1
40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.1993.265.5.H1564" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1993.265.5.H1564</a>
Pages
H1564–1570
Issue
5
Volume
265
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Daily spontaneous running did not alter vagal afferent reactivity.
Publisher
An entity responsible for making the resource available
The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-11
Subject
The topic of the resource
*Blood Pressure/drug effects; *Heart Rate/drug effects; *Physical Conditioning; Afferent Pathways/drug effects/*physiology; Analysis of Variance; Animal; Animals; Biguanides/pharmacology; Body Weight; Female; Heart/anatomy & histology/drug effects/*physiology; Hypoglycemic Agents/pharmacology; Organ Size; Rats; Sprague-Dawley; Time Factors; Vagus Nerve/drug effects/*physiology
Creator
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Scislo T J; DiCarlo S E; Collins H L
Description
An account of the resource
Exercise training alters the cardiopulmonary baroreflex regulation of the circulation; however, the mechanisms responsible are unknown. One possibility is an enhanced afferent response to cardiopulmonary stimulation. We therefore tested the hypothesis that daily spontaneous running (DSR) would enhance cardiopulmonary vagal afferent responses to mechanical (increase in left atrial pressure, LAP) and chemical (phenyl biguanide, PBG) stimulation. Reactivity of single-fiber cardiopulmonary vagal afferents was evaluated in 16 control and 12 DSR anesthetized Sprague-Dawley rats. Rats were weaned at 3 wk of age and randomly assigned to a control or DSR group. Eight to twelve weeks of DSR was associated with a 27% increase in heart weight-to-body weight ratio (3.27 +/- 0.08 vs. 2.56 +/- 0.05 g/kg, P \textless 0.001) and resting bradycardia (394 +/- 10 vs. 421 +/- 8 beats/min, P = 0.036). However, DSR did not alter the stimulus-response curves to increases in LAP (frequency of discharge vs. LAP) for either the high-frequency (maximum response, sedentary 59.6 +/- 3.2, DSR 60.1 +/- 5.0 spikes/s) or low-frequency (maximum response, sedentary 20.0 +/- 2.9 DSR 20.6 +/- 3.9 spikes/s) receptors. Dose-response curves to chemical stimulation (spikes/s vs. PBG dose) were also not altered by DSR. Thus DSR did not change vagal afferent reactivity to mechanical or chemical stimulation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.1993.265.5.H1564" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1993.265.5.H1564</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Blood Pressure/drug effects
*Heart Rate/drug effects
*Physical Conditioning
1993
Afferent Pathways/drug effects/*physiology
Analysis of Variance
Animal
Animals
Biguanides/pharmacology
Body Weight
Collins H L
DiCarlo S E
Female
Heart/anatomy & histology/drug effects/*physiology
Hypoglycemic Agents/pharmacology
Organ Size
Rats
Scislo T J
Sprague-Dawley
The American journal of physiology
Time Factors
Vagus Nerve/drug effects/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.1994.267.4.H1537" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1994.267.4.H1537</a>
Pages
H1537–1543
Issue
4
Volume
267
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Gender difference in cardiopulmonary reflex inhibition of sympathetic nerve activity.
Publisher
An entity responsible for making the resource available
The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-10
Subject
The topic of the resource
*Blood Pressure/drug effects; *Heart Rate/drug effects; *Reflex/drug effects; Analysis of Variance; Animals; Biguanides/pharmacology; Denervation; Female; Laryngeal Nerves/physiology; Male; Phenylephrine/pharmacology; Pulmonary Circulation/drug effects/physiology; Rats; Sex Characteristics; Sinoatrial Node/*physiology; Sympathetic Nervous System/drug effects/*physiology
Creator
An entity primarily responsible for making the resource
Scislo T J; DiCarlo S E
Description
An account of the resource
We tested the hypothesis that reflex responses to mechanical [increase in left atrial pressure (LAP) 0-25 mmHg] and chemical stimulation [left atrial injection of phenylbiguanide (PBG), 0.5-10 mg/kg] of cardiopulmonary receptors are greater in female (n = 9; 335 +/- 9 g) than in male (n = 10; 558 +/- 23 g) age-matched rats. Anesthetized (500 mg/kg urethan and 80 mg/kg alpha-chloralose), tracheotomized, and artificially ventilated (100% oxygen), sinoaortic-denervated animals were instrumented with left atrial, femoral venous, and arterial catheters and a Tygon occluder around the ascending aorta. Reflex inhibition of lumbar sympathetic nerve activity (LSNA) vs. LAP and dose PBG was higher in female rats. A two-way analysis of variance revealed a significant gender effect, males vs. females (P = 0.023), and a significant gender x dose interaction (P \textless 0.001) for LSNA vs. LAP. There was also a significant gender x dose interaction (P \textless 0.001) for LSNA vs. PBG. However, there was no influence of gender on the reflex inhibition of mean arterial pressure (P = 0.751) or heart rate (P = 0.561). These responses were associated with a higher left ventricular weight-to-body weight ratio in females (2.14 +/- 0.06 vs. 1.95 +/- 0.07 g/kg, P = 0.039).
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.1994.267.4.H1537" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1994.267.4.H1537</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Blood Pressure/drug effects
*Heart Rate/drug effects
*Reflex/drug effects
1994
Analysis of Variance
Animals
Biguanides/pharmacology
Denervation
DiCarlo S E
Female
Laryngeal Nerves/physiology
Male
Phenylephrine/pharmacology
Pulmonary Circulation/drug effects/physiology
Rats
Scislo T J
Sex Characteristics
Sinoatrial Node/*physiology
Sympathetic Nervous System/drug effects/*physiology
The American journal of physiology