The expanding or shrinking universe of the hospitalist
General & Internal Medicine
Mitchell D M
Journal of Hospital Medicine
2008
2008-07
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1002/jhm.346" target="_blank" rel="noreferrer noopener">10.1002/jhm.346</a>
Angiotensin II-Induced proliferation of neonatal and adult rat cardiac fibroblasts - Response
Cardiovascular System & Cardiology
Meszaros J G
Hypertension
2008
2008-06
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1161/hypertensionaha.108.112789" target="_blank" rel="noreferrer noopener">10.1161/hypertensionaha.108.112789</a>
Hand hygiene in the dermatologist's office: To wash or to rub?
Dermatology; efficacy; alcohol; transmission; infections; regimens; disinfection; health-care workers; irritant contact-dermatitis; propanol; skin irritation
Hand hygiene is a central factor in preventing the spread of disease in the dermatologist's office. The role of hand washing and alcohol-based hand rubs is considered with emphasis on compliance, effectiveness,side effects, and cost. Specific recommendations highlight the importance of using alcohol-based hand rubs as an adjunct to traditional hand-washing methods. (J Am Acad Dermatol 2008;59:1043-9.)
Messina M J; Brodell L A; Brodell R T; Mostow E N
Journal of the American Academy of Dermatology
2008
2008-12
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/j.jaad.2008.07.033" target="_blank" rel="noreferrer noopener">10.1016/j.jaad.2008.07.033</a>
Prevalence of substance use among detained youth: A midwestern experience
Pediatrics; Psychology; Environmental & Occupational Health; Public
Meltzer I J; Piatt L; Jentner N; Fitzgibbon J J
Journal of Adolescent Health
2008
2008-02
Journal Article or Conference Abstract Publication
n/a
Human anterior chamber angle development without cell death or macrophage involvement
Ophthalmology; Biochemistry & Molecular Biology; light; aqueous outflow system; human eye; human trabecular meshwork; iridocorneal angle
Purpose: The iridocorneal angle in the mammalian eye including the trabecular meshwork (TM) develops from undifferentiated mesenchyme/neural crest between the iris root and cornea. The precise mechanisms underlying anterior angle development are unclear, and the contribution of cell death and phagocytic resorption by macrophages in angle development is controversial. In this study, we examined the human anterior chamber angle during various stages of development for evidence of cell death and phagocytic resorption. Methods: Eyes from the human fetus (F) of 7, 8, 9, 10, 11, 13, 15, 18, 19, 21, 22, 23, and 27 weeks as well as eyes from 5-and 11-month-old children and donors 24, 48, and 67 years of age were obtained. Formalin-fixed and paraffin-embedded sections were examined by hematoxylin and eosin (H&E) staining. Immunohistochemistry was performed using polyclonal antibodies against CD68. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) labeling was also performed to evaluate cell death. Results: By light microscopy, the development of human angle structures appeared to progress as previously described. Histological evidence of cellular death or resorption by macrophages was not observed. Furthermore, the chamber angle tissues did not stain with CD68 at any stage of development. Few CD68 positive cells were observed in the iris stroma and the anterior ciliary body between fetal weeks 10 and 18 (F10w and F18w). TUNEL labeled nuclei were not detected in the anterior chamber angle in any fetal or infant eyes. By contrast, TUNEL positive nuclei in TM cells were observed in the examined adult donor specimens. Conclusions: The results suggest that at the time points examined, neither cell death nor phagocytic resorption with macrophages appear to play a role in the development of the human anterior chamber angle.
