1
40
103
-
Text
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URL Address
<a href="http://doi.org/10.1002/cne.25101" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/cne.25101</a>
ISSN
1096-9861 0021-9967
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Update Year & Number
January 2021 List
NEOMED College
NEOMED College of Pharmacy
NEOMED College of Medicine
NEOMED Department
Department of Pharmaceutical Sciences
Department of Anatomy & Neurobiology
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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A comparative analysis of cone photoreceptor morphology in bowhead and beluga whales.
Publisher
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The Journal of Comparative Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-12-30
Subject
The topic of the resource
cone photoreceptor; magnetosensation; mysticetes; odontocetes; retina
Creator
An entity primarily responsible for making the resource
Smith MA; Waugh DA; McBurney DL; George JC; Suydam RS; Thewissen JGM; Crish SD
Description
An account of the resource
The cetacean visual system is a product of selection pressures favoring underwater vision, yet relatively little is known about it across taxa. Previous studies report several mutations in the opsin genetic sequence in cetaceans, suggesting the evolutionary complete or partial loss of retinal cone photoreceptor function in mysticete and odontocete lineages, respectively. Despite this, limited anatomical evidence suggests cone structures are partially maintained but with absent outer and inner segments in the bowhead retina. The functional consequence and anatomical distributions associated with these unique cone morphologies remain unclear. The current study further investigates the morphology and distribution of cone photoreceptors in the bowhead whale and beluga retina and evaluates the potential functional capacity of these cells' alternative to photoreception. Refined histological and advanced microscopic techniques revealed two additional cone morphologies in the bowhead and beluga retina that have not been previously described. Two proteins involved in magnetosensation were present in these cone structures suggesting the possibility for an alternative functional role in responding to changes in geomagnetic fields. These findings highlight a revised understanding of the unique evolution of cone and gross retinal anatomy in cetaceans, and provide prefatory evidence of potential functional reassignment of these cells.
Identifier
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<a href="http://doi.org/10.1002/cne.25101" target="_blank" rel="noreferrer noopener">10.1002/cne.25101</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
cone photoreceptor
Crish SD
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
George JC
January 2021 List
journalArticle
magnetosensation
McBurney DL
mysticetes
NEOMED College of Medicine
NEOMED College of Pharmacy
odontocetes
retina
Smith MA
Suydam RS
The Journal of comparative neurology
Thewissen JGM
Waugh DA
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jac5.1119" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jac5.1119</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
321-321
Issue
3
Volume
2
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A need for a holistic residency application review process.
Publisher
An entity responsible for making the resource available
JACCP: Journal of the American College of Clinical Pharmacy
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-06
Creator
An entity primarily responsible for making the resource
Soric Mate M; Robinson Jennifer D; Ulbrich Timothy R
Identifier
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<a href="http://doi.org/10.1002/jac5.1119" target="_blank" rel="noreferrer noopener">10.1002/jac5.1119</a>
2019
Department of Pharmacy Practice
JACCP: Journal of the American College of Clinical Pharmacy
NEOMED College of Pharmacy
Robinson Jennifer D
September 2019 Update
Soric Mate M
Ulbrich Timothy R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Pages
S230-S230
Volume
68
ISSN
0002-8614
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n/a
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Medicine
NEOMED College of Pharmacy
NEOMED Department
Department of Family & Community Medicine
Department of Pharmacy Practice
Affiliated Hospital
Summa Health System Akron City Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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A novel collaboration between community resource organizations, academia and a healthcare system to implement dementia inclusive community initiatives
Publisher
An entity responsible for making the resource available
Journal of the American Geriatrics Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Creator
An entity primarily responsible for making the resource
Little M; Kropp D; Cardellini J; Bass D; Nicolay S; Elliott K; Drost J; Fosnight S; Hazelett S; Patton R; Chrzanowski B; Warren L; Brown D K; Hovland C; Niederriter J; Burman B; Williman M; Gareri M
Identifier
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n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
Bass D
Brown D K
Burman B
Cardellini J
Chrzanowski B
Department of Family & Community Medicine
Department of Pharmacy Practice
Drost J
Elliott K
Fosnight S
Gareri M
Hazelett S
Hovland C
Journal of the American Geriatrics Society
journalArticle
June 2020 Update II
Kropp D
Little M
NEOMED College of Medicine
NEOMED College of Pharmacy
Nicolay S
Niederriter J
Patton R
Summa Health System Akron City Hospital
Warren L
Williman M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
Pages
S212-S213
Volume
68
ISSN
0002-8614
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n/a
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Pharmacy
NEOMED College of Medicine
NEOMED Department
Department of Pharmacy Practice
Department of Family & Community Medicine
Affiliated Hospital
Summa Health System Akron City Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A Novel High Risk Medication Tool for Falls in Older Adults
Publisher
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Journal of the American Geriatrics Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Creator
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Fosnight S; Hazelett S; Kropp D; Gareri M; Lehotsky K; Harvan A; Sanders M; Drost J
Identifier
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n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
Department of Family & Community Medicine
Department of Pharmacy Practice
Drost J
Fosnight S
Gareri M
Harvan A
Hazelett S
Journal of the American Geriatrics Society
journalArticle
June 2020 Update II
Kropp D
Lehotsky K
NEOMED College of Medicine
NEOMED College of Pharmacy
Sanders M
Summa Health System Akron City Hospital
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/03008207.2020.1828380" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/03008207.2020.1828380</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-14
ISSN
1607-8438 0300-8207
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1080/03008207.2020.1828380" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1080/03008207.2020.1828380</a>
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Update Year & Number
October 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED College of Pharmacy
NEOMED Department
Department of Anatomy & Neurobiology
Department of Pharmacy Practice
NEOMED Student Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes.
Publisher
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Connective Tissue Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-10-12
Subject
The topic of the resource
gene regulation; chondrogenesis; extracellular matrix; chondrocyte; ZCCHC5/RTL3; RTL3; ZCCHC5
Creator
An entity primarily responsible for making the resource
Ball HC;Ansari M Y;Ahmad N;Novak K;Haqqi TM
Description
An account of the resource
PURPOSE: Transposable elements are known to remodel gene structure and provide a known source of genetic variation. Retrotransposon gag-like-3 (RTL3) is a mammalian retrotransposon-derived transcript (MART) whose function in the skeletal tissue is unknown. This study aimed to elucidate the biological significance of RTL3 in chondrogenesis and type-II collagen (COL2A1) gene expression in chondrocytes. MATERIALS AND METHODS: Expression of RTL3, SOX-9 and COL2A1 mRNAs was determined by TaqMan assays and the protein expression by immunoblotting. RTL3 and Sox-9 depletion in human chondrocytes was achieved using validated siRNAs. An RTL3 mutant (∆RTL3) lacking the zinc finger domain was created using in vitro mutagenesis. Forced expression of RTL3, ∆RTL3, and SOX-9 was achieved using CMV promoter containing expression plasmids. CRISPR-Cas9 was utilized to delete Rtl3 and create a stable ATDC5(Rlt3-/-) cell line. Matrix deposition and Col2a1 quantification during chondrogenesis were determined by Alcian blue staining and Sircol™ Soluble Collagen Assay, respectively. RESULTS: RTL3 is not ubiquitously expressed but showed strong expression in cartilage, chondrocytes and synoviocytes but not in muscle, brain, or other tissues analyzed. Loss-of-function and gain-of-function studies demonstrated a critical role of RTL3 in the regulation of SOX-9 and COL2A1 expression and matrix synthesis during chondrogenesis. Both RTL3 and SOX-9 displayed co-regulated expression in chondrocytes. Gene regulatory activity of RTL3 requires the c-terminal CCHC zinc-finger binding domain. CONCLUSIONS: Our results identify a novel regulatory mechanism of COL2A1 expression in chondrocytes that may help to further understand the skeletal development and the pathogenesis of diseases with altered COL2A1 expression.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/03008207.2020.1828380" target="_blank" rel="noreferrer noopener">10.1080/03008207.2020.1828380</a>
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Ahmad N
Ansari M Y
Ball HC
chondrocyte
chondrogenesis
Connective tissue research
Department of Anatomy & Neurobiology
Department of Pharmacy Practice
Extracellular Matrix
Gene Regulation
Haqqi TM
journalArticle
NEOMED College of Medicine
NEOMED College of Pharmacy
NEOMED Student Publications
Novak K
October 2020 List
RTL3
ZCCHC5
ZCCHC5/RTL3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/osp4.309" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/osp4.309</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
36-45
Issue
1
Volume
5
Search for Full-text
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
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Title
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A Systematic Review: The Appraisal Of The Effects Of Metformin On Lipoprotein Modification And Function
Publisher
An entity responsible for making the resource available
Obesity Science & Practice
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-02
Subject
The topic of the resource
a-i; cardiovascular-disease; cholesterol; Endocrinology & Metabolism; expression; glycation end-products; Gycation; high-density-lipoprotein; increases; Lipoproteins; metformin; methylglyoxal; oxidative stress; Type II diabetes; type-2
Creator
An entity primarily responsible for making the resource
Kheniser K G; Kashyap S R; Kasumov T
Description
An account of the resource
Aims Metformin is a commonly prescribed anti-hyperglycaemic pharmacological agent, and it remains a staple in the management of type II diabetes. In addition to metformin's glucose lowering effects, research has indicated that metformin inhibits glycation-mediated and oxidative modification of lipoprotein residues. The purpose was to discuss the effects of metformin as it relates to high-density lipoprotein (HDL) and low-density lipoprotein (LDL) modification. Materials and methods The purpose was to conduct a narrative and pragmatic review on the effects of metformin as it pertains to HDL and LDL modification. Results High-density lipoprotein (HDL) concentration is a quantitative measure and therefore does not provide insight into its function, which is a qualitative property. Dysfunctional HDLs are unable to carry out functions normally associated with HDL because they can be modified by glycating agents. Metformin may counteract HDL dysfunction by abating HDL modification. Reductions in HDL modification may improve reverse cholesterol transport ability and thus possibly diminish cardiovascular risk. Similarly, metformin-mediated attenuations in LDL modification may reduce their atherogenic potency. Conclusion Metformin may partially ameliorate HDL dysfunction and reduce LDL modification by inhibiting alpha-dicarbonyl-mediated modification of apolipoprotein residues; consequently, the results are salient because cardiovascular disease incidence may be reduced given that reverse cholesterol transport activity predicts risk, and modified LDL are proatherogenic.
Identifier
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<a href="http://doi.org/10.1002/osp4.309" target="_blank" rel="noreferrer noopener">10.1002/osp4.309</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2019
a-i
cardiovascular-disease
Cholesterol
Department of Pharmaceutical Sciences
Endocrinology & Metabolism
expression
glycation end-products
Gycation
high-density-lipoprotein
increases
Journal Article or Conference Abstract Publication
Kashyap S R
Kasumov T
Kheniser K G
Lipoproteins
metformin
methylglyoxal
NEOMED College of Pharmacy
Obesity science & practice
Oxidative Stress
Type II diabetes
type-2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/osp4.309" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/osp4.309</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
36-45
Issue
1
Volume
5
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A systematic review: the appraisal of the effects of metformin on lipoprotein modification and function.
