Browse Items (19 total)
- Tags: *Gene Expression Regulation
Orphan receptors chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and retinoid X receptor (RXR) activate and bind the rat cholesterol 7alpha-hydroxylase gene (CYP7A).
Tags: *Gene Expression Regulation, *Receptors, 1997, Animals, Chiang J Y, Chickens, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Circadian Rhythm, COUP Transcription Factor I, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Department of Integrative Medical Sciences, DNA-Binding Proteins/*metabolism, Electrophoresis, Enzymologic, Genetic, Glucocorticoid/*genetics, Models, Molecular, NEOMED College of Medicine, Nuclear Proteins/*metabolism, Polyacrylamide Gel, Promoter Regions, Rats, Receptors, Recombinant Proteins/genetics/metabolism, Retinoic Acid/*metabolism, Retinoid X Receptors, Steroid, Stroup D, The Journal of biological chemistry, Transcription Factors/*metabolism
Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA.
Tags: *Gene Expression Regulation, 1990, Amino Acid Sequence, Animals, Base Sequence, Cell Fractionation, Centrifugation, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics/immunology, Cholestyramine Resin/pharmacology, Circadian Rhythm, Cloning, Cytochrome P-450 Enzyme System/genetics, Density Gradient, Department of Integrative Medical Sciences, DNA/genetics/isolation & purification, Enzyme Induction, Enzymologic, Epitopes/analysis, Female, Immunoblotting, Inbred Strains, Kinetics, Li Y C, Liver/drug effects/*enzymology, Messenger/*genetics, Molecular Sequence Data, Molecular/methods, NEOMED College of Medicine, Nucleic Acid, Polyribosomes/metabolism/ultrastructure, Rats, Restriction Mapping, RNA, Sequence Homology, Steroid Hydroxylases/*genetics, The Journal of biological chemistry, Wang D P
Tags: *Gene Expression Regulation, 1992, Ahmad I, Animals, Autoradiography, Blotting, Finkelstein J A, Genetic, Growth Hormone/*genetics/metabolism, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, Male, Messenger/*analysis, Northern, Nucleic Acid Hybridization, Obesity/*etiology/physiopathology, Pituitary Gland/*chemistry/metabolism, Rats, RNA, Steggles A W, Transcription, Zucker
A class of genes in the HER2 regulon that is poised for transcription in breast cancer cell lines and expressed in human breast tumors.
Tags: *Gene Expression Profiling, *Gene Expression Regulation, 2015, Blotting, Breast Neoplasms/genetics/pathology, Cell Line, Char Jessica E, Chen Xin, ErbB-2/*genetics/metabolism, Franke Anna-Clara, Gene Regulatory Networks, Homeodomain Proteins/genetics/metabolism, Humans, Jia Zhenyu, Jones Frank E, McClelland Michael, MCF-7 Cells, Men Bozhao, Mercola Dan, Nanog Homeobox Protein, Neoplastic, Neoplastic Stem Cells/metabolism, Octamer Transcription Factor-3/genetics/metabolism, Oncotarget, Rahmatpanah Farah B, Receptor, Regulon/*genetics, Reverse Transcriptase Polymerase Chain Reaction, RNA Polymerase II/metabolism, SOXB1 Transcription Factors/genetics/metabolism, Tumor, Tumor Microenvironment/genetics, Western
TGFbeta1, TNFalpha, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression.
Tags: *Gene Expression Regulation, 2008, Animals, Cell Line, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Department of Integrative Medical Sciences, Enzymologic, Forkhead Transcription Factors/physiology, Humans, Insulin/*physiology, Journal of lipid research, Li Tiangang, Ma Huiyan, Male, NEOMED College of Medicine, Nerve Tissue Proteins/physiology, Rats, Signal Transduction, Smad3 Protein/antagonists & inhibitors/pharmacology, Sprague-Dawley, Transforming Growth Factor beta1/*physiology, Tumor, Tumor Necrosis Factor-alpha/*physiology
Tags: *Gene Expression Regulation, 2010, Acetylation, AMP-Activated Protein Kinases/metabolism, ATP Citrate (pro-S)-Lyase/genetics/metabolism, Bile Acids and Salts/metabolism, Cells, Chanda Dipanjan, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cultured, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Epigenesis, Genes, Genetic, Glucose/*administration & dosage, Hep G2 Cells, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/*enzymology/metabolism, Histones/metabolism, Humans, Hyperglycemia/enzymology/*metabolism, Journal of lipid research, Li Tiangang, Messenger/metabolism, Methylation, NEOMED College of Medicine, Reporter, RNA, RNA Interference, Zhang Yanqiao
Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.
