1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
1613–1618
Issue
10
Volume
5
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Anthocyanin-rich black currant extract suppresses the growth of human hepatocellular carcinoma cells.
Publisher
An entity responsible for making the resource available
Natural product communications
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-10
Subject
The topic of the resource
Humans; Cell Proliferation/drug effects; Fruit/chemistry; *Phytotherapy; Plant Extracts/pharmacology/therapeutic use; Hep G2 Cells; Antioxidants/*therapeutic use; *Ribes/chemistry; Liver Neoplasms/*prevention & control; Carcinoma; Drug Evaluation; Preclinical; Antineoplastic Agents; Hepatocellular/*prevention & control; Phytogenic/analysis
Creator
An entity primarily responsible for making the resource
Bishayee Anupam; Haznagy-Radnai Erzsebet; Mbimba Thomas; Sipos Peter; Morazzoni Paolo; Darvesh Altaf S; Bhatia Deepak; Hohmann Judit
Description
An account of the resource
Dietary antioxidants, such as anthocyanins, are helpful in the prevention and control of various diseases by counteracting the imbalance of oxidative and antioxidative factors in the living systems. Black currant (Ribes nigrum L., Grossulariaceae) is known to contain high amounts of anthocyanins (250 mg/100 g fresh fruit). Black currant fruits have been used in Asian and European traditional medicine for the treatment of a variety of diseases. Black currant extract has recently been found to be the second most effective amongst nine different berry extracts studied for their free radical scavenging activity. Constituents present in black currant juice have been found to exert a number of health-promoting effects, including immunomodulatory, antimicrobial and antiinflammatory actions, inhibition of low-density lipoprotein, and reduction of cardiovascular diseases. Although antioxidant and antiinflammatory effects of black currant juice could be of value in preventing and treating oxidative stress- and inflammation-driven cancers, no experimental evidence is available to now. The objective of the present study was to evaluate the potential antiproliferative effects of black currant fruit skin extract against HepG2 human liver cancer cells. The aqueous extract yielded an anthocyanin-rich fraction with cyanidin-3-O-rutinoside as one of the major anthocyanins. This fraction exhibited a potent cytotoxic effect on HepG2 cells and this effect was more pronounced than that of delphinidin and cyanidin, two major aglycones of anthocyanins present in black currant. Our results indicate, for the first time, that black currant skin containing an anthocyanin-rich fraction inhibits the proliferation of liver cancer cells, possibly due to additive as well as synergistic effects. This product could be useful in the prevention and treatment of human hepatocellular carcinoma.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Phytotherapy
*Ribes/chemistry
2010
Antineoplastic Agents
Antioxidants/*therapeutic use
Bhatia Deepak
Bishayee Anupam
Carcinoma
Cell Proliferation/drug effects
Darvesh Altaf S
Department of Pharmaceutical Sciences
Drug Evaluation
Fruit/chemistry
Haznagy-Radnai Erzsebet
Hep G2 Cells
Hepatocellular/*prevention & control
Hohmann Judit
Humans
Liver Neoplasms/*prevention & control
Mbimba Thomas
Morazzoni Paolo
Natural product communications
NEOMED College of Pharmacy
Phytogenic/analysis
Plant Extracts/pharmacology/therapeutic use
Preclinical
Sipos Peter
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1039/c2fo30058c" target="_blank" rel="noreferrer noopener">http://doi.org/10.1039/c2fo30058c</a>
Pages
795–809
Issue
8
Volume
3
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The health benefits of blackcurrants.
Publisher
An entity responsible for making the resource available
Food & function
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-08
Subject
The topic of the resource
*Health Promotion; *Ribes/chemistry; Anthocyanins/analysis; Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Fatty Acids; Flavonoids/analysis; Fruit/chemistry; Humans; Phytogenic; Phytotherapy; Plant Extracts/adverse effects/pharmacokinetics/pharmacology; Unsaturated/analysis
Creator
An entity primarily responsible for making the resource
Gopalan Ashwin; Reuben Sharon C; Ahmed Shamima; Darvesh Altaf S; Hohmann Judit; Bishayee Anupam
Description
An account of the resource
The blackcurrant (Ribes nigrum L., Grossulariceae), a small, perennial shrub native to central Europe and northern Asia, is cultivated throughout the world, including the United States. In addition to its anecdotal use in traditional herbal medicine, modern laboratories have demonstrated the potent anti-inflammatory, antioxidant and antimicrobial effects of blackcurrant constituents on a myriad of disease states. The properties of the blackcurrants are conferred from its biochemical constituents, some of which include anthocyans (specifically delphinidin-3-O-glucoside, delphinidin-3-O-rutinoside, cyanidin-3-O-glucoside and cyanidin-3-O-rutinoside), flavonols, phenolic acids and polyunsaturated fatty acids. A plethora of studies have been published with regards to its various therapeutic applications. This article attempts to summarize these studies, providing a general overview of the research in this field. Several studies focus on the therapeutic potential of blackcurrants with regards to hypertension and other cardiovascular-associated illnesses, neoplastic, neurodegenerative and ocular diseases, nephrolithiasis, and diabetic neuropathy. Safety concerns and future directions are also mentioned, suggesting the critical examination of the exact mechanism of action, specific radical-scavenging capabilities of the blackcurrants and the crucial need for well-designed clinical trials to ensure the successful use of blackcurrants in a clinical setting.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1039/c2fo30058c" target="_blank" rel="noreferrer noopener">10.1039/c2fo30058c</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Health Promotion
*Ribes/chemistry
2012
Ahmed Shamima
Anthocyanins/analysis
Anti-Infective Agents
Anti-Inflammatory Agents
Antineoplastic Agents
Antioxidants
Bishayee Anupam
Darvesh Altaf S
Department of Pharmaceutical Sciences
Fatty Acids
Flavonoids/analysis
Food & function
Fruit/chemistry
Gopalan Ashwin
Hohmann Judit
Humans
NEOMED College of Pharmacy
Phytogenic
Phytotherapy
Plant Extracts/adverse effects/pharmacokinetics/pharmacology
Reuben Sharon C
Unsaturated/analysis