Publisher
An entity responsible for making the resource available
Obesity science & practice
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-02
Subject
The topic of the resource
Lipoproteins; Type II diabetes; Gycation; Metformin
Creator
An entity primarily responsible for making the resource
Kheniser K G; Kashyap S R; Kasumov T
Description
An account of the resource
Aims: Metformin is a commonly prescribed anti-hyperglycaemic pharmacological agent, and it remains a staple in the management of type II diabetes. In addition to metformin's glucose lowering effects, research has indicated that metformin inhibits glycation-mediated and oxidative modification of lipoprotein residues. The purpose was to discuss the effects of metformin as it relates to high-density lipoprotein (HDL) and low-density lipoprotein (LDL) modification. Materials and methods: The purpose was to conduct a narrative and pragmatic review on the effects of metformin as it pertains to HDL and LDL modification. Results: High-density lipoprotein (HDL) concentration is a quantitative measure and therefore does not provide insight into its function, which is a qualitative property. Dysfunctional HDLs are unable to carry out functions normally associated with HDL because they can be modified by glycating agents. Metformin may counteract HDL dysfunction by abating HDL modification. Reductions in HDL modification may improve reverse cholesterol transport ability and thus possibly diminish cardiovascular risk. Similarly, metformin-mediated attenuations in LDL modification may reduce their atherogenic potency. Conclusion: Metformin may partially ameliorate HDL dysfunction and reduce LDL modification by inhibiting alpha-dicarbonyl-mediated modification of apolipoprotein residues; consequently, the results are salient because cardiovascular disease incidence may be reduced given that reverse cholesterol transport activity predicts risk, and modified LDL are proatherogenic.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/osp4.309" target="_blank" rel="noreferrer noopener">10.1002/osp4.309</a>
2019
Department of Pharmaceutical Sciences
Gycation
Kashyap S R
Kasumov T
Kheniser K G
Lipoproteins
metformin
NEOMED College of Pharmacy
Obesity science & practice
Type II diabetes
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.18632/oncotarget.27583" target="_blank" rel="noreferrer noopener">http://doi.org/10.18632/oncotarget.27583</a>
Pages
1876–1893
Issue
20
Volume
11
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
July 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED College of Pharmacy
NEOMED Department
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Department of Pediatrics
Affiliated Hospital
Akron Children's Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Aberrant epigenetic silencing of neuronatin is a frequent event in human osteosarcoma.
Publisher
An entity responsible for making the resource available
Oncotarget
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-05
Subject
The topic of the resource
DNA methylation; neuronatin; osteosarcoma; tumor suppressor genes
Creator
An entity primarily responsible for making the resource
Saeed H; Sinha S; Mella C; Kuerbitz JS; Cales ML; Steele MA; Stanke J; Damron D; Safadi F; Kuerbitz SJ
Description
An account of the resource
The paternally imprinted neuronatin (NNAT) gene has been identified as a target of aberrant epigenetic silencing in diverse cancers, but no association with pediatric bone cancers has been reported to date. In screening childhood cancers, we identified aberrant CpG island hypermethylation in a majority of osteosarcoma (OS) samples and in 5 of 6 human OS cell lines studied but not in normal bone-derived tissue samples. CpG island hypermethylation was associated with transcriptional silencing in human OS cells, and silencing was reversible upon treatment with
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.18632/oncotarget.27583" target="_blank" rel="noreferrer noopener">10.18632/oncotarget.27583</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
Cales ML
Damron D
Department of Anatomy & Neurobiology
Department of Pediatrics
Department of Pharmaceutical Sciences
DNA Methylation
journalArticle
July 2020 List
Kuerbitz JS
Kuerbitz SJ
Mella C
NEOMED College of Medicine
NEOMED College of Pharmacy
neuronatin
Oncotarget
osteosarcoma
Saeed H
Safadi F
Sinha S
Stanke J
Steele MA
tumor suppressor genes
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
850A
Issue
1
Volume
70
ISSN
0270-9139
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Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
ABLATION OF CISD2 IN HEPATOCYTES PROTECTS MICE FROM ETHANOL-INDUCED LIVER DAMAGE
Publisher
An entity responsible for making the resource available
Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-10
Creator
An entity primarily responsible for making the resource
Stahl Zachary; Li Yun; Buehler Brian; You Min
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Buehler Brian
Department of Pharmaceutical Sciences
Hepatology
Journal Article
Li Yun
NEOMED College of Pharmacy
November 2019 Update
Stahl Zachary
You Min
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.etap.2018.12.019" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.etap.2018.12.019</a>
Pages
36–42
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute exposure to a glyphosate-containing herbicide formulation inhibits Complex II and increases hydrogen peroxide in the model organism Caenorhabditis elegans.
Publisher
An entity responsible for making the resource available
Environmental toxicology and pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-02
Subject
The topic of the resource
C. elegans; Glyphosate; Hydrogen peroxide; Mitochondrial inhibition; Oxygen consumption; Reactive oxygen species
Creator
An entity primarily responsible for making the resource
Burchfield Shelbie L; Bailey Denise C; Todt Callie E; Denney Rachel D; Negga Rekek; Fitsanakis Vanessa A
Description
An account of the resource
Glyphosate-based herbicides, such as Touchdown (TD) and Roundup, are among the most heavily-used herbicides in the world. While the active ingredient is generally considered non-toxic, the toxicity resulting from exposure to commercially-sold formulations is less clear. In many cases, cell cultures or various model organisms exposed to glyphosate formulations show toxicity and, in some cases, lethality. Using Caenorhabditis elegans, we assessed potential toxic mechanisms through which a highly-concentrated commercial formulation of TD promotes neurodegeneration. Following a 30-min treatment, we assayed mitochondrial electron transport chain function and reactive oxygen species (ROS) production. Initial oxygen consumption studies indicated general mitochondrial inhibition compared to controls ((*)p \textless 0.05). When Complex II activity was further assessed, inhibition was observed in all TD-treated groups ((*)p \textless 0.05). Complex IV activity, however, was not adversely affected by TD. This electron transport chain inhibition also resulted in reduced ATP levels ((*)p \textless 0.05). Furthermore, hydrogen peroxide levels, but not other ROS, were increased ((*)p \textless 0.05). Taken together, these data indicate that commercially-available formulations of TD may exert neurotoxicity through Complex II (succinate dehydrogenase) inhibition, decreased ATP levels, and increased hydrogen peroxide production.
Identifier
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<a href="http://doi.org/10.1016/j.etap.2018.12.019" target="_blank" rel="noreferrer noopener">10.1016/j.etap.2018.12.019</a>
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2019
Bailey Denise C
Burchfield Shelbie L
C. elegans
Denney Rachel D
Department of Pharmaceutical Sciences
Environmental toxicology and pharmacology
Fitsanakis Vanessa A
Glyphosate
Hydrogen peroxide
Mitochondrial inhibition
Negga Rekek
NEOMED College of Pharmacy
Oxygen Consumption
reactive oxygen species
Todt Callie E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.etap.2018.12.019" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.etap.2018.12.019</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
36-42
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute exposure to a glyphosate-containing herbicide formulation inhibits Complex II and increases hydrogen peroxide in the model organism Caenorhabditis elegans.
Publisher
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Environmental toxicology and pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-02
Subject
The topic of the resource
C. elegans; Glyphosate; *hydrogen peroxide; Mitochondrial inhibition; Oxygen Consumption; *Reactive oxygen species; Animals; Reactive Oxygen Species/metabolism; Adenosine Triphosphate/metabolism; Herbicides/*toxicity; Caenorhabditis elegans/*drug effects/metabolism; Electron Transport Complex II/*antagonists & inhibitors/metabolism; Glycine/*analogs & derivatives/toxicity
Creator
An entity primarily responsible for making the resource
Burchfield Shelbie L; Bailey Denise C; Todt Callie E; Denney Rachel D; Negga Rekek; Fitsanakis Vanessa A
Description
An account of the resource
Glyphosate-based herbicides, such as Touchdown (TD) and Roundup, are among the most heavily-used herbicides in the world. While the active ingredient is generally considered non-toxic, the toxicity resulting from exposure to commercially-sold formulations is less clear. In many cases, cell cultures or various model organisms exposed to glyphosate formulations show toxicity and, in some cases, lethality. Using Caenorhabditis elegans, we assessed potential toxic mechanisms through which a highly-concentrated commercial formulation of TD promotes neurodegeneration. Following a 30-min treatment, we assayed mitochondrial electron transport chain function and reactive oxygen species (ROS) production. Initial oxygen consumption studies indicated general mitochondrial inhibition compared to controls ((*)p < 0.05). When Complex II activity was further assessed, inhibition was observed in all TD-treated groups ((*)p < 0.05). Complex IV activity, however, was not adversely affected by TD. This electron transport chain inhibition also resulted in reduced ATP levels ((*)p < 0.05). Furthermore, hydrogen peroxide levels, but not other ROS, were increased ((*)p < 0.05). Taken together, these data indicate that commercially-available formulations of TD may exert neurotoxicity through Complex II (succinate dehydrogenase) inhibition, decreased ATP levels, and increased hydrogen peroxide production.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.etap.2018.12.019" target="_blank" rel="noreferrer noopener">10.1016/j.etap.2018.12.019</a>
*hydrogen peroxide
*Reactive oxygen species
2019
Adenosine Triphosphate/metabolism
Animals
Bailey Denise C
Burchfield Shelbie L
C. elegans
Caenorhabditis elegans/*drug effects/metabolism
Denney Rachel D
Department of Pharmaceutical Sciences
Electron Transport Complex II/*antagonists & inhibitors/metabolism
Environmental toxicology and pharmacology
Fitsanakis Vanessa A
Glycine/*analogs & derivatives/toxicity
Glyphosate
Herbicides/*toxicity
Mitochondrial inhibition
Negga Rekek
NEOMED College of Pharmacy
Oxygen Consumption
Reactive Oxygen Species/metabolism
Todt Callie E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Pages
S74–S74
Volume
67
ISSN
0002-8614
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Title
A name given to the resource
Adaption of Geriatric Education Model Across Sites: Does Group Size Matter?
