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Tags: *IL-6

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Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1beta-induced IL-6 expression in human OA chondrocytes.

AIM OF THE STUDY: High levels of IL-6 are believed to contribute to osteoarthritis (OA) pathogenesis. The expression of IL-6 is regulated post-transcriptionally by the miR-9-MCPIP-1 axis in chondrocytes. Vorinostat (SAHA) inhibits the IL-6 expression…

Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes.

There is growing evidence in support of the involvement of inflammatory response in the pathogenesis of osteoarthritis (OA). Harpagoside, one of the bioactive components of Harpagophytum procumbens (Hp), has been shown to possess anti-inflammatory…

Tags: *c-FOS/AP-1, *harpagoside, *IL-6, *MMP-13, *OSTEOARTHRITIS, 2017, Ansari Mohammad Yunus, CCAAT-Enhancer-Binding Protein-beta/metabolism, Chemokines/metabolism, Chondrocytes/*drug effects/metabolism, Department of Anatomy & Neurobiology, Drug Evaluation, Glycosides/pharmacology/*therapeutic use, Haqqi Tariq M, Harpagophytum, Haseeb Abdul, Humans, Interleukin-1beta, Interleukin-6/antagonists & inhibitors/*metabolism, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, Matrix Metalloproteinase 13/metabolism, NEOMED College of Medicine, NF-kappa B/metabolism, Osteoarthritis/*drug therapy/metabolism, Phytotherapy, Plant Extracts/pharmacology/therapeutic use, Preclinical, Primary Cell Culture, Proto-Oncogene Proteins c-fos/metabolism, Pyrans/pharmacology/*therapeutic use, Reactive Oxygen Species/metabolism, Transcription Factor AP-1/metabolism

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