1
40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.4161/chan.24328" target="_blank" rel="noreferrer noopener">http://doi.org/10.4161/chan.24328</a>
Pages
211–214
Issue
3
Volume
7
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A TRP to cardiac fibroblast differentiation.
Publisher
An entity responsible for making the resource available
Channels (Austin, Tex.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-06
Subject
The topic of the resource
Female; Humans; Male; Animals; TRPV4; *Wound Healing; TRPV Cation Channels/*metabolism; integrin; *Cell Differentiation; cardiac fibroblast; myofibroblast; *Calcium Signaling; *Cell Transdifferentiation; Atrial Fibrillation/*metabolism; differentiation; ECM stiffness; Fibroblasts/*metabolism/*physiology; mechanical signaling; Myofibroblasts/*cytology/*metabolism; Rho/ROCK; TRPC Cation Channels/*metabolism; TRPM Cation Channels/*metabolism; Cellular; *Mechanotransduction
Creator
An entity primarily responsible for making the resource
Thodeti Charles K; Paruchuri Sailaja; Meszaros J Gary
Description
An account of the resource
The differentiation of cardiac fibroblasts to myofibroblasts is one of the key events during cardiac remodeling, however, the molecular mechanism underlying this process is not well known. Calcium signaling plays an important role in the regulation of cardiac fibroblast function, but its role in the differentiation of fibroblasts is undefined. Recently four Transient Receptor Potential (TRP) channels TRPM7, TRPC3, TRPC6 and TRPV4 were shown to be crucial for the differentiation of cardiac fibroblasts to myofibroblasts. This addendum sums up the roles described for these four TRP channels in cardiac fibroblast differentiation, and discusses the possible molecular mechanisms underlying this process and its relevance for cardiac remodeling in disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.4161/chan.24328" target="_blank" rel="noreferrer noopener">10.4161/chan.24328</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Calcium Signaling
*Cell Differentiation
*Cell Transdifferentiation
*Mechanotransduction
*Wound Healing
2013
Animals
Atrial Fibrillation/*metabolism
cardiac fibroblast
Cellular
Channels (Austin, Tex.)
Department of Integrative Medical Sciences
differentiation
ECM stiffness
Female
Fibroblasts/*metabolism/*physiology
Humans
integrin
Male
mechanical signaling
Meszaros J Gary
myofibroblast
Myofibroblasts/*cytology/*metabolism
NEOMED College of Medicine
Paruchuri Sailaja
Rho/ROCK
Thodeti Charles K
TRPC Cation Channels/*metabolism
TRPM Cation Channels/*metabolism
TRPV Cation Channels/*metabolism
TRPV4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.yjmcc.2012.10.016" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.yjmcc.2012.10.016</a>
Pages
45–52
Volume
54
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals.
Publisher
An entity responsible for making the resource available
Journal of molecular and cellular cardiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-01
Subject
The topic of the resource
*Calcium Signaling; *Cell Differentiation; *Mechanotransduction; Animals; Cellular; Extracellular Matrix/metabolism/physiology; Fibroblasts/*physiology; Gene Knockdown Techniques; Male; Monoterpenes/pharmacology; Myocardium/cytology; Myofibroblasts/metabolism; Rats; RNA; Small Interfering/genetics; Sprague-Dawley; Transforming Growth Factor beta1/physiology; TRPM Cation Channels/antagonists & inhibitors/metabolism; TRPV Cation Channels/genetics/*metabolism
Creator
An entity primarily responsible for making the resource
Adapala Ravi K; Thoppil Roslin J; Luther Daniel J; Paruchuri Sailaja; Meszaros J Gary; Chilian William M; Thodeti Charles K
Description
An account of the resource
The phenotypic switch underlying the differentiation of cardiac fibroblasts into hypersecretory myofibroblasts is critical for cardiac remodeling following myocardial infarction. Myofibroblasts facilitate wound repair in the myocardium by secreting and organizing extracellular matrix (ECM) during the wound healing process. However, the molecular mechanisms involved in myofibroblast differentiation are not well known. TGF-beta has been shown to promote differentiation and this, combined with the robust mechanical environment in the heart, lead us to hypothesize that the mechanotransduction and TGF-beta signaling pathways play active roles in the differentiation of cardiac fibroblasts to myofibroblasts. Here, we show that the mechanosensitve ion channel TRPV4 is required for TGF-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. We found that the TRPV4-specific antagonist AB159908 and siRNA knockdown of TRPV4 significantly inhibited TGFbeta1-induced differentiation as measured by incorporation of alpha-SMA into stress fibers. Further, we found that
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.yjmcc.2012.10.016" target="_blank" rel="noreferrer noopener">10.1016/j.yjmcc.2012.10.016</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Calcium Signaling
*Cell Differentiation
*Mechanotransduction
2013
Adapala Ravi K
Animals
Cellular
Chilian William M
Department of Integrative Medical Sciences
Extracellular Matrix/metabolism/physiology
Fibroblasts/*physiology
Gene Knockdown Techniques
Journal of molecular and cellular cardiology
Luther Daniel J
Male
Meszaros J Gary
Monoterpenes/pharmacology
Myocardium/cytology
Myofibroblasts/metabolism
NEOMED College of Medicine
Paruchuri Sailaja
Rats
RNA
Small Interfering/genetics
Sprague-Dawley
Thodeti Charles K
Thoppil Roslin J
Transforming Growth Factor beta1/physiology
TRPM Cation Channels/antagonists & inhibitors/metabolism
TRPV Cation Channels/genetics/*metabolism