1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0166-0934(02)00160-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0166-0934(02)00160-x</a>
Pages
153–158
Issue
2
Volume
106
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A modification of the epidermal scarification model of herpes simplex virus infection to achieve a reproducible and uniform progression of disease.
Publisher
An entity responsible for making the resource available
Journal of virological methods
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-12
Subject
The topic of the resource
*Herpesvirus 1; Animal; Animals; Disease Models; Disease Progression; Female; Herpes Simplex/pathology/physiopathology/*transmission; Human; Humans; Inbred BALB C; Mice; Reproducibility of Results; Skin/virology
Creator
An entity primarily responsible for making the resource
Goel Neena; Docherty John J; Fu Ming Ming; Zimmerman Daniel H; Rosenthal Kenneth S
Description
An account of the resource
A slight modification in the method used to remove the top keratinized layer of skin in the epidermal scarification model of HSV infection results in an easier, less painful, more uniform and reproducible means of infection. The back of mice was depilated and the top skin layer was removed either by scratching with the side of a 26 gauge needle, or by abrading with sand paper or a hand held motorized pedicure/manicure instrument. The virus was then applied on the scarified or abraded skin and the mice were observed for lesion development from day 3 to 10 post-infection. A uniform pattern of lesion development in terms of onset of lesions by day 3, progression to zosteriform by day 5 occurred for mice whose skin was abraded whereas variability in the time course, progression of symptoms and greater trauma occurred for mice whose skin was scratched with needle.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0166-0934(02)00160-x" target="_blank" rel="noreferrer noopener">10.1016/s0166-0934(02)00160-x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Herpesvirus 1
2002
Animal
Animals
Disease Models
Disease Progression
Docherty John J
Female
Fu Ming Ming
Goel Neena
Herpes Simplex/pathology/physiopathology/*transmission
Human
Humans
Inbred BALB C
Journal of virological methods
Mice
Reproducibility of Results
Rosenthal Kenneth S
Skin/virology
Zimmerman Daniel H
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf02255857" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf02255857</a>
Pages
260–266
Issue
4
Volume
5
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mice transgenic for simian immunodeficiency virus nef are immunologically compromised.
Publisher
An entity responsible for making the resource available
Journal of biomedical science
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-08
Subject
The topic of the resource
*Genes; *Herpesvirus 1; *Immunocompromised Host; 3T3 Cells; Aging; Animals; Antibodies; Antibody Formation; Cellular; Cercopithecus aethiops; Female; Herpes Simplex/*immunology; HIV/pathogenicity; Human; Humans; Immunity; Immunoglobulin G/blood; Kinetics; Male; Mice; nef; Simian Immunodeficiency Virus/*genetics/pathogenicity; Transgenic; Vero Cells; Viral/biosynthesis/blood
Creator
An entity primarily responsible for making the resource
Larsen N B; Kestler H W; Docherty J J
Description
An account of the resource
An intact nef gene is essential for rapid development of immunodeficiency in human immunodeficiency virus and simian immunodeficiency virus infections. To assess the role of nef in the immune response, mice transgenic for SIV nef were constructed and the humoral and cellular immune response to herpes simplex virus type-1 (HSV-1), measured. Mice transgenic for SIVmac239 nef exhibited a significantly increased mortality rate when challenged with HSV-1 and also showed unusual antibody kinetics in response to viral challenge. During a 32-week period following exposure to HSV, it was noted that IgG subclass titers continued to rise in the nef+ animals, while titers of nef- animals decreased. Additionally, following secondary challenge with HSV, nef- mice had a significantly greater rise in HSV-neutralizing antibody titers than nef+ mice. A decreased proliferative response to the T cell mitogen, PHA, was noted in the nef+ animals. These results suggest that the presence of nef+ is sufficient to induce immune dysfunction.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf02255857" target="_blank" rel="noreferrer noopener">10.1007/bf02255857</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Genes
*Herpesvirus 1
*Immunocompromised Host
1998
3T3 Cells
Aging
Animals
Antibodies
Antibody Formation
Cellular
Cercopithecus aethiops
Docherty J J
Female
Herpes Simplex/*immunology
HIV/pathogenicity
Human
Humans
Immunity
Immunoglobulin G/blood
Journal of biomedical science
Kestler H W
Kinetics
Larsen N B
Male
Mice
nef
Simian Immunodeficiency Virus/*genetics/pathogenicity
Transgenic
Vero Cells
Viral/biosynthesis/blood