Meghpara B; Li X; Nakamura H; Khan A; Bejjani B A; Lin S; Edward D P
Molecular Vision
2008
2008-12
Journal Article or Conference Abstract Publication
n/a
Applied epidemiology competencies for Governmental Public Health Agencies: Mapping current curriculum and the development of new curriculum
Environmental & Occupational Health; Public
McNutt L A; Furner S E; Moser M; Weist E M
Public Health Reports
2008
2008
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1177/00333549081230s106" target="_blank" rel="noreferrer noopener">10.1177/00333549081230s106</a>
The role of continuous fetal monitoring in the management of preterm premature rupture of membranes
Obstetrics & Gynecology; infection; continuous fetal monitoring; heart-rate decelerations; nonstress test; preterm premature membrane rupture
Objective. Continuous fetal monitoring (CFM) is often used in the management of preterm premature rupture of membranes (PPROM) but there is little evidence to support this approach. The objective of this study was to evaluate the clinical outcome of PPROM when managed by CFM. Methods. A retrospective review was conducted of 129 cases PPROM outcomes for the period January 1, 1998 to December 31, 2003. All women underwent CFM. Delivery was carried out for non-reassuring fetal testing, vaginal bleeding, evidence of infection, positive vaginal pool phosphatidylglycerol when available, and spontaneous labor. Results. Delivery was carried out because of an abnormal fetal heart tracing in 15 women (11.7%). The mean gestational age at admission was 32.2 weeks (95% CI 31.7-32.7), the mean gestational age at delivery was 32.7 weeks (95% CI 32.2-33.1), and the mean latency period was 3.3 days (95% CI 1.5-5.0). Gestational age at rupture of membranes was inversely correlated with latency period (n=128, r=-0.372, p < 0.001). With regard to gestational age, gravidity, and latency period there was no significant difference noted with respect to why the subjects delivered. No intrauterine deaths occurred in the study. Conclusion. In our series, fetal heart rate tracing abnormalities were the indication for delivery in a small but significant percentage of conservatively managed PPROM cases. Our review suggests that a prospective trial of CFM versus intermittent monitoring techniques should be carried out.
Davis J M; Krew M A; Gill P; Nelson K M; Hopkins M P
Journal of Maternal-Fetal & Neonatal Medicine
2008
2008
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1080/14767050802022789" target="_blank" rel="noreferrer noopener">10.1080/14767050802022789</a>
Increasing lipid adherence to goal
atherosclerosis; cholesterol; Goals; therapy; guidelines; disease; Pharmacology & Pharmacy; Lipids; program; risk; population; care; impact; trials; guidelines; Assistant; Calculator; Personal Digital
BACKGROUND: In April 2004, the National Cholesterol Education Program Adult Treatment Panel III Guidelines for management of high cholesterol encouraged even lower levels of low-density lipoprotein (LDL) than previous guidelines for high and very high risk groups. Assessing patients' risk factors to determine LDL goals is the first step to help guide therapy. OBJECTIVE: To determine whether the use of the Mobile Lipid Clinic Personal Digital Assistant (PDA) Calculator during office visits will increase the number of patients achieving their LDL goal compared to using electronic medical records or conventional methods. METHODS: Four family medicine residency programs affiliated with the Northeastern Ohio Network participated with each site using a different method. The PDA site used the Mobile Lipid Clinic Calculator, the second site used electronic health records (EHRs), the control site used usual care methods, and the transition site moved from paper charts to EHRs during the study. In 2006, baseline chart reviews were conducted to randomly enroll 100 patients per site (aged 40-75 years) with LDL levels at least 10% above goal. In 2007, follow-up chart reviews were conducted on the same patients to determine reductions in LDL and the percent of patients that reached their LDL goals. RESULTS: The percentage reaching their LDL goal and option goal were as follows: PDA site 27% and 12%, EHR site 19% and 3%, control site 4% and 1%, transition site 32% and 12%. Cholesterol-lowering medication usage increased significantly from 38% at baseline to 47% at follow-up (chi(2) = 149.5, P < 0.0001). CONCLUSIONS Using a PDA tool can be just as effective as EHRs in getting patients to their LDL goal and is better than some conventional methods, suggesting the benefit of utilizing technology to improve patient care and health outcomes. (C) 2008 National Lipid Association. All rights reserved.
