, N=589)=171.7, p<0.001). Both groups reported similar levels of agreement regarding the importance for pharmacists to have adequate knowledge of veterinary medicine. CONCLUSIONS: Our study found that while both pharmacists and veterinarians conveyed a positive attitude regarding interprofessional collaboration, they disagreed on what role the pharmacist should play in the care of veterinary patients. Rectifying the discordant perceptions of these health care professionals may be critical to developing collaborative initiatives and optimizing veterinary patient care.
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<a href="http://doi.org/10.18549/PharmPract.2020.3.1928" target="_blank" rel="noreferrer noopener">10.18549/PharmPract.2020.3.1928</a>
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journalArticle
2020
August 2020 List
Counseling
Dannemiller S
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Drug Compounding
Fredrickson ME
Horne RL
Intersectoral Collaboration
journalArticle
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
NEOMED Student Publications
Pharmacies
Pharmacists
Pharmacy Practice
Professional Role
Surveys and Questionnaires
Terlizzi H
United States
Veterinarians
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s13346-020-00829-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s13346-020-00829-x</a>
ISSN
2190-3948 2190-393X
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August 2020 List
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
NEOMED Student Publications
Department of Pharmaceutical Sciences
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Title
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Overcoming barriers confronting application of protein therapeutics in bone fracture healing.
Publisher
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Drug delivery and Translational Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-08-11
Subject
The topic of the resource
Osteoporosis; Drug delivery; Implants; Bone regeneration; Osteoinductive proteins; Osteopenia
Creator
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Czech T; Oyewumi MO
Description
An account of the resource
Bone fracture is a major contributor to debilitation and death among patients with bone diseases. Thus, osteogenic protein therapeutics and their delivery to bone have been extensively researched as strategies to accelerate fracture healing. To prevent morbidity and mortality of fractures, which occur frequently in the aging population, there is a critical need for development of first-line therapeutics. Bone morphogenic protein-2 (BMP-2) has been at the forefront of bone regeneration research for its potent osteoinduction, despite safety concerns and biophysiological obstacles of delivery to bone. However, continued pursuit of osteoinductive proteins as a therapeutic option is largely aided by drug delivery systems, playing an imperative role in enhancing safety and efficacy. In this work, we highlighted several types of drug delivery platforms and their biomaterials, to evaluate the suitability in overcoming challenges of therapeutic protein delivery for bone regeneration. To showcase the clinical considerations for each type of platform, we have assessed the most common route of administration strategies for bone regeneration, classifying the platforms as implantable or injectable. Additionally, we have analyzed the commonly utilized models and methodology for safety and efficacy evaluation of these osteogenic protein-loaded systems, to present clinical opinions for future directions of research in this field. It is hoped that this review will promote research and development of clinically translatable osteogenic protein therapeutics, while targeting first-line treatment status for achieving desired outcomes of fracture healing. Graphical abstract.
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<a href="http://doi.org/10.1007/s13346-020-00829-x" target="_blank" rel="noreferrer noopener">10.1007/s13346-020-00829-x</a>
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journalArticle
2020
August 2020 List
Bone regeneration
Czech T
Department of Pharmaceutical Sciences
Drug delivery
Drug delivery and translational research
Implants
journalArticle
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
NEOMED Student Publications
Osteoinductive proteins
osteopenia
Osteoporosis
Oyewumi MO
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.5688/ajpe7803" target="_blank" rel="noreferrer noopener">http://doi.org/10.5688/ajpe7803</a>
Pages
1001-1007
Issue
7
Volume
84
ISSN
0002-9459
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Update Year & Number
August 2020 List
NEOMED College
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmacy Practice
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The current landscape of college-sponsored postgraduate teaching and learning curriculum programs
Publisher
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American Journal of Pharmaceutical Education
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-07-01
Subject
The topic of the resource
postgraduate training; experiences; pharmacy; certificate program; teaching certificate program; teaching and learning curriculum; teaching certificate program
Creator
An entity primarily responsible for making the resource
Sheehan AH; Sprunger TL; Viswesh V; Gettig JP; Boyle J
Description
An account of the resource
Objective. To describe the landscape of teaching and learning curriculum (TLC) programs sponsored by US schools and colleges of pharmacy and evaluate their adoption of best practice recommendations. Methods. A 28-item electronic survey instrument was developed based on best practice recommendations published by the American Association of Colleges of Pharmacy (AACP), American Society of health-System Pharmacists (ASHP), and American College of Clinical Pharmacy (ACCP) for the conduct of TLC programs. The survey instrument was electronically distributed to 137 accredited colleges and schools of pharmacy in the United States. Results. Eighty-eight institutions responded, resulting in a response rate of 64%. Sixty-one TLC programs were included in the final analysis. Seventy-five percent of TLC programs reported using best practice recommendations; however, 10% of respondents indicated they were not aware of the published recommendations. Inconsistencies among programs were noted in required teaching experiences, participant evaluation, and ongoing programmatic assessment. Conclusion. Most institutions offering TLC programs are aware of published best practice guidelines and have adopted a majority of the published best practices. however, considerable variability exists across the country. Development of a formal external validation process for TLC programs is necessary to ensure consistent quality.
