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Text
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URL Address
<a href="http://doi.org/10.1152/ajpendo.1989.256.3.E345" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpendo.1989.256.3.E345</a>
Pages
E345–351
Issue
3
Volume
256
Dublin Core
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Title
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Oxygen consumption after massive sympathetic nervous system discharge.
Publisher
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The American journal of physiology
Date
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1989
1989-03
Subject
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*Blood Pressure; *Oxygen Consumption/drug effects; Adrenal Glands/physiology; Animals; Cardiac Output/drug effects; Dogs; Epinephrine/blood; Female; Heart Rate/drug effects; Male; Norepinephrine/blood; Pulmonary Artery/drug effects/physiology/physiopathology; Pulmonary Edema/physiopathology; Reference Values; Sympathetic Nervous System/*physiology/physiopathology; Veratrine/pharmacology
Creator
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Lang S A; Maron M B; Signs S A
Description
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We evaluated the possibility that massive, sympathetic nervous system (SNS) activation [as may precede the development of neurogenic pulmonary edema (NPE)] increases O2 demand. O2 consumption (VO2) and plasma concentrations of the calorigenic agents, epinephrine (EPI) and norepinephrine (NE) were measured in alpha-chloralose-anesthetized dogs under control conditions and for 3 h after the administration of either 1) intracisternal (ic) veratrine to activate the SNS, 2) intravenous (iv) veratrine, 3) ic saline, or 4) ic veratrine, after clamping the adrenal blood vessels. VO2 increased 31.7 +/- 3.6% (SE), and EPI and NE increased to, respectively, 30,853 +/- 8,347 and 8,176 +/- 2,104 pg/ml in the ic veratrine group. No increases in VO2 and EPI and attenuated increases in NE were observed in the ic veratrine animals with clamped adrenals. No significant increases in VO2 or catecholamine concentrations were observed after ic saline or iv veratrine administration. These data suggest that the elevated VO2 may have been mediated by adrenal catecholamines and that an increased metabolic rate may complicate the ability of patients with severe NPE to balance O2 supply with demand.
Identifier
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<a href="http://doi.org/10.1152/ajpendo.1989.256.3.E345" target="_blank" rel="noreferrer noopener">10.1152/ajpendo.1989.256.3.E345</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Blood Pressure
*Oxygen Consumption/drug effects
1989
Adrenal Glands/physiology
Animals
Cardiac Output/drug effects
Dogs
Epinephrine/blood
Female
Heart Rate/drug effects
Lang S A
Male
Maron M B
Norepinephrine/blood
Pulmonary Artery/drug effects/physiology/physiopathology
Pulmonary Edema/physiopathology
Reference Values
Signs S A
Sympathetic Nervous System/*physiology/physiopathology
The American journal of physiology
Veratrine/pharmacology