Browse Items · NEOMED Bibliography Database

Projections of physiologically defined subdivisions of the inferior colliculus in the mustached bat: targets in the medial geniculate body and extrathalamic nuclei.

This study examined the output of the central nucleus of the inferior colliculus to the medial geniculate body and other parts of the nervous system in the mustached bat (Pteronotus parnellii). Small deposits of anterograde tracers (horseradish…

Tags: 1994, Acoustic Stimulation, Animals, Axons/ultrastructure, Brain Mapping, Chiroptera/*physiology, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Geniculate Bodies/*physiology, Inferior Colliculi/*physiology, Larue D T, NEOMED College of Medicine, Neural Pathways/*physiology, Synaptic Transmission, Thalamic Nuclei/*physiology, The Journal of comparative neurology, Wenstrup J J, Winer J A

Development of inhibitory and excitatory synaptic transmission in the rat dentate gyrus.

We studied the ontogeny of inhibitory and excitatory processes in the rat dentate gyrus by examining paired-pulse plasticity in the hippocampal slice preparation. The mature dentate gyrus produces characteristic paired-pulse responses across a wide…

Tags: 1994, Action Potentials, Animals, DiScenna P G, Hippocampus, Hippocampus/*growth & development, Neuronal Plasticity/*physiology, Rats, Reaction Time, Synapses/physiology, Teyler T J

Multideterminant role of calcium in hippocampal synaptic plasticity.

Hippocampal CA1 cells possess several varieties of long-lasting synaptic plasticity: two different forms of long-term potentiation (LTP) and at least one form of long-term depression (LTD). All forms of synaptic plasticity are induced by afferent…

Tags: 1994, Animals, Calcium/*physiology, Cavus I, Coussens C, DiScenna P, Grover L, Hippocampus, Hippocampus/drug effects/*physiology, Humans, Lee Y P, Little Z, Neuronal Plasticity/drug effects/*physiology, Synapses/drug effects/*physiology, Teyler T J

Monoamine-activated alpha 2-macroglobulin inhibits choline acetyltransferase of embryonic basal forebrain neurons and reversal of the inhibition by NGF and BDNF but not NT-3.

Monoamine-activated alpha 2-macroglobulin (alpha 2M) has recently been shown to inhibit the growth and survival of cholinergic neurons of the basal forebrain (Liebl and Koo: J Neurosci Res 35:170-182, 1993). The mechanism of this inhibitory effect is…

Tags: 1994, alpha-Macroglobulins/antagonists & inhibitors/*pharmacology, Animals, Biogenic Monoamines/*pharmacology, Brain-Derived Neurotrophic Factor, Cells, Choline O-Acetyltransferase/*antagonists & inhibitors, Cultured, Humans, Journal of neuroscience research, Koo P H, Liebl D J, Nerve Growth Factors/*pharmacology, Nerve Tissue Proteins/pharmacology, Neurons/drug effects/*metabolism, Neurotrophin 3, Prosencephalon/*cytology, Rats

Intracranial infusion of monoamine-activated alpha 2-macroglobulin decreases dopamine concentrations within the rat caudate putamen.

Monoamine-activated alpha 2-macroglobulin (alpha 2M) has been shown to inhibit choline acetyltransferase in basal forebrain neurons as well as neurotrophin-dependent neuronal functions. The objective of this study was to determine whether…

Tags: *Nerve Degeneration, 1994, alpha-Macroglobulins/*pharmacology/physiology/toxicity, Animals, Caudate Nucleus/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, Hu Y Q, Infusion Pumps, Journal of neuroscience research, Koo P H, Male, Putamen/*drug effects/metabolism, Rats, Sprague-Dawley

Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7 alpha-hydroxylase mRNA and the CYP7 gene in HepG2 cells.

