Predictive Factors For Early Mortality After Percutaneous Endoscopic Gastrostomy
aspiration pneumonia; complications; Gastroenterology & Hepatology; jejunostomy; risk; surgical gastrostomy; tube
Background: Percutaneous endoscopic gastrostomy (PEG) is a safe access procedure for enteral nutrition. The purpose of this investigation is to identify predictive factors for early mortality after PEG. Methods: A retrospective review of the hospital records of 416 patients undergoing PEG from June 1, 1989, through December 31, 1991, was conducted. Patient demographics, admitting diagnosis, indication for PEG, risk factors for early mortality, and cause and date of death were reviewed. Logistic regression analysis was used to develop a model to predict early mortality after PEG. The follow-up period ranged from 1 to 30 months. Results: The overall mortality rate in this review was 227 of 416 patients (54.6%). The 7- and 30-day case fatality rates were 39 of 416 (9.4%) and 97 of 416 (23.3%), respectively. Logistic regression analysis showed that urinary tract infection (odds ratio (OR) = 3.05; 95% confidence interval (CI) = 1.45 - 6.43) and previous aspiration (OR = 6.86; 95% CI = 3.27 - 14.4) were predictive factors for death at 1 week after PEG. Patients who had both risk factors had a 48.4% probability of dying within 7 days after PEG insertion, whereas those who had no risk factors had a 4.3% probability of death. Urinary tract infection (OR = 2.00; 95% CI = 1.17 - 3.41), previous aspiration (OR = 3.62; 95% CI = 2.00 - 6.55), and age greater than 75 years (OR = 2.49; 95% CI = 1.47 - 4.21) were predictive factors for death at 1 month after PEG. Patients who had all three risk factors had a 67.1% probability of death at 1 month while those who had no risk factors had a 10% probability of death. Conclusions: A subgroup of patients exists that has a very high mortality rate after PEG. Less invasive ways of nutritionally supporting these high-risk patients should be evaluated.
Light V L; Slezak F A; Porter J A; Gerson L W; McCord G
Gastrointestinal Endoscopy
1995
1995-10
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/s0016-5107(95)70132-x" target="_blank" rel="noreferrer noopener">10.1016/s0016-5107(95)70132-x</a>
Hemoglobin-acetaldehyde Adduct Tests - Relationship In Alcoholic Patients To Liver-function
Substance Abuse
Liebelt R A; Hazelett S E; Truitt E B
Journal of Addictive Diseases
1995
1995
Journal Article or Conference Abstract Publication
n/a
Structural And Functional-analysis Of Human Cytochrome-b-5 Gene Promoter
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Li X R; Steggles A W
Faseb Journal
1995
1995-04
Journal Article or Conference Abstract Publication
n/a
Validity Of The Career Factors Inventory
construct; decidedness; decision scale; dimensions; indecision; Psychology; validation
The present study examined the construct and concurrent validity of the Career Factors Inventory (CFI; Chartrand, Robbins, and Morrill, 1989). The CFI, along with the Career Choice Status Inventory (Savickas, 1993), the Vocational Identity Scale (VIS; Holland, Daiger, and Power, 1980), and the Career Development Inventory-Adult Form II (CDI-A; Super, Zelkowitz, and Thompson, 1975), were completed by 227 college students. Strong support for the CFI's construct validity was provided by a principal components analysis showing four components that paralleled the four scales in the inventory and correlations in the expected direction with age and year in school. Evidence in support of the CFI's concurrent validity was provided by correlations in the expected direction with career decidedness, vocational identity, and career development.
