1
40
3
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3174/ajnr.A0966" target="_blank" rel="noreferrer noopener">http://doi.org/10.3174/ajnr.A0966</a>
Pages
828–829
Issue
4
Volume
29
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Substantia nigra MR imaging signal changes and cardiomyopathy following prenatal exposure to cocaine and heroin.
Publisher
An entity responsible for making the resource available
AJNR. American journal of neuroradiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-04
Subject
The topic of the resource
Female; Humans; Infant; Pregnancy; *Magnetic Resonance Imaging; Heroin/*adverse effects; Narcotics/*adverse effects; *Prenatal Exposure Delayed Effects; Child Development/drug effects; Cocaine/*adverse effects; Failure to Thrive/chemically induced/etiology; Substance-Related Disorders/*diagnosis/etiology; Substantia Nigra/drug effects/*pathology; Cardiomyopathy; Dilated/chemically induced/*diagnosis
Creator
An entity primarily responsible for making the resource
Arnold R; Johnson C; McNulty B; Gaisie G
Description
An account of the resource
Exposure to cocaine in utero results in behavioral and neurodevelopmental abnormalities that persist into adulthood. Conventional MR imaging has generally failed to reveal the expected structural lesions to explain these clinical findings. We report a case of focal MR imaging signal-intensity changes in the substantia nigra, locus ceruleus, and other selected nerve tracts and nuclei in a child exposed prenatally to cocaine and other drugs. The patient also had dilated cardiomyopathy.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3174/ajnr.A0966" target="_blank" rel="noreferrer noopener">10.3174/ajnr.A0966</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Magnetic Resonance Imaging
*Prenatal Exposure Delayed Effects
2008
AJNR. American journal of neuroradiology
Arnold R
Cardiomyopathy
Child Development/drug effects
Cocaine/*adverse effects
Dilated/chemically induced/*diagnosis
Failure to Thrive/chemically induced/etiology
Female
Gaisie G
Heroin/*adverse effects
Humans
Infant
Johnson C
McNulty B
Narcotics/*adverse effects
Pregnancy
Substance-Related Disorders/*diagnosis/etiology
Substantia Nigra/drug effects/*pathology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0165-3806(98)00100-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0165-3806(98)00100-x</a>
Pages
115–119
Issue
1
Volume
110
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
GABAa receptor-mediated field potentials are enhanced in area CA1 following prenatal cocaine exposure.
Publisher
An entity responsible for making the resource available
Brain research. Developmental brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-09
Subject
The topic of the resource
*Prenatal Exposure Delayed Effects; AMPA/physiology; Animals; Bicuculline/analogs & derivatives/pharmacology; Cocaine/*pharmacology; Female; GABA-A/*physiology; GABA-B/physiology; Hippocampus/drug effects/*physiology; In Vitro Techniques; Membrane Potentials/drug effects/physiology; N-Methyl-D-Aspartate/physiology; Pregnancy; Quinoxalines/pharmacology; Rabbits; Receptors; Synapses/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Little J Z; Teyler T J
Description
An account of the resource
Prenatal cocaine exposure results in several documented changes in neurotransmitter receptor number and structure. Increases have been reported for cortical catecholamine and indoleamine receptor number and binding affinity, in the subunit expression of glutamatergic NMDA and AMPA receptors in the striatum, and in GABA immunoreactivity in the anterior cingulate cortex. We sought information on the functional consequences of cocaine-induced alterations in receptor structure/number. Since hippocampal amino acid neurotransmitters are of critical importance and have been shown to be affected by cocaine, we studied field potentials produced by synaptic activation of isolated glutamatergic NMDA and AMPA receptors and GABAa and GABAb responsive receptors in area CA1 of rabbit hippocampal slices. We found the GABAa receptor population produced significantly larger field potentials in cocaine-exposed offspring compared to controls, while other receptors produced responses similar to controls.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0165-3806(98)00100-x" target="_blank" rel="noreferrer noopener">10.1016/s0165-3806(98)00100-x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Prenatal Exposure Delayed Effects
1998
AMPA/physiology
Animals
Bicuculline/analogs & derivatives/pharmacology
Brain research. Developmental brain research
Cocaine/*pharmacology
Female
GABA-A/*physiology
GABA-B/physiology
Hippocampus/drug effects/*physiology
In Vitro Techniques
Little J Z
Membrane Potentials/drug effects/physiology
N-Methyl-D-Aspartate/physiology
Pregnancy
Quinoxalines/pharmacology
Rabbits
Receptors
Synapses/drug effects/physiology
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0165-3806(95)00187-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0165-3806(95)00187-5</a>
Pages
117–119
Issue
1
Volume
92
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Prenatal cocaine exposure leads to enhanced long-term potentiation in region CA1 of hippocampus.
Publisher
An entity responsible for making the resource available
Brain research. Developmental brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-03
Subject
The topic of the resource
*Prenatal Exposure Delayed Effects; Animals; Cocaine/*administration & dosage/pharmacology; Electrophysiology; Female; Hippocampus/*drug effects/physiology; In Vitro Techniques; Long-Term Potentiation/*drug effects; Narcotics/*administration & dosage/pharmacology; Neuronal Plasticity/drug effects; Pregnancy; Rabbits; Reference Values; Synapses/drug effects
Creator
An entity primarily responsible for making the resource
Little J Z; Teyler T J
Description
An account of the resource
Cocaine use by pregnant women is currently of concern for its social and economic impact. Clinical studies of cocaine exposed offspring are limited by methodological constraints. In this study we used a rabbit model to examine the effects of gestational cocaine exposure on substrates of learning and memory. Rabbits, 30 to 40 days old, were examined for alterations in synaptic plasticity using an intact hippocampal slice preparation. Extracellular recordings revealed in utero cocaine exposure predisposed slices to larger long-term potentiation compared to controls.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0165-3806(95)00187-5" target="_blank" rel="noreferrer noopener">10.1016/0165-3806(95)00187-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Prenatal Exposure Delayed Effects
1996
Animals
Brain research. Developmental brain research
Cocaine/*administration & dosage/pharmacology
Electrophysiology
Female
Hippocampus/*drug effects/physiology
In Vitro Techniques
Little J Z
Long-Term Potentiation/*drug effects
Narcotics/*administration & dosage/pharmacology
Neuronal Plasticity/drug effects
Pregnancy
Rabbits
Reference Values
Synapses/drug effects
Teyler T J