The expression of cholesterol 7 alpha-hydroxylase mRNA levels in confluent HepG2 cultures was reduced by tauro- or glyco-conjugates of deoxycholate and chenodeoxycholate, but not by cholate. Ursodeoxycholates, on the other hand, stimulated the mRNA…

Structure and nucleotide sequences of the human cholesterol 7 alpha-hydroxylase gene (CYP7).

The human cholesterol 7 alpha-hydroxylase gene (CYP7) spans about 11 kb of the genome and contains six exons and five introns. Nucleotide sequences of a 5'-upstream region to exon III (5535 bp), a 5'-upstream EcoRI fragment (2575 bp), and an EcoRI…

Tags: 1994, Amino Acid Sequence, Base Sequence, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/chemistry/*genetics, Department of Integrative Medical Sciences, DNA, Genomics, Humans, Molecular Sequence Data, NEOMED College of Medicine, Restriction Mapping, Wang D P

Wound seeding associated with endometrial cancer.

We report a patient with well-differentiated adenocarcinoma of the endometrium who developed a recurrence in the anterior abdominal wall probably secondary to wound seeding at the time of her original surgery. She underwent total abdominal…

Tags: *Neoplasm Recurrence, *Neoplasm Seeding, 1994, Adenocarcinoma/pathology/radiotherapy/*surgery, Adult, Cross B, Curtis M G, Department of Internal Medicine, Endometrial Neoplasms/pathology/radiotherapy/*surgery, Female, Gynecologic oncology, Hopkins M P, Humans, Jenison E L, Local, NEOMED College of Medicine, Phosphorus Radioisotopes/therapeutic use, Rehmus E, Tantri M D

The antiviral activity of RNA-dye combinations.

The results of our previous studies (Jamison et al. 1988, 1989, 1990 a, b, c, d, e) have shown that the ability of intercalative dyes to modulate the antiviral activity of poly r(A-U) is related to the groove through which the dyes intercalate into…

Tags: 1994, Antiviral Agents/*toxicity, Coloring Agents/*toxicity, Double-Stranded/*toxicity, Gilloteaux J, Jamison J M, Microbial Sensitivity Tests, Poly A-U/*toxicity, Progress in molecular and subcellular biology, RNA, Structure-Activity Relationship, Summers J L

A splicing mutation in the cytochrome b5 gene from a patient with congenital methemoglobinemia and pseudohermaphrodism.

We have analyzed reticulocyte and leukocyte mRNAs isolated from a patient with congenital methemoglobinemia and pseudohermaphrodism. The cytochrome b5 cDNA sequences were amplified using specific oligonucleotide primers and the polymerase chain…

Induction of ethanol dependence increases signal peptidase mRNA levels in rat brain.

Differential Northern blot hybridization was used as a screening tool to identify mRNAs that respond quantitatively to the induction of ethanol dependence. Adult male rats were treated with repeated, high doses of ethanol for 4 consecutive days. This…

The effect of reserpine treatment in vivo upon L-dopa and amphetamine evoked dopamine and DOPAC efflux in vitro from the corpus striatum of male rats.

In the present experiment we tested the effects of L-DOPA and amphetamine upon dopamine and DOPAC efflux in vitro from superfused corpus striatal tissue fragments of male rats who had been pretreated with reserpine. Male rats were treated with…

Tags: 1994, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Amphetamine/*pharmacology, Animals, Cell Compartmentation, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, Drug Interactions, Journal of neural transmission. General section, Levodopa/*pharmacology, Liu B, Male, Rats, Research Design, Reserpine/*pharmacology, Secretory Rate/drug effects, Sprague-Dawley

The effect of estrogen administration in vivo upon catecholamine release in vitro from superfused hypothalamic tissue of ovariectomized pre-pubertal and adult mice.