Publisher
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Journal of the American Geriatrics Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-04
Subject
The topic of the resource
Geriatrics & Gerontology
Creator
An entity primarily responsible for making the resource
Drost J; Brown D K; Joan N; Sanders M; Fosnight S; Hazelett S; Kropp D
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n/a
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Description
An account of the resource
2019 Annual Scientific Meeting of the American-Geriatrics-Society (AGS)
2019
Brown D K
Department of Family & Community Medicine
Department of Pharmacy Practice
Drost J
Fosnight S
Geriatrics & Gerontology
Hazelett S
Joan N
Journal of the American Geriatrics Society
June 2019 Update
Kropp D
NEOMED College of Medicine
NEOMED College of Pharmacy
Sanders M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/YIC.0000000000000269" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/YIC.0000000000000269</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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Title
A name given to the resource
Addressing clozapine under-prescribing and barriers to initiation: a psychiatrist, advanced practice provider, and trainee survey
Publisher
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International Clinical Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-05
Creator
An entity primarily responsible for making the resource
Leung Jonathan G; Cusimano Joseph; Gannon Jessica M; Milgrom Olga; Valcourt Stephanie C; Stoklosa Joseph B; Kemp Michael; Olsufka William; Vickery P Brittany; Nichols Stephanie D; Crouse Ericka L; Paxos Chris; Johnson Emily K; Palmer Brian A
Description
An account of the resource
Clozapine use has declined, despite its superior antipsychotic efficacy in treatment-resistant schizophrenia. Implications for clozapine underutilization include suboptimal treatment outcomes and increased hospitalizations. Many barriers preventing the use of clozapine have been described in the literature, including suboptimal knowledge and poor perceptions. The aim of this study was to assess psychiatry prescribers' perception and knowledge of clozapine. A survey was distributed to advanced practice providers, psychiatrists, and trainees (i.e. residents and fellows) at 10 medical centers within the US and Canada. The survey asked respondents about their perception of clozapine use and assessed their pharmacotherapeutic knowledge of clozapine. Two hundred eleven individual submitted completed surveys of a possible 1152; a response rate of 18.3%. There were no statistically significant differences between the advanced practice provider plus psychiatrist groups and the trainee group for most perception (eight of nine) and knowledge (eight of nine) questions. The knowledge questions with the lowest scores pertained to clozapine reinitiation and myocarditis. The majority of all respondents (144, 68.2%) felt that clozapine prescribing was a burden. Findings of this study support the need for continued clozapine education regardless of a prescriber's age/experience. Future studies to assess barriers to clozapine prescribing should extend beyond academic centers.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/YIC.0000000000000269" target="_blank" rel="noreferrer noopener">10.1097/YIC.0000000000000269</a>
2019
Crouse Ericka L
Cusimano Joseph
Department of Pharmacy Practice
Gannon Jessica M
International Clinical Psychopharmacology
Johnson Emily K
June 2019 Update
Kemp Michael
Leung Jonathan G
Milgrom Olga
NEOMED College of Pharmacy
Nichols Stephanie D
Olsufka William
Palmer Brian A
Paxos Chris
Stoklosa Joseph B
Valcourt Stephanie C
Vickery P Brittany
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a class="epub-doi" href="https://doi.org/10.1111/acer.14060">https://doi.org/10.1111/acer.14060</a>
Pages
277A–277A
Volume
43
ISSN
0145-6008
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Title
A name given to the resource
ADIPOSE‐SPECIFIC LIPIN‐1 OVEREXPRESSION DISRUPTS HEPATIC ADIPONECTIN SIGNALING AND AGGRAVATES ALCOHOLIC STEATOHEPATITIS IN MICE
Publisher
An entity responsible for making the resource available
Alcoholism-Clinical and Experimental Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-06
Subject
The topic of the resource
Substance Abuse
Creator
An entity primarily responsible for making the resource
You M
Identifier
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<a class="epub-doi" href="https://doi.org/10.1111/acer.14060">https://doi.org/10.1111/acer.14060</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Description
An account of the resource
Lipin‐1 is a pivotal regulator of lipid metabolism and inflammation and is involved in adipocyte development and maturation. Adiponectin is a hormone largely secreted by adipocytes. In adipocytes, lipin‐1 and adiponectin exhibit cross‐regulation. In the present study, we investigated whether and how adipose lipin‐1‐adiponectin axis contributes to the development and progression of alcoholic steatohepatitis. The effects of ethanol on adipose lipin‐1 and experimental alcoholic steatohepatitis were assessed in cultured 3T3‐L1 adipocytes and in transgenic mice overexpressing lipin‐1 in adipose (LPIN1‐Tg). In cultured 3T3‐adipocytes, ethanol exposure perturbed lipin‐1 signaling by inhibiting lipin‐1 expression, interfering lipin‐1 pre‐mRNA splicing and inducing nucleocytoplasmic shuttling of lipin‐1. Furthermore, secretion of adiponectin into 3T3‐L1 adipocytes culture medium was markedly enhanced by overexpression of lipin‐1. Consistent with the in vitro cell culture findings, feeding LPIN1‐Tg mice with an ethanol‐containing liquid diet resulted in substantial increases in serum concentrations of total and HMW adiponectin compared to ethanol‐fed WT mice. Surprisingly, despite drastically elevated circulating adiponectin levels, ethanol‐fed LPIN1‐Tg mice showed the rapid onset and progression of steatosis, inflammation, hepatobiliary damage and mild liver fibrosis. Further mechanistic studies revealed that adipose‐specific lipin‐1 overexpression exacerbated ethanol‐mediated inhibitory effects on mRNA abundance of hepatic adiponectin receptors in mice. Concurrently, adipose‐specific lipin‐1 overexpression severely suppressed protein expression of sirtuin (Sirt) 1, one of the critical components in mediating hepatic adiponectin signaling, in mice after ethanol administration. Altogether, our findings suggest that adipose‐specific lipin‐1 overexpression may in whole or in part cause disruption of hepatic adiponectin‐Sirt1 signaling routes and ultimately exacerbate alcoholic steatohepatitis in mice.
2019
Alcoholism-Clinical and Experimental Research
Department of Pharmaceutical Sciences
June 2019 Update
NEOMED College of Pharmacy
Substance Abuse
You M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/hep4.1333" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/hep4.1333</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
656-669
Issue
5
Volume
3
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Adipose‐Specific Lipin‐1 Overexpression Renders Hepatic Ferroptosis and Exacerbates Alcoholic Steatohepatitis in Mice.
Publisher
An entity responsible for making the resource available
Hepatology Communications
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-05
Subject
The topic of the resource
APOPTOSIS; FATTY liver; PROTEIN expression
Creator
An entity primarily responsible for making the resource
Zhou Zhou; Ye Ting Jie; Bonavita Gregory; Daniels Michael; Kainrad Noah; Jogasuria Alvin; You Min
Description
An account of the resource
Lipin‐1 is a Mg2+‐dependent phosphatidic acid phosphohydrolase involved in the generation of diacylglycerol during synthesis of phospholipids and triglycerides. Ethanol‐mediated inhibitory effects on adipose‐specific lipin‐1 expression were associated with experimental steatohepatitis in rodents. In the present study, using an adipose‐specific lipin‐1 overexpression transgenic (Lpin1‐Tg) mouse model, we tested a hypothesis that adipose‐specific lipin‐1 overexpression in mice might dampen ethanol‐induced liver damage. Experimental alcoholic steatohepatitis was induced by pair‐feeding ethanol to Lpin1‐Tg and wild‐type (WT) mice using the chronic‐plus‐binge ethanol feeding protocol. Unexpectedly, following the chronic‐plus‐binge ethanol challenge, Lpin1‐Tg mice exhibited much more pronounced steatosis, exacerbated inflammation, augmented elevation of serum liver enzymes, hepatobiliary damage, and fibrogenic responses compared with the WT mice. Mechanistically, overexpression of adipose lipin‐1 in mice facilitated the onset of hepatic ferroptosis, which is an iron‐dependent form of cell death, and subsequently induced ferroptotic liver damage in mice under ethanol exposure. Concurrently, adipose lipin‐1 overexpression induced defective adiponectin signaling pathways in ethanol‐fed mice. Conclusion: We identified ferroptosis as a mechanism in mediating the detrimental effects of adipose‐specific lipin‐1 overexpression in mice under chronic‐plus‐binge ethanol exposure. Our present study sheds light on potential therapeutic approaches for the prevention and treatment of human alcoholic steatohepatitis. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/hep4.1333" target="_blank" rel="noreferrer noopener">10.1002/hep4.1333</a>
2019
Apoptosis
Bonavita Gregory
Daniels Michael
Department of Pharmaceutical Sciences
Fatty Liver
Hepatology communications
Jogasuria Alvin
June 2019 Update
Kainrad Noah
NEOMED College of Pharmacy
PROTEIN expression
Ye Ting Jie
You Min
Zhou Zhou
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
66-67
Volume
168
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NEOMED College
NEOMED College of Pharmacy
NEOMED Department
NEOMED Postdoc Publications; Department of Pharmaceutical Sciences
Dublin Core
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Title
A name given to the resource
Age And Pathology-related Changes In Neuron Density In The Chimpanzee Cortex
Publisher
An entity responsible for making the resource available
American Journal of Physical Anthropology
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-03
Subject
The topic of the resource
Anthropology; Evolutionary Biology
Creator
An entity primarily responsible for making the resource
Edler M K; Munger E L; Hof P R; Hopkins W D; Ely J J; Erwin J M; Meindl R S; Mufson E J; Sherwood C C; Raghanti M A
Identifier
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n/a
Format
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Journal Article or Conference Abstract Publication
2019
88th Annual Meeting of the American-Association-of-Physical-Anthropologists (AAPA)
American journal of physical anthropology
Anthropology
Edler M K
Ely J J
Erwin J M
Evolutionary Biology
Hof P R
Hopkins W D
Meindl R S
Mufson E J
Munger E L
NEOMED College of Pharmacy
NEOMED College of Pharmacy Postdoc
NEOMED Postdoc Publications
Raghanti M A
Sherwood C C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/02713683.2018.1516783" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/02713683.2018.1516783</a>
Pages
34–45
Issue
1
Volume
44
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Alpha 2-Adrenergic Receptor Agonist Brimonidine Stimulates ERK1/2 and AKT Signaling via Transactivation of EGF Receptors in the Human MIO-M1 Muller Cell Line.
Publisher
An entity responsible for making the resource available
Current eye research
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-01
Subject
The topic of the resource
adrenergic receptors; AKT pathway; and Src-kinase; brimonidine; EGF receptor; ERK1/2; matrix metalloproteinases; Muller cell
Creator
An entity primarily responsible for making the resource
Harun-Or-Rashid Mohammad; Hallbook Finn
Description
An account of the resource
PURPOSE: Alpha 2-adrenergic receptor (alpha2-ADR) agonists are used clinically for a range of indications including reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Animal experiments show that alpha2-ADR agonists attenuate the injury-induced Muller cell dedifferentiation by a mechanism that involves activation and regulation of extracellular signal-regulated kinase (ERK) 1/2 leading to transactivation of epidermal growth factor receptors (EGFRs). The purpose of this study was to study and corroborate the activation of this system in human cells. MATERIAL AND METHODS: The human Muller cell line MIO-M1 was treated with the alpha2A-ADR agonist brimonidine in combination with inhibitors for Src-kinase, EGFR-kinase, matrix metalloproteinase (MMP) as well as small interfering RNAs (siRNAs) for the EGFR. The cells were analyzed using immunocytochemistry, quantitative PCR and western blot techniques. RESULTS: Our results show that human MIO-M1 cells express alpha2A-ADRs and that stimulation of these receptors caused a robust increase of ERK1/2 and protein kinase B (PKB/AKT) (Thr-308) phosphorylation in
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/02713683.2018.1516783" target="_blank" rel="noreferrer noopener">10.1080/02713683.2018.1516783</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2019
adrenergic receptors
AKT pathway
and Src-kinase
brimonidine
Current eye research
Department of Pharmaceutical Sciences
EGF receptor
ERK1/2
Hallbook Finn
Harun-Or-Rashid Mohammad
matrix metalloproteinases
Muller cell
NEOMED College of Pharmacy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/jphp.13138" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/jphp.13138</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1421-1428
Issue
9
Volume
71
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Title
A name given to the resource
AMPK‐SIRT1‐independent inhibition of ANGPTL3 gene expression is a potential lipid‐lowering mechanism of metformin.
