1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/08990220020021366" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/08990220020021366</a>
Pages
66–75
Issue
1
Volume
18
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of aging on the substance P receptor, NK-1, in the spinal cord of rats with peripheral nerve injury.
Publisher
An entity responsible for making the resource available
Somatosensory & Motor Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001
Subject
The topic of the resource
*Peripheral Nerve Injuries; Aging/*physiology; Animals; Computer-Assisted; Hot Temperature; Image Processing; Immunohistochemistry; Inbred BN; Inbred F344; Neurokinin-1/*metabolism; Rats; Receptors; Spinal Cord/*metabolism; Thermosensing/physiology; Touch/physiology
Creator
An entity primarily responsible for making the resource
Cruce W L; Lovell J A; Crisp T; Stuesse S L
Description
An account of the resource
Substance P (SP) levels in the spinal cords of very old rats are less than the levels in younger rats (Bergman et al., 1996). After injury to a peripheral nerve in young rats, immunoreactivity (ir) to the SP receptor, NK-1 (neurokinin-1), increases in the spinal cord ipsilateral to the injury and the increases are correlated with the development of thermal hyperalgesia (Goff et al., 1998). Thus we postulated that aged rats might display an increased sensitivity to thermal stimulation before peripheral nerve injury and that they might respond differently to injury than do younger rats. To test this hypothesis, we used the Bennett and Xie model (1988) of chronic constriction injury (CCI) to the sciatic nerve to induce a neuropathic pain condition. We investigated the effect of age on changes in NK-1 ir in superficial layers of the dorsal horn and on numbers of NK ir cells in deeper laminae at the L4-L5 levels of the spinal cord after CCI.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/08990220020021366" target="_blank" rel="noreferrer noopener">10.1080/08990220020021366</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Peripheral Nerve Injuries
2001
Aging/*physiology
Animals
Computer-Assisted
Crisp T
Cruce W L
Hot Temperature
Image Processing
Immunohistochemistry
Inbred BN
Inbred F344
Lovell J A
Neurokinin-1/*metabolism
Rats
Receptors
Somatosensory & motor research
Spinal Cord/*metabolism
Stuesse S L
Thermosensing/physiology
Touch/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0091-3057(00)00461-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0091-3057(00)00461-5</a>
Pages
99–104
Issue
1
Volume
68
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Gender and the behavioral manifestations of neuropathic pain.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-01
Subject
The topic of the resource
*Peripheral Nerve Injuries; Animal/*physiology; Animals; Behavior; Female; Gonadal Steroid Hormones/pharmacology; Hyperalgesia/psychology; Inbred F344; Male; Orchiectomy; Ovariectomy; Pain Measurement/drug effects; Pain Threshold/drug effects; Pain/etiology/*psychology; Rats; Sex Characteristics
Creator
An entity primarily responsible for making the resource
Tall J M; Stuesse S L; Cruce W L; Crisp T
Description
An account of the resource
A model of peripheral nerve injury was used to study gender differences in the development and progression of chronic constriction injury (CCI)-induced hyperalgesia and allodynia in male and female Fischer 344 FBNF1 hybrid rats. Rats were randomly assigned to one of the following treatment groups: (1) gonadally intact unligated males (male); (2) gonadally intact ligated males (male (CCI)); (3) castrated ligated males (male (CAS/CCI)); (4) gonadally intact unligated females (female); (5) gonadally intact ligated females (female (CCI)); and (6) ovariectomized ligated females (female (OVX/CCI)). A plantar analgesia meter and calibrated von Frey pressure filaments were used as the analgesiometric assays. In the absence of nerve injury, gonadally intact males responded significantly faster than females to a thermal nociceptive stimulus. The onset of the behavioral manifestations of unilateral ligation of the sciatic nerve did not differ as a function of sex or hormonal status (e.g., gonadally intact and gonadectomized male and female rats developed thermal hyperalgesia within 14 days post-CCI). Paw withdrawal latency (PWL) values of gonadally intact males returned to baseline control values after postligation day 14, whereas gonadally intact females, ovariectomized females and castrated males continued to elicit robust thermal hyperalgesic symptoms throughout the 35-day duration of the experiment. Allodynic responses to peripheral nerve injury were less variable across genders. These data suggest that the mechanisms underlying chronic nociceptive processing differ as a function of gender and gonadal hormone status.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0091-3057(00)00461-5" target="_blank" rel="noreferrer noopener">10.1016/s0091-3057(00)00461-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Peripheral Nerve Injuries
2001
Animal/*physiology
Animals
Behavior
Crisp T
Cruce W L
Female
Gonadal Steroid Hormones/pharmacology
Hyperalgesia/psychology
Inbred F344
Male
Orchiectomy
Ovariectomy
Pain Measurement/drug effects
Pain Threshold/drug effects
Pain/etiology/*psychology
Pharmacology, biochemistry, and behavior
Rats
Sex Characteristics
Stuesse S L
Tall J M