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Text
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URL Address
<a href="http://doi.org/10.1177/1535370216675773" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/1535370216675773</a>
Pages
384–396
Issue
4
Volume
242
Dublin Core
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Title
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The contribution of interleukin-2 to effective wound healing.
Publisher
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Experimental biology and medicine (Maywood, N.J.)
Date
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2017
2017-02
Subject
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*cutaneous diseases; *cytokines; *immunotherapy; *Interleukin-2; *therapeutic targets; *wound healing; Animals; Cell Differentiation/physiology; Cell Proliferation/physiology; Diabetes Mellitus/metabolism/pathology; Humans; Interleukin-2/*metabolism; Interleukin-2/*metabolism/*therapeutic use; Lupus Erythematosus; Mice; Myocardial Infarction/metabolism/pathology; Receptors; Sarcoidosis/metabolism/pathology; Signal Transduction/physiology; Skin/*injuries; Systemic/metabolism/pathology; T-Lymphocytes/cytology/immunology; Wound Healing/*physiology
Creator
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Doersch Karen M; DelloStritto Daniel J; Newell-Rogers M Karen
Description
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Ineffective skin wound healing is a significant source of morbidity and mortality. Roughly 6.5 million Americans experience chronically open wounds and the cost of treating these wounds numbers in the billions of dollars annually. In contrast, robust wound healing can lead to the development of either hypertrophic scarring or keloidosis, both of which can cause discomfort and can be cosmetically undesirable. Appropriate wound healing requires the interplay of a variety of factors, including the skin, the local microenvironment, the immune system, and the external environment. When these interactions are perturbed, wounds can be a nidus for infection, which can cause them to remain open an extended period of time, or can scar excessively. Interleukin-2, a cytokine that directs T-cell expansion and phenotypic development, appears to play an important role in wound healing. The best-studied role for Interleukin-2 is in influencing
Identifier
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<a href="http://doi.org/10.1177/1535370216675773" target="_blank" rel="noreferrer noopener">10.1177/1535370216675773</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*cutaneous diseases
*CYTOKINES
*immunotherapy
*Interleukin-2
*therapeutic targets
*Wound Healing
2017
Animals
Cell Differentiation/physiology
Cell Proliferation/physiology
DelloStritto Daniel J
Diabetes Mellitus/metabolism/pathology
Doersch Karen M
Experimental biology and medicine (Maywood, N.J.)
Humans
Interleukin-2/*metabolism
Interleukin-2/*metabolism/*therapeutic use
Lupus Erythematosus
Mice
Myocardial Infarction/metabolism/pathology
Newell-Rogers M Karen
Receptors
Sarcoidosis/metabolism/pathology
Signal Transduction/physiology
Skin/*injuries
Systemic/metabolism/pathology
T-Lymphocytes/cytology/immunology
Wound Healing/*physiology