The Ligand Epitope Antigen Presentation System ( L. E. A. P. S. TM) approach to vaccine development utilizes immune peptides to promote the immunogenicity and influence the type of immune response generated towards epitopes in peptides which may be…
Evidence from human amyotrophic lateral sclerosis (ALS) patients and ALS-linked Cu/Zn superoxide dismutase (Cu/Zn-SOD) transgenic mice bearing the mutation of glycine to alanine at position 93 (G93A) suggests that the pro-apoptotic protein prostate…
In vivo studies, of jaw-muscle behavior have been integral factors in the development of our current understanding of the primate masticatory apparatus. However, even though it has been shown that food textures and mechanical properties influence…
Objectives: Screening for cognitive impairment in older emergency department (ED) patients is recommended to ensure quality care. The Mini-Mental State Examination (MMSE) may be too long for routine ED use. Briefer alternatives include the Six-Item…
The pathogenesis of Crohn's disease (CD), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and perpetuate mucosal inflammation in genetically susceptible individuals. Paneth cells (PC) are the…
Objective: This study was undertaken to prospectively evaluate the effect of early stage endometrial cancer, age, and obesity on quality of life (QOL). Study design: Women undergoing surgery for endometrial cancer or an adnexal mass determined at…
Purpose To describe the measurement properties of instruments reported in the literature that faculty might use to measure professionalism in medical students and residents. Method The authors reviewed studies published between 1982 and 2002 that had…
It is difficult to assess the effectiveness of the delivery of pain management care because pain management is a complex process. This article describes a quality assurance study that was conducted on a surgical unit at a community teaching hospital,…
Transformation of fibroblasts to myofibroblasts, characterized by expression of alpha-smooth muscle actin (alpha-SMA) and production of extracellular matrix (ECM) components, is a key event in connective tissue remodeling. Approaches to inhibit this…
Purpose To examine the role of gender discrimination and sexual harassment in medical students' choice of specialty and residency program. Method Anonymous, self-administered questionnaires were distributed in 1997 to fourth-year students enrolled in…
Lead poisoning in children imposes both immediate and long-term financial burdens on taxpayers. The District Board of Health of Mahoning County, Ohio, quantified some of the direct costs to taxpayers of providing medical care and public health…
The purpose of our study was to ascertain the progression of metastases in a novel ovarian cancer model designed to mimic early-stage disease by utilizing an orthotopic injection technique. Female Fischer 344 rats were injected with either 10(4) or…
In response to the overuse and misuse of antibiotics, leading to increasing bacterial resistance and decreasing development of new antibiotics, the Council for Appropriate and Rational Antibiotic Therapy (CARAT) has developed criteria to guide…
We describe director distortions in the nematic liquid crystal (LC) caused by a spherical particle with tangential surface orientation of the director and show that light transmittance through the distorted region is a steep function of the…
We describe director distortions in the nematic liquid crystal (LC) caused by a spherical particle with tangential surface orientation of the director and show that light transmittance through the distorted region is a steep function of the…
Considerable evidence suggests that left hemispheric lateralization for language comprehension in humans is associated with cortical microstructural asymmetries. However, despite the fact that left hemispheric dominance for the analysis of…
The authors identify and discuss the main themes from the discourse on the internationalization of educational and vocational guidance at the 2004 Symposium on International Perspectives on Career Development, cosponsored by the International…
Shark bite marks on mosasaur bones abound in the fossil record. Here we review examples from Kansas (USA) and the Maastrichtian type area (SE Netherlands, NE Belgium), and discuss whether they represent scavenging and/or predation. Some bite marks…
Recognition of decompression syndrome-related pathology (in the form of avascular necrosis) reveals diving behaviour in mosasaurs. Macroscopic and radiologic examination was performed to identify linear bone death characteristic of avascular necrosis…
The present study investigated whether infusion of brain-derived neurotrophic factor (BDNF) could ameliorate stress-induced impairments in spatial learning and memory as well as hippocampal long-term potentiation (LTP) of rats. Chronic immobilization…
During development and evolution, the morphology of ectodermal organs can be modulated so that an organism can adapt to different environments. We have proposed that morphoregulation can be achieved by simply tilting the balance of molecular…
Objective. The purpose of this study was to determine the accuracy of prenatal cardiac diagnosis, prognosis, and outcome of totally anomalous pulmonary venous connection (TAPVC) and to determine echocardiographic clues in the prenatal diagnosis of…
We describe our experience with prenatal diagnosis of tetralogy of Fallot with supracardiac totally anomalous pulmonary venous connection. We also suspected obstruction In the ascending vertical vein as it crossed the right bronchus and coursed…
Prenatal diagnosis of partial anomalous pulmonary venous connection (PAPVC) is rare. We describe a case in which the diagnosis was made at 24 weeks' gestation. The fetus had a double-outlet right ventricle, mitral atresia, a subaortic ventricular…
By isotopical labeling lipid lateral diffusion coefficients for each of the membrane constituents, including cholesterol, have been measured by H-1, H-2, and F-19 pulsed field gradient NMR spectroscopy in macroscopically oriented lipid bilayers. This…
Recent comprehensive studies of DNA sequences support the monophyly of Afrotheria, comprising elephants, sirenians (dugongs and manatees), hyraxes, tenrecs, golden moles, aardvarks, and elephant shrews, as well as that of Paenungulata, comprising…
INTRODUCTION: Upon designing and implementing a literature course on family values for Year 4 medical students, we found that while the supposed benefits of literary inquiry were to lead students to a deeper understanding of difficult issues such as…
Treatment options for sarcoidosis range from observation to complex immunosuppressive agents and organ transplant. A careful examination will help you assess the likelihood of spontaneous remission and determine when to initiate appropriate treatment…
OBJECTIVES: Pain related to the gurney is a frequent complaint of older emergency department (ED) patients. The authors hypothesized that these patients may have less pain and higher satisfaction if allowed to sit in a reclining hospital chair.…
