Browse Items · NEOMED Bibliography Database

Skeletal clues apparently distinguishing Waldenstrom's macroglobulinemia from multiple myeloma and leukemia.

This study was conducted to characterize macroscopically and by conventional radiography the bony lesions in a case of Waldenstrom's macroglobulinemia and to compare and contrast it with those of the other major hematologic lymphoproliferative…

Tags: 2002, American journal of human biology : the official journal of the Human Biology Council, Bone and Bones/diagnostic imaging/*pathology, Diagnosis, Differential, Humans, Leukemia/*diagnosis/pathology, Male, Middle Aged, Multiple Myeloma/*diagnosis/pathology, Radiography, Rothschild B M, Rothschild C, Ruhli F, Waldenstrom Macroglobulinemia/*diagnosis/pathology

Comparative binding of biotinylated neurotrophins to alpha(2)-macroglobulin family of proteins: relationship between cytokine-binding and neuro-modulatory activities of the macroglobulins.

Human alpha(2)-macroglobulin (alpha(2)M), pregnancy zone protein (PZP), rat alpha(1)M and acute-phase rat alpha(2)M belong to the alpha(2)M gene family of proteins, which can react covalently with nucleophilic monoamines to yield monoamine-activated…

Estrogen receptor-alpha and neural circuits to the spinal cord during pregnancy.

Estrogen receptor immunoreactivity and mRNAs are present in spinal cord neurons in locations that are associated with sensory and autonomic innervation of female reproductive organs. The present study was undertaken to examine the expression of…

Selective photothermolysis of the sebaceous glands for acne treatment.

BACKGROUND AND OBJECTIVES: The purpose of this study is to evaluate the efficacy of a long pulse diode laser (Cynosure, Inc.) to target and destroy enlarged sebaceous glands that are preloaded with Indocyanine green (ICG) chromophore. STUDY…

Tags: *Hyperthermia, *Photolysis, *Phototherapy, 2002, Acne Vulgaris/pathology/*therapy, Combined Modality Therapy, Department of Internal Medicine, Feasibility Studies, Follow-Up Studies, Humans, In Vitro Techniques, Induced, Lasers in surgery and medicine, Lloyd Jenifer R, Mirkov Mirko, NEOMED College of Medicine, Sebaceous Glands/pathology/*radiation effects, Time Factors, Treatment Outcome

Striatal dopamine output is compromised within +/- BDNF mice.

We reported previously that mice lacking one brain-derived neurotrophic factor (BDNF) allele demonstrate elevated striatal dopamine (DA) concentrations but impaired behavioral responses involving the nigrostriatal dopaminergic (NSDA) system. To test…

Pertubation of beta1 integrin function using anti-sense or function-blocking antibodies on corneal cells grown on fibronectin and tenascin.

During corneal development, neural crest derivatives from the periocular mesenchyme migrate into the cornea and differentiate into corneal fibroblasts. During this time, these cells interact with a variety of extracellular matrices for proper…

Reexamination of amphotropic murine leukemia virus neurovirulence: neural stem cell-mediated microglial infection fails to induce acute neurodegeneration.

The 4070A amphotropic murine leukemia virus (A-MuLV) has been variably reported to harbor neurovirulence determinants within its env gene. In this report we reexamined this issue by applying two approaches previously demonstrated to amplify murine…

Spontaneous prolonged hypertonic uterine contractions (essential uterine hypertonus) and a possible infective etiology.

The management of a pregnant woman presenting with prolonged hypertonic uterine contractions (essential uterine hypertonus) and mildly elevated temperature at term is described. Histology of the placenta, cord and membranes, following delivery,…

The ability of an HSV strain to initiate zosteriform spread correlates with its neuroinvasive disease potential.

The requirements for disease development in the mouse epidermal scarification-zosteriform model of HSV infection are likely to parallel those required for primary HSV disease of humans. HSV-1 strains, which are neuroinvasive in the mouse footpad…

Phosphatidylinositide 3-kinase regulates angiotensin II-induced cytosolic phospholipase A2 activity and growth in vascular smooth muscle cells.

