Browse Items · NEOMED Bibliography Database

Immunohistochemical distribution of enkephalin, substance P, and somatostatin in the brainstem of the leopard frog, Rana pipiens.

The brainstems of frogs contain many of the neurochemicals that are found in mammals. However, the clustering of nuclei near the ventricles makes it difficult to distinguish individual cell groups. We addressed this problem by combining…

Tags: *Stilbamidines, 2001, Adli D S, Animals, Brain Stem/*chemistry/cytology, Cruce W L, Enkephalins/*analysis, Fluorescent Dyes, Immunohistochemistry, Male, Microscopy research and technique, Rana pipiens/*metabolism, Somatostatin/*analysis, Spinal Cord/chemistry/cytology, Stuesse S L, Substance P/*analysis

Rotation of middle ear ossicles during cetacean development.

Cetacean middle ears are unique among mammals in that they have an elongated tympanic membrane, a greatly reduced manubrium mallei, and an incudal crus longum that is shorter than the crus breve. Elongation of the tympanic membrane and reduction of…

Tags: *Rotation, 2001, Animals, Body Patterning/*physiology, Department of Anatomy & Neurobiology, Dolphins/*embryology/*growth & development/physiology, Ear Ossicles/*embryology/*growth & development/physiology, Hearing/*physiology, Journal of morphology, Kinkel M D, NEOMED College of Medicine, Oelschlager H A, Thewissen J G

Distribution and origin of corticotropin-releasing factor-immunoreactive axons in the female rat lumbosacral spinal cord.

Corticotropin-releasing factor (CRF) is a neuropeptide traditionally known for its hormonal role in the hypothalamic/pituitary/adrenal stress axis. However, CRF has been reported in axons in sites that may be considered outside of the direct stress…

Hypothalamic paraventricular axons projecting to the female rat lumbosacral spinal cord contain oxytocin immunoreactivity.

Oxytocin-containing axons project from the hypothalamic paraventricular nucleus to the neurohypophysis and thoracic spinal cord to ultimately influence uterine contractions and autonomic activity, respectively. Whether or not oxytocin-immunoreactive…

Tags: *Synaptic Transmission, 2001, Animals, Axons/*physiology, Female, Immunohistochemistry, Journal of neuroscience research, Lumbosacral Region, Nerve Fibers/metabolism/physiology, Oxytocin/*metabolism, Papka R E, Paraventricular Hypothalamic Nucleus/*physiology, Puder B A, Rats, Spinal Cord/*physiology, Sprague-Dawley

Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice.

Deletion of a single copy of the BDNF gene has been shown to affect the nigrostriatal dopaminergic system of young adult BDNF mice. In the present report we evaluated various indices of nigrostriatal dopaminergic function between

New hominids from the Lake Turkana Basin, Kenya.

New hominid fossils from the Lake Turkana Basin range in age from ca. 3.35 to ca. 1.0 Ma. Those recovered from sediments stratigraphically just above the Tulu Bor Tuff in the Lomekwi Member of the Nachukui Formation are best attributed to…

Tags: *Fossils, 2001, Animals, Brown B, Brown F H, Femur/physiology, Geologic Sediments, Hominidae/*physiology, Humans, Journal of human evolution, Kenya, Mandible/physiology, Tibia/*physiology, Walker A

Aspects of mineral structure in normally calcifying avian tendon.

Structural characteristics of normally calcifying leg tendons of the domestic turkey Meleagris gallopavo have been observed for the first time by tapping mode atomic force microscopy (TMAFM), and phase as well as corresponding topographic images were…

Tags: 2001, Anatomic, Animals, Atomic Force/methods, Calcification, Collagen/chemistry/ultrastructure, Journal of structural biology, Landis W J, Microscopy, Minerals/*chemistry, Models, Molecular, Non-programmatic, Physiologic, Siperko L M, Tendons/*chemistry/*ultrastructure, Turkeys

Depotentiation of vdccLTP requires NMDAR activation.

Long-term potentiation is an enduring increase in synaptic efficacy following repeated stimulation of afferent fibers that is thought to underlie memory. In area CA1 of the hippocampus at least two forms of synaptic potentiation coexist at the same…

Tamoxifen eliminates estrogen's neuroprotective effect upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system.