Davidson E; Uhlenhake E; McCord G
Journal of Clinical Lipidology
2008
2008-10
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/j.jacl.2008.06.010" target="_blank" rel="noreferrer noopener">10.1016/j.jacl.2008.06.010</a>
GEOCHEMICAL RECONSTRUCTION OF THE FFEDING ECOLOGY AND HABITAT PREFERENCES OF REMINGTONOCETIDS
Paleontology
Clementz M; Bajpai S; Thewissen J G M
Journal of Vertebrate Paleontology
2008
2008-09
Journal Article or Conference Abstract Publication
n/a
Vascular Endothelial Growth Factor and the Collateral Circulation The Story Continues
angiogenesis; arteriogenesis; receptors; cells; Cardiovascular System & Cardiology; expression; Hematology; skeletal-muscle; permeability factor; vasculogenesis; vasculotropin; vegf family-members
Chilian W M; Pung Y F
Circulation Research
2008
2008-10
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1161/01.RES.0000338258.90706.2c" target="_blank" rel="noreferrer noopener">10.1161/01.RES.0000338258.90706.2c</a>
Perceived risks, drinking habits, and willingness to change among older at-risk drinkers
Geriatrics & Gerontology
Chen O; Moore A A
Journal of the American Geriatrics Society
2008
2008-04
Journal Article or Conference Abstract Publication
n/a
A male infant with anhidrotic ectodermal dysplasia/immunodeficiency accompanied by incontinentia pigmenti and a mutation in the NEMO pathway
Dermatology; dysplasia; immunodeficiency
Patients with anhidrotic ectodermal dysplasia and immunodeficiency (EDA-ID)) have mutations in the gene on the X chromosome encoding nuclear factor kappa B (NF-kappa B) essential modulator (NEMO), resulting in conical teeth, sparse hair, anhidrosis or hypohydrosis, and recurrent bacterial infections. The same gene is mutated in incontinentia pigmenti (IP), and mutations that do not completely abolish NF-kappa B activity allow survival of male fetuses. We present a case of a 1-year-old boy with a history of EDA-ID) who was evaluated for an eruption that intermittently affected his scalp, upper back, cheeks, legs, and arms. A biopsy specimen taken from the back showed the presence of compact dyskeratotic cells with fragmented nuclei and numerous apoptotic keratinocytes scattered throughout the spinous and granular layer. The diagnosis of EDA-ID) with IP was made. This case illustrates the complexity and overlapping features of the genodermatoses involving signaling pathways of the cell.
Chang T T; Behshad R; Brodell R T; Gilliam A C
Journal of the American Academy of Dermatology
2008
2008-02
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/j.jaad.2007.02.024" target="_blank" rel="noreferrer noopener">10.1016/j.jaad.2007.02.024</a>
A Dual Role for Granulocyte-Colony Stimulating Factor in Promotion of Coronary Collateral Growth and Production of Cardiomyocyte Reactive Oxygen Species
Cardiovascular System & Cardiology
Carrao A C; Chilian W M; Yun J; Kolz C; Rocic P; Buschmann I
Circulation
2008
2008-10
Journal Article or Conference Abstract Publication
n/a
Emergency Physician Geriatric Education: An Update of the 1992 Geriatric Task Force Survey. Has Anything Changed?
Emergency Medicine
Carpenter C R; Lewis L M; Caterino J M; Wilber S T; Scheatzle M D; Fiorello A B
Annals of Emergency Medicine
2008
2008-10
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/j.annemergmed.2008.06.402" target="_blank" rel="noreferrer noopener">10.1016/j.annemergmed.2008.06.402</a>
Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues
in-vitro; central-nervous-system; Hematology; blood-brain-barrier; ccx-ckr; cutting edge; d6; dendritic cell; experimental autoimmune encephalomyelitis; immune-response; sjogrens-syndrome
In vitro studies have implicated chemokine receptors in consumption and clearance of specific ligands. We studied the role that various signaling chemokine receptors play during ligand homeostasis in vivo. We examined the levels of ligands in serum and CNS tissue in mice lacking chemokine receptors. Compared with receptor-sufficient controls, Cx3cr1(-/-) mice exhibited augmented levels of CX3CL1 both in serum and brain, and circulating levels of CXCL1 and CXCL2 were increased in Cxcr2(-/-) mice. CCR2-deficient mice showed significantly increased amounts of circulating CCL2 compared with wild-type mice. Cxcr3(-/-) mice revealed increased levels of circulating and brain CXCL10 after experimental autoimmune encephalomyelitis (EAE) induction. CCR2-deficient peripheral blood and resident peritoneal cells exhibited reduced binding capacity and biologic responses to the CCR1 ligand CCL3, suggesting that elevated levels of CCR2 ligands had down-regulated CCR1. The results indicate that signaling chemokine receptors clear chemokines from circulation and tissues. These homeostatic functions of signaling chemokine receptors need to be integrated into safety and efficacy calculations when considering therapeutic receptor blockade.
