Browse Items · NEOMED Bibliography Database

Gender differences in the association between antidepressant use and restless legs syndrome.

Contradictory results have been reported for the association between antidepressant use and Restless Legs Syndrome (RLS). Our aim was to clarify the relationship and examine possible gender differences. We interviewed 1,693 veterans receiving primary…

Nomifensine alters sex differences in striatal dopaminergic function.

A series of three experiments are presented in which the acute effects of the catecholamine reuptake inhibitor, nomifensine, upon striatal dopaminergic function are compared in female and male mice. In Experiment 1, treatment with nomifensine (5 mg…

Sex differences in striatal dopaminergic function within heterozygous mutant dopamine transporter knock-out mice.

The issue of whether a deletion of the dopamine transporter (DAT) allele (+/- DAT) would differentially alter striatal dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) concentrations and DA release upon potassium and methamphetamine (MA)…

Puberty acceleration in female mice induced with a partially purified male urine extract: effects on catecholamine release from the olfactory bulbs and hypothalamus.

In the present experiment peri-pubertal female mice were treated with a partially purified puberty accelerating urine extract (PAUE). Mice treated with the PAUE showed an advance in the onset of puberty as indicated by significantly increased uterine…

Tags: *Sex Characteristics, 1992, Animals, Brain research, Catecholamines/*metabolism, Dluzen D, Female, Guan X, Hypothalamus, Inbred Strains, Male, Mice, Middle/*metabolism, Olfactory Bulb/*metabolism, Sexual Maturation/*physiology, Urine/*physiology, Vandenbergh J G

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces norepinephrine concentrations in the olfactory bulbs of male mice.

Male retired breeder C57/Bl and CD-1 mice were treated with either MPTP or its vehicle. At 7-10 days post-treatment, catecholamine concentrations within the olfactory bulbs (OB) and hypothalamus were determined. Norepinephrine concentrations within…

Tags: *Sex Characteristics, 1-Methyl-4-phenyl-1, 1992, 2, 3, 6-tetrahydropyridine/*pharmacology, Animals, Brain research, Dluzen D E, Dopamine/metabolism, Drug Resistance/genetics, Inbred C57BL, Inbred Strains, Male, Mice, Norepinephrine/*metabolism, Olfactory Bulb/*metabolism, Osmolar Concentration

Dopamine transporter function differences between male and female CD-1 mice.

It has been reported that male mice are more susceptible to the neurotoxic effects of methamphetamine (MA) upon the nigrostriatal dopaminergic (NSDA) system. Since MA utilizes the dopamine transporter (DAT) to exert its effects, in the present study,…

Tags: *Sex Characteristics, 2005, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Animals, Bhatt Sandeep D, Brain research, Corpus Striatum/physiology, Dluzen Dean E, Dopamine Plasma Membrane Transport Proteins, Dopamine/physiology, Female, Male, Membrane Glycoproteins/*physiology, Membrane Transport Proteins/*physiology, Mice, Nerve Tissue Proteins/*physiology

Effects of gender and gonadal hormones on nociceptive responses to intraplantar carrageenan in the rat.

The effects of gender and gonadal hormones on nociceptive responses to intraplantar carrageenan in the rat were investigated. A plantar analgesic meter was used to measure carrageenan-induced changes in paw withdrawal latency (PWL) values, and von…

Testosterone enhances dopamine depletion by methamphetamine in male, but not female, mice.

We examined the effects of varying concentrations of testosterone propionate (T) treatment within intact and gonadectomized male and female mice with regard to its capacity to alter striatal dopamine (DA) depletion in response to a neurotoxic regimen…

Tags: *Sex Characteristics, 2008, Animals, Castration/methods, Corpus Striatum/drug effects/metabolism, Dluzen Dean E, Dopamine Uptake Inhibitors/*pharmacology, Dopamine/*metabolism, Dose-Response Relationship, Drug, Female, Lewis Chandani, Male, Methamphetamine/*pharmacology, Mice, Neuroscience letters, Testosterone Propionate/*pharmacology

MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains.

Continuing our previous work in which we showed wide-ranging strain differences in MPTP neurotoxicity in male mice among ten BXD recombinant inbred strains, we replicated our work in females from nine of the same strains. Mice received a single s.c.…

Effects of neonatal and prepubertal hormonal manipulations upon estrogen neuroprotection of the nigrostriatal dopaminergic system within female and male mice.