The capacity for 17-alpha and 17-Beta estradiol to modulate MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system and potential antagonism of this modulation by the anti-estrogen, tamoxifen, were evaluated. Treatment of retired breeder…

Tags: 2001, Anderson L I, Dluzen D E, McDermott J L, Neurotoxicity research

Neuropathic pain in aged rats: behavioral responses and astrocytic activation.

We used the Bennett and Xie (1988) model of chronic neuropathic pain to study the effect of age on thermal and tactile sensitivity and on astrocytic activation in the dorsal horn of the spinal cord after nerve injury. Fischer 344 FBNF1 hybrid rats in…

Acquired inhibitor to factor VIII in small cell lung cancer: a case report and review of the literature.

Acquired hemophilia (antibodies or inhibitors to factor VIII) is the most common acquired disease affecting clotting factors. It has been described in association with autoimmune disease, malignancy, dermatologic disorders, in the postpartum period,…

Tags: 2001, Ahmed F, Annals of hematology, Carcinoma, Crock R, Department of Internal Medicine, Factor VIII/*antagonists & inhibitors, Humans, Lara L, Lung Neoplasms/*chemistry, Male, Middle Aged, NEOMED College of Medicine, Rutecki G W, Shwaiki A, Small Cell/*chemistry, Whittier F C

Vaginal leiomyoma co-existing with broad ligament and multiple uterine leiomyomas.

A 48 year old African American woman presented with bladder pressure leading to the diagnosis of broad ligament and multiple uterine leiomyomas. She was also found to have a lateral vaginal wall mass which was confirmed to be a leiomyoma. Unlike…

Tags: *Neoplasms, 2001, Archives of gynecology and obstetrics, Fallopian Tubes/surgery, Female, Hecht B R, Hopkins M P, Humans, Hysterectomy, Leiomyoma/*diagnosis/pathology/surgery, Leiomyomatosis/*diagnosis/pathology/surgery, Meniru G I, Middle Aged, Multiple Primary, Onuora C O, Ovariectomy, Uterine Neoplasms/*diagnosis/pathology/surgery, Vaginal Neoplasms/*diagnosis/pathology/surgery, Wasdahl D

Responses to combinations of tones in the nuclei of the lateral lemniscus.

Combination-sensitive neurons integrate specific spectral and temporal elements in biologically important sounds, and they may underlie the analysis of biosonar and social vocalizations. Combination-sensitive neurons are found in the forebrain of a…

Tags: 2001, Acoustic Stimulation/methods, Animals, Auditory Pathways/*physiology, Brain Stem/*physiology, Chiroptera, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Electrophysiology, Journal of the Association for Research in Otolaryngology : JARO, NEOMED College of Medicine, Neurons/physiology, Portfors C V, Reaction Time/physiology, Wenstrup J J

The effect of testosterone upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system.

The gonadal steroid hormone estrogen (E) can function as a neuroprotectant of nigrostriatal dopaminergic (NSDA) neurotoxicity, however, there exists very limited information on the role of testosterone (T) in this capacity. In the present report, the…

Tags: 2001, Animals, Brain research, Corpus Striatum/drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Drug Implants, Female, Gao X, Male, Methamphetamine/*toxicity, Mice, Neuroprotective Agents/pharmacology, Neurotoxins/*toxicity, Orchiectomy, Ovariectomy, Potassium/pharmacology, Substantia Nigra/drug effects/*metabolism, Testosterone/administration & dosage/*pharmacology

Par-4 is a synaptic protein that regulates neurite outgrowth by altering calcium homeostasis and transcription factor AP-1 activation.

Although Par-4 (prostate apoptosis response-4) is involved in initiation of neurodegenerative cascades associated with certain neurodegenerative disorders, normal physiological roles of Par-4 in neurons have remained elusive. It was recently reported…

Aberrant induction of Par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 M146V mutant knock-in mice.

Mutations in presenilin-1 (PS-1) have been shown to increase neuronal vulnerability to apoptosis in Alzheimer's disease (AD). Par-4 is a novel cell-death-promoting protein associated with neuronal degeneration in AD. We previously reported that, in…

Epileptic-like activity induces multiple forms of plasticity in hippocampal area CA1.