Cardona A E; Sasse M E; Liu L P; Cardona S M; Mizutani M; Savarin C; Hu T; Ransohoff R M
Blood
2008
2008-07
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1182/blood-2007-10-118497" target="_blank" rel="noreferrer noopener">10.1182/blood-2007-10-118497</a>
Successful treatment of alopecia universalis with alefacept: A case report and review of the literature
Dermatology; tumor-necrosis-factor; areata; etanercept; factor-alpha
Alopecia universalis often responds poorly to standard therapies. We report how a novel treatment option, alefacept, was successfully used in the management of a 21-year-old woman with alopecia universalis. The patient responded with complete regrowth of scalp and body hair after a single 12-week treatment course of alefacept. In addition, a review of the literature was performed pertaining to the use of biologic agents in the treatment of alopecia areata/universalis to determine which agents have a potential role in the treatment of this often refractory disease.
Bui K; Polisetty S; Gilchrist H; Jackson S M; Frederic J
Cutis
2008
2008-05
Journal Article or Conference Abstract Publication
n/a
Statement of the science concerning locoregional treatments after preoperative chemotherapy for breast cancer: A National Cancer Institute conference
Oncology; reconstruction; neoadjuvant chemotherapy; mastectomy; lymph-node biopsy; mri; b-27; local-regional recurrence; pathological tumor size; postmastectomy radiation improves; project protocol; surgical adjuvant breast
Purpose To review the state of the science with respect to diagnostic imaging and locoregional therapy for patients with breast cancer receiving preoperative chemotherapy. Methods Published data relevant to clinical staging, monitoring of tumor response, and locoregional therapy for patients with breast cancer treated with preoperative chemotherapy were reviewed. Results High-quality data from prospective randomized trials are limited. Available data suggest that locoregional therapy decisions should be based on both the pretreatment clinical extent of disease and the pathologic extent of the disease after chemotherapy. Accordingly, physical examination and imaging studies that accurately define the initial extent of disease are required before treatment. Sentinel lymph node biopsy can be performed either before or after preoperative chemotherapy for patients with clinical N0 disease. The success of breast conservation after preoperative chemotherapy depends on careful patient selection and achieving negative surgical margins. Adjuvant breast radiation is indicated for all patients treated with breast conservation. For patients treated with mastectomy, chest-wall and regional nodal radiation should be considered for those who present with clinical stage III disease or have histologically positive lymph nodes after preoperative chemotherapy. Additional prospective studies are needed to determine the value of postmastectomy radiation for patients with stage II breast cancer who have negative lymph nodes after chemotherapy. Conclusion The increased use of preoperative chemotherapy has raised new questions concerning the optimal methods to stage and monitor disease response to treatment and how to optimize locoregional treatment. The available evidence suggests that a multidisciplinary approach improves outcomes.
Buchholz T A; Lehman C D; Harris J R; Pockaj B A; Khouri N; Hylton N F; Miller M J; Whelan T; Pierce L J; Esserman L J; Newman L A; Smith B L; Bear H D; Mamounas E P
Journal of Clinical Oncology
2008
2008-02
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1200/jco.2007.15.0326" target="_blank" rel="noreferrer noopener">10.1200/jco.2007.15.0326</a>
Cost-effectiveness of wart treatment
Dermatology; efficacy; verruca-vulgaris; duct tape
Brodell R T; Mostow E
British Journal of Dermatology
2008
2008-02
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1111/j.1365-2133.2007.08327.x" target="_blank" rel="noreferrer noopener">10.1111/j.1365-2133.2007.08327.x</a>
Surfactant protein D alters allergic lung responses in mice and human subjects
inflammation; asthma; Immunology; polymorphism; lung; Allergy; endotoxin; Aspergillus; deficient mice; Allergy; aspergillus-fumigatus; d gene; emphysema; eosinophil; hygiene hypothesis; IL-13; sftpd gene; sp-a; surfactant protein D
Background: Surfactant protein (SP) D has been proposed to be protective in allergic airway responses. Objective: We aimed to determine the effect of SP-D deficiency on murine and human airway allergy. Methods: Immunologic responses of SP-D gene-deficient mice (Sftpd(-/-)) at baseline and after 4 intranasal Aspergillus fumigatus exposures were assessed. In addition, the significance of a single nucleotide polymorphism (Met(11)Thr) in the human SP-D gene (known to decrease SP-D function) was investigated. Results: Macrophage and neutrophil bronchoalveolar lavage fluid levels and large airway mucus production were increased in naive Sftpd(-/-) mice in association with increased lung CCL17 levels and CD4(+) T cell numbers. T(H)2-associated antibody levels (IgG1 and IgE) were significantly lower in 4- to 5-week-old Sftpd(-/-) mice (P <.05). Accordingly, naive Sftpd(-/-) splenocytes released significantly less IL-4 and IL-13 on anti-CD3/CD28 stimulation (P <.01). After intranasal allergen exposures, a modest decrease in bronchoalveolar lavage fluid eosinophilia and IL-13 levels was observed in Sftpd(-/-) mice compared with values seen in wild-type mice in association with decreased airway resistance (P <.01). A single nucleotide polymorphism in the SFTPD gene, affecting SP-D levels and pathogen binding, was associated with decreased atopy in black subjects and potentially lower asthma susceptibility in white subjects. Conclusion: Sftpd(-/-) mice have an impaired systemic T(H)2 response at baseline and reduced inflammation and airway responses after allergen exposure. Translational studies revealed that a polymorphism in the SFTPD gene was associated with lower atopy and possibly asthma susceptibility. Taken together, these results support the hypothesis that SP-D-dependent innate immunity influences atopy and asthma.
