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Text
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URL Address
<a href="http://doi.org/10.1152/jn.00056.2005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00056.2005</a>
Pages
314–326
Issue
1
Volume
94
Dublin Core
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Title
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Leading inhibition to neural oscillation is important for time-domain processing in the auditory midbrain.
Publisher
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Journal of neurophysiology
Date
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2005
2005-07
Subject
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*Periodicity; Acoustic Stimulation/methods; Action Potentials/drug effects/physiology; Animals; Anura; Auditory Pathways/physiology; Bicuculline/pharmacology; Chiroptera; Dose-Response Relationship; Echolocation/*physiology; GABA Antagonists/pharmacology; Mesencephalon/*cytology/physiology; Neural Inhibition/drug effects/*physiology; Neurons/drug effects/*physiology; Newborn; Radiation; Reaction Time/drug effects/*physiology; Sound; Species Specificity; Time Factors
Creator
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Galazyuk Alexander V; Lin Wenyu; Llano Daniel; Feng Albert S
Description
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A number of central auditory neurons exhibit paradoxical latency shift (PLS), a response characterized by longer response latencies at higher sound levels. PLS neurons are known to play a role in target ranging for echolocating bats that emit frequency-modulated sounds. We recently reported that early inhibition of unit's oscillatory discharges is critical for PLS in the inferior colliculus (IC) of little brown bats. The goal of this study was to determine in echolocating bats and in non-echolocating animals (frogs): 1) the detailed characteristics of PLS and whether PLS was dependent on sound level, frequency, and duration; 2) the time course of inhibition underlying PLS using a paired-pulse paradigm. We found that 22% of IC neurons in bats and 15% in frogs exhibited periodic discharge patterns in response to tone pulses at high sound levels. The firing periodicity was unit specific and independent of sound level and duration. Other IC neurons (28% in bats; 14% in frogs) exhibited PLS. These PLS neurons shared several response characteristics: 1) PLS was largely independent of sound frequency and 2) the magnitude of shift in first-spike latency was either duration dependent or duration tolerant. For PLS neurons, application of bicuculline abolished PLS and unmasked the unit's periodical firing pattern that served as the building block for PLS. In response to paired sound pulses, PLS neurons exhibited delay-dependent response suppression, confirming that high-threshold leading inhibition was responsible for PLS. Results also revealed the timing of excitatory and inhibitory inputs underlying PLS and its role in time-domain processing.
Identifier
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<a href="http://doi.org/10.1152/jn.00056.2005" target="_blank" rel="noreferrer noopener">10.1152/jn.00056.2005</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Periodicity
2005
Acoustic Stimulation/methods
Action Potentials/drug effects/physiology
Animals
Anura
Auditory Pathways/physiology
Bicuculline/pharmacology
Chiroptera
Department of Anatomy & Neurobiology
Dose-Response Relationship
Echolocation/*physiology
Feng Albert S
GABA Antagonists/pharmacology
Galazyuk Alexander V
Journal of neurophysiology
Lin Wenyu
Llano Daniel
Mesencephalon/*cytology/physiology
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurons/drug effects/*physiology
Newborn
Radiation
Reaction Time/drug effects/*physiology
Sound
Species Specificity
Time Factors