Lewis D M; Savickas M L
Journal of Career Assessment
1995
1995
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1177/106907279500300104" target="_blank" rel="noreferrer noopener">10.1177/106907279500300104</a>
Treatment Of Cleft-palate Associated With Robin-sequence - Appraisal Of Risk-factors
airway-obstruction; anomalad; cleft palate; Dentistry; management; Oral Surgery & Medicine; robin sequence; sleep-apnea; speech; Surgery
Mandibular hypoplasia, airway obstruction, and a typical wide U-shaped cleft palate comprise the Robin sequence, Although much has been written regarding the treatment of these patients in the neonatal period, the literature reveals little information regarding later care of the cleft palate in these patients, The purpose of this study is to examine patients with the Robin sequence and evaluate the risk of postsurgical problems and outcome related to the neonatal period. Thirty-six patients with the Robin sequence presenting from 1972 through 1990 were reviewed, A majority of patients had feeding and respiratory difficulties, to varying degrees, following birth, These problems were treated successfully by maneuvers ranging from positioning to two infants who eventually required tracheostomy Thirty-four patients had palate repair, Age at repair averaged 16.2 months, and one third of patients had associated anomalies, Infants who experienced problems following palatoplasty were those who had histories of severe difficulties and complications in the early months of life, In addition, patients with associated congenital anomalies had significantly more problems at the time of palate repair than those without anomalies, Those patients with the Robin sequence, who historically had minimal difficulty following birth, experienced few complications at the time of palate repair, Of the 34 patients with repaired palates, 23 demonstrated sufficient follow-up to allow for evaluation of speech outcome, Satisfactory or normal speech production was noted in 65.4%, This is not significantly different from that observed in all patients undergoing cleft palate repair during this same time period (74.9%), Secondary pharyngoplasty procedures were required in 17.4%, An overall complication rate of 29.4% was noted with palatal fistula occurring in 11.8%, Examination of an infant's immediate postnatal period, as well as for the presence of associated anomalies, will provide important predictive information on the potential difficulties following cleft palate repair, In addition, palatoplasty, as part of the overall team approach to the cleft patient, results in a satisfactory speech outcome in approximately two thirds of patients with the Robin sequence.
Lehman J A; Fishman J R A; Neiman G S
Cleft Palate-Craniofacial Journal
1995
1995-01
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1597/1545-1569(1995)032%3C0025:tocpaw%3E2.3.co;2" target="_blank" rel="noreferrer noopener">10.1597/1545-1569(1995)032%3C0025:tocpaw%3E2.3.co;2</a>
Nitric-oxide Contributes To Flow-induced Pulmonary Arterial And Venous Dilation In Rabbit Lung
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Lang S A; Hodnichak C
Faseb Journal
1995
1995-03
Journal Article or Conference Abstract Publication
n/a
Alveolar Fluid Reabsorption Is Increased During Recovery From Neurogenic Pulmonary-edema (npe)
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Lane S M; Grimme J D; Maron M B
Faseb Journal
1995
1995-03
Journal Article or Conference Abstract Publication
n/a
Origin Of Intrafusal Fibers From A Subset Of Primary Myotubes In The Rat
afferents; Anatomy & Morphology; development; Developmental Biology; developmental myosins; expression; intrafusal fibers; isoforms; muscle; muscle spindles; muscle spindles; myosin heavy chains; myosin heavy-chain
S46, a monoclonal antibody (mAb) specific for the SM-1 and SM-2 isoforms of avian slow myosin heavy chains (MHC), was used to study the earliest stages of development of intrafusal fibers in muscle spindles of the rat hindlimb. Spindles formed only in the regions of fetal muscles that contained primary myotubes reactive to mAb S46, such as the axial region of the tibialis anterior muscle. The first intrafusal fiber to form, the nuclear bag, fiber, originated from within the population of S46-reactive primary myotubes. Binding of mAb S46 by myotubes giving rise to the bag, fibers preceded the appearance of encapsulated spindles in the muscles by electron microscopy. However, reactivity to S46 intensified in the myotubes transforming into bag, fibers after the innervation of the fibers by afferents, and dissipated in myotubes differentiating into slow-twitch (type I) extrafusal fibers. Thus, afferents may enhance intrafusal expression of the MHC isoform reactive to mAb S46. The pattern of S46 binding to nuclear bag and chain intrafusal fibers in both developing and adult spindles was the same as that reported for the mAb ALD19, suggesting that both antibodies bind to the same MHC isoform. This isoform is probably a developmental form of slow myosin, because it was transiently expressed during the development of type I extrafusal fibers. The origin of bag, intrafusal and type I extrafusal fibers from a bipotential subpopulation of primary myotubes reactive to mAb S46 correlates with the location of muscle spindles in the slow regions of muscles in adult rat hindlimbs.
