1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/019131201300343810" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/019131201300343810</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
183-192
Issue
3
Volume
25
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ultrastructural Aspects Of Autoschizis: A New Cancer Cell Death Induced By The Synergistic Action Of Ascorbate/menadione On Human Bladder Carcinoma Cells
Publisher
An entity responsible for making the resource available
Ultrastructural Pathology
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-05
Subject
The topic of the resource
2-methyl-1; 4-naphthoquinone; antitumor-activity; apoptosis; autoschizis; bladder tumor; cell death; combined vitamin-c; cultured-mammalian-cells; growth-invitro; induced oxidative stress; Microscopy; necrosis; Pathology; scanning electron-microscopy; T24 ultrastructure; tumor; vitamins
Creator
An entity primarily responsible for making the resource
Gilloteaux J; Jamison J M; Arnold D; Taper H S; Summers J L
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/019131201300343810" target="_blank" rel="noreferrer noopener">10.1080/019131201300343810</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2-methyl-1
2001
4-naphthoquinone
antitumor-activity
Apoptosis
Arnold D
autoschizis
bladder tumor
Cell Death
combined vitamin-c
cultured-mammalian-cells
Gilloteaux J
growth-invitro
induced oxidative stress
Jamison J M
Microscopy
Necrosis
Pathology
scanning electron-microscopy
Summers J L
T24 ultrastructure
Taper H S
Tumor
Ultrastructural pathology
vitamins
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0024-3205(96)00466-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0024-3205(96)00466-3</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1389-1400
Issue
17
Volume
59
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Synergistic antitumor activity of vitamins C and K-3 on human urologic tumor cell lines
Publisher
An entity responsible for making the resource available
Life Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-09
Subject
The topic of the resource
2-methyl-1; 4-naphthoquinone; bladder; cancer-chemotherapy; carcinoma cells; growth; isolated hepatocytes; l-ascorbic-acid; menadione; metabolism; mitomycin-c; oxidative stress; Pharmacology & Pharmacy; prostate; Research & Experimental Medicine; urologic neoplasms; vitamin C
Creator
An entity primarily responsible for making the resource
Venugopal M; Jamison J M; Gilloteaux J; Koch J A; Summers M; Giammar D; Sowick C; Summers J L
Description
An account of the resource
A micro-tetrazolium assay was employed to evaluate vitamin C (VC), vitamin K-3 (VK3) and vitamin C/vitamin K-3 combinations (VC/VK3) for their antitumor activity against eight human urologic tumor cell lines. While the individual vitamins exhibited antitumor activity at high concentrations, co-administration of the vitamin in a VC : VK3 ratio of 100 : 1 potentiated antitumor activity 4- to 61-fold even when exposure times were as short as 1 hour. Administration of exogenous catalase destroyed the antitumor activity of the vitamins and suggested that catalase destroyed the antitumor activity of the vitamins and suggested that hydrogen peroxide and perhaps other reactive oxygen species were involved in the antitumor mechanism of these vitamins. Electron micrographs taken in a previous study demonstrated that vitamin treatment damaged mitochondria and may have impaired ATP synthesis. Analysis of cellular ATP and thiol levels as well as DNA and protein synthesis during the first five hours following a one hour VC/VK3 treatment, revealed: a transient increase in ATP production, a substantial decrease in DNA synthesis, an increase in protein synthesis and a decrease in thiol levels. These results suggested that redox cycling of the vitamin combination increased oxidative stress until it surpassed the reducing ability of the cellular thiols and cellular or genetic damage ensured.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0024-3205(96)00466-3" target="_blank" rel="noreferrer noopener">10.1016/0024-3205(96)00466-3</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1996
2-methyl-1
4-naphthoquinone
Bladder
cancer-chemotherapy
carcinoma cells
Giammar D
Gilloteaux J
growth
isolated hepatocytes
Jamison J M
Journal Article
Koch J A
l-ascorbic-acid
Life sciences
menadione
Metabolism
mitomycin-c
Oxidative Stress
Pharmacology & Pharmacy
Prostate
Research & Experimental Medicine
Sowick C
Summers J L
Summers M
urologic neoplasms
Venugopal M
vitamin C