1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1194/jlr.M069807" target="_blank" rel="noreferrer noopener">http://doi.org/10.1194/jlr.M069807</a>
Pages
1831–1844
Issue
10
Volume
57
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cholesterol 7alpha-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis.
Publisher
An entity responsible for making the resource available
Journal of lipid research
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-10
Subject
The topic of the resource
*bile acid; *Cholesterol 7-alpha-Hydroxylase/genetics/metabolism; *farnesoid X receptor; *Homeostasis; *Liver Cirrhosis/chemically induced/enzymology/genetics/prevention & control; *Liver/enzymology/pathology; *nuclear receptor; *Takeda G protein-coupled receptor 5; Animals; Cholesterol/genetics/*metabolism; G-Protein-Coupled/genetics/metabolism; Hep G2 Cells; Humans; Knockout; Mice; NF-kappa B/genetics/metabolism; Oxidative Stress; Receptors; Tumor Necrosis Factor-alpha/genetics/metabolism
Creator
An entity primarily responsible for making the resource
Liu Hailiang; Pathak Preeti; Boehme Shannon; Chiang John Y L
Description
An account of the resource
Cholesterol 7alpha-hydroxylase (CYP7A1) plays a critical role in control of bile acid and cholesterol homeostasis. Bile acids activate farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) to regulate lipid, glucose, and energy metabolism. However, the role of bile acids in hepatic inflammation and fibrosis remains unclear. In this study, we showed that adenovirus-mediated overexpression of Cyp7a1 ameliorated lipopolysaccharide (LPS)-induced inflammatory cell infiltration and pro-inflammatory cytokine production in WT and
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1194/jlr.M069807" target="_blank" rel="noreferrer noopener">10.1194/jlr.M069807</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*bile acid
*Cholesterol 7-alpha-Hydroxylase/genetics/metabolism
*Farnesoid X receptor
*Homeostasis
*Liver Cirrhosis/chemically induced/enzymology/genetics/prevention & control
*Liver/enzymology/pathology
*nuclear receptor
*Takeda G protein-coupled receptor 5
2016
Animals
Boehme Shannon
Chiang John Y L
Cholesterol/genetics/*metabolism
Department of Integrative Medical Sciences
G-Protein-Coupled/genetics/metabolism
Hep G2 Cells
Humans
Journal of lipid research
Knockout
Liu Hailiang
Mice
NEOMED College of Medicine
NF-kappa B/genetics/metabolism
Oxidative Stress
Pathak Preeti
Receptors
Tumor Necrosis Factor-alpha/genetics/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.1994.76.2.783" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1994.76.2.783</a>
Pages
783–786
Issue
2
Volume
76
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Daily exercise improved blood pressure homeostasis of rats subjected to surgical stress.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-02
Subject
The topic of the resource
*Blood Pressure; *Homeostasis; *Physical Conditioning; Animal; Animals; Female; Male; Operative/*adverse effects; Physiological/*etiology/*physiopathology; Rats; Running; Sprague-Dawley; Stress; Surgical Procedures
Creator
An entity primarily responsible for making the resource
Scislo T J; DiCarlo S E; Jarjoura D G
Description
An account of the resource
The effect of daily spontaneous running on blood pressure homeostasis (BPH) was evaluated in 19 male and 13 female control rats and 7 male and 13 female daily spontaneous running rats subjected to surgery and subsequent repetitive hemodynamic disturbances. BPH was operationally defined as the ability to maintain mean arterial pressure above 60 mmHg during the experimental protocol. The length of time the rats maintained BPH was compared across males and females and trained and control groups. Significant sex (P = 0.01) and training (P = 0.05) effects were found. Females maintained homeostasis longer than males and trained longer than controls. Sex effects were not due to differences in the body mass. The mechanisms responsible for the higher resistance to deterioration of homeostasis merit further investigation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.1994.76.2.783" target="_blank" rel="noreferrer noopener">10.1152/jappl.1994.76.2.783</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Blood Pressure
*Homeostasis
*Physical Conditioning
1994
Animal
Animals
DiCarlo S E
Female
Jarjoura D G
Journal of applied physiology (Bethesda, Md. : 1985)
Male
Operative/*adverse effects
Physiological/*etiology/*physiopathology
Rats
Running
Scislo T J
Sprague-Dawley
Stress
Surgical Procedures
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/hep.26714" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/hep.26714</a>
Pages
1761–1771
Issue
5
Volume
59
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis.
Publisher
An entity responsible for making the resource available
Hepatology (Baltimore, Md.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-05
Subject
The topic of the resource
*Homeostasis; *Lipid Metabolism; Animals; Carboxylic Ester Hydrolases/*physiology; Cholesterol/blood; Cytoplasmic and Nuclear/*physiology; Fatty Acids/metabolism; Inbred C57BL; Lipogenesis; Liver/*enzymology; Mice; Receptors; Sterol Regulatory Element Binding Protein 1/physiology; Triglycerides/metabolism
Creator
An entity primarily responsible for making the resource
Xu Jiesi; Li Yuanyuan; Chen Wei-Dong; Xu Yang; Yin Liya; Ge Xuemei; Jadhav Kavita; Adorini Luciano; Zhang Yanqiao
Description
An account of the resource
UNLABELLED: Nonalcoholic fatty liver disease (NAFLD) is one of the major health concerns worldwide. Farnesoid X receptor (FXR) is considered a therapeutic target for treatment of NAFLD. However, the mechanism by which activation of FXR lowers hepatic triglyceride (TG) levels remains unknown. Here we investigated the role of hepatic carboxylesterase 1 (CES1) in regulating both normal and FXR-controlled lipid homeostasis. Overexpression of hepatic CES1 lowered hepatic TG and plasma glucose levels in both wild-type and diabetic mice. In contrast, knockdown of hepatic CES1 increased hepatic TG and plasma cholesterol levels. These effects likely resulted from the TG hydrolase activity of CES1, with subsequent changes in fatty acid oxidation and/or de novo lipogenesis. Activation of FXR induced hepatic CES1, and reduced the levels of hepatic and plasma TG as well as plasma cholesterol in a CES1-dependent manner. CONCLUSION: Hepatic CES1 plays a critical role in regulating both lipid and carbohydrate metabolism and FXR-controlled lipid homeostasis.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/hep.26714" target="_blank" rel="noreferrer noopener">10.1002/hep.26714</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Homeostasis
*Lipid Metabolism
2014
Adorini Luciano
Animals
Carboxylic Ester Hydrolases/*physiology
Chen Wei-Dong
Cholesterol/blood
Cytoplasmic and Nuclear/*physiology
Department of Integrative Medical Sciences
Fatty Acids/metabolism
Ge Xuemei
Hepatology (Baltimore, Md.)
Inbred C57BL
Jadhav Kavita
Li Yuanyuan
Lipogenesis
Liver/*enzymology
Mice
NEOMED College of Medicine
Receptors
Sterol Regulatory Element Binding Protein 1/physiology
Triglycerides/metabolism
Xu Jiesi
Xu Yang
Yin Liya
Zhang Yanqiao