1
40
5
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
94–101
Issue
1
Volume
62
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Modulatory effects of testosterone on
Publisher
An entity responsible for making the resource available
Journal of neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-01
Subject
The topic of the resource
Male; Animals; Mice; Species Specificity; Reference Values; Dopamine/*metabolism; Corpus Striatum/drug effects/*metabolism; Orchiectomy; Drug Implants; Testosterone/administration & dosage/*pharmacology; Neurotoxins/antagonists & inhibitors/*toxicity; *MPTP Poisoning; Levodopa/pharmacology; Inbred Strains; Inbred C57BL; 3; 1-Methyl-4-phenyl-1; 2; Parkinson Disease; 6-tetrahydropyridine/antagonists & inhibitors; Secondary/chemically induced/*physiopathology
Creator
An entity primarily responsible for making the resource
Dluzen D; Jain R; Liu B
Description
An account of the resource
In this experiment, we examined the modulatory effects of testosterone on the parkinsonism-inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in two strains of mice. Orchidectomized male CD-1 and C57/B1 mice were implanted with either empty Silastic capsules or capsules containing testosterone and subsequently treated with MPTP. A small area of the corpus striatum was removed for determination of dopamine (DA) content, whereas the remainder was superfused and used to measure L-DOPA (5 microM)-evoked DA release. In animals treated with MPTP, L-DOPA-evoked DA release was reduced significantly in CD-1 mice, but not in C57/B1 mice, treated with testosterone. No differences in L-DOPA-stimulated DA release between MPTP-versus vehicle-treated mice was observed in either the CD-1 or C57/B1 mice receiving empty Silastic capsules. Corpus striatum DA contents were more severely depleted in the MPTP-sensitive C57/B1 versus the CD-1 mouse strain irrespective of hormone treatment. These results confirm previous results demonstrating differences in these two mouse strains in response to the neurotoxic effects of MPTP upon corpus striatum DA content. More interestingly, they show an important differential modulatory effect of testosterone upon
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1-Methyl-4-phenyl-1
1994
2
3
6-tetrahydropyridine/antagonists & inhibitors
Animals
Corpus Striatum/drug effects/*metabolism
Dluzen D
Dopamine/*metabolism
Drug Implants
Inbred C57BL
Inbred Strains
Jain R
Journal of neurochemistry
Levodopa/pharmacology
Liu B
Male
Mice
Neurotoxins/antagonists & inhibitors/*toxicity
Orchiectomy
Parkinson Disease
Reference Values
Secondary/chemically induced/*physiopathology
Species Specificity
Testosterone/administration & dosage/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1471-4159.1996.66020658.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1471-4159.1996.66020658.x</a>
Pages
658–666
Issue
2
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen alters MPTP-induced neurotoxicity in female mice: effects on striatal dopamine concentrations and release.
Publisher
An entity responsible for making the resource available
Journal of neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-02
Subject
The topic of the resource
*MPTP Poisoning; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/*drug effects/*metabolism; Dopamine/*metabolism; Estradiol/*pharmacology; Female; Inbred C57BL; Inbred Strains; Levodopa/pharmacology; Mice; Osmolar Concentration; Ovariectomy
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L; Liu B
Description
An account of the resource
The effects of estrogen on MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system were examined in C57Bl and CD-1 mice. Ovariectomized mice with and without estrogen were treated with MPTP or its vehicle. The effects of these treatments on striatal dopamine concentrations and L-DOPA-stimulated dopamine and L-3,4-dihydroxyphenylacetic acid (DOPAC) release in vitro were determined. Dopamine concentrations of C57Bl mice receiving estrogen before MPTP were significantly greater than those of non-estrogen-treated MPTP mice as well as estrogen-treated mice receiving the MPTP vehicle. Dopamine concentrations of the CD-1 mice did not differ with these treatments. L-DOPA-evoked dopamine release values of estrogen-treated C57Bl mice were significantly increased compared with non-estrogen-treated mice. No such differences were observed in the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1471-4159.1996.66020658.x" target="_blank" rel="noreferrer noopener">10.1046/j.1471-4159.1996.66020658.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1996
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Corpus Striatum/*drug effects/*metabolism
Dluzen D E
Dopamine/*metabolism
Estradiol/*pharmacology
Female
Inbred C57BL
Inbred Strains
Journal of neurochemistry
Levodopa/pharmacology
Liu B
McDermott J L
Mice
Osmolar Concentration
Ovariectomy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0006-8993(97)00418-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(97)00418-6</a>
Pages
9–16
Issue
1
Volume
764
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen as a neuromodulator of MPTP-induced neurotoxicity: effects upon striatal dopamine release.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-08
Subject
The topic of the resource
*MPTP Poisoning; 1-Methyl-4-phenylpyridinium/toxicity; Animals; Dopamine Agents/*toxicity; Dopamine/*metabolism; Estradiol/pharmacology; Estrogens/*physiology; Female; Neostriatum/drug effects/*metabolism; Neurotransmitter Agents/*physiology; Ovariectomy; Rats; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Disshon K A; Dluzen D E
Description
An account of the resource
The effects of estrogen upon MPTP-induced neurotoxicity were examined using in vitro superfusion. In Experiment 1, striatal tissue from ovariectomized rats was infused with MPP+ (10 microM), a combination of MPP+ and 17beta-estradiol (300 nM), the same dose of estradiol preceding MPP+, or no treatment infusion. The effects of these treatments on dopamine release rates during the infusion periods were determined. Infusion of MPP+ resulted in a significant increase in dopamine release as compared to the control. Estradiol added to the MPP+ infusion significantly attenuated this dopamine (DA) release, while estradiol treatment preceding the MPP+ had no effect. In Experiment 2, three different doses of estradiol (0.3, 3, or 300 nM) were infused simultaneously with the MPP+. Doses of estradiol below 300 nM did not attenuate the DA release. In Experiment 3, estradiol alone (300 nM) was infused, to determine dopamine release rate effects of the hormone itself. There was no difference between estradiol treated and non-infused control groups. These results demonstrate that the gonadal steroid hormone estradiol can modulate responses of striatal dopamine neurons to MPP+ by altering the immediate increase in dopamine release which occurs in response to this neurotoxin. These modulating effects of estradiol are dose-dependent, and represent a direct effect upon striatal neurons, most likely involving a non-genomic mechanism of action. These results implicate that hormonal modulation of nigrostriatal dopaminergic neurotoxicity may represent an important variable responsible for the sex differences which are reported in Parkinson's disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0006-8993(97)00418-6" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(97)00418-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1-Methyl-4-phenylpyridinium/toxicity
1997
Animals
Brain research
Disshon K A
Dluzen D E
Dopamine Agents/*toxicity
Dopamine/*metabolism
Estradiol/pharmacology
Estrogens/*physiology
Female
Neostriatum/drug effects/*metabolism
Neurotransmitter Agents/*physiology
Ovariectomy
Rats
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0892-0362(96)00086-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0892-0362(96)00086-4</a>
Pages
603–606
Issue
5
Volume
18
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen as a neuroprotectant against MPTP-induced neurotoxicity in C57/B1 mice.