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<a href="http://doi.org/10.5688/ajpe7803" target="_blank" rel="noreferrer noopener">10.5688/ajpe7803</a>
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journalArticle
2020
American journal of pharmaceutical education
August 2020 List
Boyle J
certificate program
Department of Pharmacy Practice
experiences
Gettig JP
journalArticle
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Pharmacy
postgraduate training
Sheehan AH
Sprunger TL
teaching and learning curriculum
teaching certificate program
Viswesh V
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1017/ice.2020.216" target="_blank" rel="noreferrer noopener">http://doi.org/10.1017/ice.2020.216</a>
Pages
1–3
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Update Year & Number
July 2020 List
NEOMED College
NEOMED College of Pharmacy
NEOMED College of Medicine
NEOMED Department
Department of Pharmacy Practice
Department of Internal Medicine
Affiliated Hospital
Summa Health System Akron City Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Impact of the expansion of antimicrobial stewardship services during transitions of care at an academic hospital.
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Infection Control and Hospital Epidemiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-06
Creator
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Zampino ST; Politis PA; Fosnight SM; File TM; Gothard MD
Description
An account of the resource
Antimicrobial stewardship of anti-infectives prescribed upon hospital discharge was implemented to improve the rate of appropriate prescribing at discharge. Appropriate prescribing significantly improved from 47.5% to 85.2% (P < .001), antimicrobial days of therapy decreased, and 30-day readmission rates decreased. Discharge antimicrobial stewardship was effective in improving anti-infective prescribing practices.
Identifier
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<a href="http://doi.org/10.1017/ice.2020.216" target="_blank" rel="noreferrer noopener">10.1017/ice.2020.216</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
Department of Internal Medicine
Department of Pharmacy Practice
File TM
Fosnight SM
Gothard MD
Infection control and hospital epidemiology
journalArticle
July 2020 List
NEOMED College of Medicine
NEOMED College of Pharmacy
Politis PA
Zampino ST
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.18632/oncotarget.27583" target="_blank" rel="noreferrer noopener">http://doi.org/10.18632/oncotarget.27583</a>
Pages
1876–1893
Issue
20
Volume
11
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Update Year & Number
July 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED College of Pharmacy
NEOMED Department
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Department of Pediatrics
Affiliated Hospital
Akron Children's Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Aberrant epigenetic silencing of neuronatin is a frequent event in human osteosarcoma.
Publisher
An entity responsible for making the resource available
Oncotarget
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-05
Subject
The topic of the resource
DNA methylation; neuronatin; osteosarcoma; tumor suppressor genes
Creator
An entity primarily responsible for making the resource
Saeed H; Sinha S; Mella C; Kuerbitz JS; Cales ML; Steele MA; Stanke J; Damron D; Safadi F; Kuerbitz SJ
Description
An account of the resource
The paternally imprinted neuronatin (NNAT) gene has been identified as a target of aberrant epigenetic silencing in diverse cancers, but no association with pediatric bone cancers has been reported to date. In screening childhood cancers, we identified aberrant CpG island hypermethylation in a majority of osteosarcoma (OS) samples and in 5 of 6 human OS cell lines studied but not in normal bone-derived tissue samples. CpG island hypermethylation was associated with transcriptional silencing in human OS cells, and silencing was reversible upon treatment with
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.18632/oncotarget.27583" target="_blank" rel="noreferrer noopener">10.18632/oncotarget.27583</a>
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journalArticle
2020
Cales ML
Damron D
Department of Anatomy & Neurobiology
Department of Pediatrics
Department of Pharmaceutical Sciences
DNA Methylation
journalArticle
July 2020 List
Kuerbitz JS
Kuerbitz SJ
Mella C
NEOMED College of Medicine
NEOMED College of Pharmacy
neuronatin
Oncotarget
osteosarcoma
Saeed H
Safadi F
Sinha S
Stanke J
Steele MA
tumor suppressor genes
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1176/appi.ps.202000140" target="_blank" rel="noreferrer noopener">http://doi.org/10.1176/appi.ps.202000140</a>
Pages
appips202000140
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Update Year & Number
July 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED College of Pharmacy
NEOMED Department
Department of Psychiatry
Department of Pharmacy Practice
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Informed consent: A policy prescription for communicating benefit and risk in state medical marijuana programs.
