1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0024-3205(90)90561-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0024-3205(90)90561-5</a>
Pages
17–24
Issue
1
Volume
47
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Comparison of anorectic drugs in rats trained to discriminate between satiation and deprivation.
Publisher
An entity responsible for making the resource available
Life sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1905-06
Subject
The topic of the resource
Male; Animals; Rats; Analysis of Variance; Discrimination Learning/*drug effects; Amphetamine/*pharmacology; *Food Deprivation; Fenfluramine/*analogs & derivatives/*pharmacology; Norfenfluramine/*pharmacology; Satiation/*drug effects; Dose-Response Relationship; Drug; Inbred Strains
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Eight male rats were trained to discriminate between the internal states produced by food deprivation of 3 hours (satiation) and that produced by food deprivation of 27 hours duration (deprivation). One lever, in a two-lever operant chamber, had to be pressed to receive reinforcement in the satiation state, whereas pressing the other lever was required when the rat was in the deprivation state. Once the rats were trained, increasing the number of hours of food deprivation, from 1 to 48 hours, resulted in more deprivation-appropriate lever responses in the two-lever operant task. Administration of doses of fenfluramine (0.5-1.5 mg.kg), its active metabolite norfenfluramine (0.25-1.0 mg/kg) or d-amphetamine (0.5-1.5 mg/kg) produced a dose-responsive decrease in deprivation-appropriate responses when each drug/dose was injected (i.p.) 15 min prior to deprivation (27 hours) testing. Norfenfluramine was 1.5 times more potent than fenfluramine which was 1.5 times more potent than amphetamine.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0024-3205(90)90561-5" target="_blank" rel="noreferrer noopener">10.1016/0024-3205(90)90561-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Food Deprivation
1990
Amphetamine/*pharmacology
Analysis of Variance
Animals
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Fenfluramine/*analogs & derivatives/*pharmacology
Inbred Strains
Life sciences
Male
Norfenfluramine/*pharmacology
Rats
Satiation/*drug effects
Schechter M D