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Text
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<a href="http://doi.org/10.1016/j.psyneuen.2016.11.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.psyneuen.2016.11.003</a>
Pages
203–212
Volume
75
Dublin Core
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Title
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Prenatal stress changes courtship vocalizations and bone mineral density in mice.
Publisher
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Psychoneuroendocrinology
Date
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2017
2017-01
Subject
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*Bone mineral density; *Corticosterone; *Courtship; *GR; *Prenatal stress; *Testosterone; *Ultrasonic vocalizations; Animal/*physiology; Animals; Bone Density/*physiology; Female; Inbred C57BL; Male; Mice; Pregnancy; Prenatal Exposure Delayed Effects/*metabolism/*physiopathology; Psychological/*metabolism/*physiopathology; Stress; Vocalization
Creator
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Schmidt Michaela; Lapert Florian; Brandwein Christiane; Deuschle Michael; Kasperk Christian; Grimsley Jasmine M S; Gass Peter
Description
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Stress during the prenatal period has various effects on social and sexual behavior in both human and animal offspring. The present study examines the effects of chronic restraint stress in the second vs third trimester in pregnancy and glucocorticoid receptor (GR) heterozygous mutation on C57BL/6N male offspring's vocal courtship behavior in adulthood by applying a novel analyzing method. Finally, corticosterone and testosterone levels as well as bone mineral density were measured. Prenatal stress in the third, but not in the second trimester caused a significant qualitative change in males' courtship vocalizations, independent of their GR genotype. Bone mineral density was decreased also by prenatal stress exclusively in the third trimester in GR mutant and wildtype mice and - in contrast to corticosterone and testosterone - highly correlated with courtship vocalizations. In Gr(+/-) males corticosterone serum levels were significantly increased in animals that had experienced prenatal stress in the third trimester. Testosterone serum levels were overall increased in Gr(+/-) males in comparison to wildtypes as a tendency - whereas prenatal stress had no influence. Prenatal stress alters adult males' courtship vocalizations exclusively when applied in the third trimester, with closely related changes in bone mineral density. Bone mineral density seems to reflect best the complex neuroendocrine mechanisms underlying the production of courtship vocalizations. Besides, we demonstrated for the first time elevated basal corticosterone levels in Gr(+/-) males after prenatal stress which suggests that the Gr(+/-) mouse model of depression might also serve as a model of prenatal stress in male offspring.
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<a href="http://doi.org/10.1016/j.psyneuen.2016.11.003" target="_blank" rel="noreferrer noopener">10.1016/j.psyneuen.2016.11.003</a>
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*Bone mineral density
*Corticosterone
*Courtship
*GR
*Prenatal stress
*Testosterone
*Ultrasonic vocalizations
2017
Animal/*physiology
Animals
Bone Density/*physiology
Brandwein Christiane
Deuschle Michael
Female
Gass Peter
Grimsley Jasmine M S
Inbred C57BL
Kasperk Christian
Lapert Florian
Male
Mice
Pregnancy
Prenatal Exposure Delayed Effects/*metabolism/*physiopathology
Psychological/*metabolism/*physiopathology
Psychoneuroendocrinology
Schmidt Michaela
Stress
Vocalization