Brandt E B; Mingler M K; Stevenson M D; Wang N; Hershey G K K; Whitsett J A; Rothenberg M E
Journal of Allergy and Clinical Immunology
2008
2008-05
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/j.jaci.2008.02.011" target="_blank" rel="noreferrer noopener">10.1016/j.jaci.2008.02.011</a>
Use of Horizontal Rafting Plates for Posterior Elements of Complex Tibial Plateau Fractures: Description and Case Reports
Surgery; General & Internal Medicine; internal fixation; operative treatment
Bermudez C A; Ziran B H; Barrette-Grischow M K
Journal of Trauma-Injury Infection and Critical Care
2008
2008-11
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1097/01.ta.0000222943.45563.b5" target="_blank" rel="noreferrer noopener">10.1097/01.ta.0000222943.45563.b5</a>
Decompression syndrome and the evolution of deep diving physiology in the Cetacea
Cetacea; ocean; behavior; Science & Technology - Other Topics; blue; avascular osteonecrosis; beaked-whales; behaviorally induced paleopathology; dive; diving; gas-bubble lesions; mysticeti; odontoceti; Physiology; ziphiidae
Whales repetitively dive deep to feed and should be susceptible to decompression syndrome, though they are not known to suffer the associated pathologies. Avascular osteonecrosis has been recognized as an indicator of diving habits of extinct marine amniotes. Vertebrae of 331 individual modern and 996 fossil whales were subjected to macroscopic and radiographic examination. Avascular osteonecrosis was found in the Oligocene basal odontocetes (Xenorophoidea) and in geologically younger mysticetes, such as Aglaocetus [a sister taxon to Balaenopteridae+(Balaenidae+Eschrichtiidae) clade]. These are considered as early "experiments" in repetitive deep diving, indicating that they independently converged on their similar specialized diving physiologies.
Beatty B L; Rothschild B M
Naturwissenschaften
2008
2008-09
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1007/s00114-008-0385-9" target="_blank" rel="noreferrer noopener">10.1007/s00114-008-0385-9</a>
The effect of pilot hole size on the insertion torque and pullout strength of self-tapping cortical bone screws in osteoporotic bone
Surgery; osteoporosis; General & Internal Medicine; biomechanical testing; pilot; holding power; hole size; insertion torque; pullout strength; self-tapping cortical screws
Background: All surgical screws can experience failure if the torsional, tensile, and flexion loads exerted on the screws are excessively high. The use of self-tapping screws (STS) results in higher insertion torques (IT) as these screws cut their own threads in the pilot hole drilled in the bone. In this study, the torque for inserting the STS into an osteoporotic bone block for different pilot hole sizes (PHS) was measured and the pullout strength (PS) for extraction of the screws was determined for different depths of insertion, 0 mm, 1 mm, and 2 mm beyond the far cortex. Methods: Seventy-two Synthes stainless steel STS (40 mm length and 3.5 mm diameter) were inserted into pilot holes of sizes 2.55 (A: 73% OD), 2.50 (B: 71.5%), 2.45 (C: 70 %), and 2.8 mm (D: 80 %). Using a digital torque screwdriver, screws were inserted to 0 mm, 1 mm or 2 mm past the far cortex. Pullout tests were conducted with an Instron materials testing system. Analysis of variance,and Student-Neuman-Keuls tests were performed to determine the effect of DOI and PHS on the loading energy, PS, and IT. Results: Results demonstrated that IT of the screws inserted into pilot holes A, B, and C were higher than those in D. It was also observed that PS and loading energy for 1 rum and 2 mm penetration past the far cortex were higher than those for 0 mm regardless of PHS. This study also found that an increase in PHS to 2.8 mm will reduce IT but will also reduce the PS relative to a PHS of 2.5 mm, the current standard for 3.5 mm screws. Conclusions: The results of previously published studies regarding the effect of pilot hole size on PS in healthy cortical bone cannot be applied to the osteoporotic environment. The findings presented in this research support using PHS no larger than 71.5% of the screw outer diameter (i.e., pilot hole size of 2.5 mm for 3.5 mm screws) and inserting screws at least 2 mm beyond the far cortex to maximize PS and minimize iatrogenic damage in osteoporotic bone.