Angiotensin (Ang) II via the AT(1) receptor acts as a mitogen in vascular smooth muscle cells (VSMC) through stimulation of multiple signaling mechanisms, including tyrosine kinases and mitogen-activated protein kinase (MAPK). In addition, cytosolic…

Autoschizis: a novel cell death.

Vitamin C (VC) and vitamin K(3) (VK(3)) administered in a VC:VK(3) ratio of 100:1 exhibit synergistic antitumor activity and preferentially kill tumor cells by autoschizis, a novel type of necrosis characterized by exaggerated membrane damage and…

Tags: 2002, Animals, Antioxidants/chemistry/*pharmacology/therapeutic use, Ascorbic Acid/chemistry/*pharmacology/therapeutic use, Biochemical pharmacology, Calderon Pedro Buc, Cell Death/*physiology, Gilloteaux Jacques, Humans, Jamison James M, Necrosis, Neoplasms/drug therapy/metabolism/*pathology, Oxidative Stress/*drug effects, Summers Jack L, Taper Henryk S, Vitamin K/chemistry/*pharmacology/therapeutic use

Supplements and drugs used to enhance athletic performance.

The temptation of using drugs and supplements as shortcuts to improving athletic performance or even to enhance appearance is very seductive to adolescents. This age group is often characterized by a desire for quick results and a lack of concern for…

Tags: *Dietary Supplements, 2002, Adolescent, Adolescent Behavior/*psychology, Congeni Joseph, Doping in Sports/prevention & control/*psychology, Humans, Miller Stephen, Pediatric clinics of North America

A modification of the epidermal scarification model of herpes simplex virus infection to achieve a reproducible and uniform progression of disease.

A slight modification in the method used to remove the top keratinized layer of skin in the epidermal scarification model of HSV infection results in an easier, less painful, more uniform and reproducible means of infection. The back of mice was…

Modulation of olfactory bulb tyrosine hydroxylase and catecholamine transporter mRNA by estrogen.

Since estrogen exerts wide ranging effects within the central nervous system, it is important to investigate the sites and actions of this gonadal steroid hormone at extra-hypothalamic locations. In the present report, the effects of estrogen upon…

Sensory nerves and neuropeptides in uterine cervical ripening.

At the time of parturition (fetal delivery) the uterine cervix must "ripen," becoming soft, pliable, and dilated to accommodate the fetus' delivery. The fundamental processes underlying cervical ripening remain poorly understood. Knowledge that…

Calcitonin gene-related peptide-receptor component protein expression in the uterine cervix, lumbosacral spinal cord, and dorsal root ganglia.

The neuropeptide calcitonin gene-related peptide (CGRP) may play a role in neurogenic inflammation, tissue remodeling of the uterine cervix, promoting vasodilation, parturition, and processing of sensory information in the spinal cord.…

Tags: 2002, Animals, Calcitonin Gene-Related Peptide/*biosynthesis/immunology/metabolism, Cervix Uteri/*metabolism, Dickerson I M, Female, Ganglia, Lumbosacral Region, Papka R E, Peptides, Pokabla M J, Rats, Receptors, Spinal Cord/*metabolism, Spinal/*metabolism, Sprague-Dawley, Uterus/metabolism

Castration increases nisoxetine-evoked norepinephrine levels in vivo within the olfactory bulb of male rats.

In the present experiment we compared differences in extracellular norepinephrine levels in vivo within the olfactory bulb of intact and castrated male rats following infusion of the norepinephrine transport inhibitors, nisoxetine and tomoxetine.…

The otolithic organ as a receptor of vestibular hearing revealed by vestibular-evoked myogenic potentials in patients with inner ear anomalies.

