Browse Items · NEOMED Bibliography Database

Include discussions and review of systems regarding inflammatory bowel disease in patients starting isotretinoin therapy: comment on "Isotretinoin therapy and inflammatory bowel disease".

Tags: 2011, Acne Vulgaris/*drug therapy, Archives of dermatology, Dermatologic Agents/*adverse effects/therapeutic use, Humans, Inflammatory Bowel Diseases/*chemically induced, Isotretinoin/*adverse effects/therapeutic use, Legal, Liability, Mostow Eliot N

Practice Gaps. Skin cancer detection in hair salons: opportunity knocking: comment on "Skin cancer knowledge, attitudes, and behaviors in the salon".

Tags: *Barbering, *Health Knowledge, 2011, Archives of dermatology, Attitudes, Basal Cell/*psychology, Carcinoma, Female, Humans, Male, Melanoma/*psychology, Mostow Eliot N, Practice, Skin Neoplasms/*psychology, Squamous Cell/*psychology

Discontinuing dapsone treatment and reintroducing dietary gluten in patients with dermatitis herpetiformis in remission: comment on "remission in dermatitis herpetiformis".

Tags: 2011, Archives of dermatology, Dapsone/administration & dosage/*therapeutic use, Dermatitis Herpetiformis/diet therapy/drug therapy/*physiopathology, Dermatology/methods, Diet, Evidence-Based Medicine, Gluten-Free/*methods, Glutens/administration & dosage, Humans, Mostow Eliot N, Patient Education as Topic, Practice Guidelines as Topic, Remission Induction/methods

Fetal lung epithelial ion channels relocate in the cell membrane during late gestation.

Near the end of gestation, the direction of ion and fluid flow across the alveolar epithelium rapidly changes from secretion to absorption. Thus, the relative cell membrane location of epithelial Na channels (ENaCs) and cystic fibrosis transmembrane…

Development of the skull of the pantropical spotted dolphin (Stenella attenuata).

We describe the bony and cartilaginous structures of five fetal skulls of Stenella attenuata (pantropical spotted dolphin) specimens. The specimens represent early fetal life as suggested by the presence of rostral tactile hairs and the beginnings of…

Tags: 2011, Anatomical record (Hoboken, N.J. : 2007), Animals, Department of Anatomy & Neurobiology, Ear, Ear Ossicles/anatomy & histology/growth & development, Middle/anatomy & histology/growth & development, Moran Meghan M, NEOMED College of Medicine, Nummela Sirpa, Skull/*anatomy & histology/*growth & development, Stenella/*anatomy & histology/*growth & development, Thewissen J G M

Are we looking for loads in all the right places? New research directions for studying the masticatory apparatus of New World monkeys.

New World monkeys display a wide range of masticatory apparatus morphologies related to their diverse diets and feeding strategies. While primatologists have completed many studies of the platyrrhine masticatory apparatus, particularly morphometric…

Tags: 2011, Anatomical record (Hoboken, N.J. : 2007), Animals, Biological Evolution, Eating/physiology, Feeding Behavior/*physiology, Glander Kenneth E, Jaw/anatomy & histology/physiology, Mandible/anatomy & histology/*physiology, Mastication/*physiology, Platyrrhini/anatomy & histology/*physiology, Ravosa Matthew J, Rossie James B, Ryan Timothy M, Taylor Andrea B, Teaford Mark F, Vinyard Christopher J, Williams Susan H

Design and use of peptide-based antibodies decreasing superoxide production by mitochondrial complex I and complex II.

Mitochondria are the major source of reactive oxygen species. Both complex I and complex II mediate O2*- production in mitochondria and host reactive protein thiols. To explore the functions of the specific domains involved in the redox modifications…

Overexpression of cholesterol 7alpha-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis.

UNLABELLED: We reported previously that mice overexpressing cytochrome P450 7a1 (Cyp7a1; Cyp7a1-tg mice) are protected against high fat diet-induced hypercholesterolemia, obesity, and insulin resistance. Here, we investigated the underlying mechanism…

The presence of extracellular matrix alters the chondrocyte response to endoplasmic reticulum stress.

The objective of this study was to test the hypothesis that extracellular matrix (ECM) would alter the endoplasmic reticulum (ER) stress response of chondrocytes. Chondrocytes were isolated from calf knees and maintained in monolayer culture or…

Caudate body (CB) sign: new early CT sign of hyperacute anterior cerebral circulation infarction.

