1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
614–620
Issue
11
Volume
36
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Tissue-engineered meniscal constructs.
Publisher
An entity responsible for making the resource available
American journal of orthopedics (Belle Mead, N.J.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-11
Subject
The topic of the resource
Humans; Biomechanical Phenomena; *Biocompatible Materials; *Tissue Engineering; Menisci; Tibial/*anatomy & histology/physiology
Creator
An entity primarily responsible for making the resource
Schoenfeld Andrew J; Landis William J; Kay David B
Description
An account of the resource
The medial and lateral menisci play important roles in knee biomechanics, kinematics, and stability. Unfortunately, these structures are prone to damage and, because of a tenuous blood supply, have great difficulty healing. Many interventions have been proposed for treatment of damaged meniscal tissue, but most surgical options are fraught with difficulties, from continued osteoarthritic degeneration to potential for disease transmission. The field of tissue engineering has made wide inroads into constructing meniscal tissue. Investigations involving collagenous tissue, meniscal fibrochondrocytes, chondrocytes, synthetic scaffolds, and gene therapy have all been reported in the literature. Despite these advances, however, more work needs to be done, including incorporating concepts and applications from other engineering disciplines, to potentiate the possibility of a tissue-engineered meniscus that approximates native tissue. In particular, the histologic, morphologic, and biomechanical properties of tissue-engineered meniscal constructs must be better understood to facilitate this goal.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Biocompatible Materials
*Tissue Engineering
2007
American journal of orthopedics (Belle Mead, N.J.)
Biomechanical Phenomena
Humans
Kay David B
Landis William J
Menisci
Schoenfeld Andrew J
Tibial/*anatomy & histology/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000151432" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000151432</a>
Pages
241–244
Issue
1
Volume
189
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Tissue engineering models of human digits: effect of periosteum on growth plate cartilage development.
Publisher
An entity responsible for making the resource available
Cells, tissues, organs
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009
Subject
The topic of the resource
*Models; *Tissue Engineering; Animals; Articular/*growth & development; Biological; Cartilage; Cattle; Experimental; Fingers/diagnostic imaging; Growth Plate/cytology/*growth & development; Humans; Implants; Male; Mice; Nude; Periosteum/*physiology; Radiography
Creator
An entity primarily responsible for making the resource
Landis William J; Jacquet Robin; Lowder Elizabeth; Enjo Mitsuhiro; Wada Yoshitaka; Isogai Noritaka
Description
An account of the resource
Tissue-engineered middle phalanx constructs of human digits were investigated to determine whether periosteum wrapped partly about model midshafts mediated cartilage growth plate formation. Models were fabricated by suturing ends of polymer midshafts in a human middle phalanx shape with polymer sheets seeded with heterogeneous chondrocyte populations from bovine articular cartilage. Half of each midshaft length was wrapped with bovine periosteum. Constructs were cultured, implanted in nude mice for up to 20 weeks, harvested and treated histologically to assess morphology and cartilage proteoglycans. After 20 weeks of implantation, chondrocyte-seeded sheets adjacent to periosteum-wrapped midshaft halves established cartilage growth plates resembling normal tissue in vivo. Sheets adjacent to midshafts without periosteum had disorganized cells and no plate formation. Proteoglycans were present at both midshaft ends. Periosteum appears to guide chondrocytes toward growth plate cartilage organization and tissue engineering provides means for carefully examining construct development of this tissue.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000151432" target="_blank" rel="noreferrer noopener">10.1159/000151432</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Models
*Tissue Engineering
2009
Animals
Articular/*growth & development
Biological
Cartilage
Cattle
Cells, tissues, organs
Enjo Mitsuhiro
Experimental
Fingers/diagnostic imaging
Growth Plate/cytology/*growth & development
Humans
Implants
Isogai Noritaka
Jacquet Robin
Landis William J
Lowder Elizabeth
Male
Mice
Nude
Periosteum/*physiology
Radiography
Wada Yoshitaka
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1601-6343.2005.00353.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1601-6343.2005.00353.x</a>
Pages
303–312
Issue
4
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Design and assessment of a tissue-engineered model of human phalanges and a small joint.
Publisher
An entity responsible for making the resource available
Orthodontics & craniofacial research
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-11
Subject
The topic of the resource
*Bioartificial Organs; *Biomimetic Materials; *Finger Joint; *Finger Phalanges; *Tissue Engineering; Animals; Biological; Bone and Bones; Cartilage; Cattle; Humans; Lactic Acid; Mice; Models; Nude; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Tendons
Creator
An entity primarily responsible for making the resource
Landis W J; Jacquet R; Hillyer J; Lowder E; Yanke A; Siperko L; Asamura S; Kusuhara H; Enjo M; Chubinskaya S; Potter K; Isogai N
Description
An account of the resource
OBJECTIVES: To develop models of human phalanges and small joints by suturing different cell-polymer constructs that are then implanted in athymic (nude) mice. DESIGN: Models consisted of bovine periosteum, cartilage, and/or tendon cells seeded onto biodegradable polymer scaffolds of either polyglycolic acid (PGA) or copolymers of PGA and poly-L-lactic acid (PLLA) or poly-epsilon-caprolactone (PCL) and PLLA. Constructs were fabricated to produce a distal phalanx, middle phalanx, or distal interphalangeal joint. SETTING AND SAMPLE POPULATION: Studies of more than 250 harvested implants were conducted at the Northeastern Ohio Universities College of Medicine. EXPERIMENTAL VARIABLE: Polymer scaffold, cell type, and implantation time were examined. OUTCOME MEASURE: Tissue-engineered specimens were characterized by histology, transmission electron microscopy, in situ hybridization, laser capture microdissection and qualitative and quantitative polymerase chain reaction analysis, magnetic resonance microscopy, and X-ray microtomography. RESULTS: Over periods to 60 weeks of implantation, constructs developed through vascularity from host mice; formed new cartilage, bone, and/or tendon; expressed characteristic genes of bovine origin, including type I, II and X collagen, osteopontin, aggrecan, biglycan, and bone sialoprotein; secreted corresponding proteins; responded to applied mechanical stimuli; and maintained shapes of human phalanges with small joints. CONCLUSION: Results give insight into construct processes of tissue regeneration and development and suggest more complete tissue-engineered cartilage, bone, and tendon models. These should have significant future scientific and clinical applications in medicine, including their use in plastic surgery, orthopaedics, craniofacial reconstruction, and teratology.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1601-6343.2005.00353.x" target="_blank" rel="noreferrer noopener">10.1111/j.1601-6343.2005.00353.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Bioartificial Organs
*Biomimetic Materials
*Finger Joint
*Finger Phalanges
*Tissue Engineering
2005
Animals
Asamura S
Biological
Bone and Bones
Cartilage
Cattle
Chubinskaya S
Enjo M
Hillyer J
Humans
Isogai N
Jacquet R
Kusuhara H
Lactic Acid
Landis W J
Lowder E
Mice
Models
Nude
Orthodontics & craniofacial research
Polyglycolic Acid
Polylactic Acid-Polyglycolic Acid Copolymer
Polymers
Potter K
Siperko L
Tendons
Yanke A