1
40
5
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(90)90400-c" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(90)90400-c</a>
Pages
255–260
Issue
2
Volume
36
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ethanol interoceptive cue and sleep-time duration in HAS and LAS selectively bred rats.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-06
Subject
The topic of the resource
Male; Time Factors; Animals; Phenotype; Rats; Species Specificity; Ethanol/*pharmacology; *Cues; *Discrimination Learning; *Hypnotics and Sedatives; Breeding; Sleep/*drug effects
Creator
An entity primarily responsible for making the resource
Krimmer E C
Description
An account of the resource
The drug discrimination paradigm was used to evaluate the effects of selective breeding for differential sensitivity to the hypnotic effects of ethanol. Tenth generation high alcohol sensitive (HAS) and low alcohol sensitive (LAS) rats were trained to discriminate between ethanol (0.6 g/kg, IP) and saline vehicle on a
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(90)90400-c" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(90)90400-c</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Cues
*Discrimination Learning
*Hypnotics and Sedatives
1990
Animals
Breeding
Ethanol/*pharmacology
Krimmer E C
Male
Pharmacology, biochemistry, and behavior
Phenotype
Rats
Sleep/*drug effects
Species Specificity
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0024-3205(96)00668-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0024-3205(96)00668-6</a>
Pages
PL83–90
Issue
6
Volume
60
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Serotonergic mediation of fenfluramine discriminative stimuli in fawn-hooded rats.
Publisher
An entity responsible for making the resource available
Life sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1905-06
Subject
The topic of the resource
*Discrimination Learning; 4-methylenedioxyamphetamine/pharmacology; Animals; Dose-Response Relationship; Drug; Fenfluramine/administration & dosage/*pharmacology; Fluoxetine/pharmacology; Ibogaine/pharmacology; Male; Methoxydimethyltryptamines/pharmacology; N-Methyl-3; Piperazines/pharmacology; Quipazine/pharmacology; Rats; Serotonin Agents/administration & dosage/*pharmacology; Serotonin Receptor Agonists/pharmacology; Serotonin/*metabolism; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Fenfluramine, a drug that induces increased synaptic serotonin, was used to train Fawn-Hooded rats in a drug discrimination paradigm. This strain of rats is thought to possess a genetic serotonin storage abnormality. The intent of the study was to see if the Fawn-Hooded rat was similar or dissimilar to the more frequently used strain of Sprague-Dawley rat in its ability to learn to discriminate 2.0 mg/kg fenfluramine administered intraperitoneally. In addition, drugs presumed to work upon central serotonergic neurons were given to the fenfluramine-trained Fawn-Hooded rats to investigate if the cueing properties of the training drug generalized to other agents. Results indicate that the Fawn-Hooded rats learn to discriminate fenfluramine from its vehicle at the same rate, and with a similar sensitivity to lower doses, as do the Sprague-Dawley rats. Furthermore, fenfluramine was shown to completely generalize to MDMA (over 90%); TFMPP, m-CPP, quipazine and fluoxetine produced intermediate results (over 70%) and 5-MeODMT and ibogaine were vehicle-like (less than 70%). As these results coincide with those previously found in Sprague-Dawley rats, the conclusion is that the functional capacity to discriminate fenfluramine appears to be like that of other rat lines, and serotonergically-mediated, in the Fawn-Hooded rat. Suggestions to explain these results are offered and discussed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0024-3205(96)00668-6" target="_blank" rel="noreferrer noopener">10.1016/s0024-3205(96)00668-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination Learning
1997
4-methylenedioxyamphetamine/pharmacology
Animals
Dose-Response Relationship
Drug
Fenfluramine/administration & dosage/*pharmacology
Fluoxetine/pharmacology
Ibogaine/pharmacology
Life sciences
Male
Methoxydimethyltryptamines/pharmacology
N-Methyl-3
Piperazines/pharmacology
Quipazine/pharmacology
Rats
Schechter M D
Serotonin Agents/administration & dosage/*pharmacology
Serotonin Receptor Agonists/pharmacology
Serotonin/*metabolism
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0741-8329(93)90056-t" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0741-8329(93)90056-t</a>
Pages
77–81
Issue
1
Volume
10
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ethanol discrimination in Fawn-Hooded rats is compromised when compared to other strains.
