Browse Items · NEOMED Bibliography Database

Sonographic appearance of the Angelchik prosthesis.

The Angelchik prosthesis is a silicone-filled, doughnut-shaped device used for the surgical treatment of gastroesophageal reflux. This device appears on sonograms as a C-shaped, hypoechoic structure with nonspecific Doppler waveforms. Because the…

Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells.

The human liver CYP4F2 gene (Accession No. AF221943) encodes a leukotriene B(4) omega-hydroxylase that metabolizes leukotriene B(4) (LTB(4)) to a less potent proinflammatory eicosanoid, 20-OH-LTB(4). We sequenced a 6.7-kb genomic fragment of the…

Regulation of CYP4F2 leukotriene B4 omega-hydroxylase by retinoic acids in HepG2 cells.

The human CYP4F2 gene encodes a LTB4 omega-hydroxylase P450 prominently expressed in liver and kidney that functions to metabolize and inactivate the pro-inflammatory eicosanoids, LTB4 and arachidonic acid. HepG2 cells transfected with CYP4F2 -506/-6…

The effect of GDNF on nigrostriatal dopaminergic function in response to a two-pulse K(+) stimulation.

We examined the effect of glial cell line-derived neurotrophic factor (GDNF) upon nigrostriatal dopaminergic function in response to two-pulse potassium (K(+)) stimulation in rats under in vivo microdialysis conditions. The two-pulse infusion…

Alternative medicine in gynecologic oncology: A case report.

A patient with Stage IIB squamous cell cancer of the cervix presented 10 days into her primary radiation therapy with neutropenic fever and diarrhea requiring hospitalization and delay in treatment. The patient's history revealed extensive use of…

Tags: *Complementary Therapies, 2000, Carcinoma, Diarrhea/*etiology, Female, Fever/*etiology, Gynecologic oncology, Hopkins M P, Hospitalization, Humans, Medical History Taking, Medicinal/*adverse effects, Middle Aged, Neutropenia/*etiology, Plants, Squamous Cell/drug therapy/*radiotherapy, Time Factors, Uterine Cervical Neoplasms/drug therapy/*radiotherapy, von Gruenigen V E

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Tags: 2000, Gynecologic oncology, Hopkins, von Gruenigen V E

Neural stem cells as tools for understanding retroviral neuropathogenesis.

The discovery within the past decade that neural stem cells (NSCs) from the developing and adult mammalian brain can be propagated, cloned, and genetically manipulated ex vivo for ultimate transfer back into the CNS has opened the door to a novel…

Tags: 2000, Animals, Humans, Lynch W P, Membrane Fusion/physiology, Microglia/virology, Neurons/*virology, Portis J L, Retroviridae Infections/virology, Retroviridae Proteins/metabolism, Retroviridae/*pathogenicity, Stem Cells/*virology, Viral Envelope Proteins/metabolism, Virology, Virulence

Adenocarcinoma arising in interposed colon: report of a case.

A rare occurrence of primary adenocarcinoma arising in an interposed colon nearly seven years after the surgery is described. Remarkably, there were no symptoms from a large mass in the transposed bowel. Diagnosis was made fortuitously while…

Disseminated lymphangiomatosis presenting with massive chylothorax.

BACKGROUND: Lymphangiomatosis is a disease characterized by involvement of various body constituents and can involve the skeletal system, connective tissues, and visceral organs. MATERIALS AND METHODS: We present a case of a

Tags: 2000, Bone Neoplasms/complications/*diagnosis, Child, Chylothorax/diagnosis/*etiology, Female, Goyal M, Humans, Konez O, Lymphangioma/complications/*diagnosis, Magnetic Resonance Imaging, Malignant/etiology, Pediatric radiology, Pleural Effusion, Ribs/diagnostic imaging/pathology, Tomography, Vyas P K, X-Ray Computed

Group A streptococcus necrotizing fasciitis.

Necrotizing fasciitis due to Group A streptococcus has been observed with increasing frequency over the past decade. Appropriate management requires rapid recognition of this life-threatening infection and expeditious antimicrobial therapy as well as…

A subtherapeutic international normalized ratio despite increasing doses of warfarin: could this be malabsorption?