Kucera J; Walro J M
Anatomy and Embryology
1995
1995-08
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1007/bf00186003" target="_blank" rel="noreferrer noopener">10.1007/bf00186003</a>
An Immunocytochemical Marker For Early-type-i Muscle-fibers In The Developing Rat Hindlimb
Anatomy & Morphology; Developmental Biology; expression; extrafusal; fibers; isoforms; mhc isoforms; muscle development; myosin heavy-chain; myotubes; skeletal-muscle; slow myosin; slow myosins; type i fibers
Muscle fibers develop sequentially from several generations of myotubes that express specific isoforms of myosin heavy chain (MHC). We observed that the chicken-derived monoclonal antibody (mAb) S46 binds to myotubes of the fetal rat hindlimb in a specific temporal and spatial pattern. To determine the type and fate of the S46-reactive myotubes, we immunoreacted sections of fetal, neonatal and postnatal hindlimb muscles to this antibody. The mAb S46 bound to a subpopulation of primary myotubes in the tibialis anterior, and to all primary and slow/fast secondary myotubes in the soleus muscle. The S46-reactive primary myotubes represented the oldest set of myotubes in the muscles. Reactivity to S46 was present from the earliest stages of muscle development, peaked in the late fetal period, and dissipated in the first postnatal week, suggesting that mAb S46 binds to a developmental form of slow myosin. The regional distribution of myotubes that bound S46 in fetal muscles was identical to the distribution of type I (slow-twitch) fibers in the adult, indicating that S46-reactive myotubes ultimately develop into type I extrafusal fibers. Thus, mAb S46 can be used as a marker for prospective type I extrafusal fibers in the rat hindlimb.
Kucera J; Walro J M
Anatomy and Embryology
1995
1995-08
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1007/bf00186002" target="_blank" rel="noreferrer noopener">10.1007/bf00186002</a>
Reduction In The Number Of Spinal Motor-neurons In Neurotrophin-3-deficient Mice
bdnf; cell-death; cord; expression; fusimotor neurons; motoneurons; motor neurons; muscle spindles; nerve; Neurosciences & Neurology; neurotrophic factor; neurotrophins; proprioception; rat muscle-spindles; size; survival
The effects of a deficiency of neurotrophin-3 on spinal motor neurons were assessed by determining the number of myelinated nerve fibers in lumbar ventral spinal roots of mice with a deletion in the neurotrophin-3 gene. Few or no small-caliber (fusimotor) nerve fibers were present in the L4 ventral root of homozygous mutant mice lacking both copies of the neurotrophin-3 gene, and approximately one-half of the normal complement of the fibers was present in heterozygous mice having one copy of the neurotrophin-3 gene relative to wild type mice at two weeks of age. Numbers of fusimotor nerve fibers paralleled numbers of muscle spindles, the target organs of fusimotor innervation, in hindlimb muscles. Muscle spindles and intrafusal fibers were absent in the soleus muscles of homozygous mutants, and were reduced by approximately 50% in heterozygous relative to wild type mice in accord with previous reports. Neurotrophin-3 might be generated by the intrafusal fibers and may provide a target-derived neurotrophic support for developing fusimotor neurons because in the absence of muscle spindles the neurons did not differentiate and/or survive. In contrast, a great majority of skeletomotor neurons that innervate extrafusal muscle fibers differentiated normally in the absence of neurotrophin-3. This study, analysed in conjunction with our previously reported data, suggests that neurotrophin-3 acts in a coordinated fashion to support, either directly or indirectly, the development of each of the three classes of cells-Ia and Ib sensory neurons, fusimotor neurons, and intrafusal muscle fibers-that comprise the limb proprioceptive system.