The human vestibule has preserved an ancestral sound sensitivity and it has been suggested that a reflex could originate from this property underlying cervical muscle micro-contractions secondary to strong acoustic stimulation. Previous studies have…

Excitatory and facilitatory frequency response areas in the inferior colliculus of the mustached bat.

In the mustached bat's central nucleus of the inferior colliculus (ICC), many neurons display facilitatory or inhibitory responses when presented with two tones of distinctly different frequencies. Our previous studies have focused on spectral…

Tags: 2002, Acoustic Stimulation, Animal, Animals, Auditory, Auditory Perception/*physiology, Brain Stem, Chiroptera/*physiology, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Echolocation, Evoked Potentials, Hearing research, Inferior Colliculi/*physiology, NEOMED College of Medicine, Neurons/physiology, Portfors Christine V, Vocalization, Wenstrup Jeffrey J

Isolated and combined fractures of the diaphysis of the radius and ulna.

In summary, treatment of diaphyseal fractures requires accurate assessment of the injury to rule out concomitant ligamentous injury at the wrist or the elbow. Minimally displaced ulnar fractures can be managed with bracing. Displaced diaphyseal…

Tags: 2002, Device Removal/adverse effects, Diaphyses/*injuries/surgery, Hand clinics, Humans, Orthopedic Procedures/methods, Radius Fractures/*complications/surgery, Radius/anatomy & histology/surgery, Reilly T J, Treatment Outcome, Ulna Fractures/*complications/surgery, Ulna/anatomy & histology/surgery

Outcome of treatment of respiratory tract infections due to Streptococcus pneumoniae, including drug-resistant strains, with pharmacokinetically enhanced amoxycillin/clavulanate.

The efficacy of a new pharmacokinetically enhanced formulation of amoxycillin/clavulanate (AMX/CA) 2000/125 mg, twice daily, designed to provide adequate levels of amoxycillin over the 12-h dosing interval to eradicate penicillin-resistant…

Tags: *Treatment Outcome, 2002, 80 and over, Adolescent, Adult, Aged, Amoxicillin-Potassium Clavulanate Combination/administration & dosage/*pharmacokinetics/pharmacology/*therapeutic use, Amoxicillin/adverse effects/therapeutic use, Bacterial, Bacterial/drug therapy/immunology, Bronchitis/drug therapy/microbiology, Combination/adverse effects/*therapeutic use, Department of Internal Medicine, Double-Blind Method, Drug Administration Schedule, Drug Resistance, Drug Therapy, Female, File Thomas M Jr, Follow-Up Studies, Humans, International journal of antimicrobial agents, Jacobs Michael R, Male, Microbial Sensitivity Tests, Middle Aged, Multicenter Studies as Topic, NEOMED College of Medicine, Pneumonia, Poole Michael D, Respiratory Tract Infections/*drug therapy/metabolism/microbiology, Streptococcal Infections/*drug therapy/metabolism/microbiology, Streptococcus pneumoniae/*drug effects, Wynne Brian

The structure and function of normally mineralizing avian tendons.

The leg tendons of certain avian species normally calcify. The gastrocnemius, or Achilles, tendon of the domestic turkey, Meleagris gallopavo, is one such example. Its structure and biomechanical properties have been studied to model the adaptive…

Tags: 2002, Animals, Biomechanical Phenomena, Birds/*anatomy & histology/*physiology, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, Landis William J, Minerals/*metabolism, Non-programmatic, Silver Frederick H, Tendons/anatomy & histology/*cytology/*physiology

The effect of various insufflation gases on tumor implantation in an animal model.

OBJECTIVE: The expanded use of laparoscopy has led to reports of tumor dissemination and spread to laparoscopic port sites. We previously showed that carbon dioxide insufflation produced tumor dissemination compared with laparotomy. It is unknown…

An N-terminal arginine-rich cluster and a proline-alanine-threonine repeat region determine the cellular localization of the herpes simplex virus type 1 ICP34.5 protein and its ligand, protein phosphatase 1.

