Browse Items · NEOMED Bibliography Database

Sucrose, But Not Glucose, Blocks IL1-beta-Induced Inflammatory Response in Human Chondrocytes by Inducing Autophagy via AKT/mTOR Pathway.

Pathogenesis of osteoarthritis (OA) is multifactorial but interleukin-1beta (IL-1beta) is known to be an important mediator of cartilage degradation. Autophagy is an essential cellular homeostasis mechanism and has been proposed to protect against…

Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes.

There is growing evidence in support of the involvement of inflammatory response in the pathogenesis of osteoarthritis (OA). Harpagoside, one of the bioactive components of Harpagophytum procumbens (Hp), has been shown to possess anti-inflammatory…

Tags: *c-FOS/AP-1, *harpagoside, *IL-6, *MMP-13, *OSTEOARTHRITIS, 2017, Ansari Mohammad Yunus, CCAAT-Enhancer-Binding Protein-beta/metabolism, Chemokines/metabolism, Chondrocytes/*drug effects/metabolism, Department of Anatomy & Neurobiology, Drug Evaluation, Glycosides/pharmacology/*therapeutic use, Haqqi Tariq M, Harpagophytum, Haseeb Abdul, Humans, Interleukin-1beta, Interleukin-6/antagonists & inhibitors/*metabolism, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, Matrix Metalloproteinase 13/metabolism, NEOMED College of Medicine, NF-kappa B/metabolism, Osteoarthritis/*drug therapy/metabolism, Phytotherapy, Plant Extracts/pharmacology/therapeutic use, Preclinical, Primary Cell Culture, Proto-Oncogene Proteins c-fos/metabolism, Pyrans/pharmacology/*therapeutic use, Reactive Oxygen Species/metabolism, Transcription Factor AP-1/metabolism

No rheumatoid arthritis in ancient Egypt: a reappraisal.

Antiquity of rheumatoid arthritis (RA) remains controversial, and its origins in Americas or in the Old World are disputed. Proponents of the latter frequently refer to RA in ancient Egypt, but validity of those claims has never been examined. Review…

The Role of MicroRNAs and Their Targets in Osteoarthritis.

Micro ribonucleic acid (microRNA) regulation and expression has become an emerging field in determining the mechanisms regulating a variety of inflammation-mediated diseases. Several studies have focused on specific microRNAs that are differentially…

Tags: *Cartilage, *Inflammation, *MicroRNA, *OSTEOARTHRITIS, *Targets, 2016, Articular/*metabolism, Cartilage, Current rheumatology reports, Department of Anatomy & Neurobiology, Haqqi Tariq M, Inflammation/genetics/*metabolism, Intracellular Signaling Peptides and Proteins, MicroRNAs/genetics/*metabolism, NEOMED College of Medicine, Osteoarthritis/genetics/*metabolism, Sondag Gregory R

An effective and efficient method of transfecting primary human chondrocytes in suspension.

Human chondrocytes accumulate an ECM-rich matrix by secreting matrix macromolecules during monolayer culture, which makes them difficult to transfect efficiently. Here we report a non-viral based protocol to transfect the primary human chondrocytes…

Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes.

Osteoarthritis (OA), characterized by progressive destruction of articular cartilage, is the most common form of human arthritis. Here, we evaluated the potential chondroprotective and anti-inflammatory effects of Wogonin, a naturally occurring…

Tags: *ERK1/2, *Nrf2, *OSTEOARTHRITIS, *Redox, *Wogonin, 2017, Ansari Mohammad Y, Anti-Inflammatory Agents/administration & dosage, Chondrocytes/drug effects/pathology, Department of Anatomy & Neurobiology, Devarapalli Pratap, Flavanones/*administration & dosage, Free radical biology & medicine, Gene Expression Regulation/drug effects, Haqqi Tariq M, Haseeb Abdul, Haynie Sara, Humans, Inflammation/*drug therapy/metabolism/pathology, Kelch-Like ECH-Associated Protein 1/chemistry/*genetics/metabolism, Khan Nazir M, MAP Kinase Signaling System/drug effects, Molecular Docking Simulation, NEOMED College of Medicine, NF-E2-Related Factor 2/antagonists & inhibitors/chemistry/*genetics/metabolism, Osteoarthritis/*drug therapy/metabolism/pathology, Protein Binding, Reactive Oxygen Species/metabolism, Signal Transduction/drug effects

Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis.

Nrf2, a redox regulated transcription factor, has recently been shown to play a role in cartilage integrity but the mechanism remains largely unknown. Osteoarthritis (OA) is a multifactorial disease in which focal degradation of cartilage occurs.…

Tags: *Apoptosis, *ERK1/2, *Nrf2, *OSTEOARTHRITIS, *Redox, 2018, Ahmad Imran, Department of Anatomy & Neurobiology, Free radical biology & medicine, Haqqi Tariq M, Khan Nazir M, NEOMED College of Medicine

Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics.

Osteoarthritis (OA) is the most common joint disease and the leading cause of chronic disability in middle-aged and older populations worldwide. The development of disease modifying therapy for OA is in its infancy largely because the regulatory…

Tags: *DNA methylation, *Epigenetics, *HDACs, *lncRNA, *miRNA, *OSTEOARTHRITIS, 2018, Animals, Department of Anatomy & Neurobiology, Epigenesis, Genetic, Haqqi Tariq M, Histone Deacetylase Inhibitors/*therapeutic use, Humans, Khan Nazir M, NEOMED College of Medicine, Osteoarthritis/*drug therapy/*genetics, Pharmacological research

Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1beta-induced IL-6 expression in human OA chondrocytes.

AIM OF THE STUDY: High levels of IL-6 are believed to contribute to osteoarthritis (OA) pathogenesis. The expression of IL-6 is regulated post-transcriptionally by the miR-9-MCPIP-1 axis in chondrocytes. Vorinostat (SAHA) inhibits the IL-6 expression…

Reduction of Knee Pain by Effusion Reduction.

Tags: *Knee Joint, *OSTEOARTHRITIS, 2016, Exudates and Transudates, Humans, Knee, Pain, Rothschild Bruce, The Journal of rheumatology

Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis.

Nrf2, a redox regulated transcription factor, has recently been shown to play a role in cartilage integrity but the mechanism remains largely unknown. Osteoarthritis (OA) is a multifactorial disease in which focal degradation of cartilage occurs.…

Contributions of symptomatic osteoarthritis and physical function to incident cardiovascular disease.

BACKGROUND: Osteoarthritis (OA) is associated with worsening physical function and a high prevalence of comorbid health conditions. In particular, cardiovascular disease (CVD) risk is higher in individuals with OA than the general population.…

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