Publisher
An entity responsible for making the resource available
Journal of Pharmacy & Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-09
Subject
The topic of the resource
angiopoietin‐like 3; diabetes; dyslipidaemia; lipoprotein lipase; metformin
Creator
An entity primarily responsible for making the resource
Lin Li; Burke Jamie; Venkatesh Sahana; Sadana Prabodh
Description
An account of the resource
Objectives: Hypertriglyceridaemia enhances cardiovascular disease risk in patients with diabetes. Lipoprotein lipase (LPL) regulates plasma triglyceride levels by hydrolysing chylomicrons and very‐low‐density lipoprotein (VLDL). Metformin, an antidiabetic drug, improves plasma lipids including triglycerides. We examined metformin's regulation of angiopoietin‐like 3 (ANGPTL3), a liver‐derived secretory protein with LPL inhibitory property. Methods: Using HepG2 cells, a human hepatocyte cell line, the effects of metformin on ANGPTL3 gene and protein expression were determined. The role of AMPK‐SIRT1 pathway in metformin regulation of ANGPTL3 was determined using pharmacological, RNAi and reporter assays. Metformin regulation of ANGPTL3 expression was also examined in sodium palmitate‐induced insulin resistance. Key findings: Metformin and pharmacological activators of AMPK and SIRT1 inhibited the expression of ANGPTL3 in HepG2 cells. Pharmacological or RNAi‐based antagonism of AMPK or SIRT1 failed to affect metformin inhibition of ANGPTL3. AMPK‐SIRT1 activators and metformin exhibited distinct effects on the expression of ANGPTL3 gene luciferase reporter. Sodium palmitate‐induced insulin resistance in cells resulted in increased ANGPTL3 gene expression which was suppressed by pretreatment with metformin. Conclusions: Metformin inhibits ANGPTL3 expression in the liver in an AMPK‐SIRT1‐independent manner as a potential mechanism to regulate LPL and lower plasma lipids. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/jphp.13138" target="_blank" rel="noreferrer noopener">10.1111/jphp.13138</a>
2019
angiopoietin‐like 3
Burke Jamie
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Diabetes
dyslipidaemia
Journal of Pharmacy & Pharmacology
Lin Li
Lipoprotein lipase
metformin
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Sadana Prabodh
September 2019 Update
Venkatesh Sahana
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a class="doi" href="https://doi.org/10.1016/j.xjep.2019.03.007" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer noopener">https://doi.org/10.1016/j.xjep.2019.03.007</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
114-118
Volume
15
Dublin Core
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Title
A name given to the resource
An interprofessional case study competition addressing community healthcare needs and the opioid crisis
Publisher
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Journal of Interprofessional Education & Practice
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-06
Creator
An entity primarily responsible for making the resource
DeBoth Kelle K; Stoddard-Dare Patricia; Bruce Susan; Niederriter Joan
Identifier
An unambiguous reference to the resource within a given context
<a class="doi" href="https://doi.org/10.1016/j.xjep.2019.03.007" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer noopener">https://doi.org/10.1016/j.xjep.2019.03.007</a>
2019
Bruce Susan
DeBoth Kelle K
Department of Pharmacy Practice
Journal of Interprofessional Education & Practice
June 2019 Update
NEOMED College of Pharmacy
Niederriter Joan
Stoddard-Dare Patricia
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/ncp.10474" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ncp.10474</a>
Pages
178-195
Issue
2
Volume
35
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Update Year & Number
March 2020 Update
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmacy Practice
Affiliated Hospital
Akron Children's Hospital
Dublin Core
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Title
A name given to the resource
ASPEN Consensus Recommendations for Refeeding Syndrome.
Publisher
An entity responsible for making the resource available
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Subject
The topic of the resource
magnesium; potassium; consensus; phosphorus; nutrition assessment; nutrition support; refeeding syndrome
Creator
An entity primarily responsible for making the resource
da Silva Joshua S V; Seres David S; Sabino Kim; Adams Stephen C; Berdahl Gideon J; Citty Sandra Wolfe; Cober M Petrea; Evans David C; Greaves June R; Gura Kathleen M; Michalski Austin; Plogsted Stephen; Sacks Gordon S; Tucker Anne M; Worthington Patricia; Walker Renee N; Ayers Phil
Description
An account of the resource
INTRODUCTION: In the spring of 2017, the American Society for Parenteral and Enteral Nutrition (ASPEN) Parenteral Nutrition Safety Committee and the Clinical Practice Committee convened an interprofessional task force to develop consensus recommendations for identifying patients with or at risk for refeeding syndrome (RS) and for avoiding and managing the condition. This report provides narrative review and consensus recommendations in hospitalized adult and pediatric populations. METHODS: Because of the variation in definitions and methods reported in the literature, a consensus process was developed. Subgroups of authors investigated specific issues through literature review. Summaries were presented to the entire group for discussion via email and teleconferences. Each section was then compiled into a master document, several revisions of which were reviewed by the committee. FINDINGS/RECOMMENDATIONS: This group proposes a new clinical definition, and criteria for stratifying risk with treatment and screening strategies. The authors propose that RS diagnostic criteria be stratified as follows: a decrease in any 1, 2, or 3 of serum phosphorus, potassium, and/or magnesium levels by 10%-20% (mild), 20%-30% (moderate), or >30% and/or organ dysfunction resulting from a decrease in any of these and/or due to thiamin deficiency (severe), occurring within 5 days of reintroduction of calories. CONCLUSIONS: These consensus recommendations are intended to provide guidance regarding recognizing risk and identifying, stratifying, avoiding and managing RS. This consensus definition is additionally intended to be used as a basis for further research into the incidence, consequences, pathophysiology, avoidance, and treatment of RS.
Identifier
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<a href="http://doi.org/10.1002/ncp.10474" target="_blank" rel="noreferrer noopener">10.1002/ncp.10474</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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Journal Article
2020
Adams Stephen C
Akron Children's Hospital
Ayers Phil
Berdahl Gideon J
Citty Sandra Wolfe
Cober M Petrea
Consensus
da Silva Joshua S V
Department of Pharmacy Practice
Evans David C
Greaves June R
Gura Kathleen M
Magnesium
Michalski Austin
NEOMED College of Pharmacy
Nutrition Assessment
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
nutrition support
phosphorus
Plogsted Stephen
Potassium
refeeding syndrome
Sabino Kim
Sacks Gordon S
Seres David S
Tucker Anne M
Walker Renee N
Worthington Patricia
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/cne.24610" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/cne.24610</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1179-1195
Issue
7
Volume
527
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Title
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Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees
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The Journal of Comparative Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-05
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Aging; Alzheimer's disease; astrocytes; cerebral cortex; chimpanzees; hippocampus; prefrontal cortex; RRID: AB2109645; RRID: AB223647; RRID: AB2313952; RRID: AB2314223; stereology
Creator
An entity primarily responsible for making the resource
Munger Emily L; Edler Melissa K; Hopkins William D; Ely John J; Erwin Joseph M; Perl Daniel P; Mufson Elliott J; Hof Patrick R; Sherwood Chet C; Raghanti Mary Ann
Description
An account of the resource
Astrocytes are the main homeostatic cell of the central nervous system. In addition, astrocytes mediate an inflammatory response when reactive to injury or disease known as astrogliosis. Astrogliosis is marked by an increased expression of glial fibrillary acidic protein (GFAP) and cellular hypertrophy. Some degree of astrogliosis is associated with normal aging and degenerative conditions such as Alzheimer's disease (AD) and other dementing illnesses in humans. The recent observation of pathological markers of AD (amyloid plaques and neurofibrillary tangles) in aged chimpanzee brains provided an opportunity to examine the relationships among aging, AD-type pathology, and astrocyte activation in our closest living relatives. Stereologic methods were used to quantify GFAP-immunoreactive astrocyte density and soma volume in layers I, III, and V of the prefrontal and middle temporal cortex, as well as in hippocampal fields CA1 and CA3. We found that the patterns of astrocyte activation in the aged chimpanzee brain are distinct from humans. GFAP expression does not increase with age in chimpanzees, possibly indicative of lower oxidative stress loads. Similar to humans, chimpanzee layer I astrocytes in the prefrontal cortex are susceptible to AD-like changes. Both prefrontal cortex layer I and hippocampal astrocytes exhibit a high degree of astrogliosis that is positively correlated with accumulation of amyloid beta and tau proteins. However, unlike humans, chimpanzees do not display astrogliosis in other cortical layers. These results demonstrate a unique pattern of cortical aging in chimpanzees and suggest that inflammatory processes may differ between humans and chimpanzees in response to pathology.
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<a href="http://doi.org/10.1002/cne.24610" target="_blank" rel="noreferrer noopener">10.1002/cne.24610</a>
2019
Aging
Alzheimer's disease
Astrocytes
cerebral cortex
chimpanzees
Department of Pharmaceutical Sciences
Edler Melissa K
Ely John J
Erwin Joseph M
Hippocampus
Hof Patrick R
Hopkins William D
June 2019 Update
Mufson Elliott J
Munger Emily L
NEOMED College of Pharmacy
Perl Daniel P
prefrontal cortex
Raghanti Mary Ann
RRID: AB2109645
RRID: AB223647
RRID: AB2313952
RRID: AB2314223
Sherwood Chet C
Stereology
The Journal of comparative neurology
-
Text
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URL Address
<a href="http://doi.org/10.1080/15592294.2020.1735075" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/15592294.2020.1735075</a>
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Update Year & Number
March 2020 Update
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmaceutical Sciences
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Title
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Betaine restores epigenetic control and supports neuronal mitochondria in the cuprizone mouse model of multiple sclerosis.
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Epigenetics
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-02
Creator
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Singhal Naveen K; Sternbach Sarah; Fleming Sheila; Alkhayer Kholoud; Shelestak John; Popescu Daniela; Weaver Alyx; Clements Robert; Wasek Brandi; Bottiglieri Teodoro; Freeman Ernest J; McDonough Jennifer
Description
An account of the resource
Methionine metabolism is dysregulated in multiple sclerosis (MS). The methyl donor betaine is depleted in the MS brain where it is linked to changes in levels of histone H3 trimethylated on lysine 4 (H3K4me3) and mitochondrial impairment. We investigated the effects of replacing this depleted betaine in the cuprizone mouse model of MS. Supplementation with betaine restored epigenetic control and alleviated neurological disability in cuprizone mice. Betaine increased the methylation potential (SAM/SAH ratio), levels of H3K4me3, enhanced neuronal respiration, and prevented axonal damage. We show that the methyl donor betaine and the betaine homocysteine methyltransferase (BHMT) enzyme can act in the nucleus to repair epigenetic control and activate neuroprotective transcriptional programs. ChIP-seq data suggest that BHMT acts on chromatin to increase the SAM/SAH ratio and histone methyltransferase activity locally to increase H3K4me3 and activate transcriptional programs that support neuronal energetics. These data suggest that the methyl donor betaine may provide neuroprotection in MS where mitochondrial impairment damages axons and causes disability.