Estrogen (E) can function as a neuroprotectant of the nigrostriatal dopaminergic (NSDA) system against methamphetamine (MA) neurotoxicity in female, but not male, mice. In the present report we examined whether the organizational effects of gonadal…

Differences in reserpine-induced striatal dopamine output and content between female and male mice: implications for sex differences in vesicular monoamine transporter 2 function.

In this report a series of six in vitro experiments in which reserpine-evoked dopamine output and two in vivo experiments in which the effects of reserpine injections upon dopamine content from striatal tissue of female and male mice were performed…

Tags: *Sex Characteristics, 2008, Adrenergic Uptake Inhibitors/*pharmacology, Animals, Bhatt S, Chromatography, Corpus Striatum/drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Female, High Pressure Liquid, Male, McDermott J L, Mice, Neuroscience, Orchiectomy, Ovariectomy, Reserpine/*pharmacology, Vesicular Monoamine Transport Proteins/*metabolism

Sex differences in methamphetamine-evoked striatal dopamine of mice are reversed by nomifensine.

Male mice show more severe striatal dopamine depletions to the psychostimulant, methamphetamine (MA). To gain some understanding for this sex difference, we examined MA-evoked dopamine (DA) responses from superfused striatal tissue fragments of male…

Gender differences in modulatory effects of tamoxifen upon the nigrostriatal dopaminergic system.

It has been demonstrated that the gonadal steroid hormone estrogen can exert neuroprotective effects upon the nigrostriatal dopaminergic (NSDA) system against methamphetamine (MA)-induced neurotoxicity in female, but not male, mice. In contrast, the…

Tags: *Sex Characteristics, 2005, Animals, Corpus Striatum/*drug effects/metabolism, Dluzen Dean E, Dopamine/*metabolism, Female, Male, Mice, Mickley Katherine R, Motor Activity/drug effects/physiology, Pharmacology, biochemistry, and behavior, Substantia Nigra/*drug effects/metabolism, Tamoxifen/*pharmacology

Estrogen reduces acute striatal dopamine responses in vivo to the neurotoxin MPP+ in female, but not male rats.

The effects of in vivo estrogen treatment upon MPP(+)-induced dopamine (DA) release were determined using in vivo microdialysis in female and male rats. Ovariectomized female rats were implanted or not with an estrogen pellet (0.1 mg, 17beta…

Sex differences in extracellular and intracellular calcium-mediated vascular reactivity to vasopressin in rat aorta.

In rat thoracic aorta, contractile responses to arginine vasopressin are two-fold higher in females than in males. To determine the roles of extracellular and intracellular Ca2+ in this sexual dimorphism in vascular function, vascular reactivity and…

LSD produces conditioned place preference in male but not female fawn hooded rats.

Male and female Fawn Hooded rats were examined for conditioned place preference (CPP) or aversion (CPA) to lysergic acid diethylamide (LSD). Using a biased design, experimental animals were trained with LSD (0.2 mg/kg, I.P.) administered in…

Tags: *Cues, *Sex Characteristics, 1998, Analysis of Variance, Animals, Choice Behavior/*drug effects, Conditioning, Female, Humans, Inbred Strains, Lysergic Acid Diethylamide/*pharmacology, Male, Meehan S M, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D

Gender differences in methamphetamine use and responses: a review.

BACKGROUND: Men and women differ markedly with regard to their use of, and responses to, methamphetamine (MA) and related amphetamines. However, these gender differences oftentimes are given only a cursory consideration in the analyses of these MA…

Tags: *Amphetamine-Related Disorders, *Gender Identity, *Sex Characteristics, 2008, Animals, Central Nervous System Stimulants/pharmacokinetics/*pharmacology, Depressive Disorder/drug therapy, Dluzen Dean E, Female, Gender medicine, Humans, Liu Bin, Male, Methamphetamine/pharmacokinetics/*pharmacology, Sex Factors, Substance-Related Disorders

Norepinephrine is lateralized within the olfactory bulbs of male mice.

Concentrations and in vitro release of norepinephrine were determined from left and right olfactory bulbs of adult male CD-1 mice. Norepinephrine concentrations from the left olfactory bulbs were significantly greater than those of the right (p…

Tags: *Functional Laterality, *Sex Characteristics, 1996, Animals, Dluzen D E, Dopamine/metabolism, Inbred Strains, Journal of neurochemistry, Kreutzberg J D, Male, Mice, Norepinephrine/*metabolism, Olfactory Bulb/*metabolism, Osmolar Concentration, Potassium/pharmacology, Tissue Distribution

Estrogen, anti-estrogen, and gender: differences in methamphetamine neurotoxicity.

