The sterol 12alpha-hydroxylase (CYP8B1) is a key enzyme of the bile acid biosynthetic pathway. It regulates the composition of bile acids in bile, i.e. ratio between cholic acid (CA) and chenodeoxycholic acid (CDCA). In similarity with cholesterol…
The sterol 12alpha-hydroxylase (CYP8B1) is a key enzyme of the bile acid biosynthetic pathway. It regulates the composition of bile acids in bile, i.e. ratio between cholic acid (CA) and chenodeoxycholic acid (CDCA). In similarity with cholesterol…
Although not as significant as the dissemination of your results, the sense of accomplishment associated with publishing a manuscript in a medical journal is a welcome reward for working through the research process. Three basic strategies will help…
STUDY DESIGN: A morphometric study of the lateral buttress region of the lumbar pars interarticularis from L1-L5 on 10 dried lumbar spines was performed. OBJECTIVE: To qualitatively describe and quantitatively evaluate this portion of the pars and to…
The professional development discourse currently circulating in academic medicine owes much to the work of the American Board of Internal Medicine (ABIM) and their Project Professionalism. They identify the elements of altruism, duty, excellence,…
Medical schools have been slow to include meaningful end-of-life (EOL) educational experiences in their curricula. As an area of inquiry and focused clinical experience, death is "conspicuous" by its absence, reflecting a medical culture that defines…
Twenty-eight years after the United State Supreme Court issued its landmark Roe v. Wade, the struggle continues to ensure that all women have the full range of reproductive choices, including abortion. While the struggle can be addressed through its…
Since its publication in 1978, Samuel Shem's The House of God has sold over two million copies in over 50 countries. While it has remained popular among medical students, its value as a literary text to promote critical reflection on self and…
Twenty-eight years after the United State Supreme Court issued its landmark Roe v. Wade, the struggle continues to ensure that all women have the full range of reproductive choices, including abortion. While the struggle can be addressed through its…
We determined if kainic acid, a neuroexcitotoxin, could be used to denervate the cell bodies of cardiopulmonary vagal sensory neurons. Kainic acid (5 mug) was injected into the nodose ganglion of five dogs. Ten to fourteen days following this…
The 4070A amphotropic murine leukemia virus (A-MuLV) has been variably reported to harbor neurovirulence determinants within its env gene. In this report we reexamined this issue by applying two approaches previously demonstrated to amplify murine…
The origin and early evolution of Cetacea (whales, dolphins, and porpoises) is one of the best examples of macroevolution as documented by fossils. Early whales are divided into six families that differ greatly in their habitats, which varied from…
We describe 6 patients who had bacteremic community-acquired pneumonia and unsuspected Legionella pneumophila coinfection. We reviewed case records of patients who were diagnosed as having a recent Legionella infection on the basis of either the…
Early cetaceans evolved from terrestrial quadrupeds to obligate swimmers, a change that is traditionally studied by functional analysis of the postcranial skeleton(1). Here we assess the evolution of cetacean locomotor behaviour from an independent…
Our previous work indicates that myocardial ischemia could be the mechanism responsible for the left ventricular (LV) dysfunction that frequently develops after massive sympathetic nervous system (SNS) activation. In this study, coronary blood flow…
Human alpha(2)-macroglobulin (alpha(2)M), pregnancy zone protein (PZP), rat alpha(1)M and acute-phase rat alpha(2)M belong to the alpha(2)M gene family of proteins, which can react covalently with nucleophilic monoamines to yield monoamine-activated…
We assessed the bacterial contamination of the pagers of healthcare personnel and the efficacy of disinfection with 70% isopropyl alcohol. Microorganisms were isolated from all pagers; 21% yielded Staphylococcus aureus, of which 14% were methicillin…
Fungal infection is a rare but devastating complication of total joint arthroplasty. Many patients require removal of the components and resection arthroplasty for cure; however, revision arthroplasty with medicated polymethylmethacrylate bone cement…
Angiotensin (Ang) II via the AT(1) receptor acts as a mitogen in vascular smooth muscle cells (VSMC) through stimulation of multiple signaling mechanisms, including tyrosine kinases and mitogen-activated protein kinase (MAPK). In addition, cytosolic…
The human vestibule has preserved an ancestral sound sensitivity and it has been suggested that a reflex could originate from this property underlying cervical muscle micro-contractions secondary to strong acoustic stimulation. Previous studies have…
A partial skeleton was recovered from middle Miocene Muruyur sediments near Kipsaramon in the Tugen Hills, Baringo District, Kenya. The specimen, representing much of the upper skeleton, comes from locality BPRP#122 dated between 15(.)58 Ma and…
Temporal bone morphology, as part of the basicranium, is commonly used in systematic evaluation of early hominid fossils. When an isolated right temporal bone, KNM-BC 1 (the Chemeron temporal) was discovered in the Baringo Basin, Kenya, Tobias…
Several researchers have investigated, or commented on, the relative placement of the hominin mandibular fossa with regard to brain expansion and masticatory function. Two confounding factors are identified in this previous work. First, a number of…
In the present experiment we compared differences in extracellular norepinephrine levels in vivo within the olfactory bulb of intact and castrated male rats following infusion of the norepinephrine transport inhibitors, nisoxetine and tomoxetine.…
This study investigated whether interest inventories that purport to measure the same constructs actually yield scores that correspond. The study examined the empirical relation of scores for similarly and same-named scales on five widely used…
Models of career maturity first formulated at midcentury, have been criticized for not incorporating innovations in personality and developmental psychology. This isolation from general models of and debates about personal maturity has kept career…
Before discussing how to innovate the study of career development using insights from life-span psychology and life course sociology, researchers might benefit from reconsidering whether they are studying careers or studying vocational behavior.…