Kucera J; Ernfors P; Walro J; Jaenisch R
Neuroscience
1995
1995-11
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/0306-4522(95)00221-4" target="_blank" rel="noreferrer noopener">10.1016/0306-4522(95)00221-4</a>
Serotonin-activated Alpha-2-macroglobulin (alpha-2m) And Alpha-1m Respectively Blocks And Stimulates Neurite Outgrowth Of Rat Embryonic Forebrain Neurons And Adult-rat Sciatic-nerve Regeneration
Biochemistry & Molecular Biology; Cell Biology
Koo P H; Liebl D J
Journal of Cellular Biochemistry
1995
1995-04
Journal Article or Conference Abstract Publication
n/a
The Anterior Dentition Of Sivapithecus-parvada, With Comments On The Phylogenetic Significance Of Incisor Heteromorphy In Hominoidea
Anthropology; clade; dentition; east-africa; evolution; Evolutionary Biology; hominids; hominoid phylogenetics; incisors; kenya; middle miocene; miocene hominoid; orangutan; origin; pakistan; pongo; sivapithecus; specimens
A premaxillary fragment of Sivapithecus parvada preserving the germs of the right central and lateral incisors is described. The specimen was recovered in situ during excavation at locality Y311 in the upper Nagri Formation (ca. 9.2 m.y.a.) of the Siwalik Sequence, Potwar Plateau, Pakistan. The central incisor is approximately 35% larger than the next largest Sivapithecus incisor, in keeping with the very large size of S. parvada compared to other Sivapithecus species, and is exceptionally long mesiodistally in relation to its breadth. It is also morphologically distinct, having a sharply angled distal margin and a distinct lingual tubercle. However, previous descriptions of Sivapithecus upper central incisors as having a continuous lingual shelf are in some cases erroneous and ignore the morphological variation present in the sample. In several features of anterior tooth size, morphology and proportionality, S. parvada resembles Pongo more than do other species of Sivapithecus. The I1/I2 length ratio of the new specimen is 2.12, the largest size disparity reported for any fossil catarrhine, and greater than any single value in a large sample of Pongo pygmaeus. Very great size disparity between upper central and lateral incisors is widely considered to be a synapomorphy of the orang-utan lineage. We conclude, however, that descriptions of upper incisor size heteromorphy in Pongo have in general been exaggerated and have failed to recognize substantial differences in this character between Bornean and Sumatran orang-utans. We further conclude, based on examination of a variety of Miocene hominoids and other Miocene catarrhine primates, that the character of I1/I2 proportionality has little if any phylogenetic utility within Hominoidea.
Kelley J; Anwar M; McCollum M A; Ward S C
Journal of Human Evolution
1995
1995-06
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1006/jhev.1995.1039" target="_blank" rel="noreferrer noopener">10.1006/jhev.1995.1039</a>
Error In Laparoscopic Strategy - A New Category Of Surgical Complication - Editorial Comment
Surgery
Kavic M S
Complications in Surgery
1995
1995-05
Journal Article or Conference Abstract Publication
n/a
From Projection To Insight In Statistical Consulting
cognition; education; Psychology
Statisticians continue to write about interpersonal problems they experience as consultants. In the past, they have suggested that some clients create a conflict-ridden process. More recently, they have been looking at themselves and their training to explain problems such as lack of public appreciation for the value of statistical thinking. We explore the psychological concepts of projection, mindsets, and insight to explain problems inherent in the statistical consulting process. Both consultant and client project; that is, ascribe to the other and to the data aspects they fail to recognize about themselves and about their expectations. This interferes with understanding the research problem and the data. Projection also explains the fascination consultants have with data. Projection of the client onto the consultant and the data hem the consultant into a restricted role that precludes the raising of important questions and a thorough contribution. Mindsets interfere with perception of new information. Recognition of the interference of projections and mindsets allows the consultant to move through the process with greater ease and satisfaction, and, more importantly, to develop the insights needed for a creative resolution to the process.
Jarjoura D; Speight J; Amer Stat Assoc
1995
1995
Book/Monograph
n/a
Flesh-eating Bacteria
General & Internal Medicine; Orthopedics; Sport Sciences
Jain R; Bredle D L; Helms S E; Brodell R T
Physician and Sportsmedicine
1995
1995-10
Journal Article or Conference Abstract Publication
n/a
Morphological-changes Of Rat Hippocampal-neurons After Noradrenergic Depletion
6-hydroxydopamine; adult; brain; cortex; deprivation; dsp4; locus coeruleus; postnatal-development; receptors; Zoology
Hwang H M; Lee Y P; Ho P L; Weng S C; Kao H I
Zoological Studies
1995
1995-04
Journal Article or Conference Abstract Publication
n/a
Hormone-dependent, Aggressive Angiomyxoma Of The Vulva
female pelvis; Obstetrics & Gynecology; perineum
Background: Aggressive angiomyxoma is a rare neoplasm of undetermined etiology that occurs mainly in the female vulva and perineum. It tends to recur but does not metastasize. This case report describes findings suggestive of the possible hormone dependency of this neoplasm. Case: A 41-year-old gravid woman developed an aggressive angiomyxoma of the left vulva with growth apparently related to the length of the pregnancy. The neoplasm marked strongly for progesterone receptors by immunohistochemical methods but was estrogen-receptor negative. Conclusion: The growth of the neoplasm during pregnancy and the nuclear-positive staining for progesterone receptors suggest a possible hormone (progesterone) dependency for at least some cases of aggressive angiomyxoma.
