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Text
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URL Address
<a href="http://doi.org/10.3390/molecules201219853" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/molecules201219853</a>
Pages
22315–22328
Issue
12
Volume
20
Dublin Core
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Title
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Mechanism of Breast Cancer Preventive Action of Pomegranate: Disruption of Estrogen Receptor and Wnt/beta-Catenin Signaling Pathways.
Publisher
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Molecules (Basel, Switzerland)
Date
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2015
2015-12
Subject
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Female; Animals; Cell Proliferation/drug effects; Rats; DMBA; Punicaceae/*chemistry; Down-Regulation/drug effects; Estrogen Receptor alpha/metabolism; Anticarcinogenic Agents/*pharmacology; beta Catenin/*metabolism; beta-catenin; Breast Neoplasms/*drug therapy/metabolism; Chemoprevention/methods; cyclin D1; estrogen receptors; mammary tumorigenesis; pomegranate (Punica granatum L.); Wnt Proteins/*metabolism; Wnt Signaling Pathway/*drug effects; Sprague-Dawley; Receptors; 10-Dimethyl-1; 9; Cell Transformation; 2-benzanthracene/pharmacology; Estrogen/*metabolism; Neoplastic/drug effects/metabolism
Creator
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Mandal Animesh; Bishayee Anupam
Description
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A pomegranate emulsion (PE), containing various bioactive phytochemicals, has recently been found to exert substantial chemopreventive effect against 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumorigenesis in rats via antiproliferative and proapoptotic actions. Nevertheless, the underlying mechanisms of action are not completely understood. The present study was designed to investigate the effects of PE treatment on intratumor expression of estrogen receptor (ER)-alpha, ER-beta,beta-catenin and cyclin D1 during DMBA rat mammary carcinogenesis. Mammary tumor sections were harvested from a chemopreventive study in which PE (0.2, 1.0 and 5.0 g/kg) exhibited inhibition of mammary tumorigenesis in a dose-response manner. The expressions of ER-alpha,
Identifier
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<a href="http://doi.org/10.3390/molecules201219853" target="_blank" rel="noreferrer noopener">10.3390/molecules201219853</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
10-Dimethyl-1
2-benzanthracene/pharmacology
2015
9
Animals
Anticarcinogenic Agents/*pharmacology
beta Catenin/*metabolism
beta-catenin
Bishayee Anupam
Breast Neoplasms/*drug therapy/metabolism
Cell Proliferation/drug effects
Cell Transformation
Chemoprevention/methods
Cyclin D1
DMBA
Down-Regulation/drug effects
Estrogen Receptor alpha/metabolism
estrogen receptors
Estrogen/*metabolism
Female
mammary tumorigenesis
Mandal Animesh
Molecules (Basel, Switzerland)
Neoplastic/drug effects/metabolism
pomegranate (Punica granatum L.)
Punicaceae/*chemistry
Rats
Receptors
Sprague-Dawley
Wnt Proteins/*metabolism
Wnt Signaling Pathway/*drug effects