In the present report we examined the effects of estrogen upon catecholamine release from superfused medial basal hypothalamic tissue fragments of pre-pubertal ovariectomized CD-1 mice. Prepubertal mice treated with estradiol benzoate (EB–5…

Tags: *Ovariectomy, 1994, Aging/*metabolism, Animals, Attaran M, Catecholamines/*metabolism, Dluzen D, Dopamine/metabolism, Estradiol/*pharmacology, Female, Hypothalamus/*drug effects/metabolism, Journal of endocrinological investigation, Liu B, Mice, Norepinephrine/metabolism, Organ Size/drug effects, Potassium/pharmacology, Uterus/drug effects/growth & development

Spermine depresses NMDA, K/AMPA and GABAA-mediated synaptic transmission in the rat hippocampal slice preparation.

The effects of spermine, an endogenous polyamine, were examined in area CA1 of the rat hippocampal slice preparation. Spermine, at low millimolar concentrations, rapidly and potently depressed NMDA and K/AMPA-mediated population EPSPs, and…

Conditioned place aversion produced by dopamine release inhibition.

CGS 10746B, a dopamine release inhibitor with properties similar to the atypical antipsychotic clozapine, was assessed as to its behavioral properties using spontaneous locomotor activity and the conditioned place preference test. Rats conditioned…

Antiepileptics inhibit cortical N-methyl-D-aspartate-evoked [3H]norepinephrine efflux.

The antiepileptic drugs phenytoin, valproic acid and phenobarbital were examined for their ability to inhibit N-methyl-D-aspartate (NMDA)-stimulated [3H]norepinephrine efflux from rat brain cortical slices. All three drugs inhibited efflux at varying…

Tags: 1994, Animals, Anticonvulsants/*pharmacology, Brown L M, Dose-Response Relationship, Drug, European journal of pharmacology, Female, Lee Y P, Male, N-Methylaspartate/*antagonists & inhibitors, Norepinephrine/*metabolism, Rats, Teyler T J

Sex differences in nitric oxide-mediated attenuation of vascular reactivity to vasopressin are abolished by gonadectomy.

In the rat thoracic aorta, contractile responses to vasopressin are two-fold higher in females than in males, primarily because nitric oxide-mediated attenuation of contraction is greater in males than in females. To determine the role of the gonadal…

Discriminative effects of cocaethylene in rats trained to discriminate cocaine or ethanol.

Two groups of rats were trained to discriminate between the stimulus properties of either intraperitoneally administered 10.0 mg/kg cocaine or 60 mg/kg ethanol and its vehicle in a two-lever operant chamber. Once trained, both groups exhibited a…

Tags: 1994, Animals, Cocaine/*analogs & derivatives/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Drug Interactions, Ethanol/*pharmacology, Inbred Strains, Life sciences, Male, Rats, Schechter M D

Isradipine produces neither a conditioned place preference nor aversion.

Isradipine (ISR) has been reported to block cocaine-induced conditioned place preference. Using this procedure, the pairing of this L-type calcium blocker, at doses of 2.5, 5.0 and 10 mg/kg, with a preferred (cue-distinct) environment was…

Tags: 1994, Animals, Calcagnetti D J, Cocaine/*pharmacology, Conditioning, Isradipine/administration & dosage/*pharmacology, Life sciences, Male, Operant/*drug effects, Rats, Schechter M D, Sprague-Dawley

L-dopa reverses castration-induced disruption of dishabituation responses to female chemical cues in male rats.

In the present experiment, habituation/dishabituation behavioral tests were conducted to measure discriminatory olfactory recognition responses to chemical cues among control, castrated, and castrated+L-3,4-dihydroxyphenylalanine (L-DOPA)-treated…

The development of GABAB-mediated activity in the rat dentate gyrus.

We examined the effects of GABAB receptor activation in the dentate gyrus of hippocampal slices prepared from 6-8-day-old rat pup. Baclofen (0.25-1.0 microM), a GABAB agonist, rapidly and potently disinhibited the developing dentate, similar to its…

Tags: 1994, Animals, Baclofen/analogs & derivatives/pharmacology, Brain research. Developmental brain research, DiScenna P G, Electric Stimulation, Evoked Potentials/drug effects, GABA-A Receptor Antagonists, GABA-A/drug effects/physiology, GABA-B Receptor Antagonists, GABA-B/*metabolism, Hippocampus/*growth & development/*metabolism, In Vitro Techniques, Nowicky A V, Organophosphorus Compounds/pharmacology, Rats, Receptors, Teyler T J

Age related changes of social memory/recognition in male Fischer 344 rats.