The ICP34.5 protein facilitates herpes simplex virus replication by binding and activating protein phosphatase 1 (PP1) by means of a very conserved C-terminal

Appropriate use of antimicrobials for drug-resistant pneumonia: focus on the significance of beta-lactam-resistant Streptococcus pneumoniae.

The beta-lactam antibiotics (penicillins and cephalosporins) are commonly prescribed for the treatment of community-acquired pneumonia. However, Streptococcus pneumoniae, the most common etiologic agent of community-acquired pneumonia, has become…

Tags: *beta-Lactam Resistance, 2002, beta-Lactams/economics/*therapeutic use, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Contraindications, Department of Internal Medicine, File Thomas M Jr, Humans, NEOMED College of Medicine, Pneumococcal/*drug therapy/economics/pathology, Pneumonia, Practice Guidelines as Topic, Streptococcus pneumoniae/*drug effects/metabolism

The House of God : another look.

Since its publication in 1978, Samuel Shem's The House of God has sold over two million copies in over 50 countries. While it has remained popular among medical students, its value as a literary text to promote critical reflection on self and…

Academic medicine gets a poor report card–what are we going to do?

Tags: *Career Mobility, *Physicians, *Women's Rights, 2002, Academic medicine : journal of the Association of American Medical Colleges, Faculty, Female, Humans, Leadership, Medical/*organization & administration, Nora Lois Margaret, Women

Parotid gland metastasis from renal cell carcinoma.

OBJECTIVE: To discuss the diagnosis and management of metastatic renal cell carcinoma presenting as a parotid mass by studying such cases. STUDY DESIGN: Retrospective review. METHODS: Identification of 24 previously reported cases of renal cell…

Tags: 2002, 80 and over, Aged, Biopsy, Carcinoma, Diagnosis, Differential, Female, Hlivko Thomas J, Humans, Kidney Neoplasms/*pathology, Needle, Park Youn W, Parotid Neoplasms/pathology/*secondary, Renal Cell/pathology/*secondary, Retrospective Studies, The Laryngoscope

The lateral buttress: an anatomic feature of the lumbar pars interarticularis.

STUDY DESIGN: A morphometric study of the lateral buttress region of the lumbar pars interarticularis from L1-L5 on 10 dried lumbar spines was performed. OBJECTIVE: To qualitatively describe and quantitatively evaluate this portion of the pars and to…

Tags: 2002, Humans, Lumbar Vertebrae/anatomy & histology, Lumbosacral Region, McCulloch John A, Reference Values, Spine, Spine/*anatomy & histology, Walker Matthew, Weiner Bradley K, Wiley William

Use of the alexandrite laser for treatment of seborrheic keratoses.

BACKGROUND: Seborrheic karatoses are benign lesions that are easily irritated and often cosmetically objectionable. Liquid nitrogen cryotherapy and other surgical methods are useful in treating these lesions, but are difficult to tolerate in patients…

Tags: 2002, Back, Beryllium/*therapeutic use, Brodell Robert T, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], Humans, Keratosis, Laser Therapy/*methods, Mehrabi Don, Seborrheic/*surgery

Assessment of emergency medicine residents' computer knowledge and computer skills: time for an upgrade?

OBJECTIVE: To describe emergency medicine residents' (EMRs') personal computer (PC) use and educational needs and to compare their perceived and actual PC skills. METHODS: This was a prospective, cross-sectional study. Subjects were all EMRs at seven…

Estrogen, anti-estrogen, and gender: differences in methamphetamine neurotoxicity.

In Part 1 of this report, we review data on the effects of estrogen (E), the anti-E tamoxifen (TMX), and testosterone (T) on methamphetamine (METH)-induced neurotoxicity in female and male CD-1 mice. Treatment of gonadectomized females with a…

Tags: *Neurotoxins, *Sex Characteristics, 2002, Animals, Annals of the New York Academy of Sciences, Biological, Dluzen Dean E, Estrogen Antagonists/*pharmacology, Estrogens/*physiology, Female, Humans, Male, McDermott Janet L, Methamphetamine/*toxicity, Mice, Models, Tamoxifen/pharmacology, Testosterone/pharmacology

A novel mechanism of neurokinin-1 receptor resensitization.

