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Text
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URL Address
<a href="http://doi.org/10.1016/j.heares.2016.06.006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2016.06.006</a>
Pages
80–93
Volume
339
Dublin Core
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Title
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Prepulse inhibition of the acoustic startle reflex vs. auditory brainstem response for hearing assessment.
Publisher
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Hearing research
Date
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2016
2016-09
Subject
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*Audiometric functions; *Hearing loss; *Mouse; *Permanent threshold shift; *Sound exposure; *Temporary threshold shift; Acoustic Stimulation/*methods; Animal; Animals; Audiometry; Auditory; Auditory Threshold/*physiology; Brain Stem/*physiology; Evoked Potentials; Hearing; Inbred CBA; Male; Mice; Models; Noise; Prepulse Inhibition/*physiology; Pure-Tone/*methods; Reflex; Startle/*physiology
Creator
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Longenecker R J; Alghamdi F; Rosen M J; Galazyuk A V
Description
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The high prevalence of noise-induced and age-related hearing loss in the general population has warranted the use of animal models to study the etiology of these pathologies. Quick and accurate auditory threshold determination is a prerequisite for experimental manipulations targeting hearing loss in animal models. The standard auditory brainstem response (ABR) measurement is fairly quick and translational across species, but is limited by the need for anesthesia and a lack of perceptual assessment. The goal of this study was to develop a new method of hearing assessment utilizing prepulse inhibition (PPI) of the acoustic startle reflex, a commonly used tool that measures detection thresholds in awake animals, and can be performed on multiple animals simultaneously. We found that in control mice PPI audiometric functions are similar to both ABR and traditional operant conditioning audiograms. The hearing thresholds assessed with PPI audiometry in sound exposed mice were also similar to those detected by ABR thresholds one day after exposure. However, three months after exposure PPI threshold shifts were still evident at and near the frequency of exposure whereas ABR thresholds recovered to the pre-exposed level. In contrast, PPI audiometry and ABR wave one amplitudes detected similar losses. PPI audiometry provides a high throughput automated behavioral screening tool of hearing in awake animals. Overall, PPI audiometry and ABR assessments of the auditory system are robust techniques with distinct advantages and limitations, which when combined, can provide ample information about the functionality of the auditory system.
Identifier
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<a href="http://doi.org/10.1016/j.heares.2016.06.006" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2016.06.006</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Audiometric functions
*Hearing loss
*Mouse
*Permanent threshold shift
*Sound exposure
*Temporary threshold shift
2016
Acoustic Stimulation/*methods
Alghamdi F
Animal
Animals
Audiometry
Auditory
Auditory Threshold/*physiology
Brain Stem/*physiology
Department of Anatomy & Neurobiology
Evoked Potentials
Galazyuk A V
Hearing
Hearing research
Inbred CBA
Longenecker R J
Male
Mice
Models
NEOMED College of Medicine
Noise
Prepulse Inhibition/*physiology
Pure-Tone/*methods
Reflex
Rosen M J
Startle/*physiology