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<a href="http://doi.org/10.1080/15592294.2020.1735075" target="_blank" rel="noreferrer noopener">10.1080/15592294.2020.1735075</a>
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Journal Article
2020
Alkhayer Kholoud
Bottiglieri Teodoro
Clements Robert
Department of Pharmaceutical Sciences
Epigenetics
Fleming Sheila
Freeman Ernest J
McDonough Jennifer
NEOMED College of Pharmacy
Popescu Daniela
Shelestak John
Singhal Naveen K
Sternbach Sarah
Wasek Brandi
Weaver Alyx
-
Text
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URL Address
<a href="http://doi.org/10.1021/acs.analchem.9b02757" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/acs.analchem.9b02757</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
14340-14351
Issue
22
Volume
91
ISSN
1520-6882
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Calculation of the Protein Turnover Rate Using the Number of Incorporated 2H Atoms and Proteomics Analysis of a Single Labeled Sample
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Analytical Chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-11-19
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Ilchenko Serguei; Haddad Andrew; Sadana Prabodh; Recchia Fabio A; Sadygov Rovshan G; Kasumov Takhar
Description
An account of the resource
Rate constant estimation with heavy water requires a long-term experiment with data collection at multiple time points (3-4 weeks for mitochondrial proteome dynamics in mice and much longer in other species). When tissue proteins are analyzed, this approach requires euthanizing animals at each time point or multiple tissue biopsies in humans. Although short-term protocols are available, they require knowledge of the maximum number of isotope labels (N) and accurate quantification of observed 2H-enrichment in the peptide. The high-resolution accurate mass spectrometers used for proteome dynamics studies are characterized by a systematic spectral error that compromises these measurements. To circumvent these issues, we developed a simple algorithm for the rate constant calculation based on a single labeled sample and comparable unlabeled (time 0) sample. The algorithm determines N for all proteogenic amino acids from a long-term experiment to calculate the predicted plateau 2H-labeling of peptides for a short-term protocol and estimates the rate constant based on the measured baseline and the predicted plateau 2H-labeling of peptides. The method was validated based on the rate constant estimation in a long-term experiment in mice and dogs. The improved 2 time-point method enables the rate constant calculation with less than 10% relative error compared to the bench-marked multi-point method in mice and dogs and allows us to detect diet-induced subtle changes in ApoAI turnover in mice. In conclusion, we have developed and validated a new algorithm for protein rate constant calculation based on 2-time point measurements that could also be applied to other biomolecules.
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<a href="http://doi.org/10.1021/acs.analchem.9b02757" target="_blank" rel="noreferrer noopener">10.1021/acs.analchem.9b02757</a>
PMID: 31638786
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Analytical Chemistry
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Haddad Andrew
Ilchenko Serguei
Journal Article
Kasumov Takhar
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
November 2019 Update
Recchia Fabio A
Sadana Prabodh
Sadygov Rovshan G
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.amjcard.2019.07.006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.amjcard.2019.07.006</a>
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Title
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Consensus Clinical Decision-Making Factors Driving Anticoagulation in Atrial Fibrillation
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The American Journal of Cardiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-07
Creator
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King Philip K; Fosnight Susan M; Bishop Jeffrey R
Description
An account of the resource
Guideline-recommended anticoagulation is frequently omitted in high-risk patients with atrial fibrillation (AF) for reasons not fully understood, which may result in suboptimal care. A nationally representative, expert group of physicians (cardiology, neurology, and general medicine), and clinical pharmacists participated in a consensus-seeking, modified Delphi method to identify key clinical decision-making factors driving anticoagulant prescribing in real-world AF patients. Representing >2,500 anticoagulation-related patient encounters per month, 27 of 30 participants completed the study (90% overall response rate). In Round-1, experts rated their level of agreement with factors and suggested modifications or additional factors. Of 66 factors entering Round-1, 21 met and 4 partially met consensus, 41 did not meet consensus, and 7 were newly suggested. Of 32 factors advanced for scoring in Round-2, 16 met consensus criteria. In Round-3, experts were given the option to rescue up to 2 of the 16 nonconsensus factors from Round-2. Including a concomitant need for dual antiplatelet therapy, no factor was successfully rescued into consensus. The most important factors related to risk of infarction rather than bleeding risk or other patient-specific considerations. Among factors not independently addressed in current guidelines, these included baseline hematologic indicators of potential bleeding risk, previous bleeding episodes by specific type, other risk factors for bleeding, and adherence. In conclusion, when determining anticoagulation strategies in AF, there is a need for further research on the clinical implications of these emerging factors as well as the reasons behind divergent opinions toward nonconsensus factors.
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<a href="http://doi.org/10.1016/j.amjcard.2019.07.006" target="_blank" rel="noreferrer noopener">10.1016/j.amjcard.2019.07.006</a>
2019
Bishop Jeffrey R
Department of Pharmacy Practice
Fosnight Susan M
King Philip K
NEOMED College of Pharmacy
September 2019 Update
The American journal of cardiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1155/2020/8856022" target="_blank" rel="noreferrer noopener">http://doi.org/10.1155/2020/8856022</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
8856022
Volume
2020
ISSN
2090-6501 2090-651X 2090-651X
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Update Year & Number
October 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED College of Pharmacy
NEOMED Department
Department of Internal Medicine
Department of Pharmacy Practice
Affiliated Hospital
Cleveland Clinic Akron General Hospital
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Title
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Critical low catastrophe: a case report of treatment-refractory hypoglycemia following overdose of long-acting insulin.
Publisher
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Case Reports in Endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
1905-07
Subject
The topic of the resource
BLOOD sugar; DEXTROSE; HYPOGLYCEMIA; INSULIN; INSULINOMA; PARENTERAL infusions
Creator
An entity primarily responsible for making the resource
Sandooja R;Moorman JM;Priyadarshini KM;Detoya K
Description
An account of the resource
Overdose of long-acting insulin can cause unpredictable hypoglycemia for prolonged periods of time. The initial treatment of hypoglycemia includes oral carbohydrate intake as able and/or parenteral dextrose infusion. Refractory hypoglycemia following these interventions presents a clinical challenge in the absence of clear guidelines for management. Octreotide has sometimes been used, but its use is generally limited to sulfonylurea overdose. In this case report, we present a case of refractory hypoglycemia following an overdose of 900 units of long-acting insulin glargine that failed to respond to usual modes of therapy mentioned above. Stress-dose corticosteroids were then initiated, followed by subsequent improvement in IV dextrose and glucagon requirements and blood glucose levels. Hence, corticosteroids may serve as an adjunctive therapy in managing hypoglycemia and can be considered earlier in the course of treatment in patients with refractory hypoglycemia to prevent volume overload, especially when large volumes of dextrose infusions are required.
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<a href="http://doi.org/10.1155/2020/8856022" target="_blank" rel="noreferrer noopener">10.1155/2020/8856022</a>
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journalArticle
2020
BLOOD sugar
Case Reports in Endocrinology
Cleveland Clinic Akron General Hospital
Department of Internal Medicine
Department of Pharmacy Practice
Detoya K
DEXTROSE
hypoglycemia
insulin
INSULINOMA
journalArticle
Moorman JM
NEOMED College of Medicine
NEOMED College of Pharmacy
October 2020 List
PARENTERAL infusions
Priyadarshini KM
Sandooja R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1074/jbc.RA119.007743" target="_blank" rel="noreferrer noopener">http://doi.org/10.1074/jbc.RA119.007743</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Defining α-synuclein species responsible for Parkinson disease phenotypes in mice
Publisher
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The Journal of Biological Chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-05
Subject
The topic of the resource
alpha-synuclein (a-synuclein); amyloid; cytotoxicity; fibril; Lewy Body; motor behavior defect; neurodegenerative disease; oligomer; Parkinson disease; protein aggregation
Creator
An entity primarily responsible for making the resource
Froula Jessica M; Castellana-Cruz Marta; Anabtawi Nadia M; Camino José D; Chen Serene W; Thrasher Drake R; Freire Jennifer; Yazdi Allen A; Fleming Sheila; Dobson Christopher M; Kumita Janet R; Cremades Nunilo; Volpicelli-Daley Laura A
Description
An account of the resource
Parkinson disease (PD) is a neurodegenerative disorder characterized by fibrillar neuronal inclusions composed of aggregated α-synuclein. These inclusions are associated with behavioral and pathological PD phenotypes. One strategy for therapeutic interventions is to prevent the formation of these inclusions in order to halt disease progression. α-Synuclein exists in multiple structural forms, including disordered, non-amyloid oligomers, ordered amyloid oligomers, and fibrils. It is critical to understand which conformers contribute to specific PD phenotypes. Here, we utilized a mouse model to explore the pathological effects of stable amyloid β-sheet oligomers compared with those of fibrillar α-synuclein. We biophysically characterized these species with transmission EM, atomic-force microscopy, CD spectroscopy, FTIR spectroscopy, analytical ultracentrifugation, and thioflavin T assays. We then injected these different α-synuclein forms into the mouse striatum to determine their ability to induce PD-related phenotypes. We found that β-sheet oligomers produce a small but significant loss of dopamine neurons in the substantia nigra pars compacta (SNc). Injection of small β-sheet fibril fragments, however, produced the most robust phenotypes, including reduction of striatal dopamine terminals, SNc loss of dopamine neurons, and motor behavior defects. We conclude that although the β-sheet oligomers cause some toxicity, the potent effects of the short fibrillar fragments can be attributed to their ability to recruit monomeric α-synuclein and spread in vivo and hence contribute to the development of PD-like phenotypes. These results suggest that strategies to reduce the formation and propagation of β-sheet fibrillar species could be an important route for therapeutic intervention in PD and related disorders.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1074/jbc.RA119.007743" target="_blank" rel="noreferrer noopener">10.1074/jbc.RA119.007743</a>
2019
alpha-synuclein (a-synuclein)
amyloid
Anabtawi Nadia M
Camino José D
Castellana-Cruz Marta
Chen Serene W
Cremades Nunilo
cytotoxicity
Department of Pharmaceutical Sciences
Dobson Christopher M
fibril
Fleming Sheila
Freire Jennifer
Froula Jessica M
June 2019 Update
Kumita Janet R
Lewy Body
motor behavior defect
NEOMED College of Pharmacy
neurodegenerative disease
oligomer
Parkinson Disease
Protein Aggregation
The Journal of biological chemistry
Thrasher Drake R
Volpicelli-Daley Laura A
Yazdi Allen A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1074/jbc.ra119.007743" target="_blank" rel="noreferrer noopener">http://doi.org/10.1074/jbc.ra119.007743</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
10392-10406
Issue
27
Volume
294
Search for Full-text
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Title
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Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice.