Publisher
An entity responsible for making the resource available
Alcohol (Fayetteville, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-02
Subject
The topic of the resource
*Discrimination Learning; Animals; Dose-Response Relationship; Drug; Ethanol/*pharmacology; Male; Rats; Serotonin/physiology; Species Specificity; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Schechter M D; Meehan S M
Description
An account of the resource
The drug discrimination paradigm was used to evaluate the behavioral differences in response to ethanol between three strains of rats, viz., Sprague-Dawley, N/Nih and Fawn-Hooded. This latter group is thought to have a genetically-transmitted diminished central serotonin function. Each group of rats was trained to discriminate between the stimulus properties of 600 mg/kg ethanol and its vehicle in a two-lever, food-motivated operant task. Results indicate that the Fawn-Hooded rats required a significantly longer time and a higher ethanol dose to reach criterion discrimination performance. Furthermore, the ED50 value of the Fawn-Hooded rats, once trained, was higher than the Sprague-Dawley or N/Nih rats. The possibility that a reciprocal relationship exists between lowered central serotonin concentrations and higher alcohol consumption is suggested and the hypothesis that the diminished ability to recognize the interoceptive stimuli produced by ethanol may result in larger amounts of ethanol being consumed is offered.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0741-8329(93)90056-t" target="_blank" rel="noreferrer noopener">10.1016/0741-8329(93)90056-t</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination Learning
1993
Alcohol (Fayetteville, N.Y.)
Animals
Dose-Response Relationship
Drug
Ethanol/*pharmacology
Male
Meehan S M
Rats
Schechter M D
Serotonin/physiology
Species Specificity
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0741-8329(92)90021-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0741-8329(92)90021-2</a>
Pages
117–122
Issue
2
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ethanol-produced interoceptive stimuli are time dependent in selectively bred HAS and LAS rats.
Publisher
An entity responsible for making the resource available
Alcohol (Fayetteville, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-04
Subject
The topic of the resource
*Discrimination Learning; Animals; Dose-Response Relationship; Drug; Drug Tolerance; Ethanol/administration & dosage/*pharmacology; Male; Rats; Time Factors
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Fourteenth generation high alcohol-sensitive (HAS) and low alcohol-sensitive (LAS) rats were trained to discriminate the effects of 600 mg/kg intraperitoneally administered ethanol from its vehicle at 6 and 30 min postadministration. Each of the earlier- and later-trained animals were given lower doses of ethanol and ED50 values at their trained postadministration interval were found to be nonsignificantly different. Thus, there was no difference between HAS and LAS animals as to their sensitivity to the discriminative effects of ethanol. Phase-generalization studies, where rats trained at 6 min postadministration were tested with the drug at 30 min postadministration were shown not to generalize, whereas the animals trained at 30 min postadministration and tested at 6 min postinjection were shown to readily discriminate the discriminative stimuli. This asymmetrical generalization lends evidence to the biphasic action of ethanol, and suggests that the earlier phase is quantitatively different than the latter phase. The similarity in sensitivity of the LAS and HAS animals, furthermore, suggests that the discrimination of ethanol is not based on its hypnotic effects.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0741-8329(92)90021-2" target="_blank" rel="noreferrer noopener">10.1016/0741-8329(92)90021-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination Learning
1992
Alcohol (Fayetteville, N.Y.)
Animals
Dose-Response Relationship
Drug
Drug Tolerance
Ethanol/administration & dosage/*pharmacology
Male
Rats
Schechter M D
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0741-8329(92)90012-y" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0741-8329(92)90012-y</a>
Pages
71–74
Issue
1
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
HAD and LAD rats respond differently to stimulating effect but not discriminative effects of ethanol.
Publisher
An entity responsible for making the resource available
Alcohol (Fayetteville, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-02
Subject
The topic of the resource
*Discrimination Learning; Alcohol Drinking/*physiopathology; Animals; Ethanol/administration & dosage/*pharmacology; Male; Rats
Creator
An entity primarily responsible for making the resource
Krimmer E C; Schechter M D
Description
An account of the resource
The drug discrimination paradigm (DD) was used to evaluate behavioral differences of rats selectively bred for differential ethanol drinking preferences. Seventh-generation high alcohol-drinking (HAD) and low alcohol-drinking (LAD) rats were trained to discriminate between ethanol (0.5 g/kg, IP) and saline vehicle, following a 2-min presession interval (PI), using an FR-10 schedule of reinforcement. The HAD line was more responsive than the LAD line to the stimulating effect of ethanol as measured by total response rates. ED50 values of 0.239 and 0.244 g/kg for the HAD and LAD lines, respectively, do not reflect any difference in the discriminative effects of ethanol. Response rates during DD indicated a dissociation of rate-increasing effects and discriminative performance following ethanol. In addition to differential drinking preference, these data suggest that selective breeding for the HAD and LAD animals also involves the stimulant action of ethanol but not on the discriminative effects.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0741-8329(92)90012-y" target="_blank" rel="noreferrer noopener">10.1016/0741-8329(92)90012-y</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination Learning
1992
Alcohol (Fayetteville, N.Y.)
Alcohol Drinking/*physiopathology
Animals
Ethanol/administration & dosage/*pharmacology
Krimmer E C
Male
Rats
Schechter M D