Mesial temporal lobe epilepsy is a relatively common form of epilepsy that afflicts many thousands of people. It has been suggested that the development of primary and secondary foci may involve mechanisms similar to long-term potentiation (LTP). In…

Tags: *Neuronal Plasticity, 2001, Animals, Brain research, Calcium Channels, Electrophysiology, Epilepsy/chemically induced/*physiopathology, Hippocampus/*physiopathology, Ion Channels/physiology, L-Type/physiology, Long-Evans, Long-Term Potentiation/physiology, Morgan S L, N-Methyl-D-Aspartate/metabolism, Potassium Chloride, Rats, Receptors, Synapses/physiology, Teyler T J

Synaptic plasticity and secondary epileptogenesis.

Tags: 2001, Animals, Epilepsy/etiology/*physiopathology, Humans, International review of neurobiology, Long-Term Potentiation/physiology, Morgan S L, Neuronal Plasticity/*physiology, Russell R N, Synapses/*physiology, Teyler T J, Woodside B L

Gender and the behavioral manifestations of neuropathic pain.

A model of peripheral nerve injury was used to study gender differences in the development and progression of chronic constriction injury (CCI)-induced hyperalgesia and allodynia in male and female Fischer 344 FBNF1 hybrid rats. Rats were randomly…

Changes in BiP (GRP78) levels upon HSV-1 infection are strain dependent.

BiP (grp78) is a chaperone protein which can also regulate the unfolded protein response of the cell. Levels of BiP increased in cells infected by the small plaque producing, cell associated, neuroinvasive strains of HSV-1 (SP7, 490) but decreased in…

Tags: 2001, 3T3 Cells, Animals, Carrier Proteins/*biosynthesis/genetics, Heat-Shock Proteins/*biosynthesis/genetics, Herpesvirus 1, Human/isolation & purification/*physiology, Humans, Mao H, Messenger/metabolism, Mice, Molecular Chaperones/*biosynthesis/genetics, Palmer D, RNA, Rosenthal K S, Virus research

Tamoxifen abolishes estrogen's neuroprotective effect upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system.

The effects of 17beta-estradiol and the anti-estrogen, tamoxifen, on methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system were examined in ovariectomized CD-1 mice. In Experiment 1, striatal dopamine concentrations from…

Tags: 2001, Animals, Corpus Striatum/chemistry/*drug effects/metabolism, Dluzen D E, Dopamine/analysis/*metabolism, Estrogen Antagonists/*pharmacology, Estrogens/blood/*pharmacology, Female, Gao X, Inbred Strains, Methamphetamine/*toxicity, Mice, Neuroprotective Agents/pharmacology, Neuroscience, Ovariectomy, Substantia Nigra/chemistry/*drug effects/metabolism, Sympathomimetics/*toxicity, Tamoxifen/*pharmacology

Nisoxetine infusion into the olfactory bulb enhances the capacity for male rats to identify conspecifics.

In the present report, the norepinephrine uptake inhibitor nisoxetine as well as a cocktail of nisoxetine and the alpha-adrenergic receptor antagonist phentolamine were infused unilaterally into the olfactory bulb during microdialysis to assess their…

Topographical distribution of delay-tuned responses in the mustached bat inferior colliculus.

In the mustached bat, delay-tuned neurons respond best to specific delays between the first harmonic frequency modulated (FM) component (FM1; 24-29 kHz) of the emitted biosonar pulse and a higher harmonic FM component in returning echoes (e.g. FM3,…

Tags: 2001, Acoustic Stimulation, Animals, Auditory Cortex/anatomy & histology/physiology, Chiroptera/*anatomy & histology/*physiology, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Echolocation/physiology, Hearing research, Inferior Colliculi/*anatomy & histology/*physiology, NEOMED College of Medicine, Neurons/physiology, Portfors C V, Ultrasonics, Wenstrup J J

Auditory nerve fiber differences in the normal and neurofilament deficient Japanese quail.

