1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(94)90562-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(94)90562-2</a>
Pages
515–519
Issue
2
Volume
48
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
L-dopa reverses castration-induced disruption of dishabituation responses to female chemical cues in male rats.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-06
Subject
The topic of the resource
*Cues; *Orchiectomy; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animal/*drug effects/physiology; Animals; Brain Chemistry/drug effects/physiology; Catecholamines/metabolism; Discrimination (Psychology)/drug effects; Female; Habituation; Levodopa/*pharmacology; Male; Olfactory Bulb/drug effects/metabolism/physiology; Psychophysiologic/*drug effects; Rats; Sexual Behavior; Sprague-Dawley; Urine/physiology
Creator
An entity primarily responsible for making the resource
Guan X; Dluzen D E
Description
An account of the resource
In the present experiment, habituation/dishabituation behavioral tests were conducted to measure discriminatory olfactory recognition responses to chemical cues among control, castrated, and castrated+L-3,4-dihydroxyphenylalanine (L-DOPA)-treated male rats. Castration produced a disruption of dishabituation responses to female urine, and this effect was reversed by treatment with L-DOPA. In the posterior olfactory bulb, 3,4-dihydroxyphenlacetic acid (DOPAC) levels were significantly increased in L-DOPA-treated animals compared with the vehicle-treated control and castrated groups. No significant differences in olfactory bulb norepinephrine or dopamine concentrations among the three treatment groups were obtained. The restoration of behavioral dishabituation responses following L-DOPA treatment suggests that the catecholaminergic system of the olfactory bulb may play a critical role in the recognition and possibly attractions for or preferences to female chemical cues.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(94)90562-2" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(94)90562-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Cues
*Orchiectomy
1994
3
4-Dihydroxyphenylacetic Acid/metabolism
Animal/*drug effects/physiology
Animals
Brain Chemistry/drug effects/physiology
Catecholamines/metabolism
Discrimination (Psychology)/drug effects
Dluzen D E
Female
Guan X
Habituation
Levodopa/*pharmacology
Male
Olfactory Bulb/drug effects/metabolism/physiology
Pharmacology, biochemistry, and behavior
Psychophysiologic/*drug effects
Rats
Sexual Behavior
Sprague-Dawley
Urine/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(94)90654-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(94)90654-8</a>
Pages
273–283
Issue
3
Volume
259
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in nitric oxide-mediated attenuation of vascular reactivity to vasopressin are abolished by gonadectomy.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-07
Subject
The topic of the resource
*Orchiectomy; *Ovariectomy; Acetylcholine/pharmacology; Animals; Aorta; Arginine/analogs & derivatives/pharmacology; Female; In Vitro Techniques; Male; Muscle; Muscle Contraction/drug effects; Nitric Oxide/antagonists & inhibitors/*physiology; omega-N-Methylarginine; Phenylephrine/pharmacology; Potassium Chloride/pharmacology; Rats; Sex Characteristics; Smooth; Sprague-Dawley; Thoracic/drug effects/physiology; Vascular/drug effects/*physiology; Vasopressins/*pharmacology
Creator
An entity primarily responsible for making the resource
Stallone J N
Description
An account of the resource
In the rat thoracic aorta, contractile responses to vasopressin are two-fold higher in females than in males, primarily because nitric oxide-mediated attenuation of contraction is greater in males than in females. To determine the role of the gonadal steroids in this phenomenon, the effects of gonadectomy on nitric oxide and vascular reactivity to vasopressin were examined in thoracic aortae of age-matched intact and gonadectomized male and female rats. Maximal response to vasopressin was markedly higher in gonadectomized-male than in intact-male aortae (2729 +/- 421 vs. 1375 +/- 222 mg/mg ring weight; P \textless 0.01). Inhibition of nitric oxide synthase with NG-methyl-L-arginine (L-NMMA, 250 microM) enhanced maximal response of intact-male (2824 +/- 413 mg/mg ring weight; P \textless 0.01) but not gonadectomized-male aortae (3034 +/- 365 mg/mg ring weight; P \textgreater 0.05). Sensitivity of male aortae to vasopressin was unaffected by gonadectomy or
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(94)90654-8" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(94)90654-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Orchiectomy
*Ovariectomy
1994
Acetylcholine/pharmacology
Animals
Aorta
Arginine/analogs & derivatives/pharmacology
European journal of pharmacology
Female
In Vitro Techniques
Male
Muscle
Muscle Contraction/drug effects
Nitric Oxide/antagonists & inhibitors/*physiology
omega-N-Methylarginine
Phenylephrine/pharmacology
Potassium Chloride/pharmacology
Rats
Sex Characteristics