Htwe M; Deppisch L M; Saintjulien J S
Obstetrics and Gynecology
1995
1995-10
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/0029-7844(95)00088-9" target="_blank" rel="noreferrer noopener">10.1016/0029-7844(95)00088-9</a>
Depression Prevalence And Incidence Among Inner-city Pregnant And Postpartum Women
black; childbearing; disorders; families; life; poverty; psychological distress; Psychology; psychosocial predictors; social support; stress; white
A sample of 192 financially impoverished, inner-city women was assessed for clinical depression twice during pregnancy and once postpartum. At the first and second antepartum interviews, respectively, 77.6% and 24.5% of the women were depressed, controlling for pregnancy-related somatic symptoms. Postpartum depression was found among 23.4% of women. These rates are about double those found for middle-class samples. Particularly heightened risk for antepartum depression was found among single women who did not have a cohabiting partner. African American and European American women did not differ in rates of depression. Antepartum depression was a weak but significant risk factor for postpartum depression.
Hobfoll S E; Ritter C; Lavin J; Hulsizer M R; Cameron R P
Journal of Consulting and Clinical Psychology
1995
1995-06
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1037/0022-006x.63.3.445" target="_blank" rel="noreferrer noopener">10.1037/0022-006x.63.3.445</a>
Enteral Feeding Tube Placement Success With Intravenous Metoclopramide Administration In Icu Patients
critical care medicine; efficacy; enteral nutrition; gastrointestinal intubation; General & Internal Medicine; metoclopramide; Respiratory System
Objective: The purpose of this study was to determine if intravenous push metoclopramide would facilitate immediate transpyloric passage of a small-bore feeding tube without fluoroscopy or endoscopy. Design: Prospective, randomized trial. Patients: One hundred five medical and surgical ICU patients at a community teaching hospital. Interventions: Patients were randomized to receive 10 mg of metoclopramide 10 min before tube insertion or no medication. Measurement: Successful placement was stated as radiologically verified transduodenal tube location. Results: A 54% success rate was shown with administration of the drug with 46% success for the control. Chi square analysis of the success rate showed no significant relationship between administration of metoclopramide and successful tube placement (p=0.38). Increasing years of physician training was the only variable associated with successful placement (p=0.003). No association was found between successful tube placement and presence of endotracheal tube, tracheostomy, or cervical immobility, nor any interaction of metoclopramide with these variables. Conclusion: Intravenous metoclopramide, 10 mg, administered 10 min prior to intubation with a small-bore feeding tube (10F), was ineffective in facilitating transpyloric intubation.
Heiselman D E; Hofer T; Vidovich R R
Chest
1995
1995-06
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1378/chest.107.6.1686" target="_blank" rel="noreferrer noopener">10.1378/chest.107.6.1686</a>
Ventilation Strategy In 1st Hours Of Life Affects Outcomes Of Vlbw Infants With Respiratory-distress Syndrome (rds)
Pediatrics
Heck L J
Pediatric Research
1995
1995-04
Journal Article or Conference Abstract Publication
n/a
Neonatal Neutrophil Index (nni) - A Very Sensitive Indicator Of Bacterial-infection In The Newborn
Pediatrics
Heck L J
Pediatric Research
1995
1995-04
Journal Article or Conference Abstract Publication
n/a
Developing A Theory-based Measure Of Career Decision-making - The Decisional Process Inventory
college-students; Psychology; validation; vocational indecision
The present study describes the development and an initial assessment of the psychometric properties of the Decisional Process Inventory (DPI). The DPI served as an empirical test of Gestalt therapy homeostasis theory for conceptualizing and facilitating career development and decision-making. The inventory is intended to assess career decidedness or individual level of progress toward reaching a career-decided state. The DPI consists of 70 items that address respondents' perceptions and experiences of the career decision-making process. Participants responded to the DPI (n = 248), the Career Decision Scale (CDS; Osipow, Carney, Winer, Yanico, and Koschier, 1976) (n = 242), the Occupational Alternatives Question (OAQ; Zener and Schnuelle, 1976) (n = 244), and the Gestalt Contact Styles Questionnaire-Revised (GSCQ-R; Woldt & Kepner, 1986) (n = 243). Results supported the content validity of the items and criterion-related validity of the inventory. Seven factors related to the career decision-making process are described.