OBJECTIVE: To describe a case of warfarin resistance apparently caused by malabsorption and to review the literature regarding warfarin resistance. CASE SUMMARY: A 28-year-old renal transplant patient with systemic lupus erythematosus was admitted…

Estrogen reduces acute striatal dopamine responses in vivo to the neurotoxin MPP+ in female, but not male rats.

The effects of in vivo estrogen treatment upon MPP(+)-induced dopamine (DA) release were determined using in vivo microdialysis in female and male rats. Ovariectomized female rats were implanted or not with an estrogen pellet (0.1 mg, 17beta…

Par-4 induces cholinergic hypoactivity by suppressing ChAT protein synthesis and inhibiting NGF-inducibility of ChAT activity.

Profound reductions in choline acetyl-transferase (ChAT) activity are reliable markers for cholinergic hypoactivity associated with cognitive function deficit in Alzheimer's disease (AD). Par-4 (prostate apoptosis response-4) is a novel mediator of…

Tags: *Intracellular Signaling Peptides and Proteins, 2000, Amyloid beta-Peptides/pharmacology, Animals, Apoptosis Regulatory Proteins, Brain research, Carrier Proteins/genetics/*physiology, Choline O-Acetyltransferase/*antagonists & inhibitors/biosynthesis/metabolism, Du H, Enzyme Induction/drug effects, Gene Expression/physiology, Guo Q, Leucine Zippers/genetics, Nerve Growth Factor/*pharmacology, Osmolar Concentration, PC12 Cells, Peptide Fragments/pharmacology, Rats, Xie J

Phenobarbital pre-treatment prevents kainic acid-induced impairments in acquisition learning.

This study examined the protective effect of phenobarbital on kainic acid-induced deficits in acquisition learning. A single kainic acid injection (9 mg/kg i.p.) was administered five days prior to testing using the Morris water maze test. Kainic…

Strain differences in neuropathic hyperalgesia.

The purpose of this study was to investigate strain-related differences in the onset and maintenance of thermal hyperalgesia following the induction of peripheral nerve injury in two inbred strains of rats (Fischer 344 and Lewis) and two outbred…

Tags: 2000, Animals, Chronic Disease, Crisp T, Cruce W L, Cytokines/physiology, Hyperalgesia/*etiology, Inbred F344, Inbred Lew, Ligation, Lovell J A, Male, Pharmacology, biochemistry, and behavior, Rats, Sciatic Nerve/physiology, Species Specificity, Sprague-Dawley, Stuesse S L, Wistar

Laparoscopic hernia repair: how would you have your hernia fixed?

Tags: 2000, Current surgery, Kavic

Secure cranial-mount intrathecal cannulation - a spinal administration technique in the rat.

In order to identify an acute spinally mediated pharmacological effect of a bioactive substance, without incurring untoward supraspinal effects, it is necessary to administer the agent locally onto the spinal cord. The procedure delineated herein…

Tags: 2000, Analgesics, Anesthesia, Animals, Crisp T, Dose-Response Relationship, Drug, Injections, Journal of neuroscience methods, Microinjections, Morphine/administration & dosage/pharmacology, Opioid/administration & dosage/pharmacology, Rats, Schechter J B, Spinal Cord/*physiology, Spinal/*instrumentation, Sprague-Dawley, Stereotaxic Techniques/*instrumentation

Inhibition of human papillomavirus type 16 gene expression by nordihydroguaiaretic acid plant lignan derivatives.

Several methylated derivatives of a plant lignan, nordihydroguaiaretic acid (NDGA) were found to be potent anti-viral agents by suppressing Sp1 regulated transcription within the sexually transmitted viruses human immunodeficiency virus (HIV) and…

The effect of brachium conjunctivum transection on a conditioned limb response in the cat.

Seven cats were trained to perform a forelimb conditioned response to a paired tone conditioned stimulus (CS)/shock unconditioned stimulus (UCS). Brachium conjunctivum section ipsilateral to the trained limb was carried out following criterion…

Tags: *Conditioning (Psychology), 2000, Animals, Behavioural brain research, Cats, Cerebellar Nuclei/physiology, Cerebellum/injuries/pathology/*physiology, Memory/*physiology, Nerve Net/injuries/*physiology, Voneida T J

Microglial proliferation in the spinal cord of aged rats with a sciatic nerve injury.