A primary axonal disease affecting the central and peripheral nervous system was discovered in a mutant strain of the Japanese quail, named quiver (Quv). We have previously demonstrated altered auditory evoked potentials in the neurofilament (NF)…

Tags: *Mutation, 2001, Animals, Auditory, Axons/ultrastructure, Brain Stem, Cochlear Nerve/*pathology/*physiopathology, Coturnix/genetics, Electron, Evoked Potentials, Hearing research, Kaga K, Microscopy, Mizutani M, Myelin Sheath/ultrastructure, Nerve Fibers/pathology/physiology, Neurofilament Proteins/*deficiency/*genetics, Sheykholeslami K

Medical care use by treated and untreated substance abusing medicaid patients.

Medicaid reimbursement costs for county residents at least 18 years old who used a treatment service (n = 1043) and residents who were Medicaid enrollees with a substance abuse diagnosis but who did not receive treatment (n = 2125) were compared.…

Mesenchymal hamartoma of the liver.

We present a multiseptated mesenchymal hamartoma of the liver in a 10-year-old male patient, a rare benign tumor of childhood. The characteristic ultrasound and CT appearances of this unusual tumor are reviewed. A single septal calcification…

Tags: 2001, Boinapally S B, Calcinosis/diagnostic imaging/surgery, Child, Cholangiography, Cholecystectomy, Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society, Diagnosis, Differential, Goyal M, Hamartoma/*diagnostic imaging/surgery, Humans, Konez O, Liver Diseases/*diagnostic imaging/surgery, Male, Tomography, Ultrasonography, Vyas P K, X-Ray Computed

Can tamoxifen cause a significant mammographic density change in breast parenchyma?

To evaluate tamoxifen-induced glandular tissue density changes in women who are on an adjuvant tamoxifen therapy. We examined serial mammograms of 27 women (average age 67) who had surgery for unilateral breast carcinoma and were on tamoxifen for 5…

Tags: 2001, Aged, Antineoplastic Agents, Breast Neoplasms/*diagnostic imaging/*prevention & control/surgery, Breast/anatomy & histology/*drug effects, Clinical imaging, Computer-Assisted, Female, Goyal M, Hormonal/*pharmacology, Humans, Image Processing, Konez O, Mammography, Reaven R E, Tamoxifen/*pharmacology

Vascular anatomy anterior to lumbosacral transitional vertebrae and implications for anterior lumbar interbody fusion.

BACKGROUND CONTEXT: Anterior approaches to the lumbosacral spine afford the ideal window to the disc for interbody fusion. Vascular injuries represent the most feared complications of such approaches. Unfortunately, the combination of more procedures…

Tags: *Spinal Fusion, 2001, Fraser R D, Humans, Iliac Vein/*anatomy & histology, Lumbar Vertebrae/anatomy & histology/*blood supply/*surgery, Lumbosacral Region/anatomy & histology/blood supply/surgery, Sacrum/anatomy & histology/blood supply/surgery, Spinal Diseases/surgery, The spine journal : official journal of the North American Spine Society, Walker M, Weiner B K

Getting ready for recovery: reconciling mandatory treatment with the recovery vision.

Considering treatment of serious mental illnesses, it might appear that the recovery model would be incompatible with any form of mandatory treatment. The authors suggest that this is not so. With individuals whose psychotic illness substantially…

Tags: *Commitment of Mentally Ill, *Convalescence, 2001, Community Participation, Decision Making, Department of Psychiatry, Frese F J 3rd, Humans, Mental Health Services/*organization & administration, Munetz M R, NEOMED College of Medicine, Psychiatric rehabilitation journal, Psychotic Disorders/*therapy

Skeletons of terrestrial cetaceans and the relationship of whales to artiodactyls.

Modern members of the mammalian order Cetacea (whales, dolphins and porpoises) are obligate aquatic swimmers that are highly distinctive in morphology, lacking hair and hind limbs, and having flippers, flukes, and a streamlined body. Eocene fossils…

Tags: *Biological Evolution, *Fossils, 2001, Animals, Bone and Bones/*anatomy & histology, Cetacea/anatomy & histology/*classification, Department of Anatomy & Neurobiology, Hussain S T, Nature, NEOMED College of Medicine, Phylogeny, Roe L J, Skeleton, Thewissen J G, Whales/anatomy & histology/*classification, Williams E M

Tamoxifen diminishes methamphetamine-induced striatal dopamine depletion in intact female and male mice.

