Browse Items (6 total)
- Tags: *Lipid Metabolism
Nuclear receptor regulation of lipid metabolism: potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases.
Tags: *Lipid Metabolism, 2005, Animals, Chiang John Y L, Chronic Disease, Current opinion in investigational drugs (London, England : 2000), Cytoplasmic and Nuclear/*metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus/drug therapy/metabolism, Dyslipidemias/drug therapy/metabolism, Heart Diseases/*drug therapy/metabolism, Humans, Hypoglycemic Agents/therapeutic use, Hypolipidemic Agents/therapeutic use, Liver Diseases/*drug therapy/metabolism, Metabolic Diseases/*drug therapy/metabolism, NEOMED College of Medicine, Receptors
PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine.
Tags: *Lipid Metabolism, 2007, ATP Binding Cassette Transporter, ATP Binding Cassette Transporter 1, ATP-Binding Cassette Transporters/genetics, Base Sequence, Cell Line, Chen Wenling, Chiang John Y L, Cholestanetriol 26-Monooxygenase/*metabolism, Cholesterol, Cholesterol/*metabolism, Department of Integrative Medical Sciences, Fluorinated, Genes, Genetic/drug effects, Genetic/genetics, HDL/metabolism, Hepatocytes/drug effects/enzymology/metabolism, Humans, Hydrocarbons, Hydroxycholesterols/metabolism/pharmacology, Intestinal Mucosa/metabolism, Intestines/cytology/drug effects/enzymology, Journal of lipid research, Li Tiangang, Member 1, Messenger/genetics/metabolism, Molecular Sequence Data, NEOMED College of Medicine, Pregnane X Receptor, Promoter Regions, Receptors, Reporter, Response Elements/genetics, Rifampin/pharmacology, RNA, Steroid/*metabolism, Subfamily G, Sulfonamides/pharmacology, Transcription, Up-Regulation/drug effects
Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism.
Tags: *bile acid, *bile acid metabolism, *FXR, *Gene Expression Regulation, *GLP-1, *Lipid Metabolism, *liver metabolism, *Non-alcoholic Fatty Liver Disease, *Obesity, *TGR5, *type 2 diabetes, 2017, Animals, Bile Acids and Salts/*biosynthesis/genetics, Boehme Shannon, Chiang John Y L, Cytoplasmic and Nuclear/genetics/*metabolism, Department of Integrative Medical Sciences, Dietary Fats, G-Protein-Coupled/genetics/*metabolism, Glucagon-Like Peptide 1/genetics/metabolism, Glucose/metabolism, Gonzalez Frank, Knockout, Krausz Kristopher W, Lipid Metabolism, Liu Hailiang, Liver/*metabolism, Mice, NEOMED College of Medicine, Obesity/genetics/*metabolism/pathology, Pathak Preeti, Receptors, The Journal of biological chemistry, Xie Cen
Beyond thermoregulation: metabolic function of cetacean blubber in migrating bowhead and beluga whales.
Tags: *Lipid Metabolism, 2017, Adipose Tissue/*metabolism, Aging/metabolism, Amino Acid Sequence, Animals, Ball H C, Base Sequence, Beluga Whale/*physiology, Blubber, Body Temperature Regulation, bowhead whale, Bowhead Whale/*physiology, Department of Anatomy & Neurobiology, Department of Family & Community Medicine, development, Duff R J, Female, George John C, Humans, Inbred C57BL, Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, leptin, Leptin/genetics, Leptin/genetics/metabolism, Lipase/genetics, Londraville R L, Long-Evans, Male, Metabolic activity, Mice, NEOMED College of Medicine, Prokop J W, Rats, Receptors, Seasons, Suydam R S, Thewissen J G M, Vinyard C
Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice.
Tags: *Lipid Metabolism, 2016, Adiposity, Animals, Carboxylesterase/*metabolism, Carboxylic Ester Hydrolases/genetics/*metabolism, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diabetes Mellitus, Diet, Endoplasmic Reticulum Stress, Energy Metabolism, Experimental/enzymology, Gene Knockdown Techniques, Glucose Tolerance Test, Glucose/metabolism, Hepatocyte Nuclear Factor 4/*metabolism, Hepatology (Baltimore, Md.), High-Fat/adverse effects, Homeostasis, Humans, Inbred C57BL, Jadhav Kavita, Kasumov Takhar, Li Yuanyuan, Lipogenesis, Lipolysis, Liver/enzymology, Male, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*etiology/metabolism, Obesity/enzymology/etiology, Sterol Regulatory Element Binding Protein 1/metabolism, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao
Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis.
Tags: *Homeostasis, *Lipid Metabolism, 2014, Adorini Luciano, Animals, Carboxylic Ester Hydrolases/*physiology, Chen Wei-Dong, Cholesterol/blood, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Fatty Acids/metabolism, Ge Xuemei, Hepatology (Baltimore, Md.), Inbred C57BL, Jadhav Kavita, Li Yuanyuan, Lipogenesis, Liver/*enzymology, Mice, NEOMED College of Medicine, Receptors, Sterol Regulatory Element Binding Protein 1/physiology, Triglycerides/metabolism, Xu Jiesi, Xu Yang, Yin Liya, Zhang Yanqiao