Publisher
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Psychiatric Services
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-06
Subject
The topic of the resource
Information Dissemination; Policy Making; Medical Marijuana; Drug-Related Side Effects and Adverse Reactions; Cannabis; Marijuana Use
Creator
An entity primarily responsible for making the resource
Messamore E; Dugan SE
Description
An account of the resource
In creating medical marijuana laws, state governments signal to the public that marijuana can safely and effectively treat a wide range of diseases. In many cases, these state approvals overestimate the benefits of marijuana and understate the risks. After a comprehensive review of the medical literature, the National Academies of Sciences, Engineering, and Medicine identified six medical benefits from marijuana that were supported with at least a moderate level of medical evidence and 14 potential health hazards. In contrast, the average state medical marijuana program lists 18 medical benefits, and 24 state medical marijuana program websites say nothing about possible risks. Medication approval processes through the federal government traditionally require independent analysis of data from well-designed clinical trials that measure the effectiveness and capture the risks of adverse effects from specific doses of the medicine. These considerations are generally missing from state approvals of medical marijuana. The power to declare something to be a legitimate medicine comes with the responsibility to provide information that people need to use the medicine wisely. The authors recommend that states that declare marijuana to be a medicine should inform the public about the quality of medical evidence behind each approved use and publicize all scientifically credible risks.
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<a href="http://doi.org/10.1176/appi.ps.202000140" target="_blank" rel="noreferrer noopener">10.1176/appi.ps.202000140</a>
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journalArticle
2020
Cannabis
Department of Pharmacy Practice
Department of Psychiatry
Drug-Related Side Effects and Adverse Reactions
Dugan SE
Information Dissemination
journalArticle
July 2020 List
Marijuana Use
Medical Marijuana
Messamore E
NEOMED College of Medicine
NEOMED College of Pharmacy
Policy Making
Psychiatric Services
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.nbd.2020.104956" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.nbd.2020.104956</a>
Pages
104956
Volume
142
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Update Year & Number
July 2020 List
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmaceutical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Microglia depletion rapidly and reversibly alters amyloid pathology by modification of plaque compaction and morphologies.
Publisher
An entity responsible for making the resource available
Neurobiology of Disease
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-05
Subject
The topic of the resource
Microglia; Inflammation; Neuroprotection; AD; Barrier; CSF1R; Plaques
Creator
An entity primarily responsible for making the resource
Casali BT; MacPherson KP; Reed-Geaghan EG; Landreth GE
Description
An account of the resource
Alzheimer's disease (AD) is a prominent neurodegenerative disorder characterized by deposition of β-amyloid (Aβ)-containing extracellular plaques, accompanied by a microglial-mediated inflammatory response, that leads to cognitive decline. Microglia perform many disease-modifying functions such as phagocytosis of plaques, plaque compaction, and modulation of inflammation through the secretion of cytokines. Microglia are reliant upon colony-stimulating factor receptor-1 (CSF1R) activation for survival. In AD mouse models, chronic targeted depletion of microglia via CSF1R antagonism attenuates plaque formation in early disease but fails to alter plaque burden in late disease. It is unclear if acute depletion of microglia during the peak period of plaque deposition will alter disease pathogenesis, and if so, whether these effects are reversible upon microglial repopulation. To test this, we administered the CSF1R antagonist PLX5622 to the 5XFAD mouse model of AD at four months of age for approximately one month. In a subset of mice, the drug treatment was discontinued, and the mice were fed a control diet for an additional month. We evaluated plaque burden and composition, microgliosis, inflammatory marker expression, and neuritic dystrophy. In 5XFAD animals, CSF1R blockade for 28 days depleted microglia across brain regions by over 50%, suppressed microgliosis, and reduced plaque burden. In microglial-depleted AD animals, neuritic dystrophy was enhanced, and increased diffuse-like plaques and fewer compact-like plaques were observed. Removal of PLX5622 elicited microglial repopulation and subsequent plaque remodeling, resulting in more compact plaques predominating microglia-repopulated regions. We found that microglia limit diffuse plaques by maintaining compact-like plaque properties, thereby blocking the progression of neuritic dystrophy. Microglial repopulation reverses these effects. Collectively, we show that microglia are neuroprotective through maintenance of plaque compaction and morphologies during peak disease progression.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.nbd.2020.104956" target="_blank" rel="noreferrer noopener">10.1016/j.nbd.2020.104956</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
AD
barrier
Casali BT
CSF1R
Department of Pharmaceutical Sciences
Inflammation
journalArticle
July 2020 List
Landreth GE
MacPherson KP
Microglia
NEOMED College of Pharmacy
Neurobiology of disease
Neuroprotection
Plaques
Reed-Geaghan EG
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s12035-020-01921-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s12035-020-01921-6</a>
ISSN
1559-1182 0893-7648
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Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Medicine
NEOMED College of Pharmacy
NEOMED Department
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Transgenic Overexpression of GPNMB Protects Against MPTP-Induced Neurodegeneration.