Tags: *Gene Expression Regulation, *Transcriptional Activation, 2006, Adolescent, Adult, Animals, Chiang John Y L, Child, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/genetics, Department of Integrative Medical Sciences, Ellis Ewa, Enzymologic, Female, Forkhead Box Protein O1, Forkhead Transcription Factors/*physiology, Hepatocytes/*enzymology, Humans, Insulin/metabolism/*physiology, Kong Xiaoying, Li Tiangang, Male, Middle Aged, NEOMED College of Medicine, Owsley Erika, Preschool, Rats, Sterol Regulatory Element Binding Protein 1/*physiology, Strom Stephen, The Journal of biological chemistry, Transcription Factors/*physiology
A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene.
Tags: *Gene Expression Regulation, 2006, Aged, Amino Acid Motifs, Bile Acids and Salts/metabolism, Cell Line, Cell Nucleus/metabolism, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*chemistry/*genetics, Cultured/metabolism, Department of Integrative Medical Sciences, Enzymologic, Female, Genes, Genetic, Gluconeogenesis, Glutathione Transferase/metabolism, Hepatocyte Nuclear Factor 4/metabolism/*physiology, Hepatocytes/metabolism, Homeodomain Proteins/metabolism/*physiology, Humans, Immunoprecipitation, Li Tiangang, Liver/metabolism, Luciferases/metabolism, Male, Messenger/metabolism, Middle Aged, NEOMED College of Medicine, Phosphoenolpyruvate Carboxykinase (ATP)/metabolism, Plasmids/metabolism, Protein Structure, Reporter, Response Elements, Reverse Transcriptase Polymerase Chain Reaction, RNA, Small Interfering/metabolism, Song Kwang-Hoon, Tertiary, The Journal of biological chemistry, Time Factors, Transcription, Transcriptional Activation, Transfection, Tumor Suppressor Proteins, Two-Hybrid System Techniques
Bcl-2 positively regulates Sox9-dependent chondrocyte gene expression by suppressing the MEK-ERK1/2 signaling pathway.
Tags: *Gene Expression Regulation, 2005, Adenoviridae/genetics, Animals, Apoptosis, beta-Galactosidase/metabolism, Blotting, Butadienes/pharmacology, Caspase Inhibitors, Cell Differentiation, Cell Line, Chondrocytes/*metabolism, Collagen Type II/metabolism, Department of Anatomy & Neurobiology, Down-Regulation, Enzyme Inhibitors/pharmacology, Fibroblasts/metabolism, Fluorescence, Genetic, High Mobility Group Proteins/*metabolism, Horton Walter E Jr, Lac Operon, Luciferases/metabolism, MAP Kinase Kinase Kinases/*metabolism, McBurney Denise, Messenger/metabolism, Microscopy, Mitogen-Activated Protein Kinase 1/*metabolism, Mitogen-Activated Protein Kinase 3/*metabolism, NEOMED College of Medicine, NF-kappa B/metabolism, Nitriles/pharmacology, Phenotype, Phosphorylation, Promoter Regions, Protein Kinase C-alpha, Protein Kinase C/antagonists & inhibitors, Proteoglycans/metabolism, Proto-Oncogene Proteins c-bcl-2/*metabolism, Rats, Reverse Transcriptase Polymerase Chain Reaction, RNA, Signal Transduction, Small Interfering/metabolism, SOX9 Transcription Factor, Sprague-Dawley, The Journal of biological chemistry, Time Factors, Transcription, Transcription Factors/*metabolism, Transfection, Western, Yagi Rieko
Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism.
Tags: *bile acid, *bile acid metabolism, *FXR, *Gene Expression Regulation, *GLP-1, *Lipid Metabolism, *liver metabolism, *Non-alcoholic Fatty Liver Disease, *Obesity, *TGR5, *type 2 diabetes, 2017, Animals, Bile Acids and Salts/*biosynthesis/genetics, Boehme Shannon, Chiang John Y L, Cytoplasmic and Nuclear/genetics/*metabolism, Department of Integrative Medical Sciences, Dietary Fats, G-Protein-Coupled/genetics/*metabolism, Glucagon-Like Peptide 1/genetics/metabolism, Glucose/metabolism, Gonzalez Frank, Knockout, Krausz Kristopher W, Lipid Metabolism, Liu Hailiang, Liver/*metabolism, Mice, NEOMED College of Medicine, Obesity/genetics/*metabolism/pathology, Pathak Preeti, Receptors, The Journal of biological chemistry, Xie Cen
Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity.