It has been demonstrated that the nigrostriatal dopaminergic system of male mice is more sensitive to the neurotoxic effects of methamphetamine (MA). The basis for this difference can be related to oestrogen, which has the capacity to function as a…

Waxy keratoses of childhood in a segmental distribution.

Waxy keratoses of childhood is a rare genodermatosis previously noted in both familial and isolated presentations. Three previous cases have been described in which the lesions appeared over the trunk and extremities. We report a case in which the…

Tags: 2001, Child, Diagnosis, Differential, Female, Humans, Keratosis/diagnosis/*genetics/pathology, Mehrabi D, Pediatric dermatology, Prose N S, Selim M A, Thomas J E

Complementary and alternative medicine use in the Amish.

OBJECTIVE: To examine the rate of utilization of complementary and alternative medicine (CAM) in Amish women, a population that traditionally uses non-mainstream medicine. METHODS & RESULTS: Sixty-six Amish women completed a survey concerning their…

Tags: *Christianity, 2001, Adult, Complementary therapies in medicine, Complementary Therapies/*statistics & numerical data, Female, Frasure H E, Gil K M, Hopkins M P, Humans, Jenison E L, Ohio, Phytotherapy/statistics & numerical data, Plant Preparations/therapeutic use, Pregnancy, Pregnancy Complications/therapy, Showalter A L, von Gruenigen V E

A comparison of costs associated with screening for gestational diabetes with two-tiered and one-tiered testing protocols.

OBJECTIVE: The Fourth International Workshop on Gestational Diabetes recently suggested that two techniques, a 2-tiered protocol and a 1-tiered protocol, to screen for gestational diabetes mellitus are acceptable alternatives. This study was…

Tags: 2001, American journal of obstetrics and gynecology, Cost-Benefit Analysis, Diabetes, Female, Gestational/*diagnosis/*economics, Glucose Tolerance Test/*economics/*methods, Humans, Lavin B, Lavin J P Jr, Mass Screening/economics, O'Donnell N, Pregnancy, Time Factors

Prostate apoptosis response-4 enhances secretion of amyloid beta peptide 1-42 in human neuroblastoma IMR-32 cells by a caspase-dependent pathway.

Prostate apoptosis response-4 (Par-4) is a leucine zipper protein that promotes neuronal cell death in Alzheimer's disease (AD). Neuronal degeneration in AD may result from extracellular accumulation of amyloid beta peptide (Abeta) 1-42. To examine…

Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression.

Sterol 12alpha-hydroxylase catalyzes the synthesis of cholic acid and controls the ratio of cholic acid over chenodeoxycholic acid in the bile. Transcription of CYP8B1 is inhibited by bile acids, cholesterol, and insulin. To study the mechanism of…

Effect of aging on the substance P receptor, NK-1, in the spinal cord of rats with peripheral nerve injury.

Substance P (SP) levels in the spinal cords of very old rats are less than the levels in younger rats (Bergman et al., 1996). After injury to a peripheral nerve in young rats, immunoreactivity (ir) to the SP receptor, NK-1 (neurokinin-1), increases…

Mycobacterium tuberculosis complex DNA from an extinct bison dated 17,000 years before the present.

In order to assess the presence of tuberculosis in Pleistocene bison and the origin of tuberculosis in North America, 2 separate DNA extractions were performed by 2 separate laboratories on samples from the metacarpal of an extinct long-horned bison…

Evaluation of the in vitro and in vivo antitumor activities of vitamin C and K-3 combinations against human prostate cancer.

Tags: 2001, Animals, Antineoplastic Agents/*therapeutic use, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Ascorbic Acid/*therapeutic use, Gilloteaux J, Humans, Jamison J M, Male, Prostatic Neoplasms/*prevention & control, Summers J L, Taper H S, The Journal of nutrition, Vitamin K/*therapeutic use

Reply to a letter by Inoue et al.

Tags: 2001, Ancient, Articular/pathology, Asian Continental Ancestry Group, Bone and Bones/pathology, Cartilage, China, European Continental Ancestry Group, France, History, Humans, Japan, Osteoarthritis/diagnosis/ethnology/*history, Paleopathology, Prevalence, Rheumatology (Oxford, England), Rothschild B M

Browse Items (192 total)