Nerve injury may lead to chronic neuropathic pain syndromes. We determined whether the extent of central nervous system microglial activation that accompanies nerve injury is age dependent and correlated with behavioral manifestations of pain. We…

Distribution and origin of secretoneurin-immunoreactive nerves in the female rat uterus.

Secretoneurin is a 33-amino acid peptide derived from secretogranin II. Secretoneurin immunoreactivity has been localized in the peripheral nervous system where it exerts potent chemotactic activity for monocytes and may play a role in inflammation.…

Repair of distal biceps brachii tendon ruptures.

This study consisted of 26 male patients with distal biceps tendon ruptures, 2 of whom had bilateral injuries, making the total number of ruptures 28. The average age at injury was 45 years. The treatment groups were the following: 3 were treated…

The management of significant glenoid deficiency in total shoulder arthroplasty.

Tags: 2000, Arthroplasty, Bell R H, Bone Screws, Humans, Humerus/abnormalities/pathology/*surgery, Journal of shoulder and elbow surgery, Noble J S, Replacement/*methods, Shoulder Joint/injuries/pathology/*surgery

Female circumcision: at our doorsteps and beyond.

Recent trends in international travel and emigration have brought the practice of female circumcision, also known as female genital mutilation, to the awareness of an increasing number of physicians and public policy agencies in developed countries.…

Tags: 2000, Hecht, Hopkins, Meniru, Primary care update for Ob/Gyns

Long-term evaluation of the long-pulsed alexandrite laser for the removal of bikini hair at shortened treatment intervals.

BACKGROUND: Laser-assisted hair removal is becoming the treatment of choice for removing unwanted hair. OBJECTIVE: The purpose of this work was to determine the long-term efficacy of the long-pulsed infrared (LPIR) laser at shortened treatment…

Tags: *Laser Therapy, 2000, Adolescent, Adult, Department of Internal Medicine, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], Female, Hair Removal/*methods, Humans, Lloyd J R, Male, Middle Aged, Mirkov Mirko, NEOMED College of Medicine, Time Factors, Treatment Outcome

Urokinase Plasminogen Activator Receptor (uPAR): A Potential Indicator of Invasion for In Situ Breast Cancer.

Urokinase plasminogen activator (uPA) and its cellular receptor (uPAR) are important mediators in the cellular process of cancer invasion and metastasis. Ductal carcinoma in situ (DCIS) is classified by lack of invasion into the adjacent stroma, yet…

Tags: 2000, Evans Douglas M, Guyton Daniel P, Sloan-Stakleff Kimberly D, The breast journal

The epidemiology of respiratory tract infections.

Respiratory tract infections (RTIs) are the most common, and potentially most severe, of infections treated by health care practitioners. Lower RTIs along with influenza, are the most common cause of death by infection in the United States. Risk…

Chlamydia pneumoniae pneumonia.

Chlamydia pneumoniae is a common cause of community-acquired pneumonia. At present there is no "gold” standard for diagnosis and there is no easily accessible means of rapid diagnosis available. The best indication of acute C. pneumoniae infection is…

Tags: 2000, Department of Internal Medicine, File T M Jr, NEOMED College of Medicine, Seminars in respiratory and critical care medicine, Tan J S

The bronchodilator effect of intravenous glucagon in asthma exacerbation: a randomized, controlled trial.

STUDY OBJECTIVE: Glucagon is a rapid-acting smooth muscle relaxant with a short half-life. Previous studies suggested glucagon may have bronchodilator effects. We sought to determine whether intravenous glucagon produces clinically important…

The prevalence of thromboembolic events among women with extended bed rest prescribed as part of the treatment for premature labor or preterm premature rupture of membranes.

OBJECTIVE: This study was undertaken to determine the prevalence of thromboembolic events among women with extended bed rest prescribed as part of the treatment of premature labor or preterm premature rupture of membranes. STUDY DESIGN: A…

The myths of laparoscopic surgery.