Hartung P J
Journal of Career Assessment
1995
1995
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1177/106907279500300404" target="_blank" rel="noreferrer noopener">10.1177/106907279500300404</a>
Comparison Of Dopamine To Dobutamine And Norepinephrine For Oxygen Delivery And Uptake In Septic Shock
agents; cardiac-output; catecholamines; consumption; dobutamine; dopamine; General & Internal Medicine; hemodynamics; infusion; inotropic; intra-pulmonary shunt; lactic-acidosis; norepinephrine; oxygen consumption; septic shock; severe sepsis; skeletal-muscle; therapy; transport
Objectives: To test whether dopamine infusion improves oxygen delivery (D over dot O-2) and oxygen uptake (V over dot O-2) in hyperdynamic septic shock patients stabilized by adequate volume and dobutamine alone, or by the combination of dobutamine and norepinephrine. Design: Prospective clinical trial of two patient groups. Group 1 (n = 15) was stabilized with dobutamine, and group 2 (n = 10) was stabilized with dobutamine and norepinephrine. Setting: Intensive care unit in a university hospital. Patients: Twenty-five postoperative, hyperdynamic septic shock patients. Interventions: The stabilizing catecholamine infusion was replaced in a stepwise manner by dopamine to achieve a similar mean arterial pressure (dopamine doses: group 1, mean 22 +/- 15 mu g/kg/min [range 6 to 52]; and group 2, mean 57 +/- 41 mu g/kg/min [range 15 to 130]). Measurements and Main Results: A complete hemodynamic profile was performed with oxygen transport-related variables at baseline, after replacement by dopamine and after resetting to the original catecholamine infusion. The change to dopamine resulted in increases in cardiac index (group 1: 20% [p < .01]; group 2: 33% [p < .01]), and D over dot O-2 (group 1: 19% [p < .01]; group 2: 27% [p < .01]). However, V over dot O-2, whether directly measured from the respiratory gases or calculated by the cardiovascular Fick principle, did not change in both groups with dopamine, while the oxygen extraction ratio decreased significantly in both groups with dopamine. Heart rate, pulmonary artery occlusion pressure, and pulmonary shunt fraction all increased with dopamine, Pao(2) decreased, but oxygen saturation remained stable in both groups with dopamine. Conclusions: Short-term dopamine infusion in hyperdynamic septic shock patients, de. spite producing higher global D over dot O-2, was not superior to dobutamine or the combination of dobutamine and norepinephrine infusion.
