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40
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Text
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<a href="http://doi.org/10.1016/s0006-8993(00)02329-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(00)02329-5</a>
Pages
95–104
Issue
1
Volume
868
Dublin Core
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Title
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Estrogen reduces acute striatal dopamine responses in vivo to the neurotoxin MPP+ in female, but not male rats.
Publisher
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Brain research
Date
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2000
2000-06
Subject
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*Sex Characteristics; 1-Methyl-4-phenylpyridinium/*toxicity; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/*metabolism; Dopamine/*metabolism; Estrogens/*pharmacology; Extracellular Space/metabolism; Female; Herbicides/*toxicity; Male; Microdialysis; Nerve Degeneration/chemically induced/metabolism; Parkinson Disease; Rats; Secondary/chemically induced/metabolism; Sprague-Dawley
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Disshon K A; Dluzen D E
Description
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The effects of in vivo estrogen treatment upon MPP(+)-induced dopamine (DA) release were determined using in vivo microdialysis in female and male rats. Ovariectomized female rats were implanted or not with an estrogen pellet (0.1 mg, 17beta estradiol) and subjected to microdialysis 6 days later. After baseline DA release was determined, 5 mM MPP(+) was infused through the microdialysis probe for one 20-min interval. Perfusion resumed with normal medium for the duration of the experiment. A significant attenuation of MPP(+)-induced DA release was obtained in estrogen-treated females. One week later, striatal DA and dihydroxyphenylacetic acid (DOPAC) concentrations were determined for the lesioned and non-lesioned striata of each animal. MPP(+) infusion significantly decreased striatal DA concentrations, however, there was no effect of estrogen treatment on striatal DA depletion. This experiment was repeated using orchidectomized male rats treated with 0, 0.1, or 5 mg estradiol. In contrast to the females, no differences in MPP(+)-induced DA release were seen among these males, and there was no significant effect of the varying estrogen treatments on striatal DA or DOPAC concentrations. These results demonstrate that in vivo estrogen treatment attenuates MPP(+)-induced striatal DA release in gonadectomized female, but not male, rats.
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<a href="http://doi.org/10.1016/s0006-8993(00)02329-5" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(00)02329-5</a>
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*Sex Characteristics
1-Methyl-4-phenylpyridinium/*toxicity
2000
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Brain research
Corpus Striatum/*metabolism
Disshon K A
Dluzen D E
Dopamine/*metabolism
Estrogens/*pharmacology
Extracellular Space/metabolism
Female
Herbicides/*toxicity
Male
Microdialysis
Nerve Degeneration/chemically induced/metabolism
Parkinson Disease
Rats
Secondary/chemically induced/metabolism
Sprague-Dawley