This case series describes the caudate body (CB) sign noted in computed tomography (CT) scans of patients who presented to the Emergency Department (ED) clinically manifesting symptoms suggestive of anterior cerebral circulation infarction. This sign…

Tags: *Tomography, 2011, 80 and over, Aged, Ahmed Shamima Y, Basal Ganglia – Pathology, Brain Infarction/*diagnostic imaging, Caudate Nucleus/*pathology, Emergency Medicine, Emergency radiology, Female, Humans, Infarction – Radiography, Khalaf Hamzah Suhail, Kurman Andrew J, Male, Tomography, X-Ray Computed, Young Adult

Complete remission in a patient with metastatic mixed adenocarcinoma/extrapulmonary small cell carcinoma of the prostate.

Approximately 10% of all extra-pulmonary small cell carcinoma (EPSCC) arises in the prostate either as de novo mixed adenocarcinoma with small cell components or a pure small cell carcinoma. Extensive disease carries a median survival of about 10…

Tags: 2011, Adenocarcinoma/diagnosis/*secondary, Androgen Antagonists/therapeutic use, Bone Neoplasms/*drug therapy/*secondary, Brammer Jonathan Edward, Carcinoma, Cisplatin/therapeutic use, Combined Modality Therapy, Etoposide/therapeutic use, Humans, International journal of clinical oncology, Lulla Premal, Lung Neoplasms/diagnosis/*secondary, Lynch Garrett Rush, Male, Middle Aged, Prostatic Neoplasms/*drug therapy/metabolism/*pathology, Remission Induction, Small Cell/diagnosis/*secondary

Development of tinnitus in CBA/CaJ mice following sound exposure.

Tinnitus, the perception of a sound without an external acoustic source, is a complex perceptual phenomenon affecting the quality of life in 17% of the adult population. Despite its ubiquity and morbidity, the pathophysiology of tinnitus is a work in…

Tags: 2011, Animals, Auditory, Brain Stem, Department of Anatomy & Neurobiology, Evoked Potentials, Galazyuk Alexander V, Inbred CBA, Journal of the Association for Research in Otolaryngology : JARO, Longenecker Ryan J, Mice, NEOMED College of Medicine, Noise/*adverse effects, Reflex, Startle, Tinnitus/*etiology/physiopathology

Chemopreventive doses of resveratrol do not produce cardiotoxicity in a rodent model of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC), one of the most lethal cancers, results in more than one million fatalities worldwide every year. In view of the limited therapeutic alternatives and poor prognosis of liver cancer, preventive control approaches,…

Tags: *Chemoprevention, 2011, Analysis of Variance, Animal, Animal Studies, Animal/drug effects, Animals, Antioxidants, Behavior, Bishayee Anupam, Blotting, Booth Tristan D, Carcinoma, Cardiotoxicity, Cardiotoxins/*toxicity, Chemoprevention, Data Analysis Software, Department of Integrative Medical Sciences, Descriptive Statistics, Disease Models, Doppler, Dose-Response Relationship, Drug, Echocardiography, Feeding Behavior/drug effects, Female, Fisher's Exact Test, Funding Source, Heart – Drug Effects, Heart/drug effects/physiopathology, Hepatocellular – Prevention and Control, Hepatocellular/*drug therapy/pathology/physiopathology, Hepatocytes/drug effects/pathology, Hodnichak Cheryl M, Humans, Investigational new drugs, Liver Neoplasms/*drug therapy/pathology/physiopathology, Liver/drug effects/pathology/physiopathology, Luther Daniel J, Meszaros J Gary, NEOMED College of Medicine, Ohanyan Vahagn, Polyphenols – Therapeutic Use, Rats, Resveratrol, Shamhart Patricia E, Sisakian Hamayak, Sprague-Dawley, Stilbenes/*therapeutic use, Systole/drug effects, Western

The treachery of images: how Rene Magritte informs medical education.

Using Rene Magritte's well-known painting The Treachery of Images (This is not a pipe), we argue that the current focus on competencies throughout medical education can sometimes lead educators to rely too heavily on scores, checkmarks, or other…

Tags: *Medicine in the Arts, 2011, Competency-Based Education/methods, Department of Family & Community Medicine, Department of Internal Medicine, Education, Educational Measurement/methods, Humans, Journal of general internal medicine, Medical/*methods, NEOMED College of Medicine, Paintings/*psychology, Teaching/methods, Wear Delese, Zarconi Joseph

Multimodal drugs and their future for Alzheimer's and Parkinson's disease.

