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URL Address
<a href="http://doi.org/10.1152/jn.00657.2016" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00657.2016</a>
Pages
2550–2563
Issue
6
Volume
116
Dublin Core
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Title
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L-type calcium channels refine the neural population code of sound level.
Publisher
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Journal of neurophysiology
Date
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2016
2016-12
Subject
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*auditory midbrain; *dynamic range; *inferior colliculus; *level tuning; *local circuits; *rate-level functions; *Sound; 4-Aminopyridine/analogs & derivatives/pharmacology; Acoustic Stimulation; Action Potentials/drug effects/*physiology; Amifampridine; Animals; Biophysical Phenomena/drug effects; Calcium Channel Blockers/pharmacology; Calcium Channels; Calcium/metabolism; Excitatory Amino Acid Antagonists/pharmacology; In Vitro Techniques; Inbred CBA; Inferior Colliculi/*cytology; L-Type/*metabolism; Mice; Neurons/*physiology; Nimodipine/pharmacology; omega-Conotoxin GVIA/pharmacology; Potassium Channel Blockers/pharmacology; Quinoxalines/pharmacology; Wakefulness
Creator
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Grimsley Calum Alex; Green David Brian; Sivaramakrishnan Shobhana
Description
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The coding of sound level by ensembles of neurons improves the accuracy with which listeners identify how loud a sound is. In the auditory system, the rate at which neurons fire in response to changes in sound level is shaped by local networks. Voltage-gated conductances alter local output by regulating neuronal firing, but their role in modulating responses to sound level is unclear. We tested the effects of L-type calcium channels (CaL: CaV1.1-1.4) on sound-level coding in the central nucleus of the inferior colliculus (ICC) in the auditory midbrain. We characterized the contribution of CaL to the total calcium current in brain slices and then examined its effects on rate-level functions (RLFs) in vivo using single-unit recordings in awake mice. CaL is a high-threshold current and comprises approximately 50% of the total calcium current in ICC neurons. In vivo, CaL activates at sound levels that evoke high firing rates. In RLFs that increase monotonically with sound level, CaL boosts spike rates at high sound levels and increases the maximum firing rate achieved. In different populations of RLFs that change nonmonotonically with sound level, CaL either suppresses or enhances firing at sound levels that evoke maximum firing. CaL multiplies the gain of monotonic RLFs with dynamic range and divides the gain of nonmonotonic RLFs with the width of the RLF. These results suggest that a single broad class of calcium channels activates enhancing and suppressing local circuits to regulate the sensitivity of neuronal populations to sound level.
Identifier
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<a href="http://doi.org/10.1152/jn.00657.2016" target="_blank" rel="noreferrer noopener">10.1152/jn.00657.2016</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*auditory midbrain
*dynamic range
*Inferior colliculus
*level tuning
*local circuits
*rate-level functions
*Sound
2016
4-Aminopyridine/analogs & derivatives/pharmacology
Acoustic Stimulation
Action Potentials/drug effects/*physiology
Amifampridine
Animals
Biophysical Phenomena/drug effects
Calcium Channel Blockers/pharmacology
Calcium Channels
Calcium/metabolism
Excitatory Amino Acid Antagonists/pharmacology
Green David Brian
Grimsley Calum Alex
In Vitro Techniques
Inbred CBA
Inferior Colliculi/*cytology
Journal of neurophysiology
L-Type/*metabolism
Mice
Neurons/*physiology
Nimodipine/pharmacology
omega-Conotoxin GVIA/pharmacology
Potassium Channel Blockers/pharmacology
Quinoxalines/pharmacology
Sivaramakrishnan Shobhana
Wakefulness