Smooth
Sprague-Dawley
Stallone J N
Thoracic/drug effects/physiology
Vascular/drug effects/*physiology
Vasopressins/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(91)91390-m" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(91)91390-m</a>
Pages
147–151
Issue
1
Volume
568
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Castration reduces potassium-stimulated norepinephrine release from superfused olfactory bulbs of male rats.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-12
Subject
The topic of the resource
*Orchiectomy; Animals; Inbred Strains; Kinetics; Male; Norepinephrine/*metabolism; Olfactory Bulb/drug effects/*physiology; Potassium/*pharmacology; Rats; Reference Values; Testosterone/*pharmacology
Creator
An entity primarily responsible for making the resource
Guan X B; Dluzen D
Description
An account of the resource
In order to investigate the possible relationship among the olfactory bulb (OB), norepinephrine (NE) and gonadal steroids, we measured NE release from superfused anterior and posterior OB in intact and castrated male rats (Expt. I) as well as in castrated male rats implanted with either empty or testosterone filled silastic capsules (Expt. II). Both basal and potassium (K+ 30 mM)-stimulated release of NE was greater in posterior compared to anterior OB. All groups were responsive to the K+ stimuli showing increases in NE release. The degree of K(+)-stimulated release was significantly greater in intact compared to that of castrated rats. No differences in K(+)-stimulated release were observed between castrated and castrated plus testosterone-treated groups. These results demonstrate that castration of male rats significantly reduces OB noradrenergic responsiveness to K+ stimulation, an effect which was not restored following administration of silastic capsules containing testosterone.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(91)91390-m" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(91)91390-m</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Orchiectomy
1991
Animals
Brain research
Dluzen D
Guan X B
Inbred Strains
Kinetics
Male
Norepinephrine/*metabolism
Olfactory Bulb/drug effects/*physiology
Potassium/*pharmacology
Rats
Reference Values
Testosterone/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(SICI)1098-2396(19990315)31:4%3C250::AID-SYN2%3E3.0.CO;2-Z" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(SICI)1098-2396(19990315)31:4%3C250::AID-SYN2%3E3.0.CO;2-Z</a>
Pages
250–255
Issue
4
Volume
31
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Castration differentially alters [3H]nisoxetine binding to norepinephrine uptake sites in olfactory bulb and frontal cortex of male rats.
Publisher
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Synapse (New York, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-03
Subject
The topic of the resource
*Orchiectomy; Adrenergic/drug effects/*metabolism; Animals; Fluoxetine/*analogs & derivatives/metabolism; Frontal Lobe/drug effects/*metabolism; Kinetics; Male; Norepinephrine/metabolism; Olfactory Bulb/drug effects/*metabolism; Rats; Receptors; Sprague-Dawley; Synaptosomes/drug effects/metabolism; Testosterone/pharmacology
Creator
An entity primarily responsible for making the resource
Shang Y; Boja J W; Dluzen D E
Description
An account of the resource
In the present study, [3H]nisoxetine binding to norepinephrine (NE) uptake sites and [3H]norepinephrine uptake were investigated within olfactory bulb (OB) and frontal cortex homogenates from intact and castrated male rats. Statistically significant reductions in the number of [3H]nisoxetine binding sites (Bmax) were found in OB from the castrates, while significantly increased Bmax values were obtained in the frontal cortex. Castration also significantly altered the affinity (Kd) of [3H]nisoxetine binding in the frontal cortex, but not in the OB. Assessment of [3H]norepinephrine uptake showed that in neither brain regions were there any statistically significant differences in Km nor Vmax between the castrated and intact male rats, indicating that the basal uptake process is not changed following castration in either of these brain areas. These results demonstrate the differential effects of castration upon [3H]nisoxetine binding sites between the OB and frontal cortex. Such findings provide new evidence for one of the mechanisms by which androgens may modulate central noradrenergic activity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(SICI)1098-2396(19990315)31:4%3C250::AID-SYN2%3E3.0.CO;2-Z" target="_blank" rel="noreferrer noopener">10.1002/(SICI)1098-2396(19990315)31:4%3C250::AID-SYN2%3E3.0.CO;2-Z</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Orchiectomy
1999
Adrenergic/drug effects/*metabolism
Animals
Boja J W
Dluzen D E
Fluoxetine/*analogs & derivatives/metabolism
Frontal Lobe/drug effects/*metabolism
Kinetics
Male
Norepinephrine/metabolism
Olfactory Bulb/drug effects/*metabolism
Rats
Receptors
Shang Y
Sprague-Dawley
Synapse (New York, N.Y.)
Synaptosomes/drug effects/metabolism
Testosterone/pharmacology