Publisher
An entity responsible for making the resource available
Molecular neurobiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-05-20
Subject
The topic of the resource
GPNMB; Microglia; MPTP; Neuroinflammation; Neuroprotective; Parkinson's disease
Creator
An entity primarily responsible for making the resource
Budge Kevin; Neal Matthew L; Richardson Jason R; Safadi Fayez F
Description
An account of the resource
Parkinson's disease (PD) is a progressive neurodegenerative disease highlighted by a marked loss of dopaminergic cell loss and motor disturbances. Currently, there are no drugs that slow the progression of the disease. A myriad of factors have been implicated in the pathogenesis and progression of PD including neuroinflammation. Although anti-inflammatory agents are being evaluated as potential disease-modifying therapies for PD, none has proven effective to date, suggesting that new and novel targets are needed. Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a transmembrane glycoprotein that has recently been shown to reduce inflammation in astrocytes and to be increased in post-mortem PD brain samples. Here we show that transgenic overexpression of GPNMB protects against dopaminergic neurodegeneration in a
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s12035-020-01921-6" target="_blank" rel="noreferrer noopener">10.1007/s12035-020-01921-6</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
Budge Kevin
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
GPNMB
journalArticle
June 2020 Update II
Microglia
Molecular neurobiology
MPTP
Neal Matthew L
NEOMED College of Medicine
NEOMED College of Pharmacy
Neuroinflammation
Neuroprotective
Parkinson's disease
Richardson Jason R
Safadi Fayez F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.nbd.2020.104947" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.nbd.2020.104947</a>
Pages
104947
Volume
141
ISSN
1095-953X 0969-9961
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Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmaceutical Sciences
NEOMED Student Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of alpha-synuclein-preformed fibril-induced toxicity and motor deficits.
Publisher
An entity responsible for making the resource available
Neurobiology of disease
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-05-15
Subject
The topic of the resource
Neuroinflammation; Neurotoxicity; Parkinson's; Pesticide; Sex differences; Synuclein
Creator
An entity primarily responsible for making the resource
Gezer Aysegul O; Kochmanski Joseph; VanOeveren Sarah E; Cole-Strauss Allyson; Kemp Christopher J; Patterson Joseph R; Miller Kathryn M; Kuhn Nathan C; Herman Danielle E; McIntire Alyssa; Lipton Jack W; Luk Kelvin C; Fleming Sheila M; Sortwell Caryl E; Bernstein Alison I
Description
An account of the resource
Human and animal studies have shown that exposure to the organochlorine pesticide dieldrin is associated with increased risk of Parkinson's disease (PD). Previous work showed that developmental dieldrin exposure increased neuronal susceptibility to MPTP toxicity in male C57BL/6 mice, possibly via changes in dopamine (DA) packaging and turnover. However, the relevance of the MPTP model to PD pathophysiology has been questioned. We therefore studied dieldrin-induced neurotoxicity in the alpha-synuclein (alpha-syn)-preformed fibril (PFF) model, which better reflects the alpha-syn pathology and toxicity observed in PD pathogenesis. Specifically, we used a "two-hit" model to determine whether developmental dieldrin exposure increases susceptibility to alpha-syn PFF-induced synucleinopathy. Dams were fed either dieldrin (0.3 mg/kg, every 3-4 days) or vehicle corn oil starting 1 month prior to breeding and continuing through weaning of pups at postnatal day 22. At 12 weeks of age, male and female offspring received intrastriatal alpha-syn PFF or control saline injections. Consistent with the male-specific increased susceptibility to MPTP, our results demonstrate that developmental dieldrin exposure exacerbates PFF-induced toxicity in male mice only. Specifically, in male offspring, dieldrin exacerbated
Identifier
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<a href="http://doi.org/10.1016/j.nbd.2020.104947" target="_blank" rel="noreferrer noopener">10.1016/j.nbd.2020.104947</a>
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journalArticle
2020
Bernstein Alison I
Cole-Strauss Allyson
Department of Pharmaceutical Sciences
Fleming Sheila M
Gezer Aysegul O
Herman Danielle E
journalArticle
June 2020 Update II
Kemp Christopher J
Kochmanski Joseph
Kuhn Nathan C
Lipton Jack W
Luk Kelvin C
McIntire Alyssa
Miller Kathryn M
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
NEOMED Student Publications
Neurobiology of disease
Neuroinflammation
Neurotoxicity
Parkinson's
Patterson Joseph R
Pesticide
Sex differences
Sortwell Caryl E
Synuclein
VanOeveren Sarah E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/lipd.12244" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/lipd.12244</a>
ISSN
1558-9307 0024-4201
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Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmaceutical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Relationships between Very Low-Density Lipoproteins-Ceramides, -Diacylglycerols, and -Triacylglycerols in Insulin-Resistant Men.