This chapter discusses the rationale for developing multimodal or multifunctional drugs (also called designed multiple ligands or DMLs) aimed at disease-modifying treatment strategies for the most common neurodegenerative diseases Alzheimer's and…

Tags: 2011, Alzheimer Disease/*drug therapy/*enzymology/prevention & control, Animals, Combined Modality Therapy/*methods, Forecasting, Geldenhuys Werner J, Humans, International review of neurobiology, Monoamine Oxidase Inhibitors/*pharmacology/therapeutic use, Parkinson Disease/*drug therapy/*enzymology/prevention & control, Van der Schyf Cornelis J

A multi-dimensional measure of vocational identity status.

Establishing a worker identity is among the most central aspects of the transition from adolescence to adulthood. Despite its importance, few measures with acceptable psychometric and conceptual characteristics exist to assess vocational identity…

Tags: *Career Choice, *Employment, 2011, Department of Family & Community Medicine, Female, Humans, Journal of adolescence, Lee Bora, Male, NEOMED College of Medicine, Ohio, Porfeli Erik J, Psychometrics, Surveys and Questionnaires/*standards, Vondracek Fred W, Weigold Ingrid K, Young Adult

Structure-activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B.

The neuroprotective activity of pioglitazone and rosiglitazone in the MPTP parkinsonian mouse prompted us to evaluate a set of thiazolidinedione (TZD) type compounds for monoamine oxidase A and B inhibition activity. These compounds were able to…

A novel binding assay identifies high affinity ligands to the rosiglitazone binding site of mitoNEET.

A novel outer mitochondrial membrane protein containing [2Fe-2S] clusters, mitoNEET was first identified through its binding to the anti-diabetic drug pioglitazone. Pioglitazone belongs to a family of drugs that are peroxisome proliferator-activated…

Tags: 2011, Awale Prabha S, Binding Sites/drug effects, Bioorganic & medicinal chemistry letters, Carroll Richard T, Dose-Response Relationship, Drug, Funk Max O, Geldenhuys Werner J, Ligands, Lin Li, Mitochondrial Proteins/*antagonists & inhibitors/metabolism, Molecular Structure, Recombinant Proteins/antagonists & inhibitors/metabolism, Rosiglitazone, Stereoisomerism, Structure-Activity Relationship, Thiazolidinediones/chemical synthesis/chemistry/*pharmacology

3D-Quantitative structure-activity relationship and docking studies of the tachykinin NK3 receptor.

The tachykinin NK(3) receptor (NK(3)R) is a novel drug target for schizophrenia and drug abuse. Since few non-peptide antagonists of this G protein-coupled receptor are available, we have initiated this study to gain a better understanding of the…

Tags: *Quantitative Structure-Activity Relationship, 2011, Binding Sites, Bioorganic & medicinal chemistry letters, Computer Simulation, Drug Design, Geldenhuys Werner J, Humans, Ligands, Models, Molecular, Neurokinin-3/*chemistry/metabolism, Protein Structure, Quinolines/chemistry, Receptors, Simmons Mark A, Tertiary

New diagnostic tests for pneumonia: what is their role in clinical practice?

The utility of diagnostic studies to determine the etiologic agents of community-acquired pneumonia has been controversial in part because of the lack of rapid, accurate, easily performed, and cost-effective methods. Advancements in molecular testing…

Tags: 2011, Antigens, Bacterial/*diagnosis/metabolism, Bacterial/urine, Calcitonin/blood, Clinics in chest medicine, Community-Acquired Infections/*diagnosis/metabolism/*microbiology/virology, Department of Internal Medicine, File Thomas M Jr, Humans, NEOMED College of Medicine, Nucleic Acid Amplification Techniques, Pneumonia, Polymerase Chain Reaction, Protein Precursors/blood, Viral/*diagnosis/metabolism

Vitamin B12 protects against superoxide-induced cell injury in human aortic endothelial cells.

Superoxide (O(2)(*-)) is implicated in inflammatory states including arteriosclerosis and ischemia-reperfusion injury. Cobalamin (Cbl) supplementation is beneficial for treating many inflammatory diseases and also provides protection in…

A rare case of carcinosarcoma of the fallopian tube presenting with torsion, rupture and hemoperitoneum.

