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Text
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URL Address
<a href="http://doi.org/10.1016/0028-3908(92)90050-y" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0028-3908(92)90050-y</a>
Pages
1223–1229
Issue
12
Volume
31
Dublin Core
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Title
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The aromatic amino acid decarboxylase inhibitor, NSD-1015, increases release of dopamine: response characteristics.
Publisher
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Neuropharmacology
Date
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1992
1992-12
Subject
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*Aromatic Amino Acid Decarboxylase Inhibitors; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Brain/*drug effects/metabolism; Dopamine/*metabolism; Hydrazines/*pharmacology; Male; Rats; Sprague-Dawley
Creator
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Dluzen D; Reddy A; McDermott J
Description
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Addition of the aromatic amino acid decarboxylase inhibitor, NSD-1015 (10 microM), to Krebs'-Ringer phosphate (KRP) superfusion medium, significantly increased the release of dopamine in vitro from superfused corpus striatum tissue fragments of male rats. A dose-dependent increase in release of dopamine was obtained in response to increasing concentrations of NSD-1015, with 1.0 microM being the minimally effective dose. In addition to the striatum, NSD-1015 also increased the release of dopamine from superfused hypothalamic tissue fragments. This capacity of NSD-1015 to increase release of dopamine was calcium-independent, appeared to be somewhat specific and could apparently increase the release of dopamine in vivo, as indicated by increases in the release of the metabolite of dopamine, DOPAC, under conditions of push-pull perfusion. Although the putative role of NSD-1015 is as an aromatic amino acid decarboxylase inhibitor, the present results demonstrate that, either as a result of this function and/or in addition to this role, NSD-1015 is a potent activator of the release of dopamine.
Identifier
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<a href="http://doi.org/10.1016/0028-3908(92)90050-y" target="_blank" rel="noreferrer noopener">10.1016/0028-3908(92)90050-y</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Aromatic Amino Acid Decarboxylase Inhibitors
1992
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Brain/*drug effects/metabolism
Dluzen D
Dopamine/*metabolism
Hydrazines/*pharmacology
Male
McDermott J
Neuropharmacology
Rats
Reddy A
Sprague-Dawley