Battula S; Schoenfeld A J; Sahai V; Vrabec G A; Tank J; Njus G O
Journal of Trauma-Injury Infection and Critical Care
2008
2008-04
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1097/TA.0b013e31802bf051" target="_blank" rel="noreferrer noopener">10.1097/TA.0b013e31802bf051</a>
Why smoking prevention programs sometimes fail: Does effectiveness depend on sociocultural context and individual characteristics?
General & Internal Medicine
Barriero T J; Gemmel D J
Southern Medical Journal
2008
2008-02
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1097/SMJ.0b013e31815d2bf2" target="_blank" rel="noreferrer noopener">10.1097/SMJ.0b013e31815d2bf2</a>
Age but not gender differences in serum free cortisol levels
Geriatrics & Gerontology
Bansal D; Jain A; Fedarko N S
Journal of the American Geriatrics Society
2008
2008-04
Journal Article or Conference Abstract Publication
n/a
A retrospective analysis of comminuted intra-articular fractures of the tibial plafond: Open reduction and internal fixation versus external Ilizarov fixation
outcomes; Emergency Medicine; Surgery; management; Orthopedics; General & Internal Medicine; fixation; external; Ilizarov; internal fixation; operative treatment; pilon fracture; pilon fractures; protocol; tibial plafond fracture
Intra-articular fractures of the tibial plafond are complex injuries which continue to challenge orthopaedic surgeons in achieving anatomic reduction, while allowing early weight bearing and return to activity. Although a wide range of treatment options has been described for fixation of piton fractures, the unique characteristic of each injury makes it difficult to advocate a general method of choice. We have attempted to compare a subset of AO/OTA type C piton fractures treated either by a staged procedure of external fixation and conversion to open reduction and internal fixation (ORIF) versus definitive external Ilizarov fixation. Between 1998 and 2004, 42 patients admitted to our level 1 trauma centre underwent either procedure and were followed prospectively. Twenty-eight patients were treated with ORIF and 14 were treated by Ilizarov ring fixator. The outcome measures included time to union, as well as the rates of union, nonunion, malunion and infection. Although the ORIF group had a longer time to heal, the rates of nonunion, malunion and infection were lower compared to the Ilizarov group. However, these differences between the groups were not statistically significant. Thus, based on these results, no clinical recommendation can be made as to which procedure is better and safer for the patient. Future prospective randomised trials are required to determine with more scientific accuracy the optimal treatment strategy for these challenging injuries. (c) 2007 Elsevier Ltd. All rights reserved.