Fallopian tube carcinosarcomas may present emergently with hemoperitoneum. Fallopian tube carcinosarcomas may be detected better with MR than with CT. Heterologous fallopian tube carcinosarcomas have been reported more often than the homologous type.

Tags: 2011, Carcinosarcoma, Fallopian tube carcinoma, Gupta Rajesh, Gynecologic oncology case reports, Jenison Eric L, Malignant mixed Mullerian tumor, Mixed mesodermal tumor

Cholinergic cells of the pontomesencephalic tegmentum: connections with auditory structures from cochlear nucleus to cortex.

Acetylcholine (ACh) is a neuromodulator that is likely to play a role in plasticity as well as other phenomena at many sites in the auditory system. The auditory cortex receives cholinergic innervation from the basal forebrain, whereas the cochlea…

Crisis intervention team officer dispatch, assessment, and disposition: Interactions with individuals with severe mental illness.

The Crisis Intervention Team (CIT) model is a specialized police response program for people in a mental illness crisis. We analyzed 2174 CIT officers' reports from one community, which were completed during a five year period. These officers'…

Incorporating teaching dermatoethics in a busy outpatient clinic.

Giant tumor of the posterior thigh.

Tags: 2011, Brodell Robert T, Chang Timothy, Helms Amy, Journal of the American Academy of Dermatology, Potaracke Autumn

The effect of freezing and extraction upon striatal dopaminergic function.

Determinations of striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations were compared under conditions where tissue was either frozen followed by extraction (FE) or extracted followed by freezing (EF). In Experiment 1,…

Tags: *Freezing, 2011, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Analysis of Variance, Animals, Chemical Fractionation/methods, Corpus Striatum/*metabolism, Cryopreservation/methods, Dluzen Dean E, Dopamine/*metabolism, Journal of neuroscience methods, Male, Mice, Time Factors

Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats.

Anthocyanins are known to possess potent anticarcinogenic properties against several cancers thus demonstrating potential for cancer prevention. Black currant (Ribes nigrum L., Grossulariaceae) fruits have a high anthocyanin content. This…

Total thyroidectomy: is morbidity higher for Graves' disease than nontoxic goiter?

BACKGROUND: Total thyroidectomy for treatment of Graves' disease is controversial and much of the debate centers on the concern for complications. The purpose of this study was to evaluate the morbidity of total thyroidectomy for Graves' disease and…

Tags: 2011, Adult, Aged, Female, Goiter, Graves Disease/pathology/*surgery, Humans, Hypocalcemia/epidemiology, Male, McHenry Christopher R, Middle Aged, Morbidity, Nodular/pathology/*surgery, Postoperative Complications/epidemiology, Retrospective Studies, The Journal of surgical research, Thyroidectomy/*adverse effects, Welch Kellen C

Neural processing of target distance by echolocating bats: functional roles of the auditory midbrain.

Using their biological sonar, bats estimate distance to avoid obstacles and capture moving prey. The primary distance cue is the delay between the bat's emitted echolocation pulse and the return of an echo. The mustached bat's auditory midbrain…

Tags: 2011, Animals, Auditory Cortex/physiology, Auditory Pathways/*physiology, Auditory Perception/*physiology, Brain Mapping/psychology, Chiroptera/*physiology, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Echolocation/*physiology, Inferior Colliculi/*physiology, Models, NEOMED College of Medicine, Neurological, Neurons/physiology, Neuroscience and biobehavioral reviews, Portfors Christine V, Wenstrup Jeffrey J

Parity decreases methamphetamine-induced striatal dopaminergic perturbation.

The role of parity upon methamphetamine-induced neurotoxicity of the striatal dopaminergic system was assessed. Female CD-1 mice either remained nulliparous or underwent one or three complete pregnancies and were designated as the 0, 1 or 3 pregnancy…

Tags: *Parity, 2011, Animals, Corpus Striatum/*drug effects/metabolism/physiology, Dluzen Dean E, Dopamine/*metabolism, Female, Methamphetamine/*pharmacology, Mice, Neurochemistry international, Pregnancy

mGluRs modulate neuronal firing in the auditory midbrain.

The mechanisms underlying sound-evoked suppression of neuronal firing in the auditory system are poorly understood. To explore these mechanisms in the inferior colliculus (IC), agonists and antagonists targeting different groups of metabotropic…

Neurodegeneration in glaucoma: progression and calcium-dependent intracellular mechanisms.