Publisher
An entity responsible for making the resource available
Journal of Biological Chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-07
Subject
The topic of the resource
DOPAMINERGIC neurons; FOURIER transform infrared spectroscopy; MOUSE diseases; PARKINSON'S disease; SPECIES; SUBSTANTIA nigra
Creator
An entity primarily responsible for making the resource
Froula Jessica M; Castellana-Cruz Marta; Anabtawi Nadia M; Camino José D; Chen Serene W; Thrasher Drake R; Freire Jennifer; Yazdi Allen A; Fleming Sheila; Dobson Christopher M; Kumita Janet R; Cremades Nunilo; Volpicelli-Daley Laura A
Description
An account of the resource
Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar neuronal inclusions composed of aggregatedβ-synuclein (β-syn). These inclusions are associated with behavioral and pathological PD phenotypes. One strategy for therapeutic interventions is to prevent the formation of these inclusions to halt disease progression. β-Synuclein exists in multiple structural forms, including disordered, nonamyloid oligomers, ordered amyloid oligomers, and fibrils. It is critical to understand which conformers contribute to specific PD phenotypes. Here, we utilized a mouse model to explore the pathological effects of stable α-amyloid-sheet oligomers compared with those of fibrillar β-synuclein. We biophysically characterized these species with transmission EM, atomic-force microscopy, CD spectroscopy, FTIR spectroscopy, analytical ultracentrifugation, and thioflavin T assays. We then injected these different β-synuclein forms into the mouse striatum to determine their ability to induce PD-related phenotypes. We found thatα-sheet oligomers produce a small but significant loss of dopamine neurons in the substantia nigra pars compacta (SNc). Injection of small α-sheet fibril fragments, however, produced the most robust phenotypes, including reduction of striatal dopamine terminals, SNc loss of dopamine neurons, and motor-behavior defects. We conclude that although theα-sheet oligomers cause some toxicity, the potent effects of the short fibrillar fragments can be attributed to their ability to recruit monomeric β-synuclein and spread in vivo and hence contribute to the development of PD-like phenotypes. These results suggest that strategies to reduce the formation and propagation ofα-sheet fibrillar species could be an important route for therapeutic intervention in PD and related disorders. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1074/jbc.ra119.007743" target="_blank" rel="noreferrer noopener">10.1074/jbc.ra119.007743</a>
2019
Anabtawi Nadia M
Camino José D
Castellana-Cruz Marta
Chen Serene W
Cremades Nunilo
Department of Pharmaceutical Sciences
Dobson Christopher M
DOPAMINERGIC neurons
Fleming Sheila
FOURIER transform infrared spectroscopy
Freire Jennifer
Froula Jessica M
Journal of Biological Chemistry
Kumita Janet R
MOUSE diseases
NEOMED College of Pharmacy
Parkinson's disease
September 2019 Update
SPECIES
SUBSTANTIA nigra
Thrasher Drake R
Volpicelli-Daley Laura A
Yazdi Allen A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1208/s12249-019-1333-z" target="_blank" rel="noreferrer noopener">http://doi.org/10.1208/s12249-019-1333-z</a>
Pages
116–116
Issue
3
Volume
20
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Delivery Systems as Vital Tools in Drug Repurposing.
Publisher
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AAPS PharmSciTech
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-02
Subject
The topic of the resource
combination drugs; drug delivery systems; drug development; nanocarriers; nanoparticles
Creator
An entity primarily responsible for making the resource
Czech Tori; Lalani Reza; Oyewumi Moses O
Description
An account of the resource
The process of developing an old drug for new indications is now a widely accepted strategy of shortening drug development time, reducing drug costs, and improving drug availability, especially for rare and neglected diseases. In this mini-review, we highlighted the impact of drug delivery systems in the fulfillment of crucial aspects of drug repurposing such as (i) maximizing the repurposed drug effects on a new target, (ii) minimizing off-target effects, (iii) modulating the release profiles of drug at the site of absorption, (iv) modulating the pharmacokinetics/in vivo biodistribution of the repurposed drug, (v) targeting/modulating drug retention at the sites of action, and (vi) providing a suitable platform for therapeutic application of combination drugs.
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<a href="http://doi.org/10.1208/s12249-019-1333-z" target="_blank" rel="noreferrer noopener">10.1208/s12249-019-1333-z</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2019
AAPS PharmSciTech
combination drugs
Czech Tori
Department of Pharmaceutical Sciences
Drug Delivery Systems
drug development
Lalani Reza
nanocarriers
Nanoparticles
NEOMED College of Pharmacy
Oyewumi Moses O
-
Text
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<a href="http://doi.org/10.1208/s12249-019-1333-z" target="_blank" rel="noreferrer noopener">http://doi.org/10.1208/s12249-019-1333-z</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
116-116
Issue
3
Volume
20
Dublin Core
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Title
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Delivery Systems as Vital Tools in Drug Repurposing.
Publisher
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AAPS PharmSciTech
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-02
Subject
The topic of the resource
Humans; Nanoparticles; *Drug Delivery Systems; Nanoparticles; Tissue Distribution; combination drugs; *Drug Delivery Systems; drug development; nanocarriers; *Drug Repositioning; Drug Carriers
Creator
An entity primarily responsible for making the resource
Czech Tori; Lalani Reza; Oyewumi Moses O
Description
An account of the resource
The process of developing an old drug for new indications is now a widely accepted strategy of shortening drug development time, reducing drug costs, and improving drug availability, especially for rare and neglected diseases. In this mini-review, we highlighted the impact of drug delivery systems in the fulfillment of crucial aspects of drug repurposing such as (i) maximizing the repurposed drug effects on a new target, (ii) minimizing off-target effects, (iii) modulating the release profiles of drug at the site of absorption, (iv) modulating the pharmacokinetics/in vivo biodistribution of the repurposed drug, (v) targeting/modulating drug retention at the sites of action, and (vi) providing a suitable platform for therapeutic application of combination drugs.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1208/s12249-019-1333-z" target="_blank" rel="noreferrer noopener">10.1208/s12249-019-1333-z</a>
*Drug Delivery Systems
*Drug Repositioning
2019
AAPS PharmSciTech
combination drugs
Czech Tori
Department of Pharmaceutical Sciences
Drug Carriers
drug development
Humans
Lalani Reza
nanocarriers
Nanoparticles
NEOMED College of Pharmacy
Oyewumi Moses O
Tissue Distribution
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/toxsci/kfaa144" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/toxsci/kfaa144</a>
ISSN
1096-0929
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September 2020 List
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
NEOMED Student Publications
Department of Pharmaceutical Sciences
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Title
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Deltamethrin exposure inhibits adult hippocampal neurogenesis and causes deficits in learning and memory in mice.
Publisher
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Toxicological Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-09-25
Subject
The topic of the resource
mice; pyrethroid; cognition; adult neurogenesis
Creator
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Hossain MM;Belkadi A;Al-Haddad S;Richardson JR
Description
An account of the resource
Deficits in learning and memory are often associated with disruption of hippocampal neurogenesis, which is regulated by numerous processes, including precursor cell proliferation, survival, migration, and differentiation to mature neurons. Recent studies demonstrate that adult born neurons in the dentate gyrus (DG) in the hippocampus can functionally integrate into the existing neuronal circuitry and contribute to hippocampal-dependent learning and memory. Here, we demonstrate that relatively short-term deltamethrin exposure (3 mg/kg every 3 days for 1 month) inhibits adult hippocampal neurogenesis and causes deficits in learning and memory in mice. Hippocampal-dependent cognitive functions were evaluated using two independent hippocampal-dependent behavioural tests, the novel object recognition task and Morris water maze. We found that deltamethrin-treated mice exhibited profound deficits in novel object recognition and learning and memory in water maze. Deltamethrin exposure significantly decreased bromodeoxyuridine (BrdU)-positive cells (39%) and Ki67+ cells (47%) in the dentate gyrus (DG) of the hippocampus, indicating decreased cellular proliferation. In addition, deltamethrin-treated mice exhibited a 44% decrease in nestin-expressing neural progenitor cells and a 38% reduction in the expression of doublecortin (DCX), an early neuronal differentiation marker. Furthermore, deltamethrin exposed mice exhibited a 25% reduction in total number of granule cells in the DG. These findings indicate that relatively short-term exposure to deltamethrin causes significant deficits in hippocampal neurogenesis that is associated with impaired learning and memory. (© The Author(s) 2020. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/toxsci/kfaa144" target="_blank" rel="noreferrer noopener">10.1093/toxsci/kfaa144</a>
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journalArticle
2020
adult neurogenesis
Al-Haddad S
Belkadi A
Cognition
Department of Pharmaceutical Sciences
Hossain MM
journalArticle
Mice
NEOMED College of Pharmacy
NEOMED Student Publications
Pyrethroid
Richardson JR
September 2020 List
Toxicological Sciences
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.nbd.2020.104947" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.nbd.2020.104947</a>
Pages
104947
Volume
141
ISSN
1095-953X 0969-9961
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June 2020 Update II
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmaceutical Sciences
NEOMED Student Publications
Dublin Core
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Title
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Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of alpha-synuclein-preformed fibril-induced toxicity and motor deficits.
Publisher
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Neurobiology of disease
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-05-15
Subject
The topic of the resource
Neuroinflammation; Neurotoxicity; Parkinson's; Pesticide; Sex differences; Synuclein
Creator
An entity primarily responsible for making the resource
Gezer Aysegul O; Kochmanski Joseph; VanOeveren Sarah E; Cole-Strauss Allyson; Kemp Christopher J; Patterson Joseph R; Miller Kathryn M; Kuhn Nathan C; Herman Danielle E; McIntire Alyssa; Lipton Jack W; Luk Kelvin C; Fleming Sheila M; Sortwell Caryl E; Bernstein Alison I
Description
An account of the resource
Human and animal studies have shown that exposure to the organochlorine pesticide dieldrin is associated with increased risk of Parkinson's disease (PD). Previous work showed that developmental dieldrin exposure increased neuronal susceptibility to MPTP toxicity in male C57BL/6 mice, possibly via changes in dopamine (DA) packaging and turnover. However, the relevance of the MPTP model to PD pathophysiology has been questioned. We therefore studied dieldrin-induced neurotoxicity in the alpha-synuclein (alpha-syn)-preformed fibril (PFF) model, which better reflects the alpha-syn pathology and toxicity observed in PD pathogenesis. Specifically, we used a "two-hit" model to determine whether developmental dieldrin exposure increases susceptibility to alpha-syn PFF-induced synucleinopathy. Dams were fed either dieldrin (0.3 mg/kg, every 3-4 days) or vehicle corn oil starting 1 month prior to breeding and continuing through weaning of pups at postnatal day 22. At 12 weeks of age, male and female offspring received intrastriatal alpha-syn PFF or control saline injections. Consistent with the male-specific increased susceptibility to MPTP, our results demonstrate that developmental dieldrin exposure exacerbates PFF-induced toxicity in male mice only. Specifically, in male offspring, dieldrin exacerbated
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.nbd.2020.104947" target="_blank" rel="noreferrer noopener">10.1016/j.nbd.2020.104947</a>
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journalArticle
2020
Bernstein Alison I
Cole-Strauss Allyson
Department of Pharmaceutical Sciences
Fleming Sheila M
Gezer Aysegul O
Herman Danielle E
journalArticle
June 2020 Update II
Kemp Christopher J
Kochmanski Joseph
Kuhn Nathan C
Lipton Jack W
Luk Kelvin C
McIntire Alyssa
Miller Kathryn M
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
NEOMED Student Publications
Neurobiology of disease
Neuroinflammation
Neurotoxicity
Parkinson's
Patterson Joseph R
Pesticide
Sex differences
Sortwell Caryl E
Synuclein
VanOeveren Sarah E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.nbd.2020.104947" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.nbd.2020.104947</a>
Pages
N.PAG-N.PAG
Volume
141
ISSN
9699961
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Update Year & Number
August 2020 List
NEOMED College
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
NEOMED Department
Department of Pharmaceutical Sciences
NEOMED Student Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits.