Hannemann L; Reinhart K; Grenzer O; Meierhellmann A; Bredle D L
Critical Care Medicine
1995
1995-12
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1097/00003246-199512000-00004" target="_blank" rel="noreferrer noopener">10.1097/00003246-199512000-00004</a>
Different Mechanisms May Be Required For Maintenance Of Nimda Receptor-dependent And Independent Forms Of Long-term Potentiation
activation; area; ca1; calcium; calcium channels; calmodulin inhibitors; d-aspartate receptors; dentate gyrus; depression; glutamate; hippocampal slice; induction; Neurosciences & Neurology; protein kinase; protein-kinase-c; rat hippocampal slices
In hippocampal area CA1, long-term potentiation (LTP) is induced by tetanic stimulation protocols that activate N-methyl-D-aspartate (NMDA) receptors. In addition, some stimulation protocols can induce LTP during NMDA receptor blockade. An initial signal in both NMDA receptor-dependent and independent LTPs is increased intracellular Ca2+ concentration in postsynaptic neurons. It therefore seems possible that subsequent steps leading to expression and maintenance of potentiation are shared whether or not LTP is induced through NMDA receptor activation. We tested this hypothesis by applying a broad spectrum protein kinase inhibitor, previously shown to inhibit NMDA receptor-dependent LTP. In agreement with earlier reports, we found that H-7 inhibited NMDA receptor-dependent LTP when applied either during tetanic stimulation, or beginning 30 min following tetanic stimulation. In contrast, NMDA receptor-independent LTP was not inhibited by H-7 applied during or following tetanic stimulation. We also tested for mutual occlusion between NMDA receptor-dependent and independent LTPs. Although induction of NMDA receptor-independent LTP did not occlude later induction of NMDA receptor-dependent LTP, induction of NMDA receptor-dependent LTP did occlude NMDA receptor-independent LTP. While the kinase inhibitor experiment showed a clear difference between NMDA receptor-dependent and independent LTPs, the occlusion experiments suggest an interaction between the signalling pathways for the two LTPs. (C) 1995 Wiley-Liss, Inc.
Grover L M; Teyler T J
Synapse
1995
1995-02
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1002/syn.890190208" target="_blank" rel="noreferrer noopener">10.1002/syn.890190208</a>
Crouzon Syndrome - Mutations In 2 Spliceoforms Of Fgfr2 And A Common Point Mutation Shared With Jackson-weiss Syndrome
Biochemistry & Molecular Biology; fibroblast; Genetics & Heredity
Dominant mutations in the fibroblast growth factor receptor 2 (FGFR2) gene have been recently identified as causes of four phenotypically distinct craniosynostosis syndromes, including Crouzon, Jackson-Weiss, Pfeiffer, and Apert syndromes, These data suggest that the genetics of the craniosynostosis syndromes is more complex than would be expected from their simple autosomal-dominant inheritance pattern. Identical mutations in the FGFR2 gene have been reported to cause both Pfeiffer and Crouzon syndrome phenotypes, We now report the finding of a mutation in exon IIIc of the FGFR2 gene in a kindred affected with Crouzon syndrome (C1043 to G; Ala344Gly) that is identical to the mutation previously associated with Jackson-Weiss syndrome, We also report finding in a Crouzon kindred a mutation in the 3' end of exon IIIu (formerly referred to as exon 5, exon 7, or exon U) (A878 to C; Gln289Pro) which encodes the amino terminal portion of the Ig-like III domain of the FGFR2 protein, This exon is common to both the FGFR2 and the KGFR spliceoforms of the FGFR2 gene, unlike all previously reported Crouzon mutations, which have been found only in the FGFR2 spliceoform. These findings reveal further unexpected complexity in the molecular genetics of these craniosynostosis syndromes, The data implies that second-site mutations in FGFR2 itself (outside of exon IIIc) or in other genes may determine specific aspects of the phenotypes of craniosynostosis syndromes.
Gorry M C; Preston R A; White G J; Zhang Y Z; Singhal V K; Losken H W; Parker M G; Nwokoro N A; Post J C; Ehrlich G D
Human Molecular Genetics
1995
1995-08
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1093/hmg/4.8.1387" target="_blank" rel="noreferrer noopener">10.1093/hmg/4.8.1387</a>
The Study And Characterization Of An Unusual Rna-binding Protein In The Rabbit
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Bhattacharya R; Steggles A W
Faseb Journal
1995
1995-04
Journal Article or Conference Abstract Publication