Glaucoma is an age-related optic neuropathy involving sensitivity to ocular pressure. The disease is now seen increasingly as one of the central nervous system, as powerful new approaches highlight an increasing number of similarities with other…

Tags: 2011, Calcium/*metabolism, Calkins D J, Crish S D, Department of Pharmaceutical Sciences, Disease Progression, Glaucoma/*metabolism/*pathology, Humans, Intracellular Space/metabolism, NEOMED College of Pharmacy, Nerve Degeneration/metabolism/*pathology, Neuroscience

Cholinergic cells in the tegmentum send branching projections to the inferior colliculus and the medial geniculate body.

The pontomesencephalic tegmentum (PMT) provides cholinergic input to the inferior colliculus (IC) and the medial geniculate body (MG). PMT cells are often characterized as projecting to more than one target. The purpose of this study was to determine…

Tags: 2011, Acetylcholine/metabolism, Animals, Auditory Pathways/*cytology, Department of Anatomy & Neurobiology, Female, Geniculate Bodies/*cytology, Guinea Pigs, Immunohistochemistry, Inferior Colliculi/*cytology, Male, Motts S D, NEOMED College of Medicine, Neurons/*cytology/metabolism, Neuroscience, Schofield B R, Tegmentum Mesencephali/*cytology

Multiple origins of cholinergic innervation of the cochlear nucleus.

Acetylcholine (Ach) affects a variety of cell types in the cochlear nucleus (CN) and is likely to play a role in numerous functions. Previous work in rats suggested that the acetylcholine arises from cells in the superior olivary complex, including…

Tags: *Cholinergic Fibers, 2011, Acetylcholine/metabolism, Animals, Auditory Pathways/*cytology/metabolism, Cochlear Nucleus/*anatomy & histology/metabolism, Department of Anatomy & Neurobiology, Guinea Pigs, Immunohistochemistry, Mellott J G, Motts S D, NEOMED College of Medicine, Neuroscience, Schofield B R

The emergence of designed multiple ligands for neurodegenerative disorders.

The incidence of neurodegenerative diseases has seen a constant increase in the global population, and is likely to be the result of extended life expectancy brought about by better health care. Despite this increase in the incidence of…

Tags: *Drug Design, *Ligands, 2011, Amyloid beta-Peptides/metabolism, Antiparkinson Agents/therapeutic use, Carroll Richard T, Clinical Trials as Topic, Geldenhuys Werner J, Humans, Molecular Structure, Neurodegenerative Diseases/*drug therapy, Neuroprotective Agents/*therapeutic use, Progress in neurobiology, Van der Schyf Cornelis J, Youdim Moussa B H

Adjacent segment degeneration after lumbar spinal fusion: risk factors and implications for clinical practice.

Tags: 2011, Humans, Intervertebral Disc Degeneration/*surgery, Lumbar Vertebrae/*surgery, Risk Factors, Schoenfeld Andrew J, Spinal Fusion, The spine journal : official journal of the North American Spine Society

Mortality in elderly patients with hyperostotic disease of the cervical spine after fracture: an age- and sex-matched study.

BACKGROUND CONTEXT: Several reports indicate that patients with ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH) have increased mortality after cervical spine fractures. However, outcomes of the fractured hyperostotic…

Outcomes after spine surgery among racial/ethnic minorities: a meta-analysis of the literature.

BACKGROUND CONTEXT: Prior research has identified disparities in access to care, resource utilization, and outcomes in members of racial and ethnic minorities. However, the role that race/ethnicity may play in influencing outcomes after spine surgery…

Tags: *Ethnic Groups, 2011, Bader Julia O, Belmont Philip J Jr, Bono Christopher M, Healthcare Disparities/ethnology/statistics & numerical data, Humans, Li Gang, Postoperative Complications/*ethnology, Schoenfeld Andrew J, Sieg Ryan N, Spinal Diseases/*ethnology/*surgery, Spine/*surgery, The spine journal : official journal of the North American Spine Society, Treatment Outcome

Technique for preservation of penile skin in genital reconstruction: free graft to the scrotum.

OBJECTIVE: To describe a new technique to preserve the penile epithelium with good cosmetic results when additional surgery is a significant possibility. Complex genital reconstruction can require multiple procedures. METHODS: Seven patients…

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