Publisher
An entity responsible for making the resource available
Neurobiology of Disease
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-07-15
Subject
The topic of the resource
Sex differences; Neuroinflammation; Parkinson's; Neurotoxicity; Pesticide; PARKINSON'S disease; SUBSTANTIA nigra; Synuclein; CORN oil; ORGANOCHLORINE pesticides; SALINE injections
Creator
An entity primarily responsible for making the resource
Gezer AO; Kochmanski J; VanOeveren SE; Cole-Strauss A; Kemp CJ; Patterson JR; Miller KM; Kuhn NC; Herman DE; McIntire A; Lipton JW; Luk KC; Fleming SM; Sortwell CE; Bernstein AI
Description
An account of the resource
Human and animal studies have shown that exposure to the organochlorine pesticide dieldrin is associated with increased risk of Parkinson's disease (PD). Previous work showed that developmental dieldrin exposure increased neuronal susceptibility to MPTP toxicity in male C57BL/6 mice, possibly via changes in dopamine (DA) packaging and turnover. However, the relevance of the MPTP model to PD pathophysiology has been questioned. We therefore studied dieldrin-induced neurotoxicity in the α-synuclein (α-syn)-preformed fibril (PFF) model, which better reflects the α-syn pathology and toxicity observed in PD pathogenesis. Specifically, we used a "two-hit" model to determine whether developmental dieldrin exposure increases susceptibility to α-syn PFF-induced synucleinopathy. Dams were fed either dieldrin (0.3 mg/kg, every 3–4 days) or vehicle corn oil starting 1 month prior to breeding and continuing through weaning of pups at postnatal day 22. At 12 weeks of age, male and female offspring received intrastriatal α-syn PFF or control saline injections. Consistent with the male-specific increased susceptibility to MPTP, our results demonstrate that developmental dieldrin exposure exacerbates PFF-induced toxicity in male mice only. Specifically, in male offspring, dieldrin exacerbated PFF-induced motor deficits on the challenging beam and increased DA turnover in the striatum 6 months after PFF injection. However, male offspring showed neither exacerbation of phosphorylated α-syn aggregation (pSyn) in the substantia nigra (SN) at 1 or 2 months post-PFF injection, nor exacerbation of PFF-induced TH and NeuN loss in the SN 6 months post-PFF injection. Collectively, these data indicate that developmental dieldrin exposure produces a male-specific exacerbation of synucleinopathy-induced behavioral and biochemical deficits. This sex-specific result is consistent with both previous work in the MPTP model, our previously reported sex-specific effects of this exposure paradigm on the male and female epigenome, and the higher prevalence and more severe course of PD in males. The novel two-hit environmental toxicant/PFF exposure paradigm established in this project can be used to explore the mechanisms by which other PD-related exposures alter neuronal vulnerability to synucleinopathy in sporadic PD. Unlabelled Image • Developmental dieldrin exposure increases α- syn -PFF-induced motor deficits. • Developmental dieldrin exposure increases PFF-induced deficits in DA handling. • Developmental dieldrin exposure does not affect PFF-induced loss of nigral neurons. • This is a novel paradigm modeling how environmental factors increase risk of PD. • Female mice show PFF-induced pathology, but no PFF-induced motor deficits. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.nbd.2020.104947" target="_blank" rel="noreferrer noopener">10.1016/j.nbd.2020.104947</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
August 2020 List
Bernstein AI
Cole-Strauss A
CORN oil
Department of Pharmaceutical Sciences
Fleming SM
Gezer AO
Herman DE
journalArticle
Kemp CJ
Kochmanski J
Kuhn NC
Lipton JW
Luk KC
McIntire A
Miller KM
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
NEOMED Student Publications
Neurobiology of disease
Neuroinflammation
Neurotoxicity
ORGANOCHLORINE pesticides
Parkinson's
Parkinson's disease
Patterson JR
Pesticide
SALINE injections
Sex differences
Sortwell CE
SUBSTANTIA nigra
Synuclein
VanOeveren SE
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3390/ijms21207472" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/ijms21207472</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Issue
20
Volume
21
ISSN
1422-0067 1422-0067
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Update Year & Number
October 2020 List
NEOMED College
NEOMED College of Pharmacy
NEOMED College of Graduate Studies
NEOMED Department
Department of Pharmacy Practice
Department of Pharmaceutical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Early pro-inflammatory remodeling of HDL proteome in a model of diet-induced obesity: 2H2O-metabolic labeling-based kinetic approach.
Publisher
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International Journal of Molecular Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-10-10
Subject
The topic of the resource
inflammation; NAFLD; proteome dynamics; dyslipidemia; insulin resistance; diet-induced obesity; acute-phase proteins; high-density lipoprotein; high-fat diet
Creator
An entity primarily responsible for making the resource
Sadana P;Lin Li;Aghayev M;Ilchenko S;Kasumov T
Description
An account of the resource
Mice fed a high-fat diet for 12 weeks or longer develop hyperglycemia, insulin resistance, dyslipidemia, and fatty liver. Additionally, a high-fat diet induces inflammation that remodels and affects the anti-inflammatory and antiatherogenic property of the high-density lipoprotein (HDL). However, the precise time course of metabolic disease progression and HDL remodeling remains unclear. Short-term (four weeks) high-fat feeding (60% fat calories) was performed in wild-type male C57BL/6J mice to gain insights into the early metabolic disease processes in conjunction with a HDL proteome dynamics analysis using a heavy water metabolic labeling approach. The high-fat diet-fed mice developed hyperglycemia, impaired glucose tolerance, hypercholesterolemia without hypertriglyceridemia or hepatic steatosis. A plasma HDL proteome dynamics analysis revealed increased turnover rates (and reduced half-lives) of several acute-phase response proteins involved in innate immunity, including complement C3 (12.77 ± 0.81 vs. 9.98 ± 1.20 h, p < 0.005), complement factor B (12.71 ± 1.01 vs. 10.85 ± 1.04 h, p < 0.05), complement Factor H (19.60 ± 1.84 vs. 16.80 ± 1.58 h, p < 0.05), and complement factor I (25.25 ± 1.29 vs. 19.88 ± 1.50 h, p < 0.005). Our findings suggest that an early immune response-induced inflammatory remodeling of the plasma HDL proteome precedes the diet-induced steatosis and dyslipidemia.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3390/ijms21207472" target="_blank" rel="noreferrer noopener">10.3390/ijms21207472</a>
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
acute-phase proteins
Aghayev M
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
diet-induced obesity
dyslipidemia
high-density lipoprotein
High-fat diet
Ilchenko S
Inflammation
Insulin Resistance
International journal of molecular sciences
journalArticle
Kasumov T
Lin Li
NAFLD
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
October 2020 List
Proteome dynamics
Sadana P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/" target="_blank" rel="noreferrer noopener">http://doi.org/</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
324A
Issue
1
Volume
72
ISSN
0270-9139
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Update Year & Number
October 2020 List
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmaceutical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of a high fat "western type" diet on dynamics of hepatic acetylated mitochondrial proteins in a mouse model of NAFLD
Publisher
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Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-11
Creator
An entity primarily responsible for making the resource
Kasumov T;Arias-Alvarado A;Aghayev M;Ilchenko S;McCullough AJ
Identifier
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener"></a>
Format
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journalArticle
2020
Aghayev M
Arias-Alvarado A
Department of Pharmaceutical Sciences
Hepatology
Ilchenko S
journalArticle
Kasumov T
McCullough AJ
NEOMED College of Pharmacy
October 2020 List
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ajhp/zxy084" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ajhp/zxy084</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S49-S54
Volume
76
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
effect of an interprofessional pain service on nonmalignant pain control.
Publisher
An entity responsible for making the resource available
American Journal of Health-System Pharmacy
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-06
Subject
The topic of the resource
chronic pain; chronic pain; DISCHARGE planning; HEALTH literacy; HEALTH occupations students; INTERDISCIPLINARY education; LENGTH of stay in hospitals; MEDICAL appointments & schedules; MEDICAL care; MEDICAL personnel & patient; MEDICAL protocols; MEDICAL records; MEDICAL referrals; MEDICALLY underserved persons; medication therapy management; MORPHINE; opioid; pain management; pain management; PAIN measurement; PATIENT education; PATIENT satisfaction; pharmacist; pharmacists; RETROSPECTIVE studies; SUBSTANCE abuse; SURVEYS; TELEPHONES; THERAPEUTIC use of narcotics
Creator
An entity primarily responsible for making the resource
Coffey Cory P; Ulbrich Timothy R; Baughman Kristin R; Awad Magdi H
Description
An account of the resource
Purpose The primary objective of this project was to evaluate an existing interprofessional, nonmalignant pain service by measuring the difference in patient pain scores (numeric rating scale-11) before and after a pharmacist-led pain education class and medication therapy management (MTM) visit. Secondary objectives included determining the percentage of pharmacist recommendations approved, patient satisfaction, and difference in immediate release (IR) and extended release (ER) opioid use before and after enrollment. Methods Baseline data were obtained from a retrospective chart review. Enrolled patients attended an educational pain class with the pharmacist. At the MTM visit with the pharmacist 3–14 days after the initial education class, the patient's pain score was assessed along with his/her medication use, and a care plan was developed and forwarded to the referring provider for implementation. Three months after the pain class and participation in the MTM visit, patients were contacted via telephone to complete a survey. The survey questions assessed patient satisfaction with the pain education program, their current pain score, and their knowledge of information covered during the pain class. Results Patients reported an average preenrollment pain score of 8.3/10 (n = 39) and a post-survey pain score of 5.6/10 (n = 39). The IR opioid use averaged 19.7 morphine equivalent daily dose (MEDD) at enrollment and decreased by 40% to 11.8 MEDD. The provider approval rate of the pharmacist-recommended interventions ranged from 80% to 92%, depending on the predesignated disease state category. Conclusion An interprofessional, nonmalignant-pain service including a pharmacist-led class resulted in a decrease in average pain scores and MEDD in an underserved population. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ajhp/zxy084" target="_blank" rel="noreferrer noopener">10.1093/ajhp/zxy084</a>
2019
American Journal of Health-System Pharmacy
Awad Magdi H
Baughman Kristin R
Chronic pain
Coffey Cory P
Department of Family & Community Medicine
Department of Pharmacy Practice
DISCHARGE planning
HEALTH literacy
HEALTH occupations students
INTERDISCIPLINARY education
June 2019 Update
LENGTH of stay in hospitals
MEDICAL appointments & schedules
Medical care
MEDICAL personnel & patient
MEDICAL protocols
Medical Records
MEDICAL referrals
MEDICALLY underserved persons
Medication Therapy Management
MORPHINE
NEOMED College of Medicine
NEOMED College of Pharmacy
Opioid
Pain Management
Pain Measurement
Patient Education
Patient Satisfaction
pharmacist
Pharmacists
Retrospective Studies
Substance Abuse
Surveys
TELEPHONES
THERAPEUTIC use of narcotics
Ulbrich Timothy R
-
Text
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URL Address
<a href="http://doi.org/10.1016/j.jhep.2018.10.037" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jhep.2018.10.037</a>
Pages
237–248
Issue
2
Volume
70
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of ethanol on lipid metabolism.