Bacon S; Smith W R; Morgan S J; Hasenboehler E; Philips G; Williams A; Ziran B H; Stahel P F
Injury-International Journal of the Care of the Injured
2008
2008-02
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/j.injury.2007.09.003" target="_blank" rel="noreferrer noopener">10.1016/j.injury.2007.09.003</a>
INSULIN INHIBITS FORKHEAD BOX O1 (FOXO1)-MEDIATED ACTIVATION OF HUMAN BSEP PROMOTER CONTRIBUTING TO INCREASED BILE ACID POOL SIZE IN DIABETES
Gastroenterology & Hepatology
Ananthanarayanan M; Li Y F; Balasubramaniyan N; Li T G; Chiang J; Suchy F J
Hepatology
2008
2008-10
Journal Article or Conference Abstract Publication
n/a
Community-based participatory research in psoriasis
Dermatology
Yang M F; Mostow E N; McCormick T S; Cooper K D; Korman N J
Journal of Investigative Dermatology
2008
2008-10
Journal Article
n/a
MANAGEMENT OF CHRONIC ILLNESS IN AFRICAN AMERICAN GRANDMOTHER CARING FOR GRANDCHILDREN: A CASE STUDY FROM THE AD-LIFE TRIAL
Geriatrics & Gerontology
Wright K; Hazelett S; Jarjoura D; Hua K; Kropp D; Allen K
Gerontologist
2008
2008-10
Journal Article
n/a
Correlation between stroke knowledge and adherence in a predominately elderly stoke population
Geriatrics & Gerontology
Wright K D; Hazelett S; Kropp D; Jarjoura D; Hau K; Weinhardt J; Allen K
Journal of the American Geriatrics Society
2008
2008-04
Journal Article
n/a
The diagnosis of wheezing in children
asthma; disease; General & Internal Medicine; human bocavirus; infants
Wheezing in children is a common problem encountered by family physicians. Approximately 25 to 30 percent of infants will have at least one wheezing episode, and nearly one half of children have a history of wheezing by six years of age. The most common causes of wheezing in children include asthma, allergies, infections, gastroesophageal reflux disease, and obstructive sleep apnea. Less common causes include congenital abnormalities, foreign body aspiration, and cystic fibrosis. Historical data that help in the diagnosis include family history, age at onset, pattern of wheezing, seasonality, suddenness of onset, and association with feeding, cough, respiratory illnesses, and positional changes. A, focused examination and targeted diagnostic testing guided by clinical suspicion also provide useful information. Children with recurrent wheezing or a single episode of unexplained wheezing that does not respond to bronchodilators should undergo chest radiography. Children whose history or physical examination findings suggest asthma should undergo diagnostic pulmonary function testing.
Weiss L N
American Family Physician
2008
2008-04
Journal Article
n/a
Identification and characterization of CIP98 as a novel regulator of mGluR6
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Tian L T; Kammermeier P J; Cismowski M J
Faseb Journal
2008
2008-04
Journal Article
n/a
Variation in masseter muscle fiber architecture in five strains of inbred mice: implications for heritability of fiber architecture
Anthropology; Evolutionary Biology
Taylor A B; Vinyard C J; Payseur B A
American Journal of Physical Anthropology
2008
2008
Journal Article
n/a
Prospective cohort study of type 2 Diabetes Mellitus and the risk of Parkinson's disease
Geriatrics & Gerontology
Smith A; Driver J A; Buring J E; Gaziano J M; Kurth T; Logroscino G
Journal of the American Geriatrics Society
2008
2008-04
Journal Article
n/a
Angiotensin II-induced ERK1/2 activation is mediated by PKC delta and intracellular calcium in cardiac fibroblasts
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Shamhart P; Olson E; Naugle J; Doane K; Meszaros J G
Faseb Journal
2008
2008-04
Journal Article
n/a
Personnel psychology and vocational Psychology: A family reunion for siblings separated since adolescence
Psychology
Savickas M
International Journal of Psychology
2008
2008-06
Journal Article
n/a
Hemodialysis for metformin-associated lactic acidosis
Urology & Nephrology
Sarac E; Zhang H; Detcsco T; Negrete H
American Journal of Kidney Diseases
2008
2008-04
Journal Article
n/a
Cardiovascular events and mortality in chronic kidney disease patients treated with epoetin alfa or darbeipoetin alfa
Urology & Nephrology
Sarac E; Lossev V; Misquitta D J; Dinani A; Gemunel D
American Journal of Kidney Diseases
2008
2008-04
Journal Article
n/a
Role of NAD(P)H Oxidase- and Mitochondria-derived ROS in Coronary Collateral Growth
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Rocic P; Chilian W M
Faseb Journal
2008
2008-04
Journal Article
n/a
Role of NAD(P)H Oxidase- and Mitochondria-derived Reactive Oxygen Species in Coronary Collateral Growth
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Rocic P
Faseb Journal
2008
2008-04
Journal Article
n/a
The Mechanistic Basis for the Disparate Effects of Ang II on Coronary Collateral Growth
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Rocic P
Faseb Journal
2008
2008-04
Journal Article
n/a