1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/j.neuro.2016.03.023" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuro.2016.03.023</a> Pages 72–80 Volume 54 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Trimethyltin intoxication induces the migration of ventricular/subventricular zone cells to the injured murine hippocampus. Publisher An entity responsible for making the resource available Neurotoxicology Date A point or period of time associated with an event in the lifecycle of the resource 2016 2016-05 Subject The topic of the resource *Brain injury; *Hippocampus; *Neural stem cells; *Neurogenesis; *Subventricular stem cells; *Trimethyltin; Amino Acids/metabolism; Animals; Brain Injuries/*pathology; Bromodeoxyuridine/metabolism; Cell Movement/*drug effects; Functional Laterality; Glial Fibrillary Acidic Protein/metabolism; Hippocampus/*pathology; Inbred C3H; Lateral Ventricles/drug effects/*pathology; Male; Mice; Neurogenesis/drug effects/physiology; Trimethyltin Compounds/*toxicity Creator An entity primarily responsible for making the resource Weig Blair C; Richardson Jason R; Lowndes Herbert E; Reuhl Kenneth R Description An account of the resource Following the postnatal decline of cell proliferation in the mammalian central nervous system, the adult brain retains progenitor cells with stem cell-like properties in the subventricular zone (SVZ) and the subgranular zone (SGZ) of the hippocampus. Brain injury can stimulate proliferation and redirect the migration pattern of SVZ precursor cells to the injury site. Sublethal exposure to the neurotoxicant trimethyltin (TMT) causes dose-dependent necrosis and apoptosis in the hippocampus dentate gyrus and increases SGZ stem cell proliferation to generate new granule cells. To determine whether SVZ cells also contribute to the repopulation of the TMT-damaged dentate gyrus, 6-8 week old male C3H mice were injected with the carbocyanine dye spDiI and bromodeoxyuridine (80mg/kg; ip.) to label ventricular cells prior to TMT exposure. The presence of labeled cells in hippocampus was determined 7 and 28days after TMT exposure. No significant change in the number of BrdU(+) and spDiI(+) cells was observed in the dentate gyrus 7days after TMT treatment. However, 28days after TMT treatment there was a 3-4 fold increase in the number of spDiI-labeled cells in the hippocampal hilus and dentate gyrus. Few spDiI(+) cells stained positive for the mature phenotypic markers NeuN or GFAP, suggesting they may represent undifferentiated cells. A small percentage of migrating cells were BrdU(+)/spDiI(+), indicating some newly produced, SVZ- derived precursors migrated to the hippocampus. Taken together, these data suggest that TMT-induced injury of the hippocampus can stimulate the migration of ventricular zone-derived cells to injured dentate gyrus. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.neuro.2016.03.023" target="_blank" rel="noreferrer noopener">10.1016/j.neuro.2016.03.023</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *Brain injury *Hippocampus *Neural stem cells *Neurogenesis *Subventricular stem cells *Trimethyltin 2016 Amino Acids/metabolism Animals Brain Injuries/*pathology Bromodeoxyuridine/metabolism Cell Movement/*drug effects Department of Pharmaceutical Sciences Functional Laterality Glial Fibrillary Acidic Protein/metabolism Hippocampus/*pathology Inbred C3H Lateral Ventricles/drug effects/*pathology Lowndes Herbert E Male Mice NEOMED College of Pharmacy Neurogenesis/drug effects/physiology Neurotoxicology Reuhl Kenneth R Richardson Jason R Trimethyltin Compounds/*toxicity Weig Blair C