In Part 1 of this report, we review data on the effects of estrogen (E), the anti-E tamoxifen (TMX), and testosterone (T) on methamphetamine (METH)-induced neurotoxicity in female and male CD-1 mice. Treatment of gonadectomized females with a…

Tags: *Neurotoxins, *Sex Characteristics, 2002, Animals, Annals of the New York Academy of Sciences, Biological, Dluzen Dean E, Estrogen Antagonists/*pharmacology, Estrogens/*physiology, Female, Humans, Male, McDermott Janet L, Methamphetamine/*toxicity, Mice, Models, Tamoxifen/pharmacology, Testosterone/pharmacology

Sexual dimorphism in prostanoid-potentiated vascular contraction: roles of endothelium and ovarian steroids.

The effects of constrictor prostanoid (CP) pathway inhibitors on vascular reactivity to vasopressin (VP) and phenylephrine (PE) were examined in thoracic aortas of male, female, and ovariectomized (OVX) female Sprague-Dawley rats. Maximal contractile…

Sexual dimorphism in vasopressin-induced contraction of rat aorta.

Previously, we reported that, in the rat, pressor responsiveness to vasopressin (VP) is higher in males than in females during most phases of the estrous cycle. To explore the role of the vasculature in this phenomenon, we examined vascular…

Tags: *Sex Characteristics, *Vasoconstriction, 1991, Animals, Aorta/*drug effects, Arginine Vasopressin/*pharmacology, Crofton J T, Dose-Response Relationship, Drug, Female, Male, Osmolar Concentration, Phenylephrine/pharmacology, Rats, Share L, Stallone J N, The American journal of physiology

Role of endothelium in sexual dimorphism in vasopressin-induced contraction of rat aorta.

In rat thoracic aorta, contractile responses to arginine vasopressin (AVP) are twofold higher in females than in males. To determine the role of the endothelium in this phenomenon, the effects of endothelium removal and inhibition of nitric oxide…

Daily exercise and gender influence arterial baroreflex regulation of heart rate and nerve activity.

The influence of daily spontaneous running (DSR) and gender on the arterial baroreflex regulation of heart rate (HR) and lumbar sympathetic nerve activity (LSNA) was examined in 13 male [7 sedentary (SED) and 6 DSR] and 12 female (6 SED and 6 DSR)…

Tags: *Physical Conditioning, *Sex Characteristics, 1996, Animal, Animals, Arteries/*physiology, Baroreflex/*physiology, Chen C Y, DiCarlo S E, Female, Heart Rate/*physiology, Lumbosacral Region, Male, Rats, Rest, Sprague-Dawley, Sympathetic Nervous System/*physiology, The American journal of physiology

Acute exercise and gender alter cardiac autonomic tonus differently in hypertensive and normotensive rats.

Arterial pressure (AP), heart rate (HR), cardiac sympathetic tonus (ST), and parasympathetic tonus (PT) were determined in spontaneously hypertensive rats (SHR, 8 male and 8 female) and Wistar-Kyoto normotensive rats (WKY, 8 male and 12 female)…

Developmental and genetic influences upon gender differences in methamphetamine-induced nigrostriatal dopaminergic neurotoxicity.

The gonadal steroid hormone estrogen (E) may play an important role in sex differences in methamphetamine (MA)-induced neurotoxicity of the nigrostriatal dopaminergic (NSDA) system because E can serve as a neuroprotectant in female, but not male,…

Tags: *Sex Characteristics, 2004, Animals, Annals of the New York Academy of Sciences, Corpus Striatum/*drug effects/growth & development/metabolism, Dluzen Dean E, Dopamine/*metabolism, Female, Humans, Male, McDermott Janet L, Methamphetamine/*toxicity, Substantia Nigra/*drug effects/growth & development/metabolism

Estrogen, testosterone, and gender differences.

The purpose of this report is to gain some current perspective on the definition, bases, and trends for research associated with gender differences. To accomplish this goal an analysis on the number of citations from a 1994-2004 Medline search with…

Tags: *Gender Identity, *Sex Characteristics, 2005, Dluzen Dean E, Endocrine, Estrogens/*physiology, Female, Humans, Male, Testosterone/*physiology

Estrogen receptor-alpha and -beta coexist in a subpopulation of sensory neurons of female rat dorsal root ganglia.

Immunoreactivities for estrogen receptor-alpha (ER-alpha) and ER-beta are expressed in sensory neurons of the dorsal root ganglia (DRG). It has not been established, however, if the two receptor subtypes coexist in the same neuron. Double-staining…

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