Publisher
An entity responsible for making the resource available
Lipids
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-05-15
Subject
The topic of the resource
biomarkers; Ceramides; disease; humans; inflammation; kinetics; ldl; Lipids; Metabolic syndrome; NAFLD; NAFLD; obese men; secretion; sphingolipids; VLDL; VLDL
Creator
An entity primarily responsible for making the resource
Mucinski Justine M; Manrique-Acevedo Camila; Kasumov Takhar; Garrett Timothy J; Gaballah Ayman; Parks Elizabeth J
Description
An account of the resource
This short report describes the relationships between concentrations of ceramides (CER), diacylglycerols (DAG), triacylglycerols (TAG) in very low-density lipoproteins (VLDL) particles, and hepatic lipid accumulation. VLDL particles were isolated from male subjects (n = 12, mean +/- SD, age 42.1 +/- 5.4 years, BMI 37.4 +/- 4.1 kg/m(2) , ALT 45 +/- 21 U/L) and apolipoprotein B100 (apoB100),
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/lipd.12244" target="_blank" rel="noreferrer noopener">10.1002/lipd.12244</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
Biomarkers
Ceramides
Department of Pharmaceutical Sciences
Disease
Gaballah Ayman
Garrett Timothy J
Humans
Inflammation
journalArticle
June 2020 Update II
Kasumov Takhar
Kinetics
LDL
Lipids
Manrique-Acevedo Camila
Metabolic syndrome
Mucinski Justine M
NAFLD
NEOMED College of Pharmacy
obese men
Parks Elizabeth J
secretion
sphingolipids
VLDL
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ajhp/zxaa081" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ajhp/zxaa081</a>
ISSN
1535-2900 1079-2082
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Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmacy Practice
NEOMED Student Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of pharmacy interventions at transitions of care on patient outcomes.
Publisher
An entity responsible for making the resource available
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-05-06
Subject
The topic of the resource
discharge medication reconciliation; length of stay; medication adherence; medication errors; pharmacists; readmissions
Creator
An entity primarily responsible for making the resource
Fosnight S; King Philip; Ewald Jacqueline; Feucht John; Lamtman Angela; Kropp D; Dittmer Alison; Sampson Jordan; Shah Morali
Description
An account of the resource
PURPOSE: An interdisciplinary group developed a care transitions process with a prominent pharmacist role. METHODS: The new transitions process was initiated on a 32-bed medical/surgical unit. Demographics, reconciliation data, information on medication adherence barriers, medication recommendations, and time spent performing interventions were prospectively collected for 284 consecutive patients over 54 days after the pharmacy participation was completely implemented. Outcome data, including 30-day readmission rates and length of stay, were retrospectively collected. RESULTS: When comparing metrics for all intervention patients to baseline metrics from the same months of the previous year, the readmission rate was decreased from 21.0% to 15.3% and mean length of stay decreased from 5.3 days to 4.4 days. Further improvement to a 10.2% readmission rate and a 3.6-day average length of stay were observed in the subgroup of intervention patients who received all components of the pharmacy intervention. Additionally, greater improvements were observed in intervention-period patients who received the full pharmacy intervention, as compared to those receiving only parts of the pharmacy intervention, with a 10.2-percentage-point lower readmission rate (10.2% vs 20.4%, P = 0.016) and a 1.7-day shorter length of stay (3.6 days vs. 5.3 days; 95% confidence interval, 0.814-2.68 days; P = 0.0003). For patients receiving any component of the pharmacy intervention, an average of 9.56 medication recommendations were made, with a mean of 0.89 change per patient deemed to be required to avoid harm and/or increased length of stay. CONCLUSION: A comprehensive pharmacy intervention added to a transitions intervention resulted in an average of nearly 10 medication recommendations per patient, improved length of stay, and reduced readmission rates.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ajhp/zxaa081" target="_blank" rel="noreferrer noopener">10.1093/ajhp/zxaa081</a>
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Format
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journalArticle
2020
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Department of Pharmacy Practice
discharge medication reconciliation
Dittmer Alison
Ewald Jacqueline
Feucht John
Fosnight S
journalArticle
June 2020 Update II
King Philip
Kropp D
Lamtman Angela
Length of Stay
medication adherence
Medication Errors
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
NEOMED Student Publications
Pharmacists
readmissions
Sampson Jordan
Shah Morali
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/jcpt.13138" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/jcpt.13138</a>
ISSN
1365-2710 0269-4727
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmacy Practice
Affiliated Hospital
Akron Children's Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Letter to the editor regarding dosing accuracy of female low dose syringes.
