1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.cell.2014.03.039" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.cell.2014.03.039</a>
Pages
858–868
Issue
4
Volume
157
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Impact of circadian nuclear receptor REV-ERBalpha on midbrain dopamine production and mood regulation.
Publisher
An entity responsible for making the resource available
Cell
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-05
Subject
The topic of the resource
*Affect; *Circadian Rhythm; Animals; Bipolar Disorder/genetics; CLOCK Proteins/genetics/metabolism; Cytoplasmic and Nuclear/genetics/*metabolism; Dopamine/*metabolism; Genetic; Group A; Histones/metabolism; Humans; Inbred C57BL; Knockout; Male; Member 2/metabolism; Mesencephalon/*metabolism; Mice; Mood Disorders/genetics/metabolism; Nuclear Receptor Subfamily 4; Rats; Receptors; Repressor Proteins/genetics/*metabolism; Transcription; Tyrosine 3-Monooxygenase/genetics
Creator
An entity primarily responsible for making the resource
Chung Sooyoung; Lee Eun Jeong; Yun Seongsik; Choe Han Kyoung; Park Seong-Beom; Son Hyo Jin; Kim Kwang-Soo; Dluzen Dean E; Lee Inah; Hwang Onyou; Son Gi Hoon; Kim Kyungjin
Description
An account of the resource
The circadian nature of mood and its dysfunction in affective disorders is well recognized, but the underlying molecular mechanisms are still unclear. Here, we show that the circadian nuclear receptor REV-ERBalpha, which is associated with bipolar disorder, impacts midbrain dopamine production and mood-related behavior in mice. Genetic deletion of the Rev-erbalpha gene or pharmacological inhibition of REV-ERBalpha activity in the ventral midbrain induced mania-like behavior in association with a central hyperdopaminergic state. Also, REV-ERBalpha repressed tyrosine hydroxylase (TH) gene transcription via competition with nuclear receptor-related 1 protein (NURR1), another nuclear receptor crucial for dopaminergic neuronal function, thereby driving circadian TH expression through a target-dependent antagonistic mechanism. In conclusion, we identified a molecular connection between the circadian timing system and mood regulation, suggesting that REV-ERBalpha could be targeting in the treatment of circadian rhythm-related affective disorders.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.cell.2014.03.039" target="_blank" rel="noreferrer noopener">10.1016/j.cell.2014.03.039</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Affect
*Circadian Rhythm
2014
Animals
Bipolar Disorder/genetics
Cell
Choe Han Kyoung
Chung Sooyoung
CLOCK Proteins/genetics/metabolism
Cytoplasmic and Nuclear/genetics/*metabolism
Dluzen Dean E
Dopamine/*metabolism
Genetic
Group A
Histones/metabolism
Humans
Hwang Onyou
Inbred C57BL
Kim Kwang-Soo
Kim Kyungjin
Knockout
Lee Eun Jeong
Lee Inah
Male
Member 2/metabolism
Mesencephalon/*metabolism
Mice
Mood Disorders/genetics/metabolism
Nuclear Receptor Subfamily 4
Park Seong-Beom
Rats
Receptors
Repressor Proteins/genetics/*metabolism
Son Gi Hoon
Son Hyo Jin
Transcription
Tyrosine 3-Monooxygenase/genetics
Yun Seongsik
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/00207144.2017.1246870" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/00207144.2017.1246870</a>
Pages
43–51
Issue
1
Volume
65
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Forward Affect Bridge.
Publisher
An entity responsible for making the resource available
The International journal of clinical and experimental hypnosis
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-03
Subject
The topic of the resource
*Affect; Adult; Affect; American Psychological Association; Avoidance Learning; Depression – Risk Factors; Emotions; Female; Guided Imagery; Hope; Humans; Hypnosis; Hypnosis/*methods
Creator
An entity primarily responsible for making the resource
Bonshtein Udi; Torem Moshe
Description
An account of the resource
This article presents a modification of the affect bridge technique. The Forward Affect Bridge enables practitioners to create and maintain hope when it is missing. Hope is relevant for diminishing avoidance and being involved with necessary activities. The main idea is to build up a positive atmosphere in the here and now (relying on rapport), to amplify it, and to project it forward. By using clinical vignettes, the authors illustrate these techniques.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/00207144.2017.1246870" target="_blank" rel="noreferrer noopener">10.1080/00207144.2017.1246870</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Affect
2017
Adult
Affect
American Psychological Association
Avoidance Learning
Bonshtein Udi
Depression – Risk Factors
Emotions
Female
Guided Imagery
Hope
Humans
Hypnosis
Hypnosis/*methods
The International journal of clinical and experimental hypnosis
Torem Moshe