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Text
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<a href="http://doi.org/10.1186/s12944-016-0314-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1186/s12944-016-0314-4</a>
Pages
141–141
Issue
1
Volume
15
Dublin Core
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Title
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The therapeutic efficacy of intensive medical therapy in ameliorating high-density lipoprotein dysfunction in subjects with type two diabetes.
Publisher
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Lipids in health and disease
Date
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2016
2016-08
Subject
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*Diet; *Exercise Therapy; *Intensive medical therapy; *Myeloperoxidase; *Paraoxonase one; *Pro-inflammatory high-density lipoproteins; Adult; Apolipoprotein A-I/blood/drug effects; Biguanides/pharmacology/therapeutic use; Combined Modality Therapy; Diabetes Mellitus; Diabetic; Female; HDL/blood/*drug effects; Humans; Hypoalphalipoproteinemias/complications/diet therapy/drug therapy/therapy; Hypoglycemic Agents/*pharmacology/therapeutic use; Insulin/analogs & derivatives/pharmacology/therapeutic use; Lipoproteins; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Type 2/blood/complications/*therapy
Creator
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Kashyap Sangeeta; Kheniser Karim; Li Ling; Bena James; Kasumov Takhar
Description
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BACKGROUND: To determine whether 12 months of intensive medical therapy (IMT) improves HDL functionality parameters in subjects with type II diabetes (T2D). METHODS: Retrospective, randomized, and controlled 12-month IMT intervention trial that enrolled 13-subjects with T2D (age 51- years, fasting glucose 147 mg/dL, body mass index [BMI] 36.5 kg/m(2)) and nine healthy control (46-years, fasting glucose 90 mg/dL, BMI 26.5 kg/m2). Subjects with T2D underwent IMT and HDL functionality measures (pro-inflammatory index of high-density lipoprotein (pHDL)), paraoxonase one (PON1), ceruloplasmin (Cp), and myeloperoxidase (MPO) activity were performed on samples at baseline and at 12-months following IMT. RESULTS: At baseline, pHDL index was significantly higher in subjects with T2D (p \textless 0.001) and apolipoprotein A-1 levels were significantly lower (p = 0.013) vs. CONTROLS: After 12-months, there was a trend for improved pHDL activity (p = 0.083), as indicated by intent-to-treat analysis, but when the non-adherent subject was omitted (per-protocol), significant attenuations in pHDL activity (p = 0.040) were noted; Delta pHDL activity at 12-months was associated with Delta weight (r = 0.62, p = 0.032) and Delta fasting glucose (r = 0.65, p = 0.022). Moreover, PON1 activity significantly improved (p \textless 0.001). The aforementioned occurred in association with improvements in inflammatory markers (i.e.,
Identifier
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<a href="http://doi.org/10.1186/s12944-016-0314-4" target="_blank" rel="noreferrer noopener">10.1186/s12944-016-0314-4</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Diet
*Exercise Therapy
*Intensive medical therapy
*Myeloperoxidase
*Paraoxonase one
*Pro-inflammatory high-density lipoproteins
2016
Adult
Apolipoprotein A-I/blood/drug effects
Bena James
Biguanides/pharmacology/therapeutic use
Combined Modality Therapy
Department of Pharmaceutical Sciences
Diabetes Mellitus
Diabetic
Female
HDL/blood/*drug effects
Humans
Hypoalphalipoproteinemias/complications/diet therapy/drug therapy/therapy
Hypoglycemic Agents/*pharmacology/therapeutic use
Insulin/analogs & derivatives/pharmacology/therapeutic use
Kashyap Sangeeta
Kasumov Takhar
Kheniser Karim
Li Ling
Lipids in health and disease
Lipoproteins
Male
Middle Aged
NEOMED College of Pharmacy
Retrospective Studies
Treatment Outcome
Type 2/blood/complications/*therapy