Publisher
An entity responsible for making the resource available
Journal of clinical pharmacy and therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04-07
Creator
An entity primarily responsible for making the resource
Lyman Beth; Cober Mary Petrea
Identifier
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<a href="http://doi.org/10.1111/jcpt.13138" target="_blank" rel="noreferrer noopener">10.1111/jcpt.13138</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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journalArticle
2020
Akron Children's Hospital
Cober Mary Petrea
Department of Pharmacy Practice
Journal of Clinical Pharmacy and Therapeutics
journalArticle
June 2020 Update II
Lyman Beth
NEOMED College of Pharmacy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Pages
S233-S233
Volume
68
ISSN
0002-8614
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n/a
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Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Medicine
NEOMED College of Pharmacy
NEOMED Department
Department of Family & Community Medicine
Department of Pharmacy Practice
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Interprofessional Curriculum to Increase Awareness of Care Partner Needs in Dementia
Publisher
An entity responsible for making the resource available
Journal of the American Geriatrics Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Creator
An entity primarily responsible for making the resource
Sanders M; Kropp D; Cardellini J; Bass D; Nicolay S; Elliott K; Drost J; Fosnight S; Patton R; Chrzanowski B; Warren L; Brown D K; Hovland C; Burman B; Williman M; Lipovan M; Hazelett S
Identifier
An unambiguous reference to the resource within a given context
n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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journalArticle
2020
Bass D
Brown D K
Burman B
Cardellini J
Chrzanowski B
Department of Family & Community Medicine
Department of Pharmacy Practice
Drost J
Elliott K
Fosnight S
Hazelett S
Hovland C
Journal of the American Geriatrics Society
journalArticle
June 2020 Update II
Kropp D
Lipovan M
NEOMED College of Medicine
NEOMED College of Pharmacy
Nicolay S
Patton R
Sanders M
Warren L
Williman M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Pages
S230-S230
Volume
68
ISSN
0002-8614
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n/a
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Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Medicine
NEOMED College of Pharmacy
NEOMED Department
Department of Family & Community Medicine
Department of Pharmacy Practice
Affiliated Hospital
Summa Health System Akron City Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A novel collaboration between community resource organizations, academia and a healthcare system to implement dementia inclusive community initiatives
Publisher
An entity responsible for making the resource available
Journal of the American Geriatrics Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Creator
An entity primarily responsible for making the resource
Little M; Kropp D; Cardellini J; Bass D; Nicolay S; Elliott K; Drost J; Fosnight S; Hazelett S; Patton R; Chrzanowski B; Warren L; Brown D K; Hovland C; Niederriter J; Burman B; Williman M; Gareri M
Identifier
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n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Bass D
Brown D K
Burman B
Cardellini J
Chrzanowski B
Department of Family & Community Medicine
Department of Pharmacy Practice
Drost J
Elliott K
Fosnight S
Gareri M
Hazelett S
Hovland C
Journal of the American Geriatrics Society
journalArticle
June 2020 Update II
Kropp D
Little M
NEOMED College of Medicine
NEOMED College of Pharmacy
Nicolay S
Niederriter J
Patton R
Summa Health System Akron City Hospital
Warren L
Williman M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Pages
S212-S213
Volume
68
ISSN
0002-8614
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n/a
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Pharmacy
NEOMED College of Medicine
NEOMED Department
Department of Pharmacy Practice
Department of Family & Community Medicine
Affiliated Hospital
Summa Health System Akron City Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A Novel High Risk Medication Tool for Falls in Older Adults
Publisher
An entity responsible for making the resource available
Journal of the American Geriatrics Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Creator
An entity primarily responsible for making the resource
Fosnight S; Hazelett S; Kropp D; Gareri M; Lehotsky K; Harvan A; Sanders M; Drost J
Identifier
An unambiguous reference to the resource within a given context
n/a
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Department of Family & Community Medicine
Department of Pharmacy Practice
Drost J
Fosnight S
Gareri M
Harvan A
Hazelett S
Journal of the American Geriatrics Society
journalArticle
June 2020 Update II
Kropp D
Lehotsky K
NEOMED College of Medicine
NEOMED College of Pharmacy
Sanders M
Summa Health System Akron City Hospital
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Pages
S116-S116
Volume
68
ISSN
0002-8614
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n/a