Publisher
An entity responsible for making the resource available
Neurotoxicology and teratology
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-10
Subject
The topic of the resource
*MPTP Poisoning; Animals; Corpus Striatum/drug effects/*metabolism/pathology; Dopamine/*metabolism; Drug Implants; Estradiol/administration & dosage/*pharmacology; Female; Inbred C57BL; Male; Mice; Neuroprotective Agents/administration & dosage/*pharmacology; Neurotoxins; Olfactory Pathways/drug effects/*metabolism/pathology; Orchiectomy; Ovariectomy; Sex Characteristics
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L; Liu B
Description
An account of the resource
Castrated retired breeder male and female mice were treated or not with a 17 beta-estradiol pellet. At 10 days postcastration +/- estrogen treatment all animals were treated with MPTP. Five days later, concentrations of dopamine were determined from the corpus striatum and olfactory tubercle. Both castrated male and female mice treated with estrogen had significantly greater concentrations of dopamine within the corpus striatum compared with their respective gender controls, which did not receive estrogen. By contrast, no statistically significant differences in olfactory tubercle dopamine concentrations were obtained. Overall concentrations of dopamine within the corpus striatum, but not olfactory tubercle, were substantially greater in female vs. male mice. These data demonstrate that treatment with estrogen prevents reductions in corpus striatal dopamine concentrations in castrated mice treated with MPTP. Interestingly, this effect of estrogen was observed in both male and female mice. These results suggest that estrogen may serve as a neuroprotectant against an agent that is toxic to the nigrostriatal dopaminergic system in both male and female animal models of Parkinsonism.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0892-0362(96)00086-4" target="_blank" rel="noreferrer noopener">10.1016/0892-0362(96)00086-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1996
Animals
Corpus Striatum/drug effects/*metabolism/pathology
Dluzen D E
Dopamine/*metabolism
Drug Implants
Estradiol/administration & dosage/*pharmacology
Female
Inbred C57BL
Liu B
Male
McDermott J L
Mice
Neuroprotective Agents/administration & dosage/*pharmacology
Neurotoxicology and teratology
Neurotoxins
Olfactory Pathways/drug effects/*metabolism/pathology
Orchiectomy
Ovariectomy
Sex Characteristics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(95)01566-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(95)01566-3</a>
Pages
113–118
Issue
1
Volume
715
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-04
Subject
The topic of the resource
*MPTP Poisoning; 1-Methyl-4-phenyl-1; 2; 3; 4-Dihydroxyphenylacetic Acid/metabolism; 6-tetrahydropyridine/*antagonists & inhibitors; Animals; Catecholamines/metabolism; Dopamine Agents/*toxicity; Dopamine/metabolism/*physiology; Female; Inbred C57BL; Male; Mice; Neostriatum/drug effects/metabolism/*pathology; Nervous System Diseases/chemically induced/*pathology/*prevention & control; Olfactory Bulb/drug effects/metabolism; Orchiectomy; Substantia Nigra/drug effects/metabolism/*pathology; Testosterone/*pharmacology
Creator
An entity primarily responsible for making the resource
Dluzen D E
Description
An account of the resource
We have recently reported that treatment of gonadectomized female and male C57/B1 mice with the gonadal steroid hormone, estrogen, reduced nigrostriatal dopaminergic neurotoxicity resulting from the Parkinson's-like inducing agent
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(95)01566-3" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(95)01566-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1-Methyl-4-phenyl-1
1996
2
3
4-Dihydroxyphenylacetic Acid/metabolism
6-tetrahydropyridine/*antagonists & inhibitors
Animals
Brain research
Catecholamines/metabolism
Dluzen D E
Dopamine Agents/*toxicity
Dopamine/metabolism/*physiology
Female
Inbred C57BL
Male
Mice
Neostriatum/drug effects/metabolism/*pathology
Nervous System Diseases/chemically induced/*pathology/*prevention & control
Olfactory Bulb/drug effects/metabolism
Orchiectomy
Substantia Nigra/drug effects/metabolism/*pathology
Testosterone/*pharmacology