1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/acschemneuro.7b00287" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/acschemneuro.7b00287</a>
Pages
2759–2765
Issue
12
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype.
Publisher
An entity responsible for making the resource available
ACS chemical neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-12
Subject
The topic of the resource
*aging; *Disease Models; *drug discovery; *mitochondrial dysfunction; *mitoNEET; Animal; Animals; Corpus Striatum/*metabolism/*pathology; Inbred C57BL; Iron-Binding Proteins/genetics/*metabolism; Knockout; Male; Membrane Proteins/genetics/*metabolism; Mice; Mitochondria/*metabolism/*pathology; Parkinson Disease/*metabolism/pathology
Creator
An entity primarily responsible for making the resource
Geldenhuys Werner J; Benkovic Stanley A; Lin Li; Yonutas Heather M; Crish Samuel D; Sullivan Patrick G; Darvesh Altaf S; Brown Candice M; Richardson Jason R
Description
An account of the resource
Mitochondrial dysfunction is thought to play a significant role in neurodegeneration observed in Parkinson's disease (PD), yet the mechanisms underlying this pathology remain unclear. Here, we demonstrate that loss of mitoNEET (CISD1), an iron-sulfur containing protein that regulates mitochondrial bioenergetics, results in mitochondrial dysfunction and loss of striatal dopamine and tyrosine hydroxylase. Mitochondria isolated from mice lacking mitoNEET were dysfunctional as revealed by elevated reactive oxygen species (ROS) and reduced capacity to produce ATP. Gait analysis revealed a shortened stride length and decreased rotarod performance in knockout mice, consistent with the loss of striatal dopamine. Together, these data suggest that mitoNEET KO mice exhibit many of the characteristics of early neurodegeneration in PD and may provide a novel drug discovery platform to evaluate compounds for enhancing mitochondrial function in neurodegenerative disorders.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/acschemneuro.7b00287" target="_blank" rel="noreferrer noopener">10.1021/acschemneuro.7b00287</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Aging
*Disease Models
*drug discovery
*mitochondrial dysfunction
*mitoNEET
2017
ACS chemical neuroscience
Animal
Animals
Benkovic Stanley A
Brown Candice M
Corpus Striatum/*metabolism/*pathology
Crish Samuel D
Darvesh Altaf S
Department of Pharmaceutical Sciences
Geldenhuys Werner J
Inbred C57BL
Iron-Binding Proteins/genetics/*metabolism
Knockout
Lin Li
Male
Membrane Proteins/genetics/*metabolism
Mice
Mitochondria/*metabolism/*pathology
NEOMED College of Pharmacy
Parkinson Disease/*metabolism/pathology
Richardson Jason R
Sullivan Patrick G
Yonutas Heather M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3390/molecules22060917" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/molecules22060917</a>
Issue
6
Volume
22
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases.
Publisher
An entity responsible for making the resource available
Molecules (Basel, Switzerland)
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-06
Subject
The topic of the resource
Humans; Animals; Protein Binding; Signal Transduction; atherosclerosis; *Drug Discovery; *Ligands; Adenosine/metabolism; cardiac death; Cardiovascular Diseases/drug therapy/metabolism; Cardiovascular System/metabolism; Hydrogen Bonding; Molecular Structure; myocardial infarction; Structure-Activity Relationship; vascular tone; Receptors; Models; Molecular; Purinergic P1/*chemistry/*metabolism
Creator
An entity primarily responsible for making the resource
Geldenhuys Werner J; Hanif Ahmad; Yun June; Nayeem Mohammed A
Description
An account of the resource
Cardiovascular diseases remain the number one diseases affecting patients' morbidity and mortality. The adenosine receptors are G-protein coupled receptors which have been of interest for drugs target for the treatment of multiple diseases ranging from cardiovascular to neurological. Adenosine receptors have been connected to several biological pathways affecting the physiology and pathology of the cardiovascular system. In this review, we will cover the different adenosine receptor ligands that have been identified to interact with adenosine receptors and affect the vascular system. These ligands will be evaluated from clinical as well as medicinal chemistry perspectives with more emphasis on how structural changes in structure translate into ligand potency and efficacy. Adenosine receptors represent a novel therapeutic target for development of treatment options treating a wide variety of diseases, including vascular disease and obesity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3390/molecules22060917" target="_blank" rel="noreferrer noopener">10.3390/molecules22060917</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*drug discovery
*Ligands
2017
Adenosine/metabolism
Animals
Atherosclerosis
Cardiac death
Cardiovascular Diseases/drug therapy/metabolism
Cardiovascular System/metabolism
Department of Integrative Medical Sciences
Geldenhuys Werner J
Hanif Ahmad
Humans
Hydrogen Bonding
Models
Molecular
Molecular Structure
Molecules (Basel, Switzerland)
myocardial infarction
Nayeem Mohammed A
NEOMED College of Medicine
Protein Binding
Purinergic P1/*chemistry/*metabolism
Receptors
Signal Transduction
Structure-Activity Relationship
Vascular tone
Yun June