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Medicine
NEOMED College of Pharmacy
NEOMED Department
Department of Internal Medicine
Department of Pharmacy Practice
Department of Family & Community Medicine
Affiliated Hospital
Summa Health System Akron City Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Using Telehealth to Expand Community-based Care Manager Interdisciplinary Team Reach
Publisher
An entity responsible for making the resource available
Journal of the American Geriatrics Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Creator
An entity primarily responsible for making the resource
Drost J; Fosnight S; Nauer T; Bring-Mazurek N; Morgan A; Chrzanowski B; Gareri M; Hazelett S; Kropp D
Identifier
An unambiguous reference to the resource within a given context
n/a
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Bring-Mazurek N
Chrzanowski B
Department of Family & Community Medicine
Department of Internal Medicine
Department of Pharmacy Practice
Drost J
Fosnight S
Gareri M
Hazelett S
Journal of the American Geriatrics Society
journalArticle
June 2020 Update II
Kropp D
Morgan A
Nauer T
NEOMED College of Medicine
NEOMED College of Pharmacy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1084/jem.20191374" target="_blank" rel="noreferrer noopener">http://doi.org/10.1084/jem.20191374</a>
Pages
e20191374
Issue
4
Volume
217
ISSN
0022-1007
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Pharmacy; NEOMED College of Graduate Studies
NEOMED Department
Department of Pharmaceutical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model
Publisher
An entity responsible for making the resource available
Journal of Experimental Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Subject
The topic of the resource
accumulation; distinct; dynamics; fate; macrophages; monocytes; pathology; reveals; system; turnover
Creator
An entity primarily responsible for making the resource
Reed-Geaghan Erin G; Croxford Andrew L; Becher Burkhard; Landreth Gary E
Description
An account of the resource
Alzheimer's disease (AD) is accompanied by a robust inflammatory response mediated by plaque-associated myeloid cells of the brain. These cells exhibit altered gene expression profiles and serve as a barrier, preventing neuritic dystrophy. The origin of these cells has been controversial and is of therapeutic importance. Here, we genetically labeled different myeloid populations and unequivocally demonstrated that plaque-associated myeloid cells in the AD brain are derived exclusively from resident microglia, with no contribution from circulating peripheral monocytes.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1084/jem.20191374" target="_blank" rel="noreferrer noopener">10.1084/jem.20191374</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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journalArticle
2020
accumulation
Becher Burkhard
Croxford Andrew L
Department of Pharmaceutical Sciences
distinct
dynamics
fate
Journal Article
Journal of Experimental Medicine
journalArticle
June 2020 Update I
Landreth Gary E
Macrophages
monocytes
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Pathology
Reed-Geaghan Erin G
reveals
system
Turnover
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Pages
S187-S187
Volume
28
ISSN
1063-4584
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n/a
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Medicine; NEOMED College of Pharmacy
NEOMED Department
NEOMED Student Publications; Department of Anatomy & Neurobiology
Affiliated Hospital
Nationwide Children's Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
MITOCHONDRIAL DYSFUNCTION IN OSTEOARTHRITIS AND AGED CARTILAGE TRIGGERS INFLAMMATORY RESPONSE AND MATRIX DEGRADATION VIA ROS MEDIATED ACTIVATION OF JNK-MAPK/CFOS-AP1 AXIS IN CHONDROCYTES
Publisher
An entity responsible for making the resource available
Osteoarthritis and Cartilage
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Creator
An entity primarily responsible for making the resource
Ansari M Y; Ahmad N; Voleti S; Wase S; Malik M; Novak K; Haqqi Tariq M
Identifier
An unambiguous reference to the resource within a given context
n/a
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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journalArticle
2020
Ahmad N
Ansari M Y
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Haqqi Tariq M
Journal Article
journalArticle
June 2020 Update I
Malik M
Nationwide Children's Hospital
NEOMED College of Medicine
NEOMED College of Medicine Student
NEOMED College of Pharmacy
NEOMED Student Publications
Novak K
Osteoarthritis and cartilage
Voleti S
Wase S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/1078155220914349" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/1078155220914349</a>
Pages
1078155220914349
ISSN
1477-092X 1078-1552
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1177/1078155220914349" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1177/1078155220914349</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmacy Practice
Affiliated Hospital
Akron Children's Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Stability of extemporaneously compounded temozolomide 10 mg/mL suspensions in Oral Mix SF(R) in glass and plastic bottles and plastic syringes.
