1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(90)90603-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(90)90603-7</a>
Pages
309–314
Issue
3
Volume
113
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Differential effects of NMDA receptor antagonist APV on tetanic stimulation induced and calcium induced potentiation.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-06
Subject
The topic of the resource
Animals; Action Potentials/drug effects; Electric Stimulation; In Vitro Techniques; Hippocampus/drug effects/*physiology; 2-Amino-5-phosphonovalerate/*pharmacology; Neuronal Plasticity/*drug effects; Calcium/*pharmacology; Receptors; N-Methyl-D-Aspartate; Neurotransmitter/antagonists & inhibitors/*physiology
Creator
An entity primarily responsible for making the resource
Grover L M; Teyler T J
Description
An account of the resource
Enduring synaptic potentiation can be induced in area CA1 of hippocampus by tetanic stimulation and by exposure to a medium containing high Ca2+ concentration. Both tetanic stimulation and high Ca2+ induce potentiation through voltage-dependent, post-synaptic mechanisms. Tetanus-induced long-term potentiation (LTP) was blocked by 50 microM D,L-2-amino-5-phosphonovalerate (APV) as previously reported by others. In contrast, Ca2(+)-induced long-lasting potentiation was not reduced by 50 microM APV. Thus the mechanisms by which tetanic stimulation and exposure to high Ca2+ induce synaptic potentiation may differ.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(90)90603-7" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(90)90603-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
2-Amino-5-phosphonovalerate/*pharmacology
Action Potentials/drug effects
Animals
Calcium/*pharmacology
Electric Stimulation
Grover L M
Hippocampus/drug effects/*physiology
In Vitro Techniques
N-Methyl-D-Aspartate
Neuronal Plasticity/*drug effects
Neuroscience letters
Neurotransmitter/antagonists & inhibitors/*physiology
Receptors
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/347477a0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/347477a0</a>
Pages
477–479
Issue
6292
Volume
347
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Two components of long-term potentiation induced by different patterns of afferent activation.
Publisher
An entity responsible for making the resource available
Nature
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-10
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/*pharmacology; Afferent Pathways/physiology; Animals; Calcium/*physiology; Hippocampus/*physiology; In Vitro Techniques; Membrane Potentials; Memory/*physiology; N-Methyl-D-Aspartate/*physiology; Neuronal Plasticity; Receptors; Synaptic Transmission; Time Factors
Creator
An entity primarily responsible for making the resource
Grover L M; Teyler T J
Description
An account of the resource
Long-term potentiation (LTP) of excitatory synaptic transmission could be a mechanism underlying memory. Induction of LTP requires Ca2+ influx into postsynaptic neurons through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in hippocampus (area CA1 and dentate gyrus) and neocortex. Here we report that a component of LTP not requiring the activation of NMDA receptors can be induced in area CA1. The component is dependent on tetanus frequency, requires increases in postsynaptic intracellular Ca2+ concentrations, and is suppressed by an antagonist of voltage-dependent Ca2+ channels.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/347477a0" target="_blank" rel="noreferrer noopener">10.1038/347477a0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
2-Amino-5-phosphonovalerate/*pharmacology
Afferent Pathways/physiology
Animals
Calcium/*physiology
Grover L M
Hippocampus/*physiology
In Vitro Techniques
Membrane Potentials
Memory/*physiology
N-Methyl-D-Aspartate/*physiology
Nature
Neuronal Plasticity
Receptors
Synaptic Transmission
Teyler T J
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0306-4522(92)90072-a" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0306-4522(92)90072-a</a>
Pages
7–11
Issue
1
Volume
49
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
N-methyl-D-aspartate receptor-independent long-term potentiation in area CA1 of rat hippocampus: input-specific induction and preclusion in a non-tetanized pathway.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-07
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/*pharmacology; Animals; Electron; Evoked Potentials/drug effects; Hippocampus/*physiology; In Vitro Techniques; Microscopy; N-Methyl-D-Aspartate/*physiology; N-Methylaspartate/*pharmacology; Pyramidal Tracts/drug effects/*physiology; Rats; Receptors; Time Factors
Creator
An entity primarily responsible for making the resource
Grover L M; Teyler T J
Description
An account of the resource
We previously reported that an N-methyl-D-aspartate receptor-independent component of long-term potentiation with an apparent delayed onset can be induced in area CA1 of the hippocampus. Here we show that some but not all of this delay in onset can be accounted for by a transient heterosynaptic depression. We also show that N-methyl-D-aspartate receptor-independent long-term potentiation is induced only in the input pathway tetanized, and not in a second pathway. However, prior induction of N-methyl-D-aspartate receptor-independent long-term potentiation in one pathway precludes later induction in an independent pathway. Calcium entry through dihydropyridine-sensitive Ca2+ channels may be a critical step for induction of N-methyl-D-aspartate receptor-independent long-term potentiation in area CA1 [Grover L. M. and Teyler T.J. (1990) Nature 347,
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0306-4522(92)90072-a" target="_blank" rel="noreferrer noopener">10.1016/0306-4522(92)90072-a</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
2-Amino-5-phosphonovalerate/*pharmacology
Animals
Electron
Evoked Potentials/drug effects
Grover L M
Hippocampus/*physiology
In Vitro Techniques
Microscopy
N-Methyl-D-Aspartate/*physiology
N-Methylaspartate/*pharmacology
Neuroscience
Pyramidal Tracts/drug effects/*physiology
Rats
Receptors
Teyler T J
Time Factors