Laparoscopic surgery has been rapidly accepted without rigorous scientific study. New procedures and technologies have advanced rapidly, and most gynecologists have embraced these techniques. I believe that the new technology has given rise to the…

Tags: *Laparoscopy/economics, 2000, American journal of obstetrics and gynecology, Costs and Cost Analysis, Female, Female/surgery, General Surgery/education, Genital Neoplasms, Gynecologic Surgical Procedures/methods, Hopkins M P, Humans

Panniculectomy at the time of gynecologic surgery in morbidly obese patients.

OBJECTIVE: Our goal was to demonstrate that panniculectomy performed at the time of gynecologic surgery aids in reducing the operative time and exposure and does not increase the wound infection rate in morbidly obese patients. STUDY DESIGN: A…

Using O2 to probe membrane immersion depth by 19F NMR.

A fluorinated detergent, CF(3)(CF(2))(5)C(2)H(4)-O-maltose, was reconstituted into a lipid bilayer model membrane system to demonstrate the feasibility of determining solvent accessibility and membrane immersion depth of each fluorinated group by…

Tags: *Hydrocarbons, *Oxygen, 2000, Biological, Cyclic N-Oxides, Dimyristoylphosphatidylcholine/*chemistry, Fluorinated, Fluorine, Lipid Bilayers/*chemistry, Luchette P A, Magnetic Resonance Spectroscopy/*methods, Maltose/*analogs & derivatives, Models, Phospholipid Ethers/*chemistry, Pressure, Proceedings of the National Academy of Sciences of the United States of America, Prosser R S, Spin Labels, Westerman P W

First European exposure to syphilis: the Dominican Republic at the time of Columbian contact.

Recognition of syphilis in Europe in the late 15th century and its prior absence suggest New World origin. Skeletal populations were examined from sites with documented Columbian contact in the Dominican Republic. Examination of 536 skeletal remains…

Measuring the costs of primary care education in the ambulatory setting.

In 1995, the authors obtained cost, operations, and educational activity data from 98 ambulatory care sites across the United States in which primary care teaching was occurring and compared those data with the corresponding data from 84 ambulatory…

Tags: *Ambulatory Care, 2000, Academic medicine : journal of the Association of American Medical Colleges, Boex J R, Boll A, Budgets, Costs and Cost Analysis, Department of Family & Community Medicine, Education, Franzini L, Hogan A J, Irby D, Medical/*economics, Meservey P M, NEOMED College of Medicine, Rubin R M, Seifer S D, United States, Veloski J J

Creating a culture of professionalism: an integrated approach.

Tags: *Education, *Professional Practice, 2000, Academic medicine : journal of the Association of American Medical Colleges, Coldwell L L, Department of Family & Community Medicine, Gibson D D, Kiewit S F, Medical, NEOMED College of Medicine, Ohio

The development of professionalism: curriculum matters.

The authors propose that professionalism, rather than being left to the chance that students will model themselves on ideal physicians or somehow be permeable to other elements of professionalism, is fostered by students' engagement with significant,…

Tags: *Clinical Competence, 2000, Academic medicine : journal of the Association of American Medical Colleges, Castellani B, Curriculum/standards, Delivery of Health Care/economics, Department of Family & Community Medicine, Education, Humans, Medical/standards, NEOMED College of Medicine, Professional Practice/*standards, Research, Schools, Science, Wear D

Functioning liver metastases on an I-131 whole-body scan: a case of malignant struma ovarii.

A 46-year-old women was examined for severe constipation. Pelvic examination revealed a large pelvic mass extending to the level of the umbilicus. Computed tomography showed a large multicystic, septated mass in the pelvis and a small amount of fluid…

Painless enlarging subcutaneous mass in a 58-year-old woman.

Anomalous dose assessment associated with film badge storage in a controlled area.

Higher than expected film badge readings were obtained for radiologic technologists operating computed tomography scanners. The cause of the erroneous dose assignments was determined to be improper storage of the film packet in the console area.…

Tags: *Occupational Exposure, *Photons, *Radiation Dosage, *Technology, *Tomography, 2000, Film Dosimetry/*instrumentation, Health physics, Hedrick W R, Humans, Radiation Protection, Radiologic, Reproducibility of Results, Starchman D E, Workforce, X-Ray Computed

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