Publisher
An entity responsible for making the resource available
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-03-30
Subject
The topic of the resource
drug stability; suspension; temozolomide
Creator
An entity primarily responsible for making the resource
Lingertat-Walsh Karen; Weilnau JoEllen; Cober Mary Petrea; Ostrenga Andrew; Poon Betsy; Pacita Sales; Law Shirley; Dupuis L Lee; Walker Scott E
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/1078155220914349" target="_blank" rel="noreferrer noopener">10.1177/1078155220914349</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Akron Children's Hospital
Cober Mary Petrea
Department of Pharmacy Practice
Drug Stability
Dupuis L Lee
Journal Article
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
journalArticle
June 2020 Update I
Law Shirley
Lingertat-Walsh Karen
NEOMED College of Pharmacy
Ostrenga Andrew
Pacita Sales
Poon Betsy
suspension
temozolomide
Walker Scott E
Weilnau JoEllen
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3390/biom10040520" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/biom10040520</a>
Issue
4
Volume
10
ISSN
2218-273X 2218-273X
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.3390/biom10040520" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.3390/biom10040520</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmaceutical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Temporal Dynamics of High-Density Lipoprotein Proteome in Diet-Controlled Subjects with Type 2 Diabetes.
Publisher
An entity responsible for making the resource available
Biomolecules
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-03-30
Subject
The topic of the resource
apolipoproteins; HDL dysfunction; heavy water; proteomics; type 2 diabetes
Creator
An entity primarily responsible for making the resource
Kheniser Karim G; Osme Abdullah; Kim Chunki; Ilchenko Serguei; Kasumov Takhar; Kashyap Sangeeta R
Description
An account of the resource
We examined the effect of mild hyperglycemia on high-density lipoprotein (HDL) metabolism and kinetics in diet-controlled subjects with type 2 diabetes (T2D). (2)H2O-labeling coupled with mass spectrometry was applied to quantify HDL cholesterol turnover and HDL proteome dynamics in subjects with T2D (n = 9) and age- and BMI-matched healthy controls (n = 8). The activities of lecithin-cholesterol acyltransferase (LCAT), cholesterol ester transfer protein (CETP), and the proinflammatory index of HDL were quantified. Plasma adiponectin levels were reduced in subjects with T2D, which was directly associated with suppressed ABCA1-dependent cholesterol efflux capacity of HDL. The fractional catabolic rates of HDL cholesterol, apolipoprotein A-II (ApoA-II), ApoJ, ApoA-IV, transthyretin, complement C3, and vitamin D-binding protein (all p < 0.05) were increased in subjects with T2D. Despite increased HDL flux of acute-phase HDL proteins, there was no change in the proinflammatory index of HDL. Although LCAT and CETP activities were not affected in subjects with T2D, LCAT was inversely associated with blood glucose and CETP was inversely associated with plasma adiponectin. The degradation rates of ApoA-II and ApoA-IV were correlated with hemoglobin A1c. In conclusion, there were in vivo impairments in HDL proteome dynamics and HDL metabolism in diet-controlled patients with T2D.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3390/biom10040520" target="_blank" rel="noreferrer noopener">10.3390/biom10040520</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
Apolipoproteins
Biomolecules
Department of Pharmaceutical Sciences
HDL dysfunction
Heavy water
Ilchenko Serguei
Journal Article
journalArticle
June 2020 Update I
Kashyap Sangeeta R
Kasumov Takhar
Kheniser Karim G
Kim Chunki
NEOMED College of Pharmacy
Osme Abdullah
proteomics
Type 2 diabetes
-
Text
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URL Address
<a class="doi" href="https://doi.org/10.1016/j.jpainsymman.2019.12.313" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer noopener">https://doi.org/10.1016/j.jpainsymman.2019.12.313</a>
Pages
558-558
Issue
2
Volume
59
ISSN
0885-3924
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Full text access for NEOMED users - login required - <a class="doi" href="https://doi-org.neomed.idm.oclc.org/10.1016/j.jpainsymman.2019.12.313" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer noopener">https://doi.org/10.1016/j.jpainsymman.2019.12.313</a>
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Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmacy Practice
Dublin Core
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Title
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Validation of Quick Cognitive Screen
Publisher
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Journal of Pain and Symptom Management
Date
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2020
2020-02
Creator
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Casacchia Anthony; Ahmad Sobia; Drost Jennifer; Fosnight S; Gothard David
Identifier
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<a class="doi" href="https://doi.org/10.1016/j.jpainsymman.2019.12.313" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer noopener">10.1016/j.jpainsymman.2019.12.313</a>
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journalArticle
2020
Ahmad Sobia
Casacchia Anthony
Department of Pharmacy Practice
Drost Jennifer
Fosnight S
Gothard David
Journal Article
Journal of pain and symptom management
journalArticle
June 2020 Update I
NEOMED College of Pharmacy