Tags: *Gene Expression Regulation, 2012, Animals, Bile Acids and Salts/*biosynthesis, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cytoplasmic and Nuclear/genetics/metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus, Dietary Fats/administration & dosage/adverse effects, Enzymologic, Epigenesis, Erickson Sandra K, Experimental/genetics/*metabolism, Fasting/metabolism, Francl Jessica M, Genetic/genetics, Glucose/*metabolism/pharmacology, Insulin/*metabolism, Klaassen Curtis D, Li Tiangang, Mice, NEOMED College of Medicine, Obesity/etiology/genetics/*metabolism, Ochoa Adrian, Postprandial Period/genetics, Receptors, Sweetening Agents/pharmacology, The Journal of biological chemistry, Transgenic, Zhang Youcai
Expression of pituitary adenylate cyclase activating peptide in the uterine cervix, lumbosacral dorsal root ganglia and spinal cord of rats during pregnancy.
Tags: *Gene Expression Regulation, 2006, Animals, Cervix Uteri/*metabolism, Department of Anatomy & Neurobiology, Fahrenkrug J, Female, Ganglia, Messenger, Mowa C N, NEOMED College of Medicine, Papka R E, Peptides, Pituitary Adenylate Cyclase-Activating Polypeptide/*genetics/*metabolism, Pregnancy, Rats, RNA, Spinal Cord/*metabolism, Spinal/*metabolism, Time Factors, Usip S, Workley M
Basic transcription element binding protein (BTEB) transactivates the cholesterol 7 alpha-hydroxylase gene (CYP7A).
Tags: *Gene Expression Regulation, 1998, Animals, Bile Acids and Salts/genetics, Binding Sites/genetics, Biochemical and biophysical research communications, Carcinoma, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Complementary/analysis, Cultured, Department of Integrative Medical Sciences, DNA, DNA-Binding Proteins/metabolism/*physiology, Electrophoresis, Enzyme Activation/genetics, Foti D, Genetic, Hepatocellular, Humans, Kruppel-Like Transcription Factors, Liver/enzymology, NEOMED College of Medicine, Podophyllin/analogs & derivatives/metabolism, Podophyllotoxin/analogs & derivatives, Polyacrylamide Gel, Promoter Regions, Protein Binding/genetics, Rats, Stroup D, Transcription Factors/metabolism/*physiology, Tumor Cells
Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells.
Tags: *Gene Expression Regulation, *Promoter Regions, 2000, Amino Acid Sequence, Archives of biochemistry and biophysics, Base Sequence, Cell Line, Chen L, Cloning, Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 4, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, DNA, DNA Footprinting, Enzymologic, Exons, Genes, Genetic, Genetic/drug effects, Hardwick J P, Humans, Introns, Leukotriene B4/metabolism, Mixed Function Oxygenases/metabolism, Models, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Peroxisome Proliferators/*metabolism, Receptors, Reporter, Retinoic Acid Receptor alpha, Retinoic Acid/metabolism, Sequence Analysis, Transcription, Transcription Factors/metabolism, Transfection, Tretinoin/*metabolism, Zhang X
Tags: *CARDIOVASCULAR DISEASE, *Gene Expression Regulation, *KIDNEY STONES, *METABOLIC BONE DISEASE, *MURINE MODEL, 2017, Animal, Animals, Atherosclerosis/*metabolism/pathology, Barr-Beare Evan, Calcium Oxalate/*metabolism, Disease Models, Journal of cellular biochemistry, Kidney/*metabolism/pathology, Kusumi Kirsten, Mice, Osteoporosis/*metabolism/pathology, Safedi Fayez, Saxena Vijay, Schwaderer Andrew, Urinary Calculi/*metabolism/pathology
A novel role for Bcl-2 associated-athanogene-1 (Bag-1) in regulation of the endoplasmic reticulum stress response in mammalian chondrocytes.
Tags: *Gene Expression Regulation, 2007, Animals, Apoptosis, Biological, Carlson Sara G, Cell Proliferation, Chondrocytes/*metabolism/pathology, Collagen Type II/metabolism, Department of Anatomy & Neurobiology, DNA-Binding Proteins/*metabolism/physiology, Endoplasmic Reticulum/metabolism, Horton Walter E Jr, Journal of cellular biochemistry, McBurney Denise, Models, NEOMED College of Medicine, Phenotype, Rats, RNA Interference, Subcellular Fractions/metabolism, Tang Shou-Ching, Time Factors, Transcription Factors/*metabolism/physiology, Transfection, Yang Ling
G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice.
Tags: *Gene Expression Regulation, 2017, Analysis of Variance, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Department of Integrative Medical Sciences, Disease Models, Donepudi Ajay C, Energy Metabolism/physiology, Fasting, Fatty Liver/*metabolism/pathology, G-Protein-Coupled/*genetics, Hepatology (Baltimore, Md.), Homeostasis/genetics, Inbred C57BL, Li Feng, Lipid Metabolism/genetics, Male, Mice, NEOMED College of Medicine, Oxygen Consumption/physiology, Random Allocation, Receptors, RNA-Binding Proteins/*metabolism, Signal Transduction