Prolonged or repeated activation of many G protein-coupled receptors induces rapid desensitization followed by a period during which receptors are resensitized. In this study, concanavalin A (Con A) and monensin were used to investigate the…

Tags: 2002, Animals, Bennett V J, Cell Membrane/drug effects/metabolism, CHO Cells, Concanavalin A/pharmacology, Cricetinae, Monensin/pharmacology, Neurokinin-1/*agonists/*metabolism, Perrine S A, Phosphorylation/drug effects, Rats, Receptors, Simmons M A, The Journal of pharmacology and experimental therapeutics

Circadian variation in cell-adhesion molecule expression by normal human leukocytes.

Adhesion molecules located on the surface of blood-borne leukocytes permit adherence of leukocytes to the microvascular endothelium, diapedesis of leukocytes across vessel walls, formation of intimate multicell interactions, and enhanced…

Sexual dimorphism in prostanoid-potentiated vascular contraction: roles of endothelium and ovarian steroids.

The effects of constrictor prostanoid (CP) pathway inhibitors on vascular reactivity to vasopressin (VP) and phenylephrine (PE) were examined in thoracic aortas of male, female, and ovariectomized (OVX) female Sprague-Dawley rats. Maximal contractile…

Distal air space epithelial fluid clearance in near-term rat fetuses is fast and requires endogenous catecholamines.

Knowledge about the conversion of the epithelium in the distal air spaces of the lung from secretion to absorption is imperative to the understanding of postnatal lung development; little such information is available in rats. Distal air space fluid…

Prolonged isoproterenol infusion impairs the ability of beta(2)-agonists to increase alveolar liquid clearance.

We determined if prolonged isoproterenol (Iso) infusion in rats impaired the ability of the beta(2)-adrenergic agonist terbutaline to increase alveolar liquid clearance (ALC). We infused rats with Iso (at rates of 4, 40, or 400 microg.kg(-1).h(-1))…

Effect of massive sympathetic nervous system activation on coronary blood flow and myocardial energy pool.

Our previous work indicates that myocardial ischemia could be the mechanism responsible for the left ventricular (LV) dysfunction that frequently develops after massive sympathetic nervous system (SNS) activation. In this study, coronary blood flow…

Tags: 2002, Animals, Coronary Circulation/*physiology, Energy Metabolism, Experimental biology and medicine (Maywood, N.J.), Female, Heart/innervation/*physiology, Male, Pilati Charles F, Rabbits, Smith Jennifer M, Sympathetic Nervous System/drug effects/*physiology, Veratrine/pharmacology

Bile acid regulation of gene expression: roles of nuclear hormone receptors.

Bile acids derived from cholesterol and oxysterols derived from cholesterol and bile acid synthesis pathways are signaling molecules that regulate cholesterol homeostasis in mammals. Many nuclear receptors play pivotal roles in the regulation of bile…

Tags: 2002, Animals, Bile Acids and Salts/*physiology, Chiang John Y L, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Endocrine reviews, Gene Expression Regulation/*physiology, Humans, NEOMED College of Medicine, Receptors

From pragmatism to politics: a qualitative study of abortion providers.

Twenty-eight years after the United State Supreme Court issued its landmark Roe v. Wade, the struggle continues to ensure that all women have the full range of reproductive choices, including abortion. While the struggle can be addressed through its…

Tags: *Abortion, *Attitude of Health Personnel, *Politics, 2002, Department of Family & Community Medicine, Female, Health Services Accessibility, Humans, Interviews as Topic, Legal, Motivation, NEOMED College of Medicine, Physicians/*psychology, Quality of Life, United States, Wear Delese, Women & health

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