Two different habituation-dishabituation test paradigms were used to evaluate differences in social memory/recognition among 3-, 15- and 22-month-old male Fischer 344 rats. For test 1, males received three 2-min exposures to the same stimulus…

Effects of aging on spinal opioid-induced antinociception.

Initial experiments were conducted to determine whether or not the aging process alters the ability of young, mature, or aged male Fischer 344 rats (5- to 6-, 15- to 16-, and 25- to 26-months-old, respectively) to respond to thermal nociceptive…

Conditioned place preference/aversion to fenfluramine in fawn hooded and sprague-Dawley rats.

The Fawn Hooded (FH) rat strain possesses a genetic platelet storage pool deficiency which leads to an impaired capacity for platelets to store and release serotonin. While the relationship between this deficit and possible alterations in brain…

Tags: 1994, Animals, Avoidance Learning/*drug effects, Blood Platelets/metabolism, Brain Chemistry/genetics, Fenfluramine/*pharmacology, Habituation, Inbred Strains, Meehan S M, Platelet Storage Pool Deficiency/physiopathology, Progress in neuro-psychopharmacology & biological psychiatry, Psychophysiologic/drug effects, Rats, Schechter M D, Serotonin/metabolism/physiology, Species Specificity, Sprague-Dawley

Nicotine place preference using the biased method of conditioning.

1. The objective of the experimentation was to determine whether nicotine (NIC, 0.8 mg/kg subcutaneously administered) would produce a conditioned place preference (CPP) in rats confined for thirty min to their less-preferred side in a three…

Tags: 1994, Animals, Calcagnetti D J, Conditioning, Cues, Injections, Male, Motor Activity/drug effects, Nicotine/*pharmacology, Operant/*drug effects, Progress in neuro-psychopharmacology & biological psychiatry, Rats, Schechter M D, Sprague-Dawley, Subcutaneous

Serotonergic involvement in the regulation of prolactin and vasoactive intestinal peptide mRNA expression in the rat anterior pituitary.

These studies examined the contribution of serotonin (5-HT) to the control of prolactin (PRL) and vasoactive intestinal peptide (VIP) messenger RNA expression in rat anterior pituitary. Daily injection of rats with the biosynthetic precursor to…

Deficits in shock-induced freezing and naltrexone enhancement of freezing in fawn hooded rats.

When a rat is returned to a context associated with mild electric foot shock (1 mA/0.75 s), the environmental cues elicit a species-specific defensive behavior termed freezing. Genetically divergent strains of rats given identical shock conditioning…

Tags: *Fear, 1994, Animals, Brain research bulletin, Calcagnetti D J, Classical/*drug effects, Conditioning, Electroshock, Female, Inbred Strains, Naltrexone/*pharmacology, Rats, Schechter M D

Case finding for cognitive impairment in elderly emergency department patients.

STUDY OBJECTIVES: To determine the feasibility of a case-finding program for cognitive impairment in elderly emergency department patients, and to describe the prevalence of cognitive impairment in screened patients and identify factors associated…

Hypnotherapeutic techniques in the treatment of hyperemesis gravidarum.

Hyperemesis gravidarum is not an uncommon condition in the first trimester of pregnancy. In some of these patients, the condition is so severe that it causes the development of dehydration and electrolyte imbalances. When that happens, the patient…

Tags: *Hypnosis, 1994, Adult, Female, Humans, Hyperemesis Gravidarum/*therapy, Pregnancy, Relaxation Therapy, The American journal of clinical hypnosis, Torem M S

Electromagnetic fields and infant incubators.

