1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/MOT.0b013e328359a617" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/MOT.0b013e328359a617</a>
Pages
670–674
Issue
6
Volume
17
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cell transplantation as an initiator of endogenous stem cell-based tissue repair.
Publisher
An entity responsible for making the resource available
Current opinion in organ transplantation
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-12
Subject
The topic of the resource
*Regeneration; *Stem Cell Transplantation; *Stem Cells; *Wound Healing; Cell Transplantation; Humans; Mesenchymal Stem Cell Transplantation
Creator
An entity primarily responsible for making the resource
Dong Feng; Caplan Arnold I
Description
An account of the resource
PURPOSE OF REVIEW: The aim of this review is to summarize recent findings of endogenous cell-based tissue repair triggered by a multitude of approaches, especially stem cell therapy. RECENT FINDINGS: The emerging evidence has demonstrated that an important role of transplanted cells is to act as an initiator to trigger endogenous stem cell-mediated tissue repair after injury. Multiple approaches may orchestrate endogenous regeneration. The low efficacy of endogenous stem cells may be due to deficiency of cytokines to activate and induce endogenous stem cell homing, relatively insufficient endogenous stem cell pool, diseases or aging-related dysfunction of endogenous stem cells, and hostile microenvironments that limit the capacity of endogenous stem cells to repair damaged tissue. In certain situations, external stimulation and/or exogenous stem cells may be required to catalyze the repair. SUMMARY: Endogenous stem cells are playing an important role in tissue repair. An important role of transplanted cells is to act as an initiator to trigger endogenous stem cell-based tissue repair.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/MOT.0b013e328359a617" target="_blank" rel="noreferrer noopener">10.1097/MOT.0b013e328359a617</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Regeneration
*Stem Cell Transplantation
*Stem cells
*Wound Healing
2012
Caplan Arnold I
Cell Transplantation
Current opinion in organ transplantation
Department of Integrative Medical Sciences
Dong Feng
Humans
Mesenchymal Stem Cell Transplantation
NEOMED College of Medicine
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.5966/sctm.2013-0157" target="_blank" rel="noreferrer noopener">http://doi.org/10.5966/sctm.2013-0157</a>
Pages
760–767
Issue
6
Volume
3
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Functional outcome after anal sphincter injury and treatment with mesenchymal stem cells.
Publisher
An entity responsible for making the resource available
Stem cells translational medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-06
Subject
The topic of the resource
Female; Time Factors; Animals; Rats; Mesenchymal stem cells; Transfection; Recovery of Function; Fibrosis; *Mesenchymal Stem Cell Transplantation; *Regeneration; Anal Canal/injuries/metabolism/pathology/physiopathology/*surgery; Anal pressures; Anal sphincter; Fecal incontinence; Green Fluorescent Proteins/biosynthesis/genetics; i.v. infusion; Mesenchymal Stem Cells/metabolism; Pressure; Injections; Intralesional; Sprague-Dawley; Cells; Cultured; Animal; Disease Models; Infusions; Intravenous
Creator
An entity primarily responsible for making the resource
Salcedo Levilester; Penn Marc; Damaser Margot; Balog Brian; Zutshi Massarat
Description
An account of the resource
This research demonstrates the regenerative effects of mesenchymal stem cells (MSCs) on the injured anal sphincter by comparing anal sphincter pressures following intramuscular and serial intravascular MSC infusion in a rat model of anal sphincter injury. Fifty rats were divided into injury (n = 35) and no injury (NI; n = 15) groups. Each group was further divided into i.m., serial i.v., or no-treatment (n = 5) groups and followed for 5 weeks. The injury consisted of an excision of 25% of the anal sphincter complex. Twenty-four hours after injury, 5 x 10(5) green fluorescent protein-labeled MSCs in 0.2 ml of phosphate-buffered saline (PBS) or PBS alone (sham) were injected into the anal sphincter for i.m. treatment; i.v. and sham i.v. treatments were delivered daily for 6 consecutive days via the tail vein. Anal pressures were recorded before injury and 10 days and 5 weeks after treatment. Ten days after i.m. MSC treatment, resting and peak pressures were significantly increased compared with those in sham i.m. treatment (p \textless .001). When compared with the NI group, the injury groups had anal pressures that were not significantly different 5 weeks after i.m./i.v. treatment. Both resting and peak pressures were also significantly increased after i.m./i.v. MSC treatment compared with treatment with PBS (p \textless .001), suggesting recovery. Statistical analysis was done using paired t test with Bonferroni correction. Marked decrease in fibrosis and scar tissue was seen in both MSC-treated groups. Both i.m. and i.v. MSC treatment after injury caused an increase in anal pressures sustained at 5 weeks, although fewer cells were injected i.m. The
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.5966/sctm.2013-0157" target="_blank" rel="noreferrer noopener">10.5966/sctm.2013-0157</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Mesenchymal Stem Cell Transplantation
*Regeneration
2014
Anal Canal/injuries/metabolism/pathology/physiopathology/*surgery
Anal pressures
Anal sphincter
Animal
Animals
Balog Brian
Cells
Cultured
Damaser Margot
Disease Models
Fecal incontinence
Female
Fibrosis
Green Fluorescent Proteins/biosynthesis/genetics
i.v. infusion
Infusions
Injections
Intralesional
Intravenous
Mesenchymal stem cells
Mesenchymal Stem Cells/metabolism
Penn Marc
Pressure
Rats
Recovery of Function
Salcedo Levilester
Sprague-Dawley
Stem cells translational medicine
Time Factors
Transfection
Zutshi Massarat
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(89)90142-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(89)90142-0</a>
Pages
75–79
Issue
1
Volume
97
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The re-expression of two myosin heavy chains in regenerated rat muscle spindles.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-02
Subject
The topic of the resource
Female; Animals; Immunohistochemistry; Rats; *Gene Expression Regulation; *Regeneration; Muscle Denervation; Myosins/*metabolism; Muscles/innervation/*metabolism; Neurons; Afferent/*physiology; Inbred F344
Creator
An entity primarily responsible for making the resource
Fei C; Walro J M
Description
An account of the resource
The vascular supply and tendons of the extensor digitorum longus (EDL) muscles of two adult rats were unilaterally severed and the muscles were allowed to regenerate for 40 days. Serial frozen sections of muscle grafts were cut and stained for enzymes that delineated fiber type, sensory endings and motor endings. MF30 and ALD58, two antibodies which react only to intrafusal fibers in normal rat muscle, were reacted against sections of nerve-intact muscle grafts. Data were compared to that from muscles of normal rats. Encapsulated fibers devoid of sensory innervation and some extrafusal fibers in muscle grafts had a weak to moderate reaction to MF30, but no reaction to ALD58. Regenerated, encapsulated fibers with sensory innervation bound both MF30 and ALD58. These data indicate that afferents which reinnervate regenerated spindles retain the capacity to induce expression of spindle-specific myosin isoforms in rats.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(89)90142-0" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(89)90142-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Gene Expression Regulation
*Regeneration
1989
Afferent/*physiology
Animals
Fei C
Female
Immunohistochemistry
Inbred F344
Muscle Denervation
Muscles/innervation/*metabolism
Myosins/*metabolism
Neurons
Neuroscience letters
Rats
Walro J M