n/a
Spontaneous Pneumothorax In Weightlifters
pneumothorax; spontaneous; Sport Sciences; weightlifting
Marnejon T; Sarac S; Cropp A J
Journal of Sports Medicine and Physical Fitness
1995
1995-06
Journal Article or Conference Abstract Publication
n/a
Xanthomonas-maltophilia And Pseudomonas-cepacia In Lower Respiratory Tracts Of Patients In Critical Care Units
bacteremia; identification; infection; Infectious Diseases; outbreak
Maningo E; Watanakunakorn C
Journal of Infection
1995
1995-09
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/s0163-4453(95)91985-6" target="_blank" rel="noreferrer noopener">10.1016/s0163-4453(95)91985-6</a>
Feasibility Of Percutaneous Extraction Of Transvenous Defibrillator Leads
Cardiovascular System & Cardiology
Maloney J D; Wilkoff B L; Smith H J; Zhu W X
Circulation
1995
1995-10
Journal Article or Conference Abstract Publication
n/a
Gallbladder And Cystic Duct Ultrastructure In Cholecystitis
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Gilloteaux J; Karkare S; Kelly T R
Faseb Journal
1995
1995-03
Journal Article or Conference Abstract Publication
n/a
Scanning Electron-microscopy And Transmission Electron-microscopy Aspects Of Synergistic Antitumor-activity Of Vitamin-c Vitamin K-3 Combinations Against Human Prostatic-carcinoma Cells
cancer-chemotherapy; cultured-mammalian-cells; cytoskeleton; cytotoxicity; growth-invitro; induced oxidative stress; isolated hepatocytes; l-ascorbic-acid; lines; menadione; Microscopy; prostate carcinoma; ruthenium tetroxide; toxicity; ultrastructure; vitamin-c; vitamin-k-3
Gilloteaux J; Jamison J M; Venugopal M; Giammar D; Summers J L
Scanning Microscopy
1995
1995-03
Journal Article or Conference Abstract Publication
n/a
Depressed Mens Lower Ability To Interpret Nonverbal Cues - A Preliminary-study
communication; enhanced interpretation; Psychology; reception; recognition
Giannini A J; Folts D J; Melemis S M; Giannini M C; Loiselle R H
Perceptual and Motor Skills
1995
1995-10
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1177/003151259508100239" target="_blank" rel="noreferrer noopener">10.1177/003151259508100239</a>
Late Reconstruction Of The Midfoot And Tarsometatarsal Region After Trauma
dislocations; joints; Orthopedics
Ferris L R; Vargo R; Alexander I J
Orthopedic Clinics of North America
1995
1995-04
Journal Article or Conference Abstract Publication
n/a
Spermine Increases Paired-pulse Facilitation In Area Ca1 Of Hippocampus In A Calcium-dependent Manner
activation; binding; ca1; ca2+ channel; channels; field potential; hippocampal slice; in-vitro; ischemia; Neurosciences & Neurology; ornithine decarboxylase; paired-pulse facilitation; polyamine; polyamines; pyramidal cells; rat-brain; slices; spermine
Ferchmin P A; Eterovic V A; Rivera E M; Teyler T J
Brain Research
1995
1995-08
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/0006-8993(95)00568-b" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(95)00568-b</a>
Barretts-esophagus - Over And Under-diagnosis
Gastroenterology & Hepatology
Fahmy N; King J; Doyle M
Gastroenterology
1995
1995-04
Journal Article or Conference Abstract Publication
n/a
Arthroscopic Surgery Of The Ankle
Ewing J W; Tasto J A; Tippett J W
1995
1995
Book/Monograph
n/a
Suppression Of Pulmonary Metastases Of Rat Mammary-cancer By Recombinant Urokinase Plasminogen-activator Inhibitor
adenocarcinomas; breast; cells; colon; extracellular-matrix degradation; invasion; membrane; model; monocytes; receptor-bound urokinase; Surgery
Evans D M; Lin P L
American Surgeon
1995
1995-08
Journal Article or Conference Abstract Publication
n/a
Carcinoma Of The Axillary Breast
axillary breast; breast cancer; ectopic breast; Oncology; Surgery
Evans D M; Guyton D P
Journal of Surgical Oncology
1995
1995-07
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1002/jso.2930590311" target="_blank" rel="noreferrer noopener">10.1002/jso.2930590311</a>
Establishing A Career - Developmental Tasks And Coping Responses
Psychology; tacit knowledge
Dix J E; Savickas M L
Journal of Vocational Behavior
1995
1995-08
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1006/jvbe.1995.1031" target="_blank" rel="noreferrer noopener">10.1006/jvbe.1995.1031</a>
Endurance Exercise Training Attenuates The Sympathetic-nerve Response To Exercise, In Part, By Enhanced Cardiac Afferents
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
DiCarlo S E; Stahl L K; Bishop V S
Faseb Journal
1995
1995-03
Journal Article or Conference Abstract Publication
n/a