Two models of infant incubators were studied to determine the strength of the magnetic field generated by the heater and fan motors. Measurements were taken at intervals along the center line of the incubator. The results show that fields greater…

Tags: *Electromagnetic Fields, *Incubators, 1994, Archives of environmental health, Bearer C F, Humans, Infant, Newborn, Premature

Weight loss and bedtime weakness.

Tags: *Weight Loss, 1994, Adult, Department of Internal Medicine, Greifenstein E, Hospital practice (Office ed.), Humans, Hyperthyroidism/*complications/physiopathology/therapy, Hypokalemia/etiology, Hypoparathyroidism/etiology, Iodine Radioisotopes/adverse effects/therapeutic use, Male, NEOMED College of Medicine, Paralysis/*etiology, Recurrence, Rudick J, Rutecki G W, Thyrotoxicosis/*complications/physiopathology/therapy, Torabzadeh S

Laparoscopic cholecystectomy in a community hospital: experience with 600 laparoscopic cholecystectomies.

We reviewed 600 patients who underwent laparoscopic cholecystectomy (LC) in a teaching community hospital from May 1990 to August 1992. The safety, efficacy, morbidity, and mortality of LC, as performed by one surgeon or under his direct supervision,…

Tags: 1994, Cholecystectomy, Cholecystectomy/statistics & numerical data, Community, Female, Hospitals, Humans, Intraoperative Complications/epidemiology, Journal of laparoendoscopic surgery, Laparoscopic/mortality/*statistics & numerical data, Male, Middle Aged, Postoperative Complications/epidemiology, Retrospective Studies, Silverman R S, Teaching, Williams G B

The depiction of medical education in medical school catalogs.

BACKGROUND: Medical educators bear responsibility for the informational materials that their institutions use to communicate with potential applicants. These documents, because they are often the first official correspondence that prospective…

Tags: *Catalogs as Topic, *Education, *Schools, 1994, Academic medicine : journal of the Association of American Medical Colleges, Department of Family & Community Medicine, Kohn M, Medical, NEOMED College of Medicine, Wear D

Using chart reviews to assess residents' performances of components of physical examinations: a pilot study.

PURPOSE: To evaluate chart review as a method of assessing residents' performances of physical examinations in an ambulatory care setting. METHOD: In 1992, nurse authors at the Affiliated Hospitals at Canton of the Northeastern Ohio Universities…

Financial incentives in residency recruiting for primary care: scope, characteristics, and students' perceptions.

BACKGROUND: One response to the decline in interest among medical students in residency training in primary care has been the offering, by residency programs and hospitals, of financial recruitment incentives to medical students during their…

Ventricular tachycardia in acute myocardial infarction: the role of hypophosphatemia.

The relationship between serum concentration of certain electrolytes and the pathogenesis of ventricular arrhythmia in myocardial infarction has been the subject of frequent review. The role of hypophosphatemia in the pathogenesis of arrhythmia in…

Aspergillus discitis with acute disc abscess.

STUDY DESIGN: Aspergillus osteomyelitis of the vertebral body and disc space is rare. This report discusses a case that occurred in an immunosuppressed

Analysis of the thymidine kinase of a herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2'-deoxyuridine.

The mechanism responsible for the decreased sensitivity of a clinical herpes simplex virus type 1 (HSV-1) isolate, HSV-145, to (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) was examined. Measurements of 50% inhibitory doses of several drugs…

Temporal changes in left ventricular function after massive sympathetic nervous system activation.

Intense activation of the sympathetic nervous system (SNS) decreases the contractile state of the rabbit left ventricle (LV). In this study, we determined the time course of LV dysfunction after massive central activation of the SNS in dogs.…

Scientific and ethical issues in the use of placebo controls in clinical trials.

Tags: *Ethics, *Patient Advocacy, *Placebos, 1994, Annual review of public health, Clark P I, Clinical Trials as Topic/*standards, Humans, Leaverton P E, Medical, Placebo Effect, Safety, Science/*standards, Treatment Outcome

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