Publisher
An entity responsible for making the resource available
Journal of hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-02
Subject
The topic of the resource
Alcohol-related liver disease; Lipid homeostasis; Metabolism; Steatosis
Creator
An entity primarily responsible for making the resource
You Min; Arteel Gavin E
Description
An account of the resource
Hepatic lipid metabolism is a series of complex processes that control influx and efflux of not only hepatic lipid pools, but also organismal pools. Lipid homeostasis is usually tightly controlled by expression, substrate supply, oxidation and secretion that keep hepatic lipid pools relatively constant. However, perturbations of any of these processes can lead to lipid accumulation in the liver. Although it is thought that these responses are hepatic arms of the 'thrifty genome', they are maladaptive in the context of chronic fatty liver diseases. Ethanol is likely unique among toxins, in that it perturbs almost all aspects of hepatic lipid metabolism. This complex response is due in part to the large metabolic demand placed on the organ by alcohol metabolism, but also appears to involve more nuanced changes in expression and substrate supply. The net effect is that steatosis is a rapid response to alcohol abuse. Although transient steatosis is largely an inert pathology, the chronicity of alcohol-related liver disease seems to require steatosis. Better and more specific understanding of the mechanisms by which alcohol causes steatosis may therefore translate into targeted therapies to treat alcohol-related liver disease and/or prevent its progression.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jhep.2018.10.037" target="_blank" rel="noreferrer noopener">10.1016/j.jhep.2018.10.037</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2019
Alcohol-related liver disease
Arteel Gavin E
Department of Pharmaceutical Sciences
Journal of hepatology
Lipid homeostasis
Metabolism
NEOMED College of Pharmacy
Steatosis
You Min
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ajhp/zxaa081" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ajhp/zxaa081</a>
ISSN
1535-2900 1079-2082
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1093/ajhp/zxaa081" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1093/ajhp/zxaa081</a>
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Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmacy Practice
NEOMED Student Publications
Dublin Core
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Title
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Effects of pharmacy interventions at transitions of care on patient outcomes.
Publisher
An entity responsible for making the resource available
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-05-06
Subject
The topic of the resource
discharge medication reconciliation; length of stay; medication adherence; medication errors; pharmacists; readmissions
Creator
An entity primarily responsible for making the resource
Fosnight S; King Philip; Ewald Jacqueline; Feucht John; Lamtman Angela; Kropp D; Dittmer Alison; Sampson Jordan; Shah Morali
Description
An account of the resource
PURPOSE: An interdisciplinary group developed a care transitions process with a prominent pharmacist role. METHODS: The new transitions process was initiated on a 32-bed medical/surgical unit. Demographics, reconciliation data, information on medication adherence barriers, medication recommendations, and time spent performing interventions were prospectively collected for 284 consecutive patients over 54 days after the pharmacy participation was completely implemented. Outcome data, including 30-day readmission rates and length of stay, were retrospectively collected. RESULTS: When comparing metrics for all intervention patients to baseline metrics from the same months of the previous year, the readmission rate was decreased from 21.0% to 15.3% and mean length of stay decreased from 5.3 days to 4.4 days. Further improvement to a 10.2% readmission rate and a 3.6-day average length of stay were observed in the subgroup of intervention patients who received all components of the pharmacy intervention. Additionally, greater improvements were observed in intervention-period patients who received the full pharmacy intervention, as compared to those receiving only parts of the pharmacy intervention, with a 10.2-percentage-point lower readmission rate (10.2% vs 20.4%, P = 0.016) and a 1.7-day shorter length of stay (3.6 days vs. 5.3 days; 95% confidence interval, 0.814-2.68 days; P = 0.0003). For patients receiving any component of the pharmacy intervention, an average of 9.56 medication recommendations were made, with a mean of 0.89 change per patient deemed to be required to avoid harm and/or increased length of stay. CONCLUSION: A comprehensive pharmacy intervention added to a transitions intervention resulted in an average of nearly 10 medication recommendations per patient, improved length of stay, and reduced readmission rates.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ajhp/zxaa081" target="_blank" rel="noreferrer noopener">10.1093/ajhp/zxaa081</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Department of Pharmacy Practice
discharge medication reconciliation
Dittmer Alison
Ewald Jacqueline
Feucht John
Fosnight S
journalArticle
June 2020 Update II
King Philip
Kropp D
Lamtman Angela
Length of Stay
medication adherence
Medication Errors
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
NEOMED Student Publications
Pharmacists
readmissions
Sampson Jordan
Shah Morali
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/phar.2269" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/phar.2269</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
724-729
Issue
6
Volume
39
Dublin Core
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Title
A name given to the resource
Efficacy of Tramadol for Pain Management in Patients Receiving Strong Cytochrome P450 2D6 Inhibitors
Publisher
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Pharmacotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-06
Subject
The topic of the resource
CYP2D6; cytochrome P450; drug interaction; pain control; tramadol
Creator
An entity primarily responsible for making the resource
Frost Derek A; Soric Mate M; Kaiser Ricky; Neugebauer Rachel E
Description
An account of the resource
STUDY OBJECTIVE: Tramadol is metabolized by cytochrome P450 (CYP) 2D6 to form an active metabolite that exhibits its analgesic effect. Medications that inhibit this enzyme are used often in practice, yet the clinical impact of this interaction on the analgesic effects of tramadol has yet to be fully described. The objective was to determine whether a clinically relevant decrease in pain control is observed in patients taking scheduled tramadol concomitantly with a strong CYP2D6 inhibitor. DESIGN: Retrospective cohort study. SETTING: Large health care system. PATIENTS: One hundred fifty-two adult inpatients who received scheduled tramadol for at least 24 hours with (76 patients) or without (76 patients) a strong CYP2D6 inhibitor between January 1, 2012, and February 28, 2017, were included in the analysis. Patients hospitalized for opioid use disorder or those receiving substandard dosing of tramadol were excluded. MEASUREMENTS AND MAIN RESULTS: The primary outcome was mean breakthrough opiate consumption in the presence and absence of CYP2D6 inhibitors. Secondary outcomes included mean pain scores, length of hospital stay, tramadol discontinuation rates, and prespecified subgroup analyses based on patient sex, race, and specific CYP2D6 inhibitor administered. Patients receiving concurrent CYP2D6 inhibitors required significantly more breakthrough morphine milligram equivalents per day compared with patients receiving scheduled tramadol without CYP2D6 inhibitors (geometric mean ± SD 18.2 ± 6.3 vs 5.7 ± 6.7 mg morphine milligram equivalents, p<0.001). No significant differences existed between cohorts for mean pain score, length of hospital stay, or tramadol discontinuation rate. CONCLUSION: This study demonstrated a clinically relevant decrease in the efficacy of tramadol when used for pain control in patients receiving a strong CYP2D6 inhibitor. These results should encourage clinicians to review medication lists for this interaction and adjust regimens accordingly to ensure adequate pain control.
Identifier
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<a href="http://doi.org/10.1002/phar.2269" target="_blank" rel="noreferrer noopener">10.1002/phar.2269</a>
2019
CYP2D6
cytochrome P450
Department of Pharmacy Practice
drug interaction
Frost Derek A
June 2019 Update
Kaiser Ricky
NEOMED College of Pharmacy
Neugebauer Rachel E
pain control
Pharmacotherapy
Soric Mate M
tramadol
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ajhp/zxz174" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ajhp/zxz174</a>
Pages
1492-1510
Issue
19
Volume
76
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Title
A name given to the resource
Enteral and parenteral nutrition considerations in pediatric patients
Publisher
An entity responsible for making the resource available
American journal of health-system pharmacy: AJHP: official journal of the American Society of Health-System Pharmacists
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-09
Subject
The topic of the resource
compounding; enteral; neonatal; nutrition; parenteral; pediatric; stability
October 2019 Update
Creator
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Cober Mary Petrea; Gura Kathleen M
Description
An account of the resource
PURPOSE: Current clinical practice guidelines on management of enteral nutrition (EN) and parenteral nutrition (PN) in pediatric patients are reviewed. SUMMARY: The provision of EN and PN in pediatric patients poses many unique considerations and challenges. Although indications for use of EN and PN are similar in adult and pediatric populations, recommended EN and PN practices differ for pediatric versus adult patients in areas such as selection of EN and PN formulations, timing of EN and PN initiation, advancement of nutrition support, and EN and PN goals. Additionally, provision of EN and PN to pediatric patients poses unique compounding and medication administration challenges. This article provides a review of current EN and PN best practices and special nutrition considerations for neonates, infants, and other pediatric patients. CONCLUSION: The provision of EN and PN to pediatric patients presents many unique challenges. It is important for pharmacists to keep current with pediatric- and neonatal-specific guidelines on nutritional management of various disease states, as well as strategies to address compounding and medication administration challenges, in order to optimize EN and PN outcomes.
Identifier
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<a href="http://doi.org/10.1093/ajhp/zxz174" target="_blank" rel="noreferrer noopener">10.1093/ajhp/zxz174</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2019
American journal of health-system pharmacy: AJHP: official journal of the American Society of Health-System Pharmacists
Cober Mary Petrea
compounding
Department of Pharmacy Practice
enteral
Gura Kathleen M
NEOMED College of Pharmacy
Neonatal
nutrition
October 2019 Update
Parenteral
Pediatric
Stability
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/MJT.0000000000001283" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/MJT.0000000000001283</a>
Volume
Publish Ahead of Print
ISSN
1536-3686 1075-2765
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/110.1097/MJT.0000000000001283" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1097/MJT.0000000000001283</a>
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Update Year & Number
January 2021 List
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmacy Practice
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Evaluating the impact of glucagon-like peptide-1 receptor agonists on metabolic changes in patients with type 2 diabetes on high-dose insulin.
Publisher
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American Journal of Therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-12-29
Creator
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Rentsch T; Awad M; Moorman JM; Gothard MD
Description
An account of the resource
BACKGROUND: Studies involving the glucagon-like peptide-1 receptor agonist (GLP-1 RA) liraglutide have shown reductions in hemoglobin A1c (HbA1c), weight, and insulin requirements in patients with type 2 diabetes mellitus (DM2) requiring high-dose insulin therapy. The effect of the class of GLP-1 RAs on these parameters is unknown. DATA SOURCES: A retrospective cohort analysis was conducted in patients with DM2 where a GLP-1 RA was added to high-dose insulin therapy. The primary composite outcome was the change from baseline to 9 months in HbA1c, weight, and insulin dose. RESULTS: GLP-1 RA therapy was associated with a significant reduction in HbA1c from baseline (-0.9%; P = 0.022). Weight and insulin dose were not significantly reduced from baseline. There was a moderate effect of individual agents on these outcomes, but no significant reductions were seen due to the small sample size. LIMITATIONS: Generalizability of these findings may be limited by the characteristics and size of the study population. THERAPEUTIC OPINION: The effect of GLP-1 RA therapy on HbA1c may be attributed to the medication class. The effect of individual agents on weight and insulin requirements needs further investigation.
Identifier
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<a href="http://doi.org/10.1097/MJT.0000000000001283" target="_blank" rel="noreferrer noopener">10.1097/MJT.0000000000001283</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
American journal of therapeutics
Awad M
Department of Pharmacy Practice
Gothard MD
January 2021 List
journalArticle